{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:56:25Z","timestamp":1789178185449,"version":"build-2803163510"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1038\/cmi.2012.13","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T04:44:56Z","timestamp":1335156296000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CD28 ligation increases macrophage suppression of T-cell proliferation"],"prefix":"10.1038","volume":"9","author":[{"given":"Daniel","family":"Silberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Bucknum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Composto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Kozlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Werda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackelyn","family":"Cua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene H","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Somerville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,23]]},"reference":[{"key":"BFcmi201213_CR1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1101\/SQB.1989.054.01.072","volume":"54","author":"R Schwartz","year":"1989","unstructured":"Schwartz R, Mueller D, Jenkins M, Quill H . T cell clonal anergy. Cold Spring Harbor Symp Quant Biol 1989; 54: 605\u2013610.","journal-title":"Cold Spring Harbor Symp Quant Biol"},{"key":"BFcmi201213_CR2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1146\/annurev.immunol.23.021704.115611","volume":"23","author":"R Greenwald","year":"2005","unstructured":"Greenwald R, Freeman G, Sharpe A . The B7 family revisited. Ann Rev Immunol 2005; 23: 515\u2013548.","journal-title":"Ann Rev Immunol"},{"key":"BFcmi201213_CR3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01015.x","volume":"241","author":"S Manicassamy","year":"2011","unstructured":"Manicassamy S, Pulendran B . Dendritic cell control of tolerogenic responses. Immunol Rev 2011; 241: 206\u2013227.","journal-title":"Immunol Rev"},{"key":"BFcmi201213_CR4","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.imbio.2010.04.002","volume":"216","author":"G Composto","year":"2011","unstructured":"Composto G, Gonzalez D, Bucknum A, Silberman D, Taylor J, Kozlowski M et al. Peritoneal T lymphocyte regulation by macrophages. Immunobiology 2011; 216: 256\u2013264.","journal-title":"Immunobiology"},{"key":"BFcmi201213_CR5","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/PPO.0b013e3181eb3358","volume":"16","author":"S Nagaraj","year":"2010","unstructured":"Nagaraj S, Gabrilovich D . Myeloid-derived suppressor cells in human cancers. Cancer J 2010; 16: 348\u2013353.","journal-title":"Cancer J"},{"key":"BFcmi201213_CR6","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1002\/eji.200526298","volume":"35","author":"U Hopken","year":"2005","unstructured":"Hopken U, Lehmann I, Droese J, Lipp M, Schuler T, Rehm A . The ratio between dendritic cells and T cells determines the outcome of their encounter: proliferation versus deletion. Eur J Immunol 2005; 35: 2851\u20132863.","journal-title":"Eur J Immunol"},{"key":"BFcmi201213_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nrc1256","volume":"4","author":"J Pollard","year":"2004","unstructured":"Pollard J . Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4: 71\u201378.","journal-title":"Nat Rev Cancer"},{"key":"BFcmi201213_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0065-2776(06)90002-9","volume":"90","author":"C Drake","year":"2006","unstructured":"Drake C, Jaffee E, Pardoll D . Mechanisms of immune evasion by tumors. Adv Immunol 2006; 90: 51\u201381.","journal-title":"Adv Immunol"},{"key":"BFcmi201213_CR9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.immunol.25.022106.141609","volume":"25","author":"G Rabinovich","year":"2007","unstructured":"Rabinovich G, Gabrilovich D, Sotomayor E . Immunosuppressive strategies that are mediated by tumor cells. Ann Rev Immunol 2007; 25: 267\u2013296.","journal-title":"Ann Rev Immunol"},{"key":"BFcmi201213_CR10","doi-asserted-by":"publisher","first-page":"733","DOI":"10.4049\/jimmunol.1002701","volume":"187","author":"T Denning","year":"2011","unstructured":"Denning T, Norris B, Medina-Contreras O, Manicassamy S, Geem D, Madan R et al. Functional specialization of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell\/APC ratio, source of mouse strain, and regional localization. J Immunol 2011; 187: 733\u2013747.