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Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased,\n                    <jats:italic>in vivo<\/jats:italic>\n                    approach combining morphological assesment and quantitative proteomics with\n                    <jats:italic>in silico-<\/jats:italic>\n                    based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction.\n                  <\/jats:p>","DOI":"10.1038\/cddis.2017.489","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T08:40:40Z","timestamp":1510216840000},"page":"e3166-e3166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration"],"prefix":"10.1038","volume":"8","author":[{"given":"Alejandra","family":"Catenaccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maica","family":"Llavero Hurtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J","family":"Lamont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Wishart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A","family":"Court","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"BFcddis2017489_CR1","doi-asserted-by":"crossref","unstructured":"Coleman M. 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