{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:03:51Z","timestamp":1790899431984,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacol Ther"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1038\/clpt.2010.127","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T22:07:50Z","timestamp":1280354870000},"page":"383-389","source":"Crossref","is-referenced-by-count":53,"title":["OPRM1 and CYP2B6 Gene Variants as Risk Factors in Methadone-Related Deaths"],"prefix":"10.1111","volume":"88","author":[{"given":"H","family":"Bunten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W J","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Pounder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Seneviratne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Osselton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,28]]},"reference":[{"key":"clpt2010127-bib1","unstructured":""},{"key":"clpt2010127-bib2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1997.t01-1-00591.x"},{"key":"clpt2010127-bib3","doi-asserted-by":"publisher","DOI":"10.1002\/hup.630"},{"key":"clpt2010127-bib4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00921.x"},{"key":"clpt2010127-bib5","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20707"},{"key":"clpt2010127-bib6","doi-asserted-by":"publisher","DOI":"10.1186\/cc5699"},{"key":"clpt2010127-bib7","doi-asserted-by":"publisher","DOI":"10.1177\/096032718400300305"},{"key":"clpt2010127-bib8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00179.x"},{"key":"clpt2010127-bib9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.09.006"},{"key":"clpt2010127-bib10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2007.00485.x"},{"key":"clpt2010127-bib11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100120"},{"key":"clpt2010127-bib12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2002.tb00185.x"},{"key":"clpt2010127-bib13","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0022-3565(24)29199-0","volume":"299","author":"Dai D.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"clpt2010127-bib14","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.bbagen.2006.09.024","volume":"1770","author":"Plant N.","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"clpt2010127-bib15","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4505"},{"key":"clpt2010127-bib16","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200107000-00004"},{"key":"clpt2010127-bib17","first-page":"887","volume":"29","author":"Yanagihara Y.","year":"2001","journal-title":"Drug Metab. Dispos"},{"key":"clpt2010127-bib18","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0026-895X(24)12054-8","volume":"28","author":"Faucette S.R.","year":"2000","journal-title":"Drug Metab. Dispos"},{"key":"clpt2010127-bib19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90008-4"},{"key":"clpt2010127-bib20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9608"},{"key":"clpt2010127-bib21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00772.x"},{"key":"clpt2010127-bib22","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00011"},{"key":"clpt2010127-bib23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001504"},{"key":"clpt2010127-bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.5694\/j.1326-5377.1995.tb126051.x","volume":"162","author":"Darke S.G.","year":"1995","journal-title":"Med. J. Aust"},{"key":"clpt2010127-bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0022-3565(25)21486-0","volume":"230","author":"McCormick G.Y.","year":"1984","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"clpt2010127-bib26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.08.011"},{"key":"clpt2010127-bib27","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200310000-00005"},{"key":"clpt2010127-bib28","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.031708"},{"key":"clpt2010127-bib29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000331"},{"key":"clpt2010127-bib30","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.05.019"},{"key":"clpt2010127-bib31","first-page":"1406","volume":"48","author":"Wong S.H.","year":"2003","journal-title":"J. Forensic Sci"},{"key":"clpt2010127-bib32","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03286-1"},{"key":"clpt2010127-bib33","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(90)90182-X"},{"key":"clpt2010127-bib34","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1520\/JFS14195J","volume":"42","author":"Moriya F.","year":"1997","journal-title":"J. Forensic Sci"},{"key":"clpt2010127-bib35","first-page":"37","volume":"261","author":"George S.T.","year":"1999","journal-title":"J. Biol. Chem"},{"key":"clpt2010127-bib36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504942200"},{"key":"clpt2010127-bib37","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1124\/mol.53.3.377","volume":"53","author":"Keith D.E.","year":"1998","journal-title":"Mol. Pharmacol"},{"key":"clpt2010127-bib38","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199608000-00001"},{"key":"clpt2010127-bib39","first-page":"100","volume":"29","author":"Hesse L.M.","year":"2001","journal-title":"Drug Metab. Dispos"},{"key":"clpt2010127-bib40","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0090-9556(24)12022-3","volume":"2","author":"Spaulding T.C.","year":"1974","journal-title":"Drug Metab. Dispos"},{"key":"clpt2010127-bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0022-5347(24)06140-8","volume":"7","author":"Shah N.S.","year":"1979","journal-title":"Drug Metab. Dispos"},{"key":"clpt2010127-bib42","doi-asserted-by":"publisher","DOI":"10.3109\/00498259509061850"},{"key":"clpt2010127-bib43","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006293753"},{"key":"clpt2010127-bib44","doi-asserted-by":"publisher","DOI":"10.1191\/0960327102ht303oa"},{"key":"clpt2010127-bib45","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90086-0"},{"key":"clpt2010127-bib46","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199011000-00005"},{"key":"clpt2010127-bib47","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08249FP"},{"key":"clpt2010127-bib48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13652"},{"key":"clpt2010127-bib49","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.004994"},{"key":"clpt2010127-bib50","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00002-4"}],"container-title":["Clinical Pharmacology & Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T15:05:58Z","timestamp":1740323158000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1038\/clpt.2010.127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,28]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,7,28]]},"published-print":{"date-parts":[[2010,9]]}},"alternative-id":["clpt2010127"],"URL":"https:\/\/doi.org\/10.1038\/clpt.2010.127","relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,28]]}}}