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR11","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.4049\/jimmunol.1100403","volume":"187","author":"B Zhu","year":"2011","unstructured":"Zhu B, Kennedy J, Wang Y, Sandoval-Garcia C, Cao L, Xiao S et al. Plasticity of Ly-6Chi myeloid cells in T cell regulation. J Immunol 2011; 187: 2418\u20132432.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR12","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/nri1668","volume":"5","author":"V Bronte","year":"2005","unstructured":"Bronte V, Zanovello P . Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 2005; 5: 641\u2013654.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201213_CR13","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/j.1365-2567.2005.02312.x","volume":"117","author":"R Matlack","year":"2006","unstructured":"Matlack R, Yeh K, Rosini L, Gonzalez D, Taylor J, Silberman D et al. Peritoneal macrophages suppress T-cell activation by amino acid catabolism. Immunology 2006; 117: 386\u2013395.","journal-title":"Immunology"},{"key":"BFcmi201213_CR14","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.4049\/jimmunol.1002045","volume":"185","author":"M Hamilton","year":"2010","unstructured":"Hamilton M, Antiganano F, Rossum A, Boucher J, Bennewith K, Krystal G . TLR agonists that induce IFN-\u03b2 abrogate resident macrophage suppression of T cells. J Immunol 2010; 185: 4545\u20134553.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0022-1759(96)00138-X","volume":"197","author":"E Lagasse","year":"1996","unstructured":"Lagasse E, Weissman I . Flow cytometric identification of murine neutrophils and monocytes. J Immunol Meth 1996; 197: 139\u2013150.","journal-title":"J Immunol Meth"},{"key":"BFcmi201213_CR16","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1073\/pnas.84.5.1374","volume":"84","author":"O Leo","year":"1987","unstructured":"Leo O, Foo M, Sachs D, Samelson L, Bluestone J . Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci 1987; 84: 1374\u20131378.","journal-title":"Proc Natl Acad Sci"},{"key":"BFcmi201213_CR17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.149.2.380","volume":"149","author":"J Gross","year":"1992","unstructured":"Gross J, Callas E, Allison J . Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol 1992; 149: 380\u2013388.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR18","first-page":"1","volume":"122","author":"M Potter","year":"1985","unstructured":"Potter M . History of the BALB\/c family. Curr Top Microbiol Immunol 1985; 122: 1\u20135.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BFcmi201213_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/genetics\/163.1.1","volume":"163","author":"K Paigen","year":"2003","unstructured":"Paigen K . One hundred years of mouse genetics: an intellectual history. I. The classical period (1902\u20131980). Genetics 2003; 163: 1\u20137.","journal-title":"Genetics"},{"key":"BFcmi201213_CR20","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.imbio.2004.05.004","volume":"209","author":"R Rochford","year":"2004","unstructured":"Rochford R, Riggs J, Clavo A, Ernst D, Hobbs M . Differential effect of CD28 costimulation upon cytokine production by CD4+ and CD8+ T cells. Immunobiology 2004; 209: 513\u2013522.","journal-title":"Immunobiology"},{"key":"BFcmi201213_CR21","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nri2326","volume":"8","author":"W Zou","year":"2008","unstructured":"Zou W, Chen L . Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008; 8: 467\u2013477.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201213_CR22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1600-065X.2011.01007.x","volume":"241","author":"S Quezada","year":"2011","unstructured":"Quezada S, Peggs K, Simpson T, Allison J . Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. Immunol Rev 2011; 241: 104\u201318.","journal-title":"Immunol Rev"},{"key":"BFcmi201213_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1600-065X.2008.00661.x","volume":"224","author":"JD Bouaziz","year":"2008","unstructured":"Bouaziz JD, Yanaba K, Tedder T . Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev 2008; 224: 201\u2013214.","journal-title":"Immunol Rev"},{"key":"BFcmi201213_CR24","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ijc.25429","volume":"127","author":"H Nishikawa","year":"2010","unstructured":"Nishikawa H, Sakaguchi S . Regulatory T cells in tumor immunity. Int J Cancer 2010; 127: 759\u201367.","journal-title":"Int J Cancer"},{"key":"BFcmi201213_CR25","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.coi.2006.01.002","volume":"18","author":"D Munn","year":"2006","unstructured":"Munn D . Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation. Curr Opin Immunol 2006; 18: 220\u2013225.","journal-title":"Curr Opin Immunol"},{"key":"BFcmi201213_CR26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ccr.2005.02.013","volume":"7","author":"F Balkwill","year":"2005","unstructured":"Balkwill F, Charles K, Mantovani A . Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7: 211\u2013217.","journal-title":"Cancer Cell"},{"key":"BFcmi201213_CR27","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.semcancer.2007.06.003","volume":"17","author":"N Martin-Orozco","year":"2007","unstructured":"Martin-Orozco N, Dong D . Inhibitory costimulation and anti-tumor immunity. Semin Cancer Biol 2007; 17: 288\u201396.","journal-title":"Semin Cancer Biol"},{"key":"BFcmi201213_CR28","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/ni.2035","volume":"12","author":"J Wherry","year":"2011","unstructured":"Wherry J . T cell exhaustion. Nat Immunol 2011; 12: 492\u2013499.","journal-title":"Nat Immunol"},{"key":"BFcmi201213_CR29","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/intimm\/8.4.519","volume":"8","author":"M Krummel","year":"1996","unstructured":"Krummel M, Sullivan T, Allison J . Superantigen response and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int Immunol 1996; 8: 519\u2013523.","journal-title":"Int Immunol"},{"key":"BFcmi201213_CR30","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S1074-7613(00)80284-8","volume":"6","author":"V Perez","year":"1997","unstructured":"Perez V, van Parijs L, Biuckians A, Zheng X, Strom T, Abbas A . Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997; 6: 411\u2013417.","journal-title":"Immunity"},{"key":"BFcmi201213_CR31","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.4049\/jimmunol.164.9.4564","volume":"164","author":"X Yu","year":"2000","unstructured":"Yu X, Bidwell S, Martin P, Anasetti C . CD28-specific antibody prevents graft-versus-host disease in mice. J Immunol 2000; 164: 4564\u20134568.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR32","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.4049\/jimmunol.154.10.5121","volume":"154","author":"M Tacke","year":"1995","unstructured":"Tacke M, Clark G, Dallman M, Hunig Y . Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporine A sensitivity of costimulated T cell responses by phorbol ester. J Immunol 1995; 154: 5121\u20135127.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR33","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/00007890-199902150-00009","volume":"67","author":"T Dengler","year":"1999","unstructured":"Dengler T, Szabo G, Sido B, Nottmeyer W, Zimmerman R, Vahl C et al. Prolonged allograft survival but not tolerance induction by modulating CD28 antibody JJ319 after high-responder heart transplantation. Transplantation 1999; 67: 392\u2013398.","journal-title":"Transplantation"},{"key":"BFcmi201213_CR34","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1111\/j.1600-6143.2005.01018.x","volume":"5","author":"F Haspot","year":"2005","unstructured":"Haspot F, Seveno C, Dugast AS, Coulon F, Renaudin K, Usal C et al. Anti-CD28 antibody-induced kidney allograft tolerance related to tryptophan degradation and TCR-Class II-B7+ regulatory cells. Am J Transplant 2005; 5: 2339\u20132348.","journal-title":"Am J Transplant"},{"key":"BFcmi201213_CR35","doi-asserted-by":"publisher","first-page":"8164","DOI":"10.4049\/jimmunol.179.12.8164","volume":"179","author":"C Guillonneau","year":"2007","unstructured":"Guillonneau C, Seveno C, Dugast AS, Li XL, Renaudin K, Haspot F et al. 2007. Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. J Immunol 2007; 179: 8164\u20138171.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR36","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.4049\/jimmunol.178.4.2132","volume":"178","author":"P Pandiyan","year":"2007","unstructured":"Pandiyan P, Hege J, Krueger M, Quandt D, Brunner-Weinzierl C . High IFN-\u03b3 production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4). J Immunol 2007; 178: 2132\u20132140.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR37","doi-asserted-by":"publisher","first-page":"4328","DOI":"10.1182\/blood-2008-03-146662","volume":"112","author":"N Beyersdorf","year":"2008","unstructured":"Beyersdorf N, Ding X, Blank G, Dennehy K, Kerkau T, Hunig T . Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody. Blood 2008; 112: 4328\u20134336.","journal-title":"Blood"},{"key":"BFcmi201213_CR38","doi-asserted-by":"publisher","first-page":"17ra10","DOI":"10.1126\/scitranslmed.3000116","volume":"2","author":"N Poirier","year":"2010","unstructured":"Poirier N, Azimzadeh A, Zhang T, Dilek N, Mary C, Nguyen B et al. Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation. Sci Transl Med 2010; 2: 17ra10.","journal-title":"Sci Transl Med"},{"key":"BFcmi201213_CR39","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/eji.200838913","volume":"39","author":"J Chang","year":"2009","unstructured":"Chang J, Kim Y, Han S, Kang C . IFN-gamma-STAT 1 signal regulates the differentiation of inducible Treg: potential role for ROS-mediated apoptosis. Eur J Immunol 2009; 39: 1241\u20131251.","journal-title":"Eur J Immunol"},{"key":"BFcmi201213_CR40","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4049\/jimmunol.0900753","volume":"184","author":"N Singh","year":"2010","unstructured":"Singh N, Yamamoto M, Takami M, Seki Y, Takezaki M, Mellor A et al. CD4+CD25+ regulatory T cell resist a novel form of CD28- and Fas-dependent p53-induced T cell apoptosis. J Immunol 2010; 184: 94\u2013104.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR41","first-page":"1619","volume":"39","author":"R Carrio","year":"2011","unstructured":"Carrio R, Torroella-Kouri M, Libreros S, Garcia-Areas R, Iragavarapu-Charyulu V, Lopez D . Decreased accumulation of immune regulatory cells is correlated to the antitumor effect of IFN-\u03b3 overexpression in the tumor. Int J Oncol 2011; 39: 1619\u20131627.","journal-title":"Int J Oncol"},{"key":"BFcmi201213_CR42","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.4049\/jimmunol.1100485","volume":"186","author":"SW Lee","year":"2011","unstructured":"Lee SW, Choi H, Eun SY, Fukuyama S, Croft M . Nitric oxide modulates TGF-\u03b2-directive signals to suppress Foxp3+ regulatory T cell differentiation and potentiate Th1 development. J Immunol 2011; 186: 6972\u20136980.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR43","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.4049\/jimmunol.0900986","volume":"183","author":"B Baban","year":"2009","unstructured":"Baban B, Chandler P, Sharma M, Pihkala J, Koni P, Munn D et al. IDO activates regulatory T cells and blocks their conversion into Th17-like cells. J Immunol 2009; 183: 2475-2483.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1365-2249.2009.03877.x","volume":"156","author":"AS Dugast","year":"2009","unstructured":"Dugast AS, Vanhove B . Immune regulation by non-lymphoid cells in transplantation. Clin Exp Immunol 2009; 156: 25\u201334.","journal-title":"Clin Exp Immunol"},{"key":"BFcmi201213_CR45","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.4049\/jimmunol.158.6.2856","volume":"158","author":"R Wang","year":"1997","unstructured":"Wang R, Fang Q, Zhang L, Radvany L, Sharma A, Noben-Trauth N et al. CD28 ligation prevents bacterial toxin-induced septic shock in mice by inducing IL-10 expression. J Immunol 1997; 158: 2856\u20132861.","journal-title":"J Immunol"},{"issue":"10","key":"BFcmi201213_CR46","doi-asserted-by":"publisher","first-page":"5569","DOI":"10.4049\/jimmunol.1100284","volume":"186","author":"N. A. Carter","year":"2011","unstructured":"Carter N, Vasconcellos R, Rosser E, Tulone C, Munoz-Suano A, Kamanaka M et al. 2011. Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1\/Th17 but a decrease in regulatory T cells. J Immunol 186: 5569\u20135579.","journal-title":"The Journal of Immunology"},{"key":"BFcmi201213_CR47","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni.1937","volume":"11","author":"S Biswas","year":"2010","unstructured":"Biswas S, Mantovani A . Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 2010; 11: 889\u2013896.","journal-title":"Nat Immunol"},{"key":"BFcmi201213_CR48","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nri2784","volume":"10","author":"F Geissmann","year":"2010","unstructured":"Geissmann F, Gordon S, Hume D, Mowat A, Randolph G . Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol 2010; 10: 453\u2013460.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201213_CR49","doi-asserted-by":"publisher","first-page":"6523","DOI":"10.1182\/blood-2010-11-317321","volume":"117","author":"B Hoechst","year":"2011","unstructured":"Hoechst B, Gamrekelashvili J, Manns M, Greten T, Korangy F . Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells. Blood 2011; 117: 6523-6541.","journal-title":"Blood"},{"key":"BFcmi201213_CR50","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1067\/mai.2001.112845","volume":"107","author":"R Blumenthal","year":"2001","unstructured":"Blumenthal R, Campbell D, Hwang P, DeKruyff R, Frankel L, Umetsu D . Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells. J Allergy Clin Immunol 2001; 107: 258\u2013264.","journal-title":"J Allergy Clin Immunol"},{"key":"BFcmi201213_CR51","doi-asserted-by":"publisher","first-page":"6494","DOI":"10.4049\/jimmunol.179.10.6494","volume":"179","author":"A Borowski","year":"2007","unstructured":"Borowski A, Boesteanu A, Mueller Y, Carafieds C, Topham D, Altman J et al. Memory CD8+ T cells require CD28 costimulation. J Immunol 2007; 179: 6494\u20136503.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR52","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nm863","volume":"5","author":"T Curiel","year":"2003","unstructured":"Curiel T, Wei S, Dong H, Alvarez X, Cheng P, Mottram P et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003; 5: 562\u2013567.","journal-title":"Nat Med"},{"key":"BFcmi201213_CR53","doi-asserted-by":"publisher","first-page":"10691","DOI":"10.1073\/pnas.0307252101","volume":"101","author":"Y Latchman","year":"2004","unstructured":"Latchman Y, Liang S, Wu Y, Chernova T, RSobel R, Klemm M et al. PD-L1 deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Nat Acad Sci 2004; 101: 10691\u201310696.","journal-title":"Proc Nat Acad Sci"},{"key":"BFcmi201213_CR54","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1146\/annurev.immunol.26.021607.090331","volume":"26","author":"M Keir","year":"2008","unstructured":"Keir M, Butte M, Freeman G, Sharpe A . PD-1 and its ligands in tolerance and immunity. Ann Rev Immunol 2008; 26: 677\u2013704.","journal-title":"Ann Rev Immunol"},{"key":"BFcmi201213_CR55","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/70932","volume":"5","author":"H Dong","year":"1999","unstructured":"Dong H, Zhu G, Tamada K, Chen L . B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999; 5: 1365\u20131369.","journal-title":"Nat Med"},{"key":"BFcmi201213_CR56","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/ni.2112","volume":"12","author":"V Lukacs-Kornek","year":"2011","unstructured":"Lukacs-Kornek V, Malhotra D, Fletcher A, Acton S, Elpek K, Tayalia P et al. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol 2011; 12: 1096\u20131105.","journal-title":"Nat Immunol"},{"key":"BFcmi201213_CR57","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.4049\/jimmunol.175.3.1586","volume":"175","author":"T Yamazaki","year":"2005","unstructured":"Yamazaki T, Akiba H, Koyanagi A, Azuma M, Yagita H, Okumura K . Blockade of B7-H1 on macrophages suppresses CD4+T cell proliferation by augmenting IFN-g-induced nitric oxide production. J Immunol 2005; 175: 1586\u20131592.