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Over-activated osteoclastogenesis plays a vital role in POMP. Here we developed a novel bioactive compound MASM (M19) based on sophocarpine. Although it showed no significant effects on osteogenesis and adipogenesis for bone marrow-derived mesenchymal stem cells (BMSCs) <jats:italic>in vitro<\/jats:italic>, it could significantly inhibit RANKL\/M-CSF induced osteoclastogenesis through suppressing NF-<jats:italic>\u03ba<\/jats:italic>B, MAPKs and PI3K\/Akt pathways <jats:italic>in vitro<\/jats:italic> and ameliorate bone loss in ovariectomized mice <jats:italic>in vivo<\/jats:italic>. Ribosomal protein s5 (RPS5) has been identified as a target of M19 and regulates PI3K\/Akt, NF-<jats:italic>\u03ba<\/jats:italic>B and MAPKs pathways in osteoclastogenesis. Overexpressions of RPS5 synergistically inhibited osteoclastogenesis with M19 while silencing RPS5 compromised M19 inhibitory effects on osteoclastogenesis <jats:italic>in vitro<\/jats:italic>. Among the three pathways, Akt plays a major role in M19 effects. The Akt activator SC<jats:sub>79<\/jats:sub> partially reversed the inhibitory effects on osteoclastogenesis by M19 and RPS5-knocking-down. It indicates that RPS5 serves as a potential candidate target for inhibiting osteoclastogenesis and osteoporosis therapy and M19 is a promising agent for POMP treatment.<\/jats:p>","DOI":"10.1038\/cddis.2017.394","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T19:15:46Z","timestamp":1504811746000},"page":"e3037-e3037","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["RETRACTED ARTICLE: Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis"],"prefix":"10.1038","volume":"8","author":[{"given":"Xiao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liehu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weizong","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honggang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qirong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiacan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"BFcddis2017394_CR1","first-page":"527","volume":"29","author":"A Del Puente","year":"2015","unstructured":"Del Puente A, Esposito A, Del Puente A, Costa L, Caso F, Scarpa R . physiopathology of osteoporosis: from risk factors analysis to treatment. 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