{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:13:04Z","timestamp":1783177984886,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacol Ther"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/clpt.2011.273","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T20:41:56Z","timestamp":1330548116000},"page":"666-672","source":"Crossref","is-referenced-by-count":42,"title":["A Modeling and Simulation Approach to Characterize Methadone QT Prolongation Using Pooled Data From Five Clinical Trials in MMT Patients"],"prefix":"10.1111","volume":"91","author":[{"given":"J","family":"Florian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"Garnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S C","family":"Nallani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Rappaport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Throckmorton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"key":"clpt2011273-bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0885-3924(95)00191-3","volume":"11","author":"Gardner-Nix J.S.","year":"1996","journal-title":"J. Pain Symptom Manage"},{"key":"clpt2011273-bib2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/pds.1112","volume":"14","author":"Pearson E.C.","year":"2005","journal-title":"Pharmacoepidemiol. Drug Saf"},{"key":"clpt2011273-bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1213\/01.ANE.0000099723.75548.DF","volume":"98","author":"Callahan R.J.","year":"2004","journal-title":"Anesth. Analg"},{"key":"clpt2011273-bib4","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1124\/jpet.102.038240","volume":"303","author":"Katchman A.N.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"clpt2011273-bib5","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1001\/archinte.166.12.1280","volume":"166","author":"Ehret G.B.","year":"2006","journal-title":"Arch. Intern. Med"},{"key":"clpt2011273-bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.12968\/hmed.2007.68.4.221","volume":"68","author":"George S.","year":"2007","journal-title":"Br. J. Hosp. Med. (Lond)"},{"key":"clpt2011273-bib7","first-page":"43","volume":"100","author":"Iskandar S.B.","year":"2007","journal-title":"Tenn. Med"},{"key":"clpt2011273-bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0304-3959(03)00205-7","volume":"105","author":"Kornick C.A.","year":"2003","journal-title":"Pain"},{"key":"clpt2011273-bib9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.7326\/0003-4819-137-6-200209170-00010","volume":"137","author":"Krantz M.J.","year":"2002","journal-title":"Ann. Intern. Med"},{"key":"clpt2011273-bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.amjcard.2003.12.071","volume":"94","author":"Lucchini A.","year":"2004","journal-title":"Am. J. Cardiol"},{"key":"clpt2011273-bib11","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.amjcard.2004.11.055","volume":"95","author":"Martell B.A.","year":"2005","journal-title":"Am. J. Cardiol"},{"key":"clpt2011273-bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5055\/jom.2006.0008","volume":"2","author":"Schmittner J.","year":"2006","journal-title":"J. Opioid Manag"},{"key":"clpt2011273-bib13","first-page":"2289; auth","volume":"166","author":"Schmittner J.","year":"2006","journal-title":"Arch. Intern. Med"},{"key":"clpt2011273-bib14","unstructured":""},{"key":"clpt2011273-bib15","unstructured":""},{"key":"clpt2011273-bib16","unstructured":""},{"key":"clpt2011273-bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7326\/0003-4819-150-6-200903170-00103","volume":"150","author":"Krantz M.J.","year":"2009","journal-title":"Ann. Intern. Med"},{"key":"clpt2011273-bib18","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.amjcard.2003.11.066","volume":"93","author":"Krantz M.J.","year":"2004","journal-title":"Am. J. Cardiol"},{"key":"clpt2011273-bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1360-0443.2006.01668.x","volume":"102","author":"Peles E.","year":"2007","journal-title":"Addiction"},{"key":"clpt2011273-bib20","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/sj.clpt.6100120","volume":"81","author":"Eap C.B.","year":"2007","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2011273-bib21","unstructured":""},{"key":"clpt2011273-bib22","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1056\/NEJMra032426","volume":"350","author":"Roden D.M.","year":"2004","journal-title":"N. Engl. J. Med"},{"key":"clpt2011273-bib23","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1001\/archinte.167.22.2469","volume":"167","author":"Wedam E.F.","year":"2007","journal-title":"Arch. Intern. Med"},{"key":"clpt2011273-bib24","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1046\/j.1360-0443.2000.951217717.x","volume":"95","author":"Wolff