{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:25:33Z","timestamp":1768829133328,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial infarction is caused by insufficient coronary blood supply, which leads to myocardial damage and eventually the heart failure. Molecular mechanisms associated with the loss of cardiomyocytes during myocardial infarction (MI) and ischemia-related cardiac diseases are not yet fully understood. Nogo-C is an endoplasmic reticulum protein ubiquitously expressed in tissues including in the heart, however, the cardiac function of Nogo-C is still unknown. In the present study, we found that Nogo-C was upregulated in mouse hearts after MI, and hypoxic treatments also increased Nogo-C protein level in cardiomyocytes. Adenovirus mediated overexpression of Nogo-C led to cardiomyocyte apoptosis, whereas knockdown of Nogo-c by shRNA protected cardiomyocytes from hypoxia-induced cell apoptosis. Importantly, Nogo-C knockout mice displayed improved cardiac function, smaller infarct area, and less apoptotic cells after MI. Moreover, we found that miR-182 negatively regulated Nogo-C expression and was downregulated during MI, expressing miR-182 in cardiomyocytes protected hypoxia- and Nogo-C-mediated cell apoptosis. Our results indicate that increased cardiac Nogo-C expression is both sufficient and necessary for ischemia-induced cardiomyocyte apoptosis and cardiac dysfunction, suggesting that deregulation of Nogo-C by miRNA may be a potential therapeutic target for ischemia-related heart diseases.<\/jats:p>","DOI":"10.1038\/cddis.2016.331","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T12:52:47Z","timestamp":1476967967000},"page":"e2432-e2432","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Nogo-C regulates cardiomyocyte apoptosis during mouse myocardial infarction"],"prefix":"10.1038","volume":"7","author":[{"given":"Shi","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangpo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"BFcddis2016331_CR1","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ijcard.2012.10.046","volume":"168","author":"JA Finegold","year":"2013","unstructured":"Finegold JA, Asaria P, Francis DP . Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol 2013; 168: 934\u2013945.","journal-title":"Int J Cardiol"},{"key":"BFcddis2016331_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.2190\/HS.43.3.d","volume":"43","author":"AR Katz","year":"2013","unstructured":"Katz AR . Noncommunicable diseases: global health priority or market opportunity? An illustration of the World Health Organization at its worst and at its best. Int J Health Serv 2013; 43: 437\u2013458.","journal-title":"Int J Health Serv"},{"key":"BFcddis2016331_CR3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jacc.2014.11.006","volume":"65","author":"RA Kloner","year":"2015","unstructured":"Kloner RA . New observations regarding post-ischemia\/reperfusion myocardial swelling. J Am Coll Cardiol 2015; 65: 324\u2013326.","journal-title":"J Am Coll Cardiol"},{"key":"BFcddis2016331_CR4","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.freeradbiomed.2011.05.004","volume":"51","author":"K Sugamura","year":"2011","unstructured":"Sugamura K, Keaney JF Jr. . Reactive oxygen species in cardiovascular disease. Free Radic Biol Med 2011; 51: 978\u2013992.","journal-title":"Free Radic Biol Med"},{"key":"BFcddis2016331_CR5","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/j.cellsig.2014.05.002","volume":"26","author":"AA Waza","year":"2014","unstructured":"Waza AA, Andrabi K, Hussain MU . Protein kinase C (PKC) mediated interaction between conexin43 (Cx43) and K(+)(ATP) channel subunit (Kir6.1) in cardiomyocyte mitochondria: Implications in cytoprotection against hypoxia induced cell apoptosis. Cell Signal 2014; 26: 1909\u20131917.","journal-title":"Cell Signal"},{"key":"BFcddis2016331_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.gene.2015.09.030","volume":"575","author":"T Yokota","year":"2016","unstructured":"Yokota T, Wang Y . p38 MAP kinases in the heart. Gene 2016; 575: 369\u2013376.","journal-title":"Gene"},{"key":"BFcddis2016331_CR7","first-page":"1573","volume":"76","author":"Y Senga","year":"1985","unstructured":"Senga Y, Satomi Y, Fukuda M, Misugi K . A case of renal cell carcinoma in childhood. Nihon Hinyokika Gakkai Zasshi 1985; 76: 1573\u20131579.","journal-title":"Nihon Hinyokika Gakkai Zasshi"},{"key":"BFcddis2016331_CR8","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/35000219","volume":"403","author":"MS Chen","year":"2000","unstructured":"Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000; 403: 434\u2013439.","journal-title":"Nature"},{"key":"BFcddis2016331_CR9","doi-asserted-by":"publisher","first-page":"8061","DOI":"10.1523\/JNEUROSCI.20-21-08061.2000","volume":"20","author":"C Brosamle","year":"2000","unstructured":"Brosamle C, Huber AB, Fiedler M, Skerra A, Schwab ME . Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment. J Neurosci 2000; 20: 8061\u20138068.","journal-title":"J Neurosci"},{"key":"BFcddis2016331_CR10","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1242\/dev.048371","volume":"137","author":"MM Petrinovic","year":"2010","unstructured":"Petrinovic MM, Duncan CS, Bourikas D, Weinman O, Montani L, Schroeter A et al. Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Development 2010; 137: 2539\u20132550.","journal-title":"Development"},{"key":"BFcddis2016331_CR11","doi-asserted-by":"publisher","first-page":"E1943","DOI":"10.1073\/pnas.1216203110","volume":"110","author":"T Walchli","year":"2013","unstructured":"Walchli T, Pernet V, Weinmann O, Shiu JY, Guzik-Kornacka A, Decrey G et al. Nogo-A is a negative regulator of CNS angiogenesis. Proc Natl Acad Sciences USA 2013; 110: E1943\u2013E1952.","journal-title":"Proc Natl Acad Sciences USA"},{"key":"BFcddis2016331_CR12","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1523\/JNEUROSCI.22-09-03553.2002","volume":"22","author":"AB Huber","year":"2002","unstructured":"Huber AB, Weinmann O, Brosamle C, Oertle T, Schwab ME . Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions. J Neurosci 2002; 22: 3553\u20133567.","journal-title":"J Neurosci"},{"key":"BFcddis2016331_CR13","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3389\/fncel.2015.00454","volume":"9","author":"C Eckharter","year":"2015","unstructured":"Eckharter C, Junker N, Winter L, Fischer I, Fogli B, Kistner S et al. Schwann cell expressed Nogo-B modulates axonal branching of adult sensory neurons through the Nogo-B receptor NgBR. Front Cell Neurosci 2015; 9: 454.","journal-title":"Front Cell Neurosci"},{"key":"BFcddis2016331_CR14","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1182\/blood-2010-04-281956","volume":"117","author":"A Di Lorenzo","year":"2011","unstructured":"Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC . Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood 2011; 117: 2284\u20132295.","journal-title":"Blood"},{"key":"BFcddis2016331_CR15","doi-asserted-by":"publisher","first-page":"88ra55","DOI":"10.1126\/scitranslmed.3002194","volume":"3","author":"G Sutendra","year":"2011","unstructured":"Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z et al. The role of Nogo and the mitochondria\u2013endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med 2011; 3: 88ra55.","journal-title":"Sci Transl Med"},{"key":"BFcddis2016331_CR16","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.neuroscience.2009.06.042","volume":"163","author":"N Marklund","year":"2009","unstructured":"Marklund N, Morales D, Clausen F, Hanell A, Kiwanuka O, Pitkanen A et al. Functional outcome is impaired following traumatic brain injury in aging Nogo-A\/B-deficient mice. Neuroscience 2009; 163: 540\u2013551.","journal-title":"Neuroscience"},{"key":"BFcddis2016331_CR17","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s003359900748","volume":"9","author":"JG Geisler","year":"1998","unstructured":"Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML . Molecular cloning of a novel mouse gene with predominant muscle and neural expression. Mamm Genome 1998; 9: 274\u2013282.","journal-title":"Mamm Genome"},{"key":"BFcddis2016331_CR18","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S1044-7431(03)00076-9","volume":"23","author":"JE Kim","year":"2003","unstructured":"Kim JE, Bonilla IE, Qiu D, Strittmatter SM . Nogo-C is sufficient to delay nerve regeneration. Mol Cell Neurosci 2003; 23: 451\u2013459.","journal-title":"Mol Cell Neurosci"},{"key":"BFcddis2016331_CR19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s11033-007-9190-3","volume":"36","author":"Y Chen","year":"2009","unstructured":"Chen Y, Tang X, Zhang X, Zhuang L . New mutations of Nogo-C in hepatocellular carcinoma. Mol Biol Rep 2009; 36: 377\u2013380.","journal-title":"Mol Biol Rep"},{"key":"BFcddis2016331_CR20","first-page":"2044","volume":"7","author":"X Liu","year":"2014","unstructured":"Liu X, Cui SJ, Zhu SJ, Geng DC, Yu L . Nogo-C contributes to HCC tumorigenesis via suppressing cell growth and its interactome analysis with comparative proteomics research. Int J Clin Exp Pathol 2014; 7: 2044\u20132055.","journal-title":"Int J Clin Exp Pathol"},{"key":"BFcddis2016331_CR21","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.bbrc.2006.07.166","volume":"348","author":"Y Chen","year":"2006","unstructured":"Chen Y, Tang X, Cao X, Chen H, Zhang X . Human Nogo-C overexpression induces HEK293 cell apoptosis via a mechanism that involves JNK-c-Jun pathway. Biochem Biophys Res Commun 2006; 348: 923\u2013928.