{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:22:18Z","timestamp":1790338938329,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T00:00:00Z","timestamp":1223596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T00:00:00Z","timestamp":1223596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Gene Ther"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1038\/cgt.2008.74","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T10:23:06Z","timestamp":1223634186000},"page":"266-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Enhanced oncolytic potency of vesicular stomatitis virus through vector-mediated inhibition of NK and NKT cells"],"prefix":"10.1038","volume":"16","author":[{"given":"J","family":"Altomonte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Meseck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Garcia-Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mandeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S L C","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,10]]},"reference":[{"key":"BFcgt200874_CR1","first-page":"163","volume":"62","author":"DM Parkin","year":"1984","unstructured":"Parkin DM, Sthernsward J, Muir CS . Estimates of the worldwide frequency of twelve major cancers. Bull World Health Organ 1984; 62: 163\u2013182.","journal-title":"Bull World Health Organ"},{"key":"BFcgt200874_CR2","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1126\/science.274.5288.740","volume":"274","author":"CJ Murray","year":"1996","unstructured":"Murray CJ, Lopez AD . Evidence-based health policy\u2014lessons from the Global Burden of Disease Study. Science 1996; 274: 740\u2013743.","journal-title":"Science"},{"key":"BFcgt200874_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ijc.1440","volume":"94","author":"DM Parkin","year":"2001","unstructured":"Parkin DM, Bray F, Ferlay J, Pisani P . Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001; 94: 153\u2013156.","journal-title":"Int J Cancer"},{"key":"BFcgt200874_CR4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1056\/NEJM199903113401001","volume":"340","author":"HB El-Serag","year":"1999","unstructured":"El-Serag HB, Mason AC . Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999; 340: 745\u2013750.","journal-title":"N Engl J Med"},{"key":"BFcgt200874_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1365-2036.2005.02504.x","volume":"22","author":"Z Dyer","year":"2005","unstructured":"Dyer Z, Peltekian K, van Zanten SV . The changing epidemiology of hepatocellular carcinoma in Canada. Aliment Pharmacol Ther 2005; 22: 17\u201322.","journal-title":"Aliment Pharmacol Ther"},{"key":"BFcgt200874_CR6","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1111\/j.1572-0241.2005.00229.x","volume":"100","author":"YP Yeung","year":"2005","unstructured":"Yeung YP, Lo CM, Liu CL, Wong BC, Fan ST, Wong J . Natural history of untreated nonsurgical hepatocellular carcinoma. Am J Gastroenterol 2005; 100: 1995\u20132004.","journal-title":"Am J Gastroenterol"},{"key":"BFcgt200874_CR7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.suronc.2007.08.010","volume":"16","author":"S Cunningham","year":"2007","unstructured":"Cunningham S, Choti MA, Bellavance EC, Pawlik TM . Palliation of hepatic tumors. Surg Oncol 2007; 16: 277\u2013291.","journal-title":"Surg Oncol"},{"key":"BFcgt200874_CR8","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1053\/j.seminoncol.2007.01.007","volume":"34","author":"P Rougier","year":"2007","unstructured":"Rougier P, Mitry E, Barbare JC, Taieb J . Hepatocellular carcinoma (HCC): an update. Semin Oncol 2007; 34: S12\u2013S20.","journal-title":"Semin Oncol"},{"key":"BFcgt200874_CR9","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/89901","volume":"7","author":"D Kirn","year":"2001","unstructured":"Kirn D, Martuza RL, Zwiebel J . Replication-selective virotherapy for cancer: biological principles, risk management, and future directions. Nat Med 2001; 7: 781\u2013787.","journal-title":"Nat Med"},{"key":"BFcgt200874_CR10","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1126\/science.282.5392.1332","volume":"282","author":"MC Coffey","year":"1998","unstructured":"Coffey MC, Strong JE, Forsyth PA, Lee PW . Reovirus therapy of tumors with activated Ras pathway. Science 1998; 282: 1332\u20131334.","journal-title":"Science"},{"key":"BFcgt200874_CR11","first-page":"6017","volume":"54","author":"RM Lorence","year":"1994","unstructured":"Lorence RM, Katubig BB, Reichard KW, Reyes HM, Phuangsab A, Sassetti MD et al. Complete regression of human fibrosarcoma xenografts