{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:18:18Z","timestamp":1784873898556,"version":"3.55.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T00:00:00Z","timestamp":1456358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Death Dis"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CCAAT\/enhancer binding protein beta (C\/EBP<jats:italic>\u03b2<\/jats:italic>), a transcription factor expressed in muscle satellite cells (SCs), inhibits the myogenic program and is downregulated early in differentiation. In a conditional null model in which C\/EBP<jats:italic>\u03b2<\/jats:italic> expression is knocked down in paired box protein 7+ (Pax7+) SCs, cardiotoxin (CTX) injury is poorly repaired, although muscle regeneration is efficient in control littermates. While myoblasts lacking C\/EBP<jats:italic>\u03b2<\/jats:italic> can differentiate efficiently in culture, after CTX injury poor regeneration was attributed to a smaller than normal Pax7+ population, which was not due to a failure of SCs to proliferate. Rather, the percentage of apoptotic SCs was increased in muscle lacking C\/EBP<jats:italic>\u03b2<\/jats:italic>. Given that an injury induced by BaCl<jats:sub>2<\/jats:sub> is repaired with greater efficiency than controls in the absence of C\/EBP<jats:italic>\u03b2<\/jats:italic>, we investigated the inflammatory response following BaCl<jats:sub>2<\/jats:sub> and CTX injury and found that the levels of interleukin-1<jats:italic>\u03b2<\/jats:italic> (IL-1<jats:italic>\u03b2<\/jats:italic>), a proinflammatory cytokine, were robustly elevated following CTX injury and could induce C\/EBP<jats:italic>\u03b2<\/jats:italic> expression in myoblasts. High levels of C\/EBP<jats:italic>\u03b2<\/jats:italic> expression in myoblasts correlated with resistance to apoptotic stimuli, while its loss increased sensitivity to thapsigargin-induced cell death. Using cancer cachexia as a model for chronic inflammation, we found that C\/EBP<jats:italic>\u03b2<\/jats:italic> expression was increased in SCs and myoblasts of tumor-bearing cachectic animals. Further, in cachectic conditional knockout animals lacking C\/EBP<jats:italic>\u03b2<\/jats:italic> in Pax7+ cells, the SC compartment was reduced because of increased apoptosis, and regeneration was impaired. Our findings indicate that the stimulation of C\/EBP<jats:italic>\u03b2<\/jats:italic> expression by IL-1<jats:italic>\u03b2<\/jats:italic> following muscle injury and in cancer cachexia acts to promote SC survival, and is therefore a protective mechanism for SCs and myoblasts in the face of inflammation.<\/jats:p>","DOI":"10.1038\/cddis.2016.4","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T13:49:03Z","timestamp":1456408143000},"page":"e2109-e2109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["CCAAT\/enhancer binding protein beta protects muscle satellite cells from apoptosis after injury and in cancer cachexia"],"prefix":"10.1038","volume":"7","author":[{"given":"F","family":"Marchildon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Lala-Tabbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Wiper-Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,25]]},"reference":[{"key":"BFcddis20164_CR1","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1242\/dev.064162","volume":"138","author":"MM Murphy","year":"2011","unstructured":"Murphy MM, Lawson JA, Mathew SJ, Hutcheson DA, Kardon G . Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development 2011; 138: 3625\u20133637.","journal-title":"Development"},{"key":"BFcddis20164_CR2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)00066-0","volume":"102","author":"P Seale","year":"2000","unstructured":"Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA . Pax7 is required for the specification of myogenic satellite cells. Cell 2000; 102: 777\u2013786.","journal-title":"Cell"},{"key":"BFcddis20164_CR3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.semcdb.2010.09.003","volume":"21","author":"S Biressi","year":"2010","unstructured":"Biressi S, Rando TA . Heterogeneity in the muscle satellite cell population. Semin Cell Dev Biol 2010; 21: 845\u2013854.","journal-title":"Semin Cell Dev Biol"},{"key":"BFcddis20164_CR4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1152\/physrev.00019.2003","volume":"84","author":"SB