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Eva1a is expressed in the myocardium, but its function in myocytes has not yet been investigated. Therefore, we generated inducible, cardiomyocyte-specific <jats:italic>Eva1a<\/jats:italic> knockout mice with an aim to determine the role of <jats:italic>Eva1a<\/jats:italic> in cardiac remodelling in the adult heart. Data from experiments showed that loss of <jats:italic>Eva1a<\/jats:italic> in the adult heart increased cardiac fibrosis, promoted cardiac hypertrophy, and led to cardiomyopathy and death. Further investigation suggested that this effect was associated with impaired autophagy and increased apoptosis in <jats:italic>Eva1a<\/jats:italic> knockout hearts. Moreover, knockout of <jats:italic>Eva1a<\/jats:italic> activated Mtor signalling and the subsequent inhibition of autophagy. In addition, <jats:italic>Eva1a<\/jats:italic> knockout hearts showed disorganized sarcomere structure and mitochondrial misalignment and aggregation, leading to the lack of ATP generation. Collectively, these data demonstrated that Eva1a improves cardiac function and inhibits cardiac hypertrophy and fibrosis by increasing autophagy. In conclusion, our results demonstrated that Eva1a may have an important role in maintaining cardiac homeostasis.<\/jats:p>","DOI":"10.1038\/cddis.2017.17","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T13:45:39Z","timestamp":1486043139000},"page":"e2586-e2586","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy"],"prefix":"10.1038","volume":"8","author":[{"given":"Shu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"BFcddis201717_CR1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","volume":"322","author":"D Levy","year":"1990","unstructured":"Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP . 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