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcddis2016331_CR22","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.3892\/mmr.2014.2050","volume":"9","author":"CQ Hao","year":"2014","unstructured":"Hao CQ, Zhou Y, Wang JP, Peng MJ, Xie YM, Kang WZ et al. Role of NogoA in the regulation of hepatocellular carcinoma SMMC7721 cell apoptosis. Mol Med Rep 2014; 9: 1743\u20131748.","journal-title":"Mol Med Rep"},{"key":"BFcddis2016331_CR23","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.yjmcc.2011.03.004","volume":"50","author":"JP Sarkey","year":"2011","unstructured":"Sarkey JP, Chu M, McShane M, Bovo E, Ait Mou Y, Zima AV et al. Nogo-A knockdown inhibits hypoxia\/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. J Mol Cell Cardiol 2011; 50: 1044\u20131055.","journal-title":"J Mol Cell Cardiol"},{"key":"BFcddis2016331_CR24","doi-asserted-by":"publisher","first-page":"H2726","DOI":"10.1152\/ajpheart.2001.280.6.H2726","volume":"280","author":"E Palojoki","year":"2001","unstructured":"Palojoki E, Saraste A, Eriksson A, Pulkki K, Kallajoki M, Voipio-Pulkki LM et al. Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats. Am J Physiol Heart Circ Physiol 2001; 280: H2726\u2013H2731.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFcddis2016331_CR25","first-page":"86","volume":"74","author":"J Kajstura","year":"1996","unstructured":"Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajewski S et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 1996; 74: 86\u2013107.","journal-title":"Lab Invest"},{"key":"BFcddis2016331_CR26","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/35000309","volume":"403","author":"JL Goldberg","year":"2000","unstructured":"Goldberg JL, Barres BA . Nogo in nerve regeneration. Nature 2000; 403: 369\u2013370.","journal-title":"Nature"},{"key":"BFcddis2016331_CR27","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/35000226","volume":"403","author":"T GrandPre","year":"2000","unstructured":"GrandPre T, Nakamura F, Vartanian T, Strittmatter SM . Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 2000; 403: 439\u2013444.","journal-title":"Nature"},{"key":"BFcddis2016331_CR28","first-page":"237","volume":"2","author":"JB Weiss","year":"2012","unstructured":"Weiss JB, Eisenhardt SU, Stark GB, Bode C, Moser M, Grundmann S . MicroRNAs in ischemia-reperfusion injury. Am J Cardiovasc Dis 2012; 2: 237\u2013247.","journal-title":"Am J Cardiovasc Dis"},{"key":"BFcddis2016331_CR29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1161\/CIRCULATIONAHA.115.018174","volume":"133","author":"V Nagpal","year":"2016","unstructured":"Nagpal V, Rai R, Place AT, Murphy SB, Verma SK, Ghosh AK et al. MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis. Circulation 2016; 133: 291\u2013301.","journal-title":"Circulation"},{"key":"BFcddis2016331_CR30","doi-asserted-by":"publisher","first-page":"e0148480","DOI":"10.1371\/journal.pone.0148480","volume":"11","author":"Q Li","year":"2016","unstructured":"Li Q, Xie J, Wang B, Li R, Bai J, Ding L et al. Overexpression of microRNA-99a attenuates cardiac hypertrophy. PLoS One 2016; 11: e0148480.","journal-title":"PLoS One"},{"key":"BFcddis2016331_CR31","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cmet.2013.08.009","volume":"18","author":"H el Azzouzi","year":"2013","unstructured":"el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K et al. The hypoxia-inducible microRNA cluster miR-199a approximately 214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation. Cell Metab 2013; 18: 341\u2013354.","journal-title":"Cell Metab"},{"key":"BFcddis2016331_CR32","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1161\/CIRCRESAHA.111.244442","volume":"110","author":"TG Hullinger","year":"2012","unstructured":"Hullinger TG, Montgomery RL, Seto AG, Dickinson BA, Semus HM, Lynch JM et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res 2012; 110: 71\u201381.","journal-title":"Circ Res"},{"key":"BFcddis2016331_CR33","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3390\/ijms17040502","volume":"17","author":"LL Wong","year":"2016","unstructured":"Wong LL, Wang J, Liew OW, Richards AM, Chen YT . MicroRNA and heart failure. Int J Mol Sci 2016; 17: 502.","journal-title":"Int J Mol Sci"},{"key":"BFcddis2016331_CR34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.gene.2016.03.015","volume":"585","author":"M Li","year":"2016","unstructured":"Li M, Wang N, Zhang J, He HP, Gong HQ, Zhang R et al. MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes. Gene 2016; 585: 44\u201350.","journal-title":"Gene"},{"key":"BFcddis2016331_CR35","doi-asserted-by":"publisher","first-page":"E507","DOI":"10.1073\/pnas.1212655110","volume":"110","author":"S Lumayag","year":"2013","unstructured":"Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S et al. Inactivation of the microRNA-183\/96\/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci USA 2013; 110: E507\u2013E516.