{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:10:59Z","timestamp":1791414659441,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacol Ther"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1038\/clpt.2013.172","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T13:28:11Z","timestamp":1377782891000},"page":"640-645","source":"Crossref","is-referenced-by-count":286,"title":["Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing"],"prefix":"10.1111","volume":"94","author":[{"given":"K E","family":"Caudle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C F","family":"Thorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T E","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J","family":"Swen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H L","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R B","family":"Diasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"clpt2013172-bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00003088-198916040-00002","volume":"16","author":"Diasio R.B.","year":"1989","journal-title":"Clin. Pharmacokinet"},{"key":"clpt2013172-bib2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/clpt.2010.279","volume":"89","author":"Relling M.V.","year":"2011","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2013172-bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/FPC.0b013e32833c6107","volume":"21","author":"Thorn C.F.","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"clpt2013172-bib4","first-page":"2899","volume":"52","author":"Fleming R.A.","year":"1992","journal-title":"Cancer Res"},{"key":"clpt2013172-bib5","first-page":"768","volume":"8","author":"Johnson M.R.","year":"2002","journal-title":"Clin. Cancer Res"},{"key":"clpt2013172-bib6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/geno.1998.5379","volume":"51","author":"Wei X.","year":"1998","journal-title":"Genomics"},{"key":"clpt2013172-bib7","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1172\/JCI118830","volume":"98","author":"Wei X.","year":"1996","journal-title":"J. Clin. Invest"},{"key":"clpt2013172-bib8","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/S0959-8049(97)00261-X","volume":"33","author":"Van Kuilenburg A.B.","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"clpt2013172-bib9","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1158\/0008-5472.CAN-12-3858","volume":"73","author":"Offer S.M.","year":"2013","journal-title":"Cancer Res"},{"key":"clpt2013172-bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clinbiochem.2009.09.024","volume":"43","author":"Ofverholm A.","year":"2010","journal-title":"Clin. Biochem"},{"key":"clpt2013172-bib11","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1200\/JCO.2006.10.4182","volume":"26","author":"Schwab M.","year":"2008","journal-title":"J. Clin. Oncol"},{"key":"clpt2013172-bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2710.2008.00898.x","volume":"33","author":"He Y.F.","year":"2008","journal-title":"J. Clin. Pharm. Ther"},{"key":"clpt2013172-bib13","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.crvi.2007.08.003","volume":"330","author":"Ben Fredj R.","year":"2007","journal-title":"C. R. Biol"},{"key":"clpt2013172-bib14","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1007\/s10038-007-0186-6","volume":"52","author":"Maekawa K.","year":"2007","journal-title":"J. Hum. Genet"},{"key":"clpt2013172-bib15","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/clpt.2011.34","volume":"89","author":"Swen J.J.","year":"2011","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2013172-bib16","first-page":"4705","volume":"6","author":"van Kuilenburg A.B.","year":"2000","journal-title":"Clin. Cancer Res"},{"key":"clpt2013172-bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s004390050637","volume":"101","author":"Vreken P.","year":"1997","journal-title":"Hum. Genet"},{"key":"clpt2013172-bib18","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1158\/1535-7163.MCT-06-0327","volume":"5","author":"Morel A.","year":"2006","journal-title":"Mol. Cancer Ther"},{"key":"clpt2013172-bib19","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2217\/pgs.09.28","volume":"10","author":"Amstutz U.","year":"2009","journal-title":"Pharmacogenomics"},{"key":"clpt2013172-bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/clpt.2013.69","volume":"94","author":"Offer S.M.","year":"2013","journal-title":"Clin. Pharmacol. Ther"},{"key":"clpt2013172-bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ijc.10599","volume":"101","author":"Van Kuilenburg A.B.","year":"2002","journal-title":"Int. J. Cancer"},{"key":"clpt2013172-bib22","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.2217\/pgs.11.72","volume":"12","author":"Amstutz U.","year":"2011","journal-title":"Pharmacogenomics"},{"key":"clpt2013172-bib23","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1158\/1078-0432.CCR-10-2209","volume":"17","author":"Deenen M.J.","year":"2011","journal-title":"Clin. Cancer Res"},{"key":"clpt2013172-bib24","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1158\/1078-0432.CCR-04-0337","volume":"10","author":"Noguchi T.","year":"2004","journal-title":"Clin. Cancer Res"},{"key":"clpt2013172-bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.lungcan.2011.12.018","volume":"77","author":"Hirota T.","year":"2012","journal-title":"Lung Cancer"},{"key":"clpt2013172-bib26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00008571-200210000-00007","volume":"12","author":"Van Kuilenburg A.B.","year":"2002","journal-title":"Pharmacogenetics"},{"key":"clpt2013172-bib27","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/humu.9201","volume":"22","author":"Gross E.","year":"2003","journal-title":"Hum. Mutat"},{"key":"clpt2013172-bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1005356806329","volume":"20","author":"van Gennip A.H.","year":"1997","journal-title":"J. Inherit. Metab. Dis"},{"key":"clpt2013172-bib29","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s10545-005-0133-7","volume":"28","author":"Schmidt C.","year":"2005","journal-title":"J. Inherit. Metab. Dis"},{"key":"clpt2013172-bib30","unstructured":""},{"key":"clpt2013172-bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00280-010-1282-4","volume":"67","author":"Yang C.G.","year":"2011","journal-title":"Cancer Chemother. Pharmacol"},{"key":"clpt2013172-bib32","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/sj.tpj.6500476","volume":"8","author":"Capitain O.","year":"2008","journal-title":"Pharmacogenomics J"},{"key":"clpt2013172-bib33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1172\/JCI113308","volume":"81","author":"Diasio R.B.","year":"1988","journal-title":"J. Clin. Invest"},{"key":"clpt2013172-bib34","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6600208","volume":"86","author":"Maring J.G.","year":"2002","journal-title":"Br. J. Cancer"},{"key":"clpt2013172-bib35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.canlet.2006.09.006","volume":"249","author":"Boisdron-Celle M.","year":"2007","journal-title":"Cancer Lett"},{"key":"clpt2013172-bib36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-2407-11-98","volume":"11","author":"Cellier P.","year":"2011","journal-title":"BMC Cancer"},{"key":"clpt2013172-bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10545-009-1094-z","volume":"32","author":"Jurecka A.","year":"2009","journal-title":"J. Inherit. Metab. Dis"},{"key":"clpt2013172-bib38","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1200\/JCO.1994.12.11.2248","volume":"12","author":"Etienne M.C.","year":"1994","journal-title":"J. Clin. Oncol"},{"key":"clpt2013172-bib39","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/sj.bjc.6690098","volume":"79","author":"Milano G.","year":"1999","journal-title":"Br. J. Cancer"},{"key":"clpt2013172-bib40","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1200\/JCO.2007.13.3934","volume":"26","author":"Gamelin E.","year":"2008","journal-title":"J. Clin. Oncol"}],"container-title":["Clinical Pharmacology & Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:26:57Z","timestamp":1699363617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/clpt.2013.172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,8,29]]},"published-print":{"date-parts":[[2013,12]]}},"alternative-id":["clpt2013172"],"URL":"https:\/\/doi.org\/10.1038\/clpt.2013.172","relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}