K.","year":"2000","journal-title":"Addiction"},{"key":"clpt2011273-bib25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1365-2125.2004.02079.x","volume":"57","author":"Foster D.J.","year":"2004","journal-title":"Br. J. Clin. Pharmacol"},{"key":"clpt2011273-bib26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1365-2125.2005.02464.x","volume":"60","author":"Hanna J.","year":"2005","journal-title":"Br. J. Clin. Pharmacol"},{"key":"clpt2011273-bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-2125.1997.t01-1-00591.x","volume":"44","author":"Wolff K.","year":"1997","journal-title":"Br. J. Clin. Pharmacol"},{"key":"clpt2011273-bib28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/AAC.00559-06","volume":"51","author":"Liu P.","year":"2007","journal-title":"Antimicrob. Agents Chemother"},{"key":"clpt2011273-bib29","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1592\/phco.28.7.863","volume":"28","author":"Cao Y.J.","year":"2008","journal-title":"Pharmacotherapy"},{"key":"clpt2011273-bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/0091270010365558","volume":"51","author":"Sekar V.","year":"2011","journal-title":"J. Clin. Pharmacol"},{"key":"clpt2011273-bib31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.clpt.2004.09.008","volume":"77","author":"Sulkowski M.","year":"2005","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2011273-bib32","first-page":"353","volume":"7","author":"Bazett, J.C.","year":"1920","journal-title":"Heart"},{"key":"clpt2011273-bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.0954-6820.1920.tb18266.x","volume":"53","author":"Fridericia, L.S","year":"1920","journal-title":"Acta Med Scand"},{"key":"clpt2011273-bib34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2165\/00002018-200730120-00003","volume":"30","author":"Shah R.R.","year":"2007","journal-title":"Drug Saf"},{"key":"clpt2011273-bib35","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJMoa022147","volume":"348","author":"Priori S.G.","year":"2003","journal-title":"N. Engl. J. Med"},{"key":"clpt2011273-bib36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jacc.2005.08.067","volume":"47","author":"Straus S.M.","year":"2006","journal-title":"J. Am. Coll. Cardiol"},{"key":"clpt2011273-bib37","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1001\/jama.1993.03510210076031","volume":"270","author":"Makkar R.R.","year":"1993","journal-title":"JAMA"},{"key":"clpt2011273-bib38","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0002-9149(02)02337-8","volume":"89","author":"Bednar M.M.","year":"2002","journal-title":"Am. J. Cardiol"},{"key":"clpt2011273-bib39","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/hrt.2006.100180","volume":"93","author":"Fanoe S.","year":"2007","journal-title":"Heart"},{"key":"clpt2011273-bib40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jpainsymman.2004.06.012","volume":"29","author":"Cruciani R.A.","year":"2005","journal-title":"J. Pain Symptom Manage"},{"key":"clpt2011273-bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000081416","volume":"11","author":"Maremmani I.","year":"2005","journal-title":"Eur. Addict. Res"},{"key":"clpt2011273-bib42","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0022-3565(24)29321-6","volume":"299","author":"Ferreira S.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"clpt2011273-bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1300\/J069v24n01_05","volume":"24","author":"Krantz M.J.","year":"2005","journal-title":"J. Addict. Dis"},{"key":"clpt2011273-bib44","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/QAD.0b013e32833407d3","volume":"24","author":"Bruce R.D.","year":"2010","journal-title":"AIDS"},{"key":"clpt2011273-bib45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00007691-199402000-00006","volume":"16","author":"Bertschy G.","year":"1994","journal-title":"Ther. Drug Monit"},{"key":"clpt2011273-bib46","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.clpt.2004.05.003","volume":"76","author":"Kharasch E.D.","year":"2004","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2011273-bib47","unstructured":""}],"container-title":["Clinical Pharmacology & Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T06:42:51Z","timestamp":1742625771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/clpt.2011.273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,29]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,2,29]]},"published-print":{"date-parts":[[2012,4]]}},"alternative-id":["clpt2011273"],"URL":"https:\/\/doi.org\/10.1038\/clpt.2011.273","relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,29]]}}}