Charge","year":"2004","unstructured":"Charge SB, Rudnicki MA . Cellular and molecular regulation of muscle regeneration. Physiol Rev 2004; 84: 209\u2013238.","journal-title":"Physiol Rev"},{"key":"BFcddis20164_CR5","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.1038\/sj.onc.1210764","volume":"26","author":"AD Friedman","year":"2007","unstructured":"Friedman AD . Transcriptional control of granulocyte and monocyte development. Oncogene 2007; 26: 6816\u20136828.","journal-title":"Oncogene"},{"key":"BFcddis20164_CR6","doi-asserted-by":"publisher","first-page":"953","DOI":"10.4161\/cc.5.9.2733","volume":"5","author":"T Sebastian","year":"2006","unstructured":"Sebastian T, Johnson PF . Stop and go: anti-proliferative and mitogenic functions of the transcription factor C\/EBPbeta. Cell Cycle 2006; 5: 953\u2013957.","journal-title":"Cell Cycle"},{"key":"BFcddis20164_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1023\/A:1025900908026","volume":"8","author":"SL Grimm","year":"2003","unstructured":"Grimm SL, Rosen JM . The role of C\/EBPbeta in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 2003; 8: 191\u2013204.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"BFcddis20164_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1053\/jhep.2003.50155","volume":"37","author":"M Buck","year":"2003","unstructured":"Buck M, Chojkier M . Signal transduction in the liver: C\/EBPbeta modulates cell proliferation and survival. Hepatology 2003; 37: 731\u2013738.","journal-title":"Hepatology"},{"key":"BFcddis20164_CR9","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1101\/gad.14.11.1293","volume":"14","author":"ED Rosen","year":"2000","unstructured":"Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM . Transcriptional regulation of adipogenesis. Genes Dev 2000; 14: 1293\u20131307.","journal-title":"Genes Dev"},{"key":"BFcddis20164_CR10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/j.1460-2075.1994.tb06328.x","volume":"13","author":"M Buck","year":"1994","unstructured":"Buck M, Turler H, Chojkier M . LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation. EMBO J 1994; 13: 851\u2013860.","journal-title":"EMBO J"},{"key":"BFcddis20164_CR11","doi-asserted-by":"publisher","first-page":"7181","DOI":"10.1128\/MCB.19.10.7181","volume":"19","author":"S Zhu","year":"1999","unstructured":"Zhu S, Oh HS, Shim M, Sterneck E, Johnson PF, Smart RC . C\/EBPbeta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression. Mol Cell Biol 1999; 19: 7181\u20137190.","journal-title":"Mol Cell Biol"},{"key":"BFcddis20164_CR12","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1101\/gad.12.12.1907","volume":"12","author":"GW Robinson","year":"1998","unstructured":"Robinson GW, Johnson PF, Hennighausen L, Sterneck E . The C\/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev 1998; 12: 1907\u20131916.","journal-title":"Genes Dev"},{"key":"BFcddis20164_CR13","doi-asserted-by":"publisher","first-page":"7432","DOI":"10.1093\/emboj\/16.24.7432","volume":"16","author":"T Tanaka","year":"1997","unstructured":"Tanaka T, Yoshida N, Kishimoto T, Akira S . Defective adipocyte differentiation in mice lacking the C\/EBPbeta and\/or C\/EBPdelta gene. EMBO J 1997; 16: 7432\u20137443.","journal-title":"EMBO J"},{"key":"BFcddis20164_CR14","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1101\/gad.11.17.2153","volume":"11","author":"E Sterneck","year":"1997","unstructured":"Sterneck E, Tessarollo L, Johnson PF . An essential role for C\/EBPb in female reproduction. Genes Dev 1997; 11: 2153\u20132162.","journal-title":"Genes Dev"},{"key":"BFcddis20164_CR15","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1002\/j.1460-2075.1990.tb08316.x","volume":"9","author":"S Akira","year":"1990","unstructured":"Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y et al. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C\/EBP family. EMBO J 1990; 9: 1897\u20131906.","journal-title":"EMBO J"},{"key":"BFcddis20164_CR16","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1002\/j.1460-2075.1995.tb07185.x","volume":"14","author":"I Screpanti","year":"1995","unstructured":"Screpanti I, Romani L, Musiani P, Modesti A, Fattori E, Lazzaro D et al. Lymphoproliferative disorder and imbalanced T-helper response in C\/EBP beta-deficient mice. EMBO J 1995; 14: 1932\u20131941.","journal-title":"EMBO J"},{"key":"BFcddis20164_CR17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/0092-8674(95)90418-2","volume":"80","author":"T Tanaka","year":"1995","unstructured":"Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 1995; 80: 353\u2013361.","journal-title":"Cell"},{"key":"BFcddis20164_CR18","doi-asserted-by":"publisher","first-page":"10200","DOI":"10.1074\/jbc.M115.638577","volume":"290","author":"D Fu","year":"2015","unstructured":"Fu D, Lala-Tabbert N, Lee H, Wiper-Bergeron N . Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT\/enhancer binding protein beta. J Biol Chem 2015; 290: 10200\u201310207.","journal-title":"J Biol Chem"},{"key":"BFcddis20164_CR19","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1002\/stem.1248","volume":"30","author":"F Marchildon","year":"2012","unstructured":"Marchildon F, Lala N, Li G, St-Louis C, Lamothe D, Keller C et al. CCAAT\/enhancer binding protein beta is expressed in satellite cells and controls myogenesis. Stem Cells 2012; 30: 2619\u20132630.","journal-title":"Stem Cells"},{"key":"BFcddis20164_CR20","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1038\/mt.2012.189","volume":"20","author":"M Bencze","year":"2012","unstructured":"Bencze M, Negroni E, Vallese D, Yacoub-Youssef H, Chaouch S, Wolff A et al. Proinflammatory macrophages enhance the regenerative capacity of human myoblasts by modifying their kinetics of proliferation and differentiation. Mol Ther 2012; 20: 2168\u20132179.","journal-title":"Mol Ther"},{"key":"BFcddis20164_CR21","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1242\/dev.098285","volume":"141","author":"JG Tidball","year":"2014","unstructured":"Tidball JG, Dorshkind K, Wehling-Henricks M . Shared signaling systems in myeloid cell-mediated muscle regeneration. Development 2014; 141: 1184\u20131196.","journal-title":"Development"},{"key":"BFcddis20164_CR22","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cell.2013.02.053","volume":"153","author":"JE Heredia","year":"2013","unstructured":"Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM et al. Type 2 innate signals stimulate fibro\/adipogenic progenitors to facilitate muscle regeneration. Cell 2013; 153: 376\u2013388.","journal-title":"Cell"},{"key":"BFcddis20164_CR23","doi-asserted-by":"publisher","first-page":"R1173","DOI":"10.1152\/ajpregu.00735.2009","volume":"298","author":"JG Tidball","year":"2010","unstructured":"Tidball JG, Villalta SA . Regulatory interactions between muscle and the immune system during muscle regeneration. Am J Physiol Regul Integr Comp Physiol 2010; 298: R1173\u2013R1187.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFcddis20164_CR24","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1096\/fj.00-0463","volume":"15","author":"RC Langen","year":"2001","unstructured":"Langen RC, Schols AM, Kelders MC, Wouters EF, Janssen-Heininger YM . Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J 2001; 15: 1169\u20131180.","journal-title":"FASEB J"},{"key":"BFcddis20164_CR25","doi-asserted-by":"publisher","first-page":"e17392","DOI":"10.1371\/journal.pone.0017392","volume":"6","author":"KG Toth","year":"2011","unstructured":"Toth KG, McKay BR, De Lisio M, Little JP, Tarnopolsky MA, Parise G . IL-6 induced STAT3 signalling is associated with the proliferation of human muscle satellite cells following acute muscle damage. PLoS One 2011; 6: e17392.","journal-title":"PLoS One"},{"key":"BFcddis20164_CR26","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1002\/(SICI)1097-4598(199906)22:6<724::AID-MUS9>3.0.CO;2-O","volume":"22","author":"F Merly","year":"1999","unstructured":"Merly F, Lescaudron L, Rouaud T, Crossin F, Gardahaut MF . Macrophages enhance muscle satellite cell proliferation and delay their differentiation. Muscle nerve 1999; 22: 724\u2013732.","journal-title":"Muscle nerve"},{"key":"BFcddis20164_CR27","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.cmet.2013.06.017","volume":"18","author":"R Mounier","year":"2013","unstructured":"Mounier R, Theret M, Arnold L, Cuvellier S, Bultot L, Goransson O et al. AMPKalpha1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab 2013; 18: 251\u2013264.","journal-title":"Cell Metab"},{"key":"BFcddis20164_CR28","doi-asserted-by":"publisher","first-page":"17475","DOI":"10.1073\/pnas.0908641106","volume":"106","author":"D Ruffell","year":"2009","unstructured":"Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez RG, Rosenthal N et al. A CREB-C\/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci USA 2009; 106: 17475\u201317480.