{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:38:36Z","timestamp":1770910716541,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/cmi.2011.65","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T09:49:14Z","timestamp":1328521754000},"page":"131-135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Synergistic and feedback signaling mechanisms in the regulation of inflammation in respiratory infections"],"prefix":"10.1038","volume":"9","author":[{"given":"Wenzhuo Y","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae","family":"Hyang Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,6]]},"reference":[{"issue":"Suppl S1","key":"BFcmi201165_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/jac\/dkf809","volume":"50","author":"D Nicolau","year":"2002","unstructured":"Nicolau D . Clinical and economic implications of antimicrobial resistance for the management of community-acquired respiratory tract infections. J Antimicrob Chemother 2002; 50 (Suppl S1): 61\u201370.","journal-title":"J Antimicrob Chemother"},{"key":"BFcmi201165_CR2","first-page":"S400","volume":"10","author":"DI Brixner","year":"2004","unstructured":"Brixner DI . Clinical and economic outcomes in the treatment of lower respiratory tract infections. Am J Manag Care 2004; 10: S400\u2013S407.","journal-title":"Am J Manag Care"},{"key":"BFcmi201165_CR3","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1378\/chest.120.6.2021","volume":"120","author":"R Guthrie","year":"2001","unstructured":"Guthrie R . Community-acquired lower respiratory tract infections: etiology and treatment. Chest 2001; 120: 2021\u20132034.","journal-title":"Chest"},{"key":"BFcmi201165_CR4","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1183\/09031936.96.09091913","volume":"9","author":"OA Khair","year":"1996","unstructured":"Khair OA, Davies RJ, Devalia JL . Bacterial-induced release of inflammatory mediators by bronchial epithelial cells. Eur Respir J 1996; 9: 1913\u20131922.","journal-title":"Eur Respir J"},{"key":"BFcmi201165_CR5","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/sj.emboj.7601546","volume":"26","author":"H Ishinaga","year":"2007","unstructured":"Ishinaga H, Jono H, Lim JH, Kweon SM, Xu H, Ha UH et al. TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. EMBO J 2007; 26: 1150\u20131162.","journal-title":"EMBO J"},{"key":"BFcmi201165_CR6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.bbrc.2006.10.052","volume":"351","author":"SM Kweon","year":"2006","unstructured":"Kweon SM, Wang B, Rixter D, Lim JH, Koga T, Ishinaga H et al. Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta\u2013IkappaBalpha, and p38 MAPK. Biochem Biophys Res Commun 2006; 351: 368\u2013375.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcmi201165_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2172-9-40","volume":"9","author":"JH Lim","year":"2008","unstructured":"Lim JH, Jono H, Ha UH, Xu H, Ishinaga H, Morino S et al. Streptococcus pneumoniae synergizes with nontypeable Haemophilus influenzae to induce inflammation via upregulating TLR2. BMC Immunol 2008; 9: 40.","journal-title":"BMC Immunol"},{"key":"BFcmi201165_CR8","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1073\/pnas.0500599102","volume":"102","author":"AJ Ratner","year":"2005","unstructured":"Ratner AJ, Lysenko ES, Paul MN, Weiser JN . Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfaces. Proc Natl Acad Sci USA 2005; 102: 3429\u20133434.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201165_CR9","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1073\/pnas.0400557101","volume":"101","author":"T Watanabe","year":"2004","unstructured":"Watanabe T, Jono H, Han J, Lim DJ, Li JD . Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proc Natl Acad Sci USA 2004; 101: 3563\u20133568.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201165_CR10","first-page":"2532","volume":"116","author":"JC Deng","year":"2006","unstructured":"Deng JC, Cheng G, Newstead MW, Zeng X, Kobayashi K, Flavell RA et al. