{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:58:55Z","timestamp":1778767135790,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacol Ther"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/clpt.2011.178","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T12:08:07Z","timestamp":1320235687000},"page":"442-449","source":"Crossref","is-referenced-by-count":41,"title":["Evidence of CYP3A Allosterism In Vivo: Analysis of Interaction Between Fluconazole and Midazolam"],"prefix":"10.1111","volume":"91","author":[{"given":"J","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Isoherranen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Paine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E","family":"Thummel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,2]]},"reference":[{"key":"clpt2011178-bib1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2165\/00126839-200607060-00004","volume":"7","author":"Tracy T.S.","year":"2006","journal-title":"Drugs R. D"},{"key":"clpt2011178-bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1359-6446(04)03072-7","volume":"9","author":"Atkins W.M.","year":"2004","journal-title":"Drug Discov. Today"},{"key":"clpt2011178-bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1389200013338658","volume":"2","author":"Tang W.","year":"2001","journal-title":"Curr. Drug Metab"},{"key":"clpt2011178-bib4","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1517\/17425250802500028","volume":"4","author":"Davydov D.R.","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol"},{"key":"clpt2011178-bib5","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0022-3565(24)35211-5","volume":"291","author":"Tang W.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"clpt2011178-bib6","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1124\/dmd.109.029397","volume":"37","author":"van Waterschoot R.A.","year":"2009","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1067\/mcp.2000.105756","volume":"67","author":"Backman J.T.","year":"2000","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2011178-bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0928-0987(01)00144-0","volume":"14","author":"Hutzler J.M.","year":"2001","journal-title":"Eur. J. Pharm. Sci"},{"key":"clpt2011178-bib9","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1124\/jpet.102.047530","volume":"305","author":"Egnell A.C.","year":"2003","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"clpt2011178-bib10","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S1359-6446(04)03109-5","volume":"9","author":"Jones J.P.","year":"2004","journal-title":"Drug Discov. Today"},{"key":"clpt2011178-bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1124\/dmd.30.4.355","volume":"30","author":"Hutzler J.M.","year":"2002","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/00000542-198503000-00017","volume":"62","author":"Reves J.G.","year":"1985","journal-title":"Anesthesiology"},{"key":"clpt2011178-bib13","doi-asserted-by":"crossref","first-page":"14143","DOI":"10.1021\/bi051689t","volume":"44","author":"Cameron M.D.","year":"2005","journal-title":"Biochemistry"},{"key":"clpt2011178-bib14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1124\/dmd.30.8.883","volume":"30","author":"Williams J.A.","year":"2002","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib15","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0090-9556(25)07487-2","volume":"24","author":"Ghosal A.","year":"1996","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib16","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/bja\/73.5.658","volume":"73","author":"Wandel C.","year":"1994","journal-title":"Br. J. Anaesth"},{"key":"clpt2011178-bib17","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/0006-2952(94)90543-6","volume":"47","author":"Gorski J.C.","year":"1994","journal-title":"Biochem. Pharmacol"},{"key":"clpt2011178-bib18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1124\/dmd.107.018382","volume":"36","author":"Isoherranen N.","year":"2008","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/j.1552-4604.1996.tb04251.x","volume":"36","author":"von Moltke L.L.","year":"1996","journal-title":"J. Clin. Pharmacol"},{"key":"clpt2011178-bib20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0090-9556(24)15374-3","volume":"28","author":"Wang R.W.","year":"2000","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib21","first-page":"502","volume":"25","author":"Wang R.W.","year":"1997","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1081\/DMR-120026870","volume":"35","author":"Houston J.B.","year":"2003","journal-title":"Drug Metab. Rev"},{"key":"clpt2011178-bib23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2165\/00003495-199039060-00006","volume":"39","author":"Grant S.M.","year":"1990","journal-title":"Drugs"},{"key":"clpt2011178-bib24","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1124\/dmd.104.001313","volume":"32","author":"Huang W.","year":"2004","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/bja\/73.5.658","volume":"73","author":"Wandel C.","year":"1994","journal-title":"Br. J. Anaesth"},{"key":"clpt2011178-bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0163-7258(81)90056-5","volume":"15","author":"Houston J.B.","year":"1981","journal-title":"Pharmacol. Ther"},{"key":"clpt2011178-bib27","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1124\/dmd.110.035295","volume":"38","author":"Seo K.A.","year":"2010","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2125.2009.03386.x","volume":"67","author":"Hyland R.","year":"2009","journal-title":"Br. J. Clin. Pharmacol"},{"key":"clpt2011178-bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/dmd.107.017962","volume":"36","author":"Zhu B.","year":"2008","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.pharmtox.38.1.389","volume":"38","author":"Thummel K.E.","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"clpt2011178-bib31","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1021\/bi00187a009","volume":"33","author":"Shou M.","year":"1994","journal-title":"Biochemistry"},{"key":"clpt2011178-bib32","doi-asserted-by":"crossref","first-page":"13682","DOI":"10.1073\/pnas.0603236103","volume":"103","author":"Ekroos M.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"clpt2011178-bib33","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1124\/mol.61.3.495","volume":"61","author":"Khan K.K.","year":"2002","journal-title":"Mol. Pharmacol"},{"key":"clpt2011178-bib34","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1021\/bi992765t","volume":"39","author":"Hosea N.A.","year":"2000","journal-title":"Biochemistry"},{"key":"clpt2011178-bib35","first-page":"141S","volume":"10","author":"Dudley M.N.","year":"1990","journal-title":"Pharmacotherapy"},{"key":"clpt2011178-bib36","first-page":"231","volume":"60","author":"Eap C.B.","year":"2004","journal-title":"Eur. J. Clin. Pharmacol"},{"key":"clpt2011178-bib37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.clpt.2004.03.009","volume":"76","author":"Yu K.S.","year":"2004","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2011178-bib38","unstructured":""},{"key":"clpt2011178-bib39","first-page":"830","volume":"26","author":"Hawes E.M.","year":"1998","journal-title":"Drug Metab. Dispos"},{"key":"clpt2011178-bib40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0009-9236(96)90162-9","volume":"60","author":"Paine M.F.","year":"1996","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2011178-bib41","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/mutage\/17.6.471","volume":"17","author":"Wild C.P.","year":"2002","journal-title":"Mutagenesis"},{"key":"clpt2011178-bib42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1021\/tx050358e","volume":"19","author":"Kamdem L.K.","year":"2006","journal-title":"Chem. Res. Toxicol"},{"key":"clpt2011178-bib43","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1124\/jpet.104.065607","volume":"310","author":"Desta Z.","year":"2004","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"clpt2011178-bib44","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2165\/00003088-200544040-00002","volume":"44","author":"Rochat B.","year":"2005","journal-title":"Clin. Pharmacokinet"},{"key":"clpt2011178-bib45","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0022-3565(24)37149-6","volume":"283","author":"Paine M.F.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther"}],"container-title":["Clinical Pharmacology & Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:11:45Z","timestamp":1741875105000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1038\/clpt.2011.178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,2]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,11,2]]},"published-print":{"date-parts":[[2012,3]]}},"alternative-id":["clpt2011178"],"URL":"https:\/\/doi.org\/10.1038\/clpt.2011.178","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13945985.15401091","asserted-by":"object"}]},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,2]]}}}