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis20164_CR29","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1084\/jem.20070075","volume":"204","author":"L Arnold","year":"2007","unstructured":"Arnold L, Henry A, Poron F, Baba-Amer Y, van Rooijen N, Plonquet A et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 2007; 204: 1057\u20131069.","journal-title":"J Exp Med"},{"key":"BFcddis20164_CR30","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.4049\/jimmunol.1103180","volume":"189","author":"B Deng","year":"2012","unstructured":"Deng B, Wehling-Henricks M, Villalta SA, Wang Y, Tidball JG . IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration. J Immunol 2012; 189: 3669\u20133680.","journal-title":"J Immunol"},{"key":"BFcddis20164_CR31","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3748\/wjg.v9.i7.1567","volume":"9","author":"W Zhou","year":"2003","unstructured":"Zhou W, Jiang ZW, Tian J, Jiang J, Li N, Li JS . Role of NF-kappaB and cytokine in experimental cancer cachexia. World J Gastroenterol 2003; 9: 1567\u20131570.","journal-title":"World J Gastroenterol"},{"key":"BFcddis20164_CR32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.cytogfr.2006.09.006","volume":"17","author":"A Saini","year":"2006","unstructured":"Saini A, Al-Shanti N, Stewart CE . Waste management - cytokines, growth factors and cachexia. Cytokine Growth Factor Rev 2006; 17: 475\u2013486.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFcddis20164_CR33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.urology.2006.09.039","volume":"69","author":"K Kuroda","year":"2007","unstructured":"Kuroda K, Nakashima J, Kanao K, Kikuchi E, Miyajima A, Horiguchi Y et al. Interleukin 6 is associated with cachexia in patients with prostate cancer. Urology 2007; 69: 113\u2013117.","journal-title":"Urology"},{"key":"BFcddis20164_CR34","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev-med-061509-131248","volume":"62","author":"S Dodson","year":"2011","unstructured":"Dodson S, Baracos VE, Jatoi A, Evans WJ, Cella D, Dalton JT et al. Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies. Annu Rev Med 2011; 62: 265\u2013279.","journal-title":"Annu Rev Med"},{"key":"BFcddis20164_CR35","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1172\/JCI112815","volume":"79","author":"CF Nathan","year":"1987","unstructured":"Nathan CF . Secretory products of macrophages. J Clin Invest 1987; 79: 319\u2013326.","journal-title":"J Clin Invest"},{"key":"BFcddis20164_CR36","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/ncomms1890","volume":"3","author":"M Latil","year":"2012","unstructured":"Latil M, Rocheteau P, Chatre L, Sanulli S, Memet S, Ricchetti M et al. Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity. Nat Commun 2012; 3: 903.","journal-title":"Nat Commun"},{"issue":"3 Pt A","key":"BFcddis20164_CR37","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.scr.2014.08.005","volume":"13","author":"L Vahidi Ferdousi","year":"2014","unstructured":"Vahidi Ferdousi L, Rocheteau P, Chayot R, Montagne B, Chaker Z, Flamant P et al. More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny. Stem Cell Res 2014; 13 (3 Pt A): 492\u2013507.","journal-title":"Stem Cell Res"},{"key":"BFcddis20164_CR38","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1126\/science.273.5273.359","volume":"273","author":"J Wang","year":"1996","unstructured":"Wang J, Walsh K . Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science 1996; 273: 359\u2013361.","journal-title":"Science"},{"key":"BFcddis20164_CR39","doi-asserted-by":"publisher","first-page":"10200","DOI":"10.1074\/jbc.M115.638577","volume":"290","author":"D Fu","year":"2015","unstructured":"Fu D, Lala-Tabbert N, Lee H, Wiper-Bergeron N . Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT\/enhancer-binding protein beta. J Biol Chem 2015; 290: 10200\u201310207.","journal-title":"J Biol Chem"},{"key":"BFcddis20164_CR40","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1128\/MCB.00872-09","volume":"30","author":"C Ramathal","year":"2010","unstructured":"Ramathal C, Bagchi IC, Bagchi MK . Lack of CCAAT enhancer binding protein beta (C\/EBPbeta) in uterine epithelial cells impairs estrogen-induced DNA replication, induces DNA damage response pathways, and promotes apoptosis. Mol Cell Biol 2010; 30: 1607\u20131619.","journal-title":"Mol Cell Biol"},{"key":"BFcddis20164_CR41","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/sj.onc.1209797","volume":"26","author":"K Yoon","year":"2007","unstructured":"Yoon K, Zhu S, Ewing SJ, Smart RC . Decreased survival of C\/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function. Oncogene 2007; 26: 360\u2013367.","journal-title":"Oncogene"},{"key":"BFcddis20164_CR42","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S1097-2765(01)00374-4","volume":"8","author":"M Buck","year":"2001","unstructured":"Buck M, Poli V, Hunter T, Chojkier M . C\/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol Cell 2001; 8: 807\u2013816.","journal-title":"Mol Cell"},{"issue":"Pt 19","key":"BFcddis20164_CR43","doi-asserted-by":"publisher","first-page":"3958","DOI":"10.1242\/jcs.03160","volume":"119","author":"H Shiraishi","year":"2006","unstructured":"Shiraishi H, Okamoto H, Yoshimura A, Yoshida H . ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1. J Cell Sci 2006; 119 (Pt 19): 3958\u20133966.","journal-title":"J Cell Sci"},{"key":"BFcddis20164_CR44","doi-asserted-by":"publisher","first-page":"50375","DOI":"10.1074\/jbc.M408493200","volume":"279","author":"N Morishima","year":"2004","unstructured":"Morishima N, Nakanishi K, Tsuchiya K, Shibata T, Seiwa E . Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis. J Biol Chem 2004; 279: 50375\u201350381.","journal-title":"J Biol Chem"},{"key":"BFcddis20164_CR45","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/1097-0045(20000601)43:4<303::AID-PROS10>3.0.CO;2-V","volume":"43","author":"B Tombal","year":"2000","unstructured":"Tombal B, Weeraratna AT, Denmeade SR, Isaacs JT . Thapsigargin induces a calmodulin\/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells. Prostate 2000; 43: 303\u2013317.","journal-title":"Prostate"},{"key":"BFcddis20164_CR46","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/S0899-9007(99)00095-7","volume":"15","author":"PW Emery","year":"1999","unstructured":"Emery PW . Cachexia in experimental models. Nutrition 1999; 15: 600\u2013603.","journal-title":"Nutrition"},{"key":"BFcddis20164_CR47","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1007\/s00520-010-0972-0","volume":"19","author":"N Bennani-Baiti","year":"2011","unstructured":"Bennani-Baiti N, Walsh D . Animal models of the cancer anorexia-cachexia syndrome. Support Care Cancer 2011; 19: 1451\u20131463.","journal-title":"Support Care Cancer"},{"key":"BFcddis20164_CR48","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.1172\/JCI68523","volume":"123","author":"WA He","year":"2013","unstructured":"He WA, Berardi E, Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J et al. NF-kappaB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest 2013; 123: 4821\u20134835.","journal-title":"J Clin Invest"},{"key":"BFcddis20164_CR49","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/sj.cdd.4400489","volume":"6","author":"DH Burgess","year":"1999","unstructured":"Burgess DH, Svensson M, Dandrea T, Gronlund K, Hammarquist F, Orrenius S et al. Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1. Cell Death Differ 1999; 6: 256\u2013261.","journal-title":"Cell Death Differ"},{"key":"BFcddis20164_CR50","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1083\/jcb.200508044","volume":"172","author":"F Relaix","year":"2006","unstructured":"Relaix F, Montarras D, Zaffran S, Gayraud-Morel B, Rocancourt D, Tajbakhsh S et al. Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol 2006; 172: 91\u2013102.","journal-title":"J Cell Biol"},{"key":"BFcddis20164_CR51","doi-asserted-by":"publisher","first-page":"3430","DOI":"10.1038\/sj.emboj.7600346","volume":"23","author":"S Oustanina","year":"2004","unstructured":"Oustanina S, Hause G, Braun T . Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification. EMBO J 2004; 23: 3430\u20133439.","journal-title":"EMBO J"},{"key":"BFcddis20164_CR52","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1002\/jcp.25031","volume":"230","author":"T Padilla-Benavides","year":"2015","unstructured":"Padilla-Benavides T, Nasipak BT, Imbalzano AN . Brg1 controls the expression of Pax7 to promote viability and proliferation of mouse primary myoblasts. J Cell Physiol 2015; 230: 2990\u20132997.","journal-title":"J Cell Physiol"},{"key":"BFcddis20164_CR53","doi-asserted-by":"publisher","first-page":"16552","DOI":"10.1073\/pnas.0708145104","volume":"104","author":"A Asakura","year":"2007","unstructured":"Asakura A, Hirai H, Kablar B, Morita S, Ishibashi J, Piras BA et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle. Proc Natl Acad Sci USA 2007; 104: 16552\u201316557.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis20164_CR54","doi-asserted-by":"publisher","first-page":"6127","DOI":"10.1002\/j.1460-2075.1995.tb00303.x","volume":"14","author":"C Muller","year":"1995","unstructured":"Muller C, Kowenz-Leutz E, Grieser-Ade S, Graf T, Leutz A . NF-M (chicken C\/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line. EMBO J 1995; 14: 6127\u20136135.","journal-title":"EMBO J"},{"key":"BFcddis20164_CR55","doi-asserted-by":"publisher","first-page":"4525","DOI":"10.1073\/pnas.1402714111","volume":"111","author":"WA He","year":"2014","unstructured":"He WA, Calore F, Londhe P, Canella A, Guttridge DC, Croce CM . Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci USA 2014; 111: 4525\u20134529.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcddis20164_CR56","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.clnu.2007.06.005","volume":"26","author":"S Busquets","year":"2007","unstructured":"Busquets S, Deans C, Figueras M, Moore-Carrasco R, Lopez-Soriano FJ, Fearon KC et al. Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients. Clin Nutr 2007; 26: 614\u2013618.","journal-title":"Clin Nutr"},{"key":"BFcddis20164_CR57","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/0269216312441382","volume":"27","author":"J Reid","year":"2013","unstructured":"Reid J, Hughes CM, Murray LJ, Parsons C, Cantwell MM . Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review. Palliative Med 2013; 27: 295\u2013303.","journal-title":"Palliative Med"},{"key":"BFcddis20164_CR58","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1038\/sj.onc.1209144","volume":"25","author":"E Sterneck","year":"2006","unstructured":"Sterneck E, Zhu S, Ramirez A, Jorcano JL, Smart RC . Conditional ablation of C\/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis. Oncogene 2006; 25: 1272\u20131276.","journal-title":"Oncogene"},{"key":"BFcddis20164_CR59","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1096\/fj.08-128116","volume":"23","author":"K Nishijo","year":"2009","unstructured":"Nishijo K, Hosoyama T, Bjornson CR, Schaffer BS, Prajapati SI, Bahadur AN et al. Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J 2009; 23: 2681\u20132690.","journal-title":"FASEB J"},{"key":"BFcddis20164_CR60","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/BF02721371","volume":"23","author":"ML Springer","year":"1997","unstructured":"Springer ML, Blau HM . High-efficiency retroviral infection of primary myoblasts. Somat Cell Mol Genet 1997; 23: 203\u2013209.","journal-title":"Somat Cell Mol Genet"},{"key":"BFcddis20164_CR61","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1093\/emboj\/cdg218","volume":"22","author":"N Wiper-Bergeron","year":"2003","unstructured":"Wiper-Bergeron N, Wu D, Pope L, Schild-Poulter C, Hache RJ . Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex. EMBO J 2003; 22: 2135\u20132145.","journal-title":"EMBO J"}],"container-title":["Cell Death &amp; Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cddis20164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis20164","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cddis20164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T09:02:28Z","timestamp":1672822948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cddis20164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,25]]},"references-count":61,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2]]}},"alternative-id":["BFcddis20164"],"URL":"https:\/\/doi.org\/10.1038\/cddis.2016.4","relation":{},"ISSN":["2041-4889"],"issn-type":[{"value":"2041-4889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,25]]},"assertion":[{"value":"28 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}