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2016331_CR36","doi-asserted-by":"publisher","first-page":"31749","DOI":"10.1074\/jbc.M111.259028","volume":"286","author":"Q Zhu","year":"2011","unstructured":"Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T et al. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)\/96\/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem 2011; 286: 31749\u201331760.","journal-title":"J Biol Chem"},{"key":"BFcddis2016331_CR37","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1073\/pnas.0808263106","volume":"106","author":"MF Segura","year":"2009","unstructured":"Segura MF, Hanniford D, Menendez S, Reavie L, Zou X, Alvarez-Diaz S et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci USA 2009; 106: 1814\u20131819.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis2016331_CR38","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s12032-014-0225-z","volume":"31","author":"Q Chen","year":"2014","unstructured":"Chen Q, Yang L, Xiao Y, Zhu J, Li Z . Circulating microRNA-182 in plasma and its potential diagnostic and prognostic value for pancreatic cancer. Med Oncol 2014; 31: 225.","journal-title":"Med Oncol"},{"key":"BFcddis2016331_CR39","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/modpathol.2012.118","volume":"25","author":"BD McMillen","year":"2012","unstructured":"McMillen BD, Aponte MM, Liu Z, Helenowski IB, Scholtens DM, Buttin BM et al. Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma. Mod Pathol 2012; 25: 1644\u20131653.","journal-title":"Mod Pathol"},{"key":"BFcddis2016331_CR40","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13046-015-0182-1","volume":"34","author":"C Du","year":"2015","unstructured":"Du C, Weng X, Hu W, Lv Z, Xiao H, Ding C et al. Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma. J Exp Clin Cancer Res 2015; 34: 67.","journal-title":"J Exp Clin Cancer Res"},{"key":"BFcddis2016331_CR41","doi-asserted-by":"publisher","first-page":"e1003451","DOI":"10.1371\/journal.ppat.1003451","volume":"9","author":"S Kelada","year":"2013","unstructured":"Kelada S, Sethupathy P, Okoye IS, Kistasis E, Czieso S, White SD et al. miR-182 and miR-10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation. PLoS Pathog 2013; 9: e1003451.","journal-title":"PLoS Pathog"},{"key":"BFcddis2016331_CR42","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.4049\/jimmunol.1402261","volume":"194","author":"JN Pucella","year":"2015","unstructured":"Pucella JN, Yen WF, Kim MV, van der Veeken J, Luo CT, Socci ND et al. miR-182 is largely dispensable for adaptive immunity: lack of correlation between expression and function. J Immunol 2015; 194: 2635\u20132642.","journal-title":"J Immunol"},{"key":"BFcddis2016331_CR43","doi-asserted-by":"publisher","first-page":"21228","DOI":"10.1038\/srep21228","volume":"6","author":"N Li","year":"2016","unstructured":"Li N, Hwangbo C, Jaba IM, Zhang J, Papangeli I, Han J et al. miR-182 modulates myocardial hypertrophic response induced by angiogenesis in heart. Sci Rep 2016; 6: 21228.","journal-title":"Sci Rep"},{"key":"BFcddis2016331_CR44","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1101\/gad.257394.114","volume":"29","author":"FM Kouri","year":"2015","unstructured":"Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L et al. miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. Genes Dev 2015; 29: 732\u2013745.","journal-title":"Genes Dev"},{"key":"BFcddis2016331_CR45","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s13277-013-1004-8","volume":"35","author":"M Wang","year":"2014","unstructured":"Wang M, Wang Y, Zang W, Wang H, Chu H, Li P et al. Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells. Tumour Biol 2014; 35: 39\u201346.","journal-title":"Tumour Biol"},{"key":"BFcddis2016331_CR46","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.110.223925","volume":"107","author":"E Gao","year":"2010","unstructured":"Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M et al. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res 2010; 107: 1445\u20131453.","journal-title":"Circ Res"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cddis2016331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2016331","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis2016331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T09:07:54Z","timestamp":1672823274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis2016331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10]]}},"alternative-id":["BFcddis2016331"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2016.331","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]},"assertion":[{"value":"3 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}