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest 2006; 116: 2532\u20132542.","journal-title":"J Clin Invest"},{"key":"BFcmi201165_CR11","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","volume":"289","author":"EG Lee","year":"2000","unstructured":"Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000; 289: 2350\u20132354.","journal-title":"Science"},{"key":"BFcmi201165_CR12","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1111\/j.1462-5822.2008.01204.x","volume":"10","author":"JH Lim","year":"2008","unstructured":"Lim JH, Ha UH, Woo CH, Xu H, Li JD . CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. Cell Microbiol 2008; 10: 2247\u20132256.","journal-title":"Cell Microbiol"},{"key":"BFcmi201165_CR13","doi-asserted-by":"publisher","first-page":"e1032","DOI":"10.1371\/journal.pone.0001032","volume":"2","author":"JH Lim","year":"2007","unstructured":"Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P et al. Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. PLoS ONE 2007; 2: e1032.","journal-title":"PLoS ONE"},{"key":"BFcmi201165_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/cdd.2009.43","volume":"17","author":"SC Sun","year":"2010","unstructured":"Sun SC . CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ 2010; 17: 25\u201334.","journal-title":"Cell Death Differ"},{"key":"BFcmi201165_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0168-1656(99)00113-3","volume":"73","author":"J Kyd","year":"1999","unstructured":"Kyd J, Cripps A . Nontypeable Haemophilus influenzae: challenges in developing a vaccine. J Biotechnol 1999; 73: 103\u2013108.","journal-title":"J Biotechnol"},{"key":"BFcmi201165_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1254\/jphs.91.1","volume":"91","author":"JD Li","year":"2003","unstructured":"Li JD . Exploitation of host epithelial signaling networks by respiratory bacterial pathogens. J Pharmacol Sci 2003; 91: 1\u20137.","journal-title":"J Pharmacol Sci"},{"key":"BFcmi201165_CR17","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1097\/INF.0b013e3181b6d7ec","volume":"28","author":"TF Murphy","year":"2009","unstructured":"Murphy TF, Bakaletz LO, Smeesters PR . Microbial interactions in the respiratory tract. Pediatr Infect Dis J 2009; 28: S121\u2013S126.","journal-title":"Pediatr Infect Dis J"},{"key":"BFcmi201165_CR18","first-page":"1847","volume":"168","author":"L Ferrero-Miliani","year":"2006","unstructured":"Ferrero-Miliani L, Seidelin JB, Nielsen OH . Regulation of cytokine production in inflammatory bowel disease. Ugeskr Laeger 2006; 168 1847\u20131850. Danish.","journal-title":"Ugeskr Laeger"},{"key":"BFcmi201165_CR19","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov R . Origin and physiological roles of inflammation. Nature 2008; 454: 428\u2013435.","journal-title":"Nature"},{"key":"BFcmi201165_CR20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3928\/0090-4481-19980201-06","volume":"27","author":"SA Chartrand","year":"1998","unstructured":"Chartrand SA, Pong A . Acute otitis media in the 1990s: the impact of antibiotic resistance. Pediatr Ann 1998; 27: 86\u201395.","journal-title":"Pediatr Ann"},{"key":"BFcmi201165_CR21","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0194-5998(96)70243-7","volume":"114","author":"GA Gates","year":"1996","unstructured":"Gates GA . Cost-effectiveness considerations in otitis media treatment. Otolaryngol Head Neck Surg 1996; 114: 525\u2013530.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"BFcmi201165_CR22","first-page":"1","volume":"50","author":"AM Minino","year":"2002","unstructured":"Minino AM, Arias E, Kochanek KD, Murphy SL, Smith BL . Deaths: final data for 2000. Natl Vital Stat Rep 2002; 50: 1\u2013119.","journal-title":"Natl Vital Stat Rep"},{"key":"BFcmi201165_CR23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2147\/COPD.S15417","volume":"6","author":"SJ Moghaddam","year":"2011","unstructured":"Moghaddam SJ, Ochoa CE, Sethi S, Dickey BF . Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer. Int J Chron Obstruct Pulmon Dis 2011; 6: 113\u2013123.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"BFcmi201165_CR24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1471-2466-11-34","volume":"11","author":"AL Rubinstein","year":"2011","unstructured":"Rubinstein AL, Irazola VE, Bazzano LA, Sobrino E, Calandrelli M, Lanas F et al. Detection and follow-up of chronic obstructive pulmonary disease (COPD) and risk factors in the Southern Cone of Latin America: the pulmonary risk in South America (PRISA) study. BMC Pulm Med 2011; 11: 34.","journal-title":"BMC Pulm Med"},{"key":"BFcmi201165_CR25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2334-6-12","volume":"6","author":"SK Moon","year":"2006","unstructured":"Moon SK, Lee HY, Pan H, Takeshita T, Park R, Cha K et al. Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells. BMC Infect Dis 2006; 6: 12.","journal-title":"BMC Infect Dis"},{"key":"BFcmi201165_CR26","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.tibs.2004.03.008","volume":"29","author":"P ten Dijke","year":"2004","unstructured":"ten Dijke P, Hill CS . New insights into TGF-beta\u2013Smad signalling. Trends Biochem Sci 2004; 29: 265\u2013273.","journal-title":"Trends Biochem Sci"},{"key":"BFcmi201165_CR27","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1084\/jem.180.5.1587","volume":"180","author":"SM Wahl","year":"1994","unstructured":"Wahl SM . Transforming growth factor beta: the good, the bad, and the ugly. J Exp Med 1994; 180: 1587\u20131590.","journal-title":"J Exp Med"},{"key":"BFcmi201165_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1172\/JCI0211638","volume":"109","author":"ML Huynh","year":"2002","unstructured":"Huynh ML, Fadok VA, Henson PM . Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 2002; 109: 41\u201350.","journal-title":"J Clin Invest"},{"key":"BFcmi201165_CR29","doi-asserted-by":"publisher","first-page":"e28216","DOI":"10.1371\/journal.pone.0028216","volume":"6","author":"XS Xu","year":"2011","unstructured":"Xu XS, Steere RR, Fedorchuk CA, Pang J, Lee JY, Lim JH et al. Activation of epidermal grwoth factor receptor is required for NTHi-induced NF-\u03baB-dependent inflammation. PLoS ONE 2011; 6: e28216.","journal-title":"PLoS ONE"},{"key":"BFcmi201165_CR30","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1158\/0008-5472.CAN-10-3626","volume":"71","author":"T Jiang","year":"2011","unstructured":"Jiang T, Grabiner B, Zhu YF, Jiang CY, Li HX, You Y et al. CARMA3 is crucial for EGFR-induced activation of NF-kappaB and tumor progression. Cancer Res 2011; 71: 2183\u20132192.","journal-title":"Cancer Res"},{"key":"BFcmi201165_CR31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7883\/yoken.JJID.2005.50","volume":"58","author":"E Ozyilmaz","year":"2005","unstructured":"Ozyilmaz E, Akan OA, Gulhan M, Ahmed K, Nagatake T . Major bacteria of community-acquired respiratory tract infections in Turkey. Jpn J Infect Dis 2005; 58: 50\u201352.","journal-title":"Jpn J Infect Dis"},{"key":"BFcmi201165_CR32","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1378\/chest.129.2.317","volume":"129","author":"TM Wilkinson","year":"2006","unstructured":"Wilkinson TM, Hurst JR, Perera WR, Wilks M, Donaldson GC, Wedzicha JA et al. Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD. Chest 2006; 129: 317\u2013324.","journal-title":"Chest"},{"key":"BFcmi201165_CR33","doi-asserted-by":"publisher","first-page":"800","DOI":"10.2353\/ajpath.2010.090596","volume":"176","author":"LN Lee","year":"2010","unstructured":"Lee LN, Dias P, Han D, Yoon S, Shea A, Zakharov V et al. A mouse model of lethal synergism between influenza virus and Haemophilus influenzae. Am J Pathol 2010; 176: 800\u2013811.","journal-title":"Am J Pathol"},{"key":"BFcmi201165_CR34","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.4049\/jimmunol.177.4.2051","volume":"177","author":"JA Hamerman","year":"2006","unstructured":"Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL . Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 2006; 177: 2051\u20132055.","journal-title":"J Immunol"},{"key":"BFcmi201165_CR35","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1073\/pnas.022628499","volume":"99","author":"D Metcalf","year":"2002","unstructured":"Metcalf D, Mifsud S, Di Rago L, Nicola NA, Hilton DJ, Alexander WS . Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc Natl Acad Sci USA 2002; 99: 943\u2013948.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201165_CR36","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/76006","volume":"25","author":"GR Bignell","year":"2000","unstructured":"Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet 2000; 25: 160\u2013165.","journal-title":"Nat Genet"},{"key":"BFcmi201165_CR37","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nature01811","volume":"424","author":"TR Brummelkamp","year":"2003","unstructured":"Brummelkamp TR, Nijman SM, Dirac AM, Bernards R . Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 2003; 424: 797\u2013801.","journal-title":"Nature"},{"key":"BFcmi201165_CR38","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/nature01802","volume":"424","author":"A Kovalenko","year":"2003","unstructured":"Kovalenko A, Chable-Bessia C, Cantarella G, Isra\u00ebl A, Wallach D, Courtois G . The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 2003; 424: 801\u2013805.","journal-title":"Nature"},{"key":"BFcmi201165_CR39","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nature01803","volume":"424","author":"E Trompouki","year":"2003","unstructured":"Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 2003; 424: 793\u2013796.","journal-title":"Nature"},{"key":"BFcmi201165_CR40","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1101\/gad.9.13.1586","volume":"9","author":"Z Chen","year":"1995","unstructured":"Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D et al. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev 1995; 9: 1586\u20131597.","journal-title":"Genes Dev"},{"key":"BFcmi201165_CR41","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/ncb0805-758","volume":"7","author":"ZJ Chen","year":"2005","unstructured":"Chen ZJ . Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 2005; 7: 758\u2013765.","journal-title":"Nat Cell Biol"},{"key":"BFcmi201165_CR42","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.tibs.2010.02.007","volume":"35","author":"R Massoumi","year":"2010","unstructured":"Massoumi R . Ubiquitin chain cleavage: CYLD at work. Trends Biochem Sci 2010; 35: 392\u2013399.","journal-title":"Trends Biochem Sci"},{"key":"BFcmi201165_CR43","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/ni.2157","volume":"12","author":"N Ahmed","year":"2011","unstructured":"Ahmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C et al. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat Immunol 2011; 12: 1176\u20131183.","journal-title":"Nat Immunol"},{"key":"BFcmi201165_CR44","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1084\/jem.20062694","volume":"204","author":"WW Reiley","year":"2007","unstructured":"Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF et al. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 2007; 204: 1475\u20131485.","journal-title":"J Exp Med"},{"key":"BFcmi201165_CR45","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00018-007-7465-4","volume":"65","author":"G Courtois","year":"2008","unstructured":"Courtois G . Tumor suppressor CYLD: negative regulation of NF-kappaB signaling and more. Cell Mol Life Sci 2008; 65: 1123\u20131132.","journal-title":"Cell Mol Life Sci"},{"key":"BFcmi201165_CR46","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1172\/JCI34257","volume":"118","author":"W Jin","year":"2008","unstructured":"Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W et al. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest 2008; 118: 1858\u20131866.","journal-title":"J Clin Invest"},{"key":"BFcmi201165_CR47","doi-asserted-by":"publisher","first-page":"15884","DOI":"10.1074\/jbc.M609952200","volume":"282","author":"W Jin","year":"2007","unstructured":"Jin W, Reiley WR, Lee AJ, Wright A, Wu X, Zhang M et al. Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem 2007; 282: 15884\u201315893.","journal-title":"J Biol Chem"},{"key":"BFcmi201165_CR48","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1038\/emboj.2010.31","volume":"29","author":"AJ Lee","year":"2010","unstructured":"Lee AJ, Zhou X, Chang M, Hunzeker J, Bonneau RH, Zhou D et al. Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J 2010; 29: 1600\u20131612.","journal-title":"EMBO J"},{"key":"BFcmi201165_CR49","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1084\/jem.20062694","volume":"204","author":"WW Reiley","year":"2007","unstructured":"Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF et al. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 2007; 204: 1475\u20131485.","journal-title":"J Exp Med"},{"key":"BFcmi201165_CR50","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.devcel.2007.09.007","volume":"13","author":"A Wright","year":"2007","unstructured":"Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M et al. Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell 2007; 13: 705\u2013716.","journal-title":"Dev Cell"},{"key":"BFcmi201165_CR51","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ni1315","volume":"7","author":"WW Reiley","year":"2006","unstructured":"Reiley WW, Zhang MY, Jin W, Losiewicz M, Donohue KB, Norbury CC et al. