{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:13:27Z","timestamp":1790345607989,"version":"4.1.0"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/cmi.2014.97","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T08:35:36Z","timestamp":1413794136000},"page":"510-521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Ovarian autoimmune disease: clinical concepts and animal models"],"prefix":"10.1038","volume":"11","author":[{"given":"Bryce D","family":"Warren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K","family":"Kinsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda K","family":"McGinnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lane K","family":"Christenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Jasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K","family":"Petroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret G","family":"Petroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"BFcmi201497_CR1","doi-asserted-by":"publisher","first-page":"e1001356","DOI":"10.1371\/journal.pmed.1001356","volume":"9","author":"MN Mascarenhas","year":"2012","unstructured":"Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA . National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med 2012; 9: e1001356.","journal-title":"PLoS Med"},{"key":"BFcmi201497_CR2","first-page":"4177","volume":"83","author":"G Forti","year":"1998","unstructured":"Forti G, Krausz C . Evaluation and treatment of the infertile couple. J Clin Endocrinol Metab 1998; 83: 4177\u20134188.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR3","first-page":"1","volume":"67","author":"A Chandra","year":"2013","unstructured":"Chandra A, Copen CE . Infertility and impaired fecundity in the United States, 1982\u20132010: data from the National Survey of Family Growth. Natl Health Stat Rep 2013; 67: 1\u201319.","journal-title":"Natl Health Stat Rep"},{"key":"BFcmi201497_CR4","volume-title":"Sexually Transmitted Disease Surveillance 2012","author":"J Braxton","year":"2013","unstructured":"Braxton J, Carey D, Davis D, Footman A, Flagg E, Grier L et al. Sexually Transmitted Disease Surveillance 2012. Atlanta, GA: Department of Health and Human Services: National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, 2013."},{"key":"BFcmi201497_CR5","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.rbmo.2013.09.006","volume":"27","author":"DR Brison","year":"2013","unstructured":"Brison DR, Roberts SA, Kimber SJ . How should we assess the safety of IVF technologies? Reprod Biomed Online 2013; 27: 710\u2013721.","journal-title":"Reprod Biomed Online"},{"key":"BFcmi201497_CR6","volume-title":"Recent Advances in Medically Assisted Conception","author":"AA Acosta","year":"1992","unstructured":"Acosta AA, Anand Kumar TC, Andino N, Cooke ID, DeCherney AH, Qin-Sheng G et al. Recent Advances in Medically Assisted Conception. Geneva: World Health Organization, 1992."},{"key":"BFcmi201497_CR7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1365-2265.2007.03073.x","volume":"68","author":"C Welt","year":"2008","unstructured":"Welt C . Primary ovarian insufficiency: a more accurate term for premature ovarian failure. Clin Endocrinol 2008; 68: 499\u2013509.","journal-title":"Clin Endocrinol"},{"key":"BFcmi201497_CR8","first-page":"604","volume":"76","author":"CB Coulam","year":"1986","unstructured":"Coulam CB, Adamson SC, Annegers JF . Incidence of premature ovarian failure. Obstet Gynecol 1986; 76: 604\u2013606.","journal-title":"Obstet Gynecol"},{"key":"BFcmi201497_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1093\/humupd\/5.5.483","volume":"5","author":"Y van Kasteren","year":"1999","unstructured":"van Kasteren Y, Schoemaker J . Premature ovarian failure: a systematic review on therapeutic interventions to restore ovarian function and achieve pregnancy. Hum Reprod Update 1999; 5: 483\u2013492.","journal-title":"Hum Reprod Update"},{"key":"BFcmi201497_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/humrep\/12.2.241","volume":"12","author":"J Farhi","year":"1997","unstructured":"Farhi J, Homburg R, Ferber A, Orvieto R, Ben Rafael Z . Non-response to ovarian stimulation in normogonadotrophic, normogonadal women: a clinical sign of impending onset of ovarian failure pre-empting the rise in basal follicle stimulating hormone levels. Hum Reprod 1997; 12: 241\u2013243.","journal-title":"Hum Reprod"},{"key":"BFcmi201497_CR11","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1093\/humrep\/17.4.1106","volume":"17","author":"D Nikolaou","year":"2002","unstructured":"Nikolaou D, Lavery S, Turner C, Margara R, Trew G . Is there a link between an extremely poor response to ovarian hyperstimulation and early ovarian failure? Hum Reprod 2002; 17: 1106\u20131111.","journal-title":"Hum Reprod"},{"key":"BFcmi201497_CR12","first-page":"243","volume":"4","author":"KE Valdez","year":"2004","unstructured":"Valdez KE, Petroff BK . Potential roles of the aryl hydrocarbon receptor in female reproductive senescence. Reprod Biol 2004; 4: 243\u2013258.","journal-title":"Reprod Biol"},{"key":"BFcmi201497_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/BF00296207","volume":"51","author":"AC Bagur","year":"1992","unstructured":"Bagur AC, Mautalen CA . Risk of developing