{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:56:41Z","timestamp":1791107801415,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacol Ther"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1038\/clpt.2011.227","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T09:01:52Z","timestamp":1325062912000},"page":"289-297","source":"Crossref","is-referenced-by-count":72,"title":["Mineralocorticoid Receptor Blocker Eplerenone Improves Endothelial Function and Inhibits Rho-Associated Kinase Activity in Patients With Hypertension"],"prefix":"10.1111","volume":"91","author":[{"given":"N","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Noma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Soga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Idei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Maruhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J K","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"clpt2011227-bib1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5304.1308"},{"key":"clpt2011227-bib2","doi-asserted-by":"publisher","DOI":"10.1038\/40187"},{"key":"clpt2011227-bib3","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.509"},{"key":"clpt2011227-bib4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5542"},{"key":"clpt2011227-bib5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000753200"},{"key":"clpt2011227-bib6","doi-asserted-by":"publisher","DOI":"10.1161\/hh1801.096337"},{"key":"clpt2011227-bib7","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.062265"},{"key":"clpt2011227-bib8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602099200"},{"key":"clpt2011227-bib9","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.096541"},{"key":"clpt2011227-bib10","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328340902d"},{"key":"clpt2011227-bib11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"clpt2011227-bib12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153339.27064.14"},{"key":"clpt2011227-bib13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007053230105"},{"key":"clpt2011227-bib14","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1161\/01.CIR.97.22.2222","volume":"97","author":"Taddei S.","year":"1998","journal-title":"Circulation"},{"key":"clpt2011227-bib15","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/01.CIR.100.11.1194","volume":"100","author":"Higashi Y.","year":"1999","journal-title":"Circulation"},{"key":"clpt2011227-bib16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/01.HYP.25.4.699","volume":"25","author":"Schiffrin E.L.","year":"1995","journal-title":"Hypertension"},{"key":"clpt2011227-bib17","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00561-6"},{"key":"clpt2011227-bib18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"clpt2011227-bib19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"clpt2011227-bib20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009492"},{"key":"clpt2011227-bib21","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01241-X"},{"key":"clpt2011227-bib22","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02321-9"},{"key":"clpt2011227-bib23","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199322005-00003"},{"key":"clpt2011227-bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.HYP.24.4.499","volume":"24","author":"Creager M.A.","year":"1994","journal-title":"Hypertension"},{"key":"clpt2011227-bib25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/01.RES.68.2.450","volume":"68","author":"Daemen M.J.","year":"1991","journal-title":"Circ. Res."},{"key":"clpt2011227-bib26","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/01.CIR.93.9.1734","volume":"93","author":"Sudhir K.","year":"1996","journal-title":"Circulation"},{"key":"clpt2011227-bib27","doi-asserted-by":"publisher","DOI":"10.1159\/000075945"},{"key":"clpt2011227-bib28","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000157408.43807.5a"},{"key":"clpt2011227-bib29","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1294"},{"key":"clpt2011227-bib30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000129307.26791.8E"},{"key":"clpt2011227-bib31","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.017368"},{"key":"clpt2011227-bib32","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1510-8"},{"key":"clpt2011227-bib33","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0393"},{"key":"clpt2011227-bib34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022287"},{"key":"clpt2011227-bib35","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-000-0061-8"},{"key":"clpt2011227-bib36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/01.HYP.32.1.16","volume":"32","author":"Higashi Y.","year":"1998","journal-title":"Hypertension"},{"key":"clpt2011227-bib37","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08089-3"},{"key":"clpt2011227-bib38","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.1407"},{"key":"clpt2011227-bib39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00148.2008"},{"key":"clpt2011227-bib40","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121375"},{"key":"clpt2011227-bib41","doi-asserted-by":"publisher","DOI":"10.1161\/hc1002.105938"},{"key":"clpt2011227-bib42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.043"},{"key":"clpt2011227-bib43","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.12.023"},{"key":"clpt2011227-bib44","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.3"},{"key":"clpt2011227-bib45","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.10.005"},{"key":"clpt2011227-bib46","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01657-4"},{"key":"clpt2011227-bib47","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000251668.39526.c7"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:30:04Z","timestamp":1699345804000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1038\/clpt.2011.227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,28]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,12,28]]},"published-print":{"date-parts":[[2012,2]]}},"alternative-id":["clpt2011227"],"URL":"https:\/\/doi.org\/10.1038\/clpt.2011.227","relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,28]]}}}