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Here, we performed\n                    <jats:italic>in vivo<\/jats:italic>\n                    bacterial infection screening using several mouse models of hemochromatosis, including\n                    <jats:italic>Hfe<\/jats:italic>\n                    (\n                    <jats:italic>Hfe<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ),\n                    <jats:italic>hemojuvelin<\/jats:italic>\n                    (\n                    <jats:italic>Hjv<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    ), and macrophage-specific\n                    <jats:italic>ferroportin-1<\/jats:italic>\n                    (\n                    <jats:italic>Fpn1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    ;\n                    <jats:italic>LysM-Cre<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    ) knockout mice. We found that\n                    <jats:italic>Hjv<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, but not\n                    <jats:italic>Hfe<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    or\n                    <jats:italic>Fpn1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>fl\/fl<\/jats:italic>\n                    <\/jats:sup>\n                    ;\n                    <jats:italic>LysM-Cre<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    mice, are highly susceptible to peritoneal infection by both Gram-negative and Gram-positive bacteria. Interestingly, phagocytic cells in the peritoneum of\n                    <jats:italic>Hjv<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice have reduced bacterial clearance, IFN-\u03b3 secretion, and nitric oxide production; in contrast, both cell migration and phagocytosis are normal. Expressing\n                    <jats:italic>Hjv<\/jats:italic>\n                    in RAW264.7 cells increased the level of phosphorylated Stat1 and nitric oxide production. Moreover, macrophage-specific\n                    <jats:italic>Hjv<\/jats:italic>\n                    knockout mice are susceptible to bacterial infection. Finally, we found that Hjv facilitates the secretion of IFN-\u03b3 via the IL-12\/Jak2\/Stat4 signaling pathway. Together, these findings reveal a novel protective role of Hjv in the early stages of antimicrobial defense.\n                  <\/jats:p>","DOI":"10.1038\/celldisc.2017.28","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T05:01:18Z","timestamp":1502773278000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice"],"prefix":"10.1038","volume":"3","author":[{"given":"Qian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0003","authenticated-orcid":false,"given":"Fudi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxia","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"BFcelldisc201728_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/224380a0","volume":"224","author":"JJ Bullen","year":"1969","unstructured":"Bullen JJ, Rogers HJ . 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