after local Newcastle disease virus therapy. Cancer Res 1994; 54: 6017\u20136021.","journal-title":"Cancer Res"},{"key":"BFcgt200874_CR12","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1182\/blood.V98.7.2002","volume":"98","author":"KW Peng","year":"2001","unstructured":"Peng KW, Ahmann GJ, Pham L, Greipp PR, Cattaneo R, Russell SJ . Systemic therapy of myeloma xenografts by an attenuated measles virus. Blood 2001; 98: 2002\u20132007.","journal-title":"Blood"},{"key":"BFcgt200874_CR13","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/77558","volume":"6","author":"DF Stojdl","year":"2000","unstructured":"Stojdl DF, Lichty B, Knowles S, Marius R, Atkins H, Sonenberg N et al. Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med 2000; 6: 821\u2013825.","journal-title":"Nat Med"},{"key":"BFcgt200874_CR14","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1053\/tvjl.1998.0303","volume":"157","author":"GJ Letchworth","year":"1999","unstructured":"Letchworth GJ, Rodriguez LL, Del C, Barrera J . Vesicular stomatitis. Vet J 1999; 157: 239\u2013260.","journal-title":"Vet J"},{"key":"BFcgt200874_CR15","first-page":"1221","volume-title":"Fields Virology","author":"JK Rose","year":"2001","unstructured":"Rose JK, Whitt MA . Rhabdoviridae: the viruses and their replication. In: Knipe DM, Howley PM (eds). Fields Virology, 4th edn. Lippincott Williams & Wilkins: Philadelphia, 2001, pp 1221\u20131242."},{"key":"BFcgt200874_CR16","first-page":"611","volume":"63","author":"O Ebert","year":"2003","unstructured":"Ebert O, Shinozaki K, Huang TG, Savontaus MJ, Garcia-Sastre A, Woo SLC . Oncolytic vesicular stomatitis virus for treatment of orthotopic hepatocellular carcinoma in immune-competent rats. Cancer Res 2003; 63: 611\u2013613.","journal-title":"Cancer Res"},{"key":"BFcgt200874_CR17","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ymthe.2003.12.004","volume":"9","author":"K Shinozaki","year":"2004","unstructured":"Shinozaki K, Ebert O, Kournioti C, Tai YS, Woo SL . Oncolysis of multifocal hepatocellular carcinoma in the rat liver by hepatic artery infusion of vesicular stomatitis virus. Mol Ther 2004; 9: 368\u2013376.","journal-title":"Mol Ther"},{"key":"BFcgt200874_CR18","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1158\/0008-5472.CAN-03-3753","volume":"64","author":"O Ebert","year":"2004","unstructured":"Ebert O, Shinozaki K, Kournioti C, Park MS, Garc\u00eda-Sastre A, Woo SL . Syncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer. Cancer Res 2004; 64: 3265\u20133270.","journal-title":"Cancer Res"},{"key":"BFcgt200874_CR19","doi-asserted-by":"publisher","first-page":"13705","DOI":"10.1128\/JVI.79.21.13705-13713.2005","volume":"79","author":"K Shinozaki","year":"2005","unstructured":"Shinozaki K, Ebert O, Suriawinata A, Thung S, Woo S . Prophylactic alpha interferon treatment increases the therapeutic index of oncolytic vesicular stomatitis virus virotherapy for advanced hepatocellular carcinoma. J Virol 2005a; 79: 13705\u201313713.","journal-title":"J Virol"},{"key":"BFcgt200874_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1146\/annurev.immunol.19.1.65","volume":"19","author":"LG Guidotti","year":"2001","unstructured":"Guidotti LG, Chisari FV . Noncytolytic control of viral infections by the innate and adaptive immune response. Ann Rev Immunol 2001; 19: 65\u201391.","journal-title":"Ann Rev Immunol"},{"key":"BFcgt200874_CR21","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/sj.gt.3302038","volume":"10","author":"H Wakimoto","year":"2003","unstructured":"Wakimoto H, Johnson PR, Knipe DM, Chiocca EA . Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Therapy 2003; 10: 983\u2013990.","journal-title":"Gene Therapy"},{"key":"BFcgt200874_CR22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/sj.gt.3302143","volume":"11","author":"H Wakimoto","year":"2004","unstructured":"Wakimoto H, Fulci G, Tuminiski E, Chiocca EA . Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene Therapy 2004; 11: 214\u2013223.","journal-title":"Gene Therapy"},{"key":"BFcgt200874_CR23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/sj.mt.6300343","volume":"16","author":"J Altomonte","year":"2008","unstructured":"Altomonte J, Wu L, Chen L, Meseck M, Ebert O, Garcia-Sastre A et al. Exponential enhancement of oncolytic vesicular stomatitis virus potency by vector-mediated suppression of inflammatory responses in vivo. Mol Ther 2008; 16: 146\u2013153.","journal-title":"Mol Ther"},{"key":"BFcgt200874_CR24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nri980","volume":"3","author":"A Alcami","year":"2003","unstructured":"Alcami A . Viral mimicry of cytokines, chemokines, and their receptors. Nat Immunol 2003; 3: 36\u201350.","journal-title":"Nat Immunol"},{"key":"BFcgt200874_CR25","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/emboj\/cdg092","volume":"22","author":"NA Bryant","year":"2003","unstructured":"Bryant NA, Davis-Poynter N, Vanderplasschen A, Alcami A . Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins. EMBO J 2003; 22: 833\u2013846.","journal-title":"EMBO J"},{"key":"BFcgt200874_CR26","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/ni1156","volume":"6","author":"P Tomasec","year":"2005","unstructured":"Tomasec P, Wang E, Davison A, Vojtesek B, Armstrong M, Griffin C et al. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nat Immunol 2005; 6: 181\u2013188.","journal-title":"Nat Immunol"},{"key":"BFcgt200874_CR27","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1073\/pnas.92.10.4477","volume":"92","author":"ND Lawson","year":"1995","unstructured":"Lawson ND, Stillman EA, Whitt MA, Rose JK . Recombinant vesicular stomatitis viruses from DNA. Proc Natl Acad Sci USA 1995; 92: 4477\u20134481.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcgt200874_CR28","doi-asserted-by":"publisher","first-page":"8388","DOI":"10.1073\/pnas.92.18.8388","volume":"92","author":"SP Whelan","year":"1995","unstructured":"Whelan SP, Ball LA, Barr JN, Wertz GT . Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones. Proc Natl Acad Sci USA 1995; 92: 8388\u20138392.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcgt200874_CR29","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/hep.20536","volume":"41","author":"K Shinozaki","year":"2005","unstructured":"Shinozaki K, Ebert O, Woo SL . Eradication of advanced hepatocellular carcinoma in rats via repeated hepatic arterial infusions of recombinant VSV. Hepatology 2005; 41: 196\u2013203.","journal-title":"Hepatology"},{"key":"BFcgt200874_CR30","first-page":"207","volume":"298","author":"M Guma","year":"2006","unstructured":"Guma M, Angulo A, Lopez-Botet M . NK cell receptors involved in the response to human cytomegalovirus infection. Curr Top Microbiol Immunol 2006; 298: 207\u2013223.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BFcgt200874_CR31","first-page":"91","volume":"4","author":"A Lin","year":"2007","unstructured":"Lin A, Xu H, Yan W . Modulation of HLA expression in human cytomegalovirus immune evasion. Cell Mol Immunol 2007; 4: 91\u201398.","journal-title":"Cell Mol Immunol"},{"key":"BFcgt200874_CR32","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1034\/j.1600-065X.2001.1810116.x","volume":"181","author":"M Lopez-Botet","year":"2001","unstructured":"Lopez-Botet M, Llano M, Ortega M . Human cytomegalovirus and natural killer-mediated surveillance of HLA class I expression: a paradigm of host-pathogen adaptation. Immunol Rev 2001; 181: 193\u2013202.","journal-title":"Immunol Rev"},{"key":"BFcgt200874_CR33","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/ni1102-1006","volume":"3","author":"JS Orange","year":"2002","unstructured":"Orange JS, Fassett MS, Koopman LA, Boyson JE, Strominger JL . Viral evasion of natural killer cells. Nat Immunol 2002; 3: 1006\u20131012.","journal-title":"Nat Immunol"},{"key":"BFcgt200874_CR34","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.it.2005.06.008","volume":"26","author":"S Rajagopalan","year":"2005","unstructured":"Rajagopalan S, Long EO . Viral evasion of NK-cell activation. Trends Immunol 2005; 26: 403\u2013405.","journal-title":"Trends Immunol"},{"key":"BFcgt200874_CR35","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jcv.2007.10.027","volume":"41","author":"G Wilkinson","year":"2008","unstructured":"Wilkinson G, Tomasec P, Stanton RJ, Armstrong M, Prod'homme V, Aicheler R et al. Modulation of natural killer cells by human cytomegalovirus. J Clin Virol 2008; 41: 206\u2013212.","journal-title":"J Clin Virol"},{"key":"BFcgt200874_CR36","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1084\/jem.20030788","volume":"198","author":"C Bottino","year":"2003","unstructured":"Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B et al. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 2003; 198: 557\u2013567.","journal-title":"J Exp Med"},{"key":"BFcgt200874_CR37","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.4049\/jimmunol.172.7.3994","volume":"172","author":"A Fuchs","year":"2004","unstructured":"Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M . Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol 2004; 172: 3994\u20133998.","journal-title":"J Immunol"},{"key":"BFcgt200874_CR38","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev.immunol.17.1.189","volume":"17","author":"CA Biron","year":"1999","unstructured":"Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP . Natural killer cells in antiviral defense: function and regulation by innate cytokines. Ann Rev Immunol 1999; 17: 189\u2013220.","journal-title":"Ann Rev Immunol"},{"key":"BFcgt200874_CR39","first-page":"169","volume":"5","author":"RM Welsh","year":"1986","unstructured":"Welsh RM . Regulation of virus infections by natural killer cells. Nat Immun Cell Growth Reg 1986; 5: 169\u2013199.","journal-title":"Nat Immun Cell Growth Reg"},{"key":"BFcgt200874_CR40","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0065-2776(08)60664-1","volume":"47","author":"G Trinchieri","year":"1989","unstructured":"Trinchieri G . Biology of natural killer cells. Adv Immunol 1989; 47: 187.","journal-title":"Adv Immunol"},{"key":"BFcgt200874_CR41","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/35095564","volume":"1","author":"A Cerwenka","year":"2001","unstructured":"Cerwenka A, Lanier LL . Natural killer cells, viruses and cancer. Nat Rev Immunol 2001; 1: 41\u201349.","journal-title":"Nat Rev Immunol"},{"key":"BFcgt200874_CR42","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1128\/jvi.69.7.3967-3971.1995","volume":"69","author":"RR Brutkiewicz","year":"1995","unstructured":"Brutkiewicz RR, Welsh RM . Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells. J Virol 1995; 69: 3967\u20133971.","journal-title":"J Virol"},{"key":"BFcgt200874_CR43","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/sj.bmt.1701825","volume":"24","author":"L Baraz","year":"1999","unstructured":"Baraz L, Khazanov E, Condiotti R, Kotler M, Nagler A . Natural killer (NK) cells prevent virus production in cell culture. Bone Marrow Transplant 1999; 24: 179\u2013189.","journal-title":"Bone Marrow Transplant"},{"key":"BFcgt200874_CR44","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/S0952-7915(00)00241-7","volume":"13","author":"CA Biron","year":"2001","unstructured":"Biron CA, Brossay L . NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol 2001; 13: 458\u2013464.","journal-title":"Curr Opin Immunol"},{"key":"BFcgt200874_CR45","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.4049\/jimmunol.162.11.6410","volume":"162","author":"G Eberl","year":"1999","unstructured":"Eberl G, Lees R, Smiley ST, Taniguchi M, Grusby MJ, MacDonald HR . Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T-cells. J Immunol 1999; 162: 6410\u20136419.","journal-title":"J Immunol"},{"key":"BFcgt200874_CR46","doi-asserted-by":"publisher","first-page":"6396","DOI":"10.1073\/pnas.101136398","volume":"98","author":"T Todo","year":"2001","unstructured":"Todo T, Martuza RL, Rabkin SD, Johnson PA . Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing. Proc Natl Acad Sci USA 2001; 98: 6396\u20136401.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcgt200874_CR47","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S1525-0016(03)00236-3","volume":"8","author":"D Thomas","year":"2003","unstructured":"Thomas D, Fraser NW . HSV-1 therapy of primary tumors reduces the number of metastases in an immune-competent model of metastatic breast cancer. Mol Ther 2003; 8: 543\u2013551.","journal-title":"Mol Ther"},{"key":"BFcgt200874_CR48","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.1158\/0008-5472.CAN-06-3974","volume":"67","author":"R Diaz","year":"2007","unstructured":"Diaz R, Galivo F, Kottke T, Wongthida P, Qiao J, Thompson J et al. Oncolytic immunovirotherapy for melanoma using vesicular stomatitis virus. Cancer Res 2007; 67: 2840\u20132848.","journal-title":"Cancer Res"}],"container-title":["Cancer Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cgt200874.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cgt200874","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cgt200874.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T10:25:06Z","timestamp":1684578306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cgt200874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,10]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["BFcgt200874"],"URL":"https:\/\/doi.org\/10.1038\/cgt.2008.74","relation":{},"ISSN":["0929-1903","1476-5500"],"issn-type":[{"value":"0929-1903","type":"print"},{"value":"1476-5500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,10]]},"assertion":[{"value":"13 April 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}