osteoporosis in untreated premature menopause. Calcif Tissue Int 1992; 51: 4\u201312.","journal-title":"Calcif Tissue Int"},{"key":"BFcmi201497_CR14","doi-asserted-by":"publisher","first-page":"983","DOI":"10.2105\/AJPH.83.7.983","volume":"83","author":"D Kritz-Silverstein","year":"1993","unstructured":"Kritz-Silverstein D, Barret-Connor E . Early menopause, number of reproductive years and bone mineral density in postmenopausal women. Am J Public Health 1993; 83: 983\u2013991.","journal-title":"Am J Public Health"},{"key":"BFcmi201497_CR15","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1001\/jama.288.3.321","volume":"288","author":"JE Rossouw","year":"2002","unstructured":"Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. J Am Med Assoc 2002; 288: 321\u2013333.","journal-title":"J Am Med Assoc"},{"key":"BFcmi201497_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1089\/jwh.1999.8.227","volume":"8","author":"ED Silbergeld","year":"1999","unstructured":"Silbergeld ED, Flaws JA . Chemicals and menopause: effects on age at menopause and on health status in the postmenopausal period. J Women's Health 1999; 8: 227\u2013234.","journal-title":"J Women's Health"},{"key":"BFcmi201497_CR17","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1093\/humrep\/14.7.1777","volume":"14","author":"SN Kalantaridou","year":"1999","unstructured":"Kalantaridou SN, Braddock DT, Patronas NJ, Nelson LM . Treatment of autoimmune premature ovarian failure: case report. Hum Reprod 1999; 14: 1777\u20131782.","journal-title":"Hum Reprod"},{"key":"BFcmi201497_CR18","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.autrev.2014.01.003","volume":"13","author":"CA Silva","year":"2014","unstructured":"Silva CA, Yamakami LY, Aikawa NE, Araujo DB, Carvalho JF, Bonfa E . Autoimmune primary ovarian insufficiency. Autoimmun Rev 2014; 13: 427\u2013430.","journal-title":"Autoimmun Rev"},{"key":"BFcmi201497_CR19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/00004347-199007000-00001","volume":"9","author":"P Bannatyne","year":"1990","unstructured":"Bannatyne P, Russell P, Shearman RP . Autoimmune oophoritis: a clinicopathologic assessment of 12 cases. Int J Gynecol Pathol 1990; 9: 191\u2013207.","journal-title":"Int J Gynecol Pathol"},{"key":"BFcmi201497_CR20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00004347-198703000-00009","volume":"6","author":"DD Sedmak","year":"1987","unstructured":"Sedmak DD, Hart WR, Tubbs RR . Autoimmune oophoritis: a histopathologic study of involved ovaries with immunologic characterization of the mononuclear cell infiltrate. Int J Gynecol Pathol 1987; 6: 73\u201381.","journal-title":"Int J Gynecol Pathol"},{"key":"BFcmi201497_CR21","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.fertnstert.2005.04.060","volume":"84","author":"VK Bakalov","year":"2005","unstructured":"Bakalov VK, Anasti JN, Calis KA, Vanderhoof VH, Premkumar A, Chen S et al. Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure. Fertil Steril 2005; 84: 958\u2013965.","journal-title":"Fertil Steril"},{"key":"BFcmi201497_CR22","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.autrev.2014.01.025","volume":"13","author":"RA Brandao Neto","year":"2014","unstructured":"Brandao Neto RA, de Carvalho JF . Diagnosis and classification of Addison's disease (autoimmune adrenalitis). Autoimmun Rev 2014; 13: 408\u2013411.","journal-title":"Autoimmun Rev"},{"key":"BFcmi201497_CR23","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/S0140-6736(57)91687-2","volume":"1","author":"JR Anderson","year":"1957","unstructured":"Anderson JR, Goudie RB, Gray KG, Timbury GC . Autoantibodies in Addison's disease. Lancet 1957; 1: 1123\u20131124.","journal-title":"Lancet"},{"key":"BFcmi201497_CR24","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/0140-6736(92)91829-W","volume":"339","author":"O Winqvist","year":"1992","unstructured":"Winqvist O, Karlsson FA, K\u00e4mpe O . 21-hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 1992; 339: 1559\u20131562.","journal-title":"Lancet"},{"key":"BFcmi201497_CR25","first-page":"1871","volume":"81","author":"S Chen","year":"1996","unstructured":"Chen S, Sawika J, Betterle C, Powell M, Prentice L, Volpato M et al. Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. J Clin Endocrinol Metab 1996; 81: 1871\u20131876.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR26","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S0015-0282(02)03205-3","volume":"78","author":"A Falorni","year":"2002","unstructured":"Falorni A, Laureti S, Candeloro P, Perrino S, Coronella C, Bizzarro A et al. Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity. Fertil Steril 2002; 78: 270\u2013279.","journal-title":"Fertil Steril"},{"key":"BFcmi201497_CR27","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1530\/eje.0.1480565","volume":"148","author":"C Dal Pra","year":"2003","unstructured":"Dal Pra C, Chen S, Furmaniak J, Smith B, Pedini B, Moscon A et al. Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease. Eur J Endocrinol 2003; 148: 565\u2013570.","journal-title":"Eur J Endocrinol"},{"key":"BFcmi201497_CR28","first-page":"5892","volume":"86","author":"S Arif","year":"2001","unstructured":"Arif S, Varela-Clvino R, Conway GS, Peakman M . 3\u03