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CD44 isoforms are involved in several signaling pathways essential for life such as growth factor-induced signaling by EGF, HGF or VEGF. CD44 is also the main hyaluronan (HA) receptor and as such is involved in HA-dependent processes. To allow a genetic dissection of CD44 functions in homeostasis and disease, we generated a\n                    <jats:italic>Cd44<\/jats:italic>\n                    floxed allele allowing tissue- and time-specific inactivation of all CD44 isoforms\n                    <jats:italic>in vivo<\/jats:italic>\n                    . As a proof of principle, we inactivated\n                    <jats:italic>Cd44<\/jats:italic>\n                    in the skin epidermis using the\n                    <jats:italic>K14Cre<\/jats:italic>\n                    allele. Although the skin of such\n                    <jats:italic>Cd44<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u0394ker<\/jats:italic>\n                    <\/jats:sup>\n                    mutants appeared morphologically normal, epidermal stiffness was reduced, wound healing delayed and TPA induced epidermal thickening decreased. These phenotypes might be caused by cell autonomous defects in differentiation and HA production as well as impaired adhesion and migration on HA by\n                    <jats:italic>Cd44<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u0394ker<\/jats:italic>\n                    <\/jats:sup>\n                    keratinocytes. These findings support the usefulness of the conditional\n                    <jats:italic>Cd44<\/jats:italic>\n                    allele in unraveling essential physiological and pathological functions of CD44 isoforms.\n                  <\/jats:p>","DOI":"10.1038\/cddis.2016.342","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T08:46:52Z","timestamp":1478767612000},"page":"e2461-e2461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress"],"prefix":"10.1038","volume":"7","author":[{"given":"M","family":"Shatirishvili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S","family":"Burk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kastilan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Breuhahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hinterseer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dierich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Bakiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E F","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ponta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T N","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Orian-Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"BFcddis2016342_CR1","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.ejca.2010.02.024","volume":"46","author":"V Orian-Rousseau","year":"2010","unstructured":"Orian-Rousseau V . 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