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Owing to the complexity of the pigmentary system, <jats:italic>in vivo<\/jats:italic> animal models for pigmentation study are limited. Planarians are capable of regenerating any missing part including the dark-brown pigments, providing a promising model for pigmentation study. However, the molecular mechanism of planarian body pigmentation is poorly understood. We found in an RNA interference screen that a forkhead containing transcription factor, <jats:italic>Albino<\/jats:italic>, was required for pigmentation without affecting survival or other regeneration processes. In addition, the body color recovered after termination of <jats:italic>Albino<\/jats:italic> double stranded RNA feeding owing to the robust stem cell system. Further expression analysis revealed a spatial and temporal correlation between <jats:italic>Albino<\/jats:italic> and pigmentation process. Gene expression arrays revealed that the expression of three tetrapyrrole biosynthesis enzymes, <jats:italic>ALAD, ALAS<\/jats:italic> and <jats:italic>PBGD<\/jats:italic>, was impaired upon <jats:italic>Albino<\/jats:italic> RNA interference. RNA interference of <jats:italic>PBGD<\/jats:italic> led to a similar albinism phenotype caused by <jats:italic>Albino<\/jats:italic> RNA interference. Moreover, <jats:italic>PBGD<\/jats:italic> was specifically expressed in pigment cells and can serve as a pigment cell molecular marker. Our results revealed that <jats:italic>Albino<\/jats:italic> controls planarian body color pigmentation dominantly via regulating tetrapyrrole biogenesis. These results identified <jats:italic>Albino<\/jats:italic> as the key regulator of the tetrapyrrole-based planarian body pigmentation, suggesting a role of <jats:italic>Albino<\/jats:italic> during stem cell-pigment cell fate decision and provided new insights into porphyria pathogenesis.<\/jats:p>","DOI":"10.1038\/celldisc.2016.29","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T09:17:20Z","timestamp":1470129440000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian"],"prefix":"10.1038","volume":"2","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Shuai","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Wen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Xian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-1214","authenticated-orcid":false,"given":"Qing","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"BFcelldisc201629_CR1","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1146\/annurev.cellbio.20.010403.095114","volume":"20","author":"PW Reddien","year":"2004","unstructured":"Reddien PW, Sanchez Alvarado A . 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