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 2006; 7: 411\u2013417.","journal-title":"Nat Immunol"},{"key":"BFcmi201165_CR52","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1593\/neo.81424","volume":"11","author":"E Trompouki","year":"2009","unstructured":"Trompouki E, Tsagaratou A, Kosmidis SK, Dolle P, Qian J, Kontoyiannis DL et al. Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia 2009; 11: 469\u2013476.","journal-title":"Neoplasia"},{"key":"BFcmi201165_CR53","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ni1315","volume":"7","author":"WW Reiley","year":"2006","unstructured":"Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC et al. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol 2006; 7: 411\u2013417.","journal-title":"Nat Immunol"},{"key":"BFcmi201165_CR54","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.cell.2006.03.041","volume":"125","author":"R Massoumi","year":"2006","unstructured":"Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, Fassler R . Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell 2006; 125: 665\u2013677.","journal-title":"Cell"},{"key":"BFcmi201165_CR55","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1172\/JCI28746","volume":"116","author":"J Zhang","year":"2006","unstructured":"Zhang J, Stirling B, Temmerman ST, Ma CA, Fuss IJ, Derry JMJ et al. Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest 2006; 116: 3042\u20133049.","journal-title":"J Clin Invest"},{"key":"BFcmi201165_CR56","doi-asserted-by":"publisher","first-page":"41111","DOI":"10.1074\/jbc.M509526200","volume":"280","author":"H Yoshida","year":"2005","unstructured":"Yoshida H, Jono H, Kai H, Li JD . The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for Toll-like receptor 2 signaling via negative cross-talk with TRAF6 and TRAF7. J Biol Chem 2005; 280: 41111\u201341121.","journal-title":"J Biol Chem"},{"key":"BFcmi201165_CR57","doi-asserted-by":"publisher","first-page":"36171","DOI":"10.1074\/jbc.M406638200","volume":"279","author":"H Jono","year":"2004","unstructured":"Jono H, Lim JH, Chen LF, Xu H, Trompouki E, Pan ZK et al. NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway. J Biol Chem 2004; 279: 36171\u201336174.","journal-title":"J Biol Chem"},{"issue":"1","key":"BFcmi201165_CR58","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1462-5822.2010.01526.x","volume":"13","author":"Ver\u00f3nica Regueiro","year":"2010","unstructured":"Regueiro V, Moranta D, Frank CG, Larrarte E, Margareto J, March C et al. Klebsiella pneumoniae subverts the activation of inflammatory responses in a NOD1-dependent manner. Cell Microbiol 011 13: 135\u2013153.","journal-title":"Cellular Microbiology"},{"key":"BFcmi201165_CR59","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.immuni.2007.07.011","volume":"27","author":"JH Lim","year":"2007","unstructured":"Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH et al. Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity 2007; 27: 349\u2013360 (2007).","journal-title":"Immunity"},{"key":"BFcmi201165_CR60","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/nature02794","volume":"430","author":"IE Wertz","year":"2004","unstructured":"Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004; 430: 694\u2013699.","journal-title":"Nature"},{"key":"BFcmi201165_CR61","doi-asserted-by":"publisher","first-page":"7036","DOI":"10.1074\/jbc.M708690200","volume":"283","author":"K Enesa","year":"2008","unstructured":"Enesa K, Zakkar M, Chaudhury H, Luong le A, Rawlinson L, Mason JC et al. NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J Biol Chem 2008; 283: 7036\u20137045.","journal-title":"J Biol Chem"}],"container-title":["Cellular &amp; Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201165","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:37:13Z","timestamp":1713487033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,6]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["BFcmi201165"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2011.65","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,6]]},"assertion":[{"value":"30 November 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}