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR58","doi-asserted-by":"publisher","first-page":"5336","DOI":"10.1073\/pnas.0931259100","volume":"100","author":"P Loke","year":"2003","unstructured":"Loke P, Allison J . PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Nat Acad Sci 2003; 100: 5336-5341.","journal-title":"Proc Nat Acad Sci"},{"key":"BFcmi201213_CR59","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S1074-7613(02)00362-X","volume":"17","author":"A Collins","year":"2002","unstructured":"Collins A, Brodie D, Gilbert R, Laboni A, Manso-Sancho R, Walse B et al. The interaction properties of costimulatory molecules revisited. Immunity 2002; 17: 201\u2013210.","journal-title":"Immunity"},{"key":"BFcmi201213_CR60","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.immuni.2007.05.016","volume":"27","author":"M Butte","year":"2007","unstructured":"Butte M, Keir M, Phamduy T, Sharpe A, Freeman G . Programmed death-ligand 1 interacts specifically with B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007; 27: 111\u2013122.","journal-title":"Immunity"},{"key":"BFcmi201213_CR61","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nri1349","volume":"4","author":"L Chen","year":"2004","unstructured":"Chen L . Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004; 4: 336\u2013350.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201213_CR62","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1056\/NEJMoa063842","volume":"355","author":"G Suntharalingam","year":"2006","unstructured":"Suntharalingam G, Perry M, Ward S, Brett S, Castello-Cortes A, Brunner M et al. Cytokine storm in a phase I trial of the anti-CD28 monoclonal antibody TGN1412. New Engl J Med 2006; 355: 1018\u20131028.","journal-title":"New Engl J Med"},{"key":"BFcmi201213_CR63","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrd3003","volume":"9","author":"T Hansel","year":"2010","unstructured":"Hansel T, Kropshofer H, Singer T, Mitchell J, George A . The safety and side effects of monoclonal antibodies. Nat Rev Drug Disc 2010; 9: 325\u2013338.","journal-title":"Nat Rev Drug Disc"},{"key":"BFcmi201213_CR64","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.4049\/jimmunol.179.5.3325","volume":"179","author":"R Stebbings","year":"2007","unstructured":"Stebbings R, Findlay L, Edwards C, Eastwood D, Bird C, North D et al. \u2018Cytokine Storm\u2019 in the phase I trial of monoclonal antibody TGN1412: understanding the causes to improve preclinical testing of immunotherapeutics. J Immunol 2007; 179: 3325\u20133331.","journal-title":"J Immunol"},{"key":"BFcmi201213_CR65","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1172\/JCI35382","volume":"118","author":"St","year":"2008","unstructured":"St. Clair E. The calm after the cytokine storm: lessons from the TGN1412 trial. J Clin Invest 2008; 118: 1344\u20131347.","journal-title":"J Clin Invest"},{"key":"BFcmi201213_CR66","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1111\/j.1365-2249.2010.04264.x","volume":"162","author":"G Sandilands","year":"2011","unstructured":"Sandilands G, Wilson M, Huser C, Jolly L, Sands W, McSharry C . Were monocytes responsible for initiating the cytokine storm in the TGH1412 clinical trial tragedy? Clin Exp Immunol 2011; 162: 516\u201327.","journal-title":"Clin Exp Immunol"},{"key":"BFcmi201213_CR67","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1146\/annurev.med.56.082103.104549","volume":"57","author":"T Waldmann","year":"2006","unstructured":"Waldmann T . Effective cancer therapy through immunomodulation. Ann Rev Med 2006; 57: 65\u201381.","journal-title":"Ann Rev Med"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201213","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T14:12:14Z","timestamp":1713881534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,23]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["BFcmi201213"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2012.13","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,23]]},"assertion":[{"value":"28 November 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}