{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:28:36Z","timestamp":1791412116468,"version":"4.3.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1038\/cmi.2014.49","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T04:38:19Z","timestamp":1405485499000},"page":"213-222","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Type 1 interferon-induced IL-7 maintains CD8+ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis"],"prefix":"10.1038","volume":"12","author":[{"given":"Lifei","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuliang","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayura","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Soong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaren","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"BFcmi201449_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/1074-7613(94)90074-4","volume":"1","author":"Y Yang","year":"1994","unstructured":"Yang Y, Ertl HC, Wilson JM . MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994; 1: 433\u2013442.","journal-title":"Immunity"},{"key":"BFcmi201449_CR2","doi-asserted-by":"publisher","first-page":"4589","DOI":"10.1073\/pnas.93.10.4589","volume":"93","author":"LG Guidotti","year":"1996","unstructured":"Guidotti LG, Borrow P, Hobbs MV, Matzke B, Gresser I, Oldstone MB et al. Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc Natl Acad Scie USA 1996; 93: 4589\u20134594.","journal-title":"Proc Natl Acad Scie USA"},{"key":"BFcmi201449_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1084\/jem.20022235","volume":"198","author":"Y Iwai","year":"2003","unstructured":"Iwai Y, Terawaki S, Ikegawa M, Okazaki T, Honjo T . PD-1 inhibits antiviral immunity at the effector phase in the liver. J Exp Med 2003; 198: 39\u201350.","journal-title":"J Exp Med"},{"key":"BFcmi201449_CR4","doi-asserted-by":"publisher","first-page":"9249","DOI":"10.1128\/JVI.00409-07","volume":"81","author":"L Golden-Mason","year":"2007","unstructured":"Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR . Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 2007; 81: 9249\u20139258.","journal-title":"J Virol"},{"key":"BFcmi201449_CR5","doi-asserted-by":"publisher","first-page":"451694","DOI":"10.1155\/2011\/451694","volume":"2011","author":"KA Hofmeyer","year":"2011","unstructured":"Hofmeyer KA, Jeon H, Zang X . The PD-1\/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J Biomed Biotechnol 2011; 2011: 451694.","journal-title":"J Biomed Biotechnol"},{"key":"BFcmi201449_CR6","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","volume":"77","author":"EJ Wherry","year":"2003","unstructured":"Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R . Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003; 77: 4911\u20134927.","journal-title":"J Virol"},{"key":"BFcmi201449_CR7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1053\/j.gastro.2005.11.017","volume":"130","author":"CP Day","year":"2006","unstructured":"Day CP . From fat to inflammation. Gastroenterology 2006; 130: 207\u2013210.","journal-title":"Gastroenterology"},{"key":"BFcmi201449_CR8","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1172\/JCI40040","volume":"120","author":"SN Mueller","year":"2010","unstructured":"Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN et al. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest 2010; 120: 2508\u20132515.","journal-title":"J Clin Invest"},{"key":"BFcmi201449_CR9","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1128\/JVI.01579-09","volume":"84","author":"SD Blackburn","year":"2010","unstructured":"Blackburn SD, Crawford A, Shin H, Polley A, Freeman GJ, Wherry EJ . Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion. J Virol 2010; 84: 2078\u20132089.","journal-title":"J Virol"},{"key":"BFcmi201449_CR10","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1084\/jem.20051776","volume":"203","author":"ME Keir","year":"2006","unstructured":"Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA et al. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 2006; 203: 883\u2013895.","journal-title":"J Exp Med"},{"key":"BFcmi201449_CR11","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.jhep.2006.05.007","volume":"45","author":"M M\u00fchlbauer","year":"2006","unstructured":"M\u00fchlbauer M, Fleck M, Sch\u00fctz C, Weiss T, Froh M, Blank C et al. PD-L1 is induced in hepatocytes by viral infection and by interferon-\u03b1 and -\u03b2 and mediates T cell apoptosis. J Hepatol 2006; 45: 520\u2013528.","journal-title":"J Hepatol"},{"key":"BFcmi201449_CR12","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1053\/j.gastro.2008.07.016","volume":"135","author":"IV Pinchuk","year":"2008","unstructured":"Pinchuk IV, Saada JI, Beswick EJ, Boya G, Qiu SM, Mifflin RC et al. PD-1 ligand expression by human colonic myofibroblasts\/fibroblasts regulates CD4+ T-cell activity. Gastroenterology 2008; 135: 1228\u20131237.e2.","journal-title":"Gastroenterology"},{"key":"BFcmi201449_CR13","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nature04444","volume":"439","author":"DL Barber","year":"2006","unstructured":"Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006; 439: 682\u2013687.","journal-title":"Nature"},{"key":"BFcmi201449_CR14","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1128\/JVI.02021-06","volume":"81","author":"H Radziewicz","year":"2007","unstructured":"Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, Wehbi M et al. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 2007; 81: 2545\u20132553.","journal-title":"J Virol"},{"key":"BFcmi201449_CR15","first-page":"169","volume-title":"Advances in Pharmacology. Vol. 67. Chapter 5: Hepatitis C Virus: Standard-of-Care Treatment","author":"JM Pawlotsky","year":"2013","unstructured":"Pawlotsky JM, de Erik C . Advances in Pharmacology. Vol. 67. Chapter 5: Hepatitis C Virus: Standard-of-Care Treatment. New York: Academic Press, 2013: 169\u2013215."},{"key":"BFcmi201449_CR16","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/ni978","volume":"4","author":"A Le Bon","year":"2003","unstructured":"Le Bon A, Etchart N, Rossmann C, Ashton M, Hou S, Gewert D et al. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat Immunol 2003; 4: 1009\u20131015.","journal-title":"Nat Immunol"},{"key":"BFcmi201449_CR17","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.immuni.2009.01.007","volume":"30","author":"Y Sawa","year":"2009","unstructured":"Sawa Y, Arima Y, Ogura H, Kitabayashi C, Jiang JJ, Fukushima T et al. Hepatic interleukin-7 expression regulates T cell responses. Immunity 2009; 30: 447\u2013457.","journal-title":"Immunity"},{"key":"BFcmi201449_CR18","doi-asserted-by":"publisher","first-page":"621","DOI":"10.4049\/jimmunol.1201970","volume":"190","author":"L Hou","year":"2013","unstructured":"Hou L, Jie Z, Desai M, Liang Y, Soong L, Wang T et al. Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis. J Immunol 2013; 190: 621\u2013629.","journal-title":"J Immunol"},{"key":"BFcmi201449_CR19","doi-asserted-by":"publisher","first-page":"12674","DOI":"10.1073\/pnas.1203795109","volume":"109","author":"LF Lee","year":"2012","unstructured":"Lee LF, Logronio K, Tu GH, Zhai W, Ni I, Mei L et al. Anti-IL-7 receptor-alpha reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci USA 2012; 109: 12674\u201312679.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201449_CR20","doi-asserted-by":"publisher","first-page":"12668","DOI":"10.1073\/pnas.1203692109","volume":"109","author":"C Penaranda","year":"2012","unstructured":"Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS et al. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector\/memory T cells. Proc Natl Acad Sci USA 2012; 109: 12668\u201312673.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201449_CR21","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1002\/hep.21365","volume":"44","author":"L Golden-Mason","year":"2006","unstructured":"Golden-Mason L, Burton JR Jr, Castelblanco N, Klarquist J, Benlloch S, Wang C et al. Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence. Hepatology 2006; 44: 1098\u2013109.","journal-title":"Hepatology"},{"key":"BFcmi201449_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/1743-422X-7-207","volume":"7","author":"G Lv","year":"2010","unstructured":"Lv G, Ying L, Ma WJ, Jin X, Zheng L, Li L et al. Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment. Virol J 2010; 7: 207.","journal-title":"Virol J"},{"key":"BFcmi201449_CR23","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.cell.2011.01.011","volume":"144","author":"M Pellegrini","year":"2011","unstructured":"Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011; 144: 601\u2013613.","journal-title":"Cell"},{"key":"BFcmi201449_CR24","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.4049\/jimmunol.1203218","volume":"190","author":"XZ Tang","year":"2013","unstructured":"Tang XZ, Jo J, Tan AT, Sandalova E, Chia A, Tan KC et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol 2013; 190: 3142\u20133152.","journal-title":"J Immunol"},{"key":"BFcmi201449_CR25","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1002\/hep.24270","volume":"53","author":"J Yan","year":"2011","unstructured":"Yan J, Jie Z, Hou L, Wanderley JL, Soong L, Gupta S et al. Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice. Hepatology 2011; 53: 1455\u20131467.","journal-title":"Hepatology"},{"key":"BFcmi201449_CR26","doi-asserted-by":"publisher","first-page":"5666","DOI":"10.4049\/jimmunol.1300117","volume":"190","author":"Y Liang","year":"2013","unstructured":"Liang Y, Jie Z, Hou L, Aguilar-Valenzuela R, Vu D, Soong L et al. IL-33 Induces nuocytes and modulates liver injury in viral hepatitis. J Immunol 2013; 190: 5666\u20135675.","journal-title":"J Immunol"},{"key":"BFcmi201449_CR27","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.4049\/jimmunol.178.6.3505","volume":"178","author":"J Zhu","year":"2007","unstructured":"Zhu J, Huang X, Yang Y . Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus. J Immunol 2007; 178: 3505\u20133510.","journal-title":"J Immunol"},{"key":"BFcmi201449_CR28","doi-asserted-by":"publisher","first-page":"5538","DOI":"10.4049\/jimmunol.169.10.5538","volume":"169","author":"T Yamazaki","year":"2002","unstructured":"Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y et al. Expression of programmed death 1 ligands by murine T cells and APC. J Immunol 2002; 169: 5538\u20135545.","journal-title":"J Immunol"},{"key":"BFcmi201449_CR29","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/mt.2008.88","volume":"16","author":"J Zhu","year":"2008","unstructured":"Zhu J, Huang X, Yang Y . A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. Mol Ther 2008; 16: 1300\u20131307.","journal-title":"Mol Ther"},{"key":"BFcmi201449_CR30","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cytogfr.2005.05.004","volume":"16","author":"Q Jiang","year":"2005","unstructured":"Jiang Q, Li WQ, Aiello FB, Mazzucchelli R, Asefa B, Khaled AR et al. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev 2005; 16: 513\u2013533.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFcmi201449_CR31","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nri2023","volume":"7","author":"R Mazzucchelli","year":"2007","unstructured":"Mazzucchelli R, Durum SK . Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol 2007; 7: 144\u2013154.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201449_CR32","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jhep.2012.03.023","volume":"57","author":"L Barbier","year":"2012","unstructured":"Barbier L, Tay SS, McGuffog C, Triccas JA, McCaughan GW, Bowen DG et al. Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. J Hepatol 2012; 57: 352\u2013358.","journal-title":"J Hepatol"},{"key":"BFcmi201449_CR33","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1128\/JVI.72.4.2945-2954.1998","volume":"72","author":"K Jooss","year":"1998","unstructured":"Jooss K, Ertl HC, Wilson JM . Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver. J Virol 1998; 72: 2945\u20132954.","journal-title":"J Virol"},{"key":"BFcmi201449_CR34","doi-asserted-by":"publisher","first-page":"10730","DOI":"10.1128\/JVI.79.16.10730-10739.2005","volume":"79","author":"J Sun","year":"2005","unstructured":"Sun J, Tumurbaatar B, Jia J, Diao H, Bodola F, Lemon SM et al. Parenchymal expression of CD86\/B7.2 contributes to hepatitis C virus-related liver injury. J Virol 2005; 79: 10730\u201310739.","journal-title":"J Virol"},{"key":"BFcmi201449_CR35","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S1074-7613(94)80016-2","volume":"1","author":"L Huang","year":"1994","unstructured":"Huang L, Soldevila G, Leeker M, Flavell R, Crispe IN . The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity 1994; 1: 741\u2013749.","journal-title":"Immunity"},{"key":"BFcmi201449_CR36","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/80868","volume":"1","author":"KS Schluns","year":"2000","unstructured":"Schluns KS, Kieper WC, Jameson SC, Lefrancois L . Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 2000; 1: 426\u2013432.","journal-title":"Nat Immunol"},{"key":"BFcmi201449_CR37","doi-asserted-by":"publisher","first-page":"3704","DOI":"10.1182\/blood-2008-06-160945","volume":"112","author":"MP Rubinstein","year":"2008","unstructured":"Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA et al. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood 2008; 112: 3704\u20133712.","journal-title":"Blood"},{"key":"BFcmi201449_CR38","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.4049\/jimmunol.168.10.4827","volume":"168","author":"KS Schluns","year":"2002","unstructured":"Schluns KS, Williams K, Ma A, Zheng XX, Lefrancois L . Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 2002; 168: 4827\u20134831.","journal-title":"J Immunol"},{"key":"BFcmi201449_CR39","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S1074-7613(04)00050-0","volume":"20","author":"H Dong","year":"2004","unstructured":"Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L . B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. Immunity 2004; 20: 327\u2013336.","journal-title":"Immunity"}],"container-title":["Cellular &amp; Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201449","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T06:13:57Z","timestamp":1672726437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,14]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["BFcmi201449"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2014.49","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,14]]},"assertion":[{"value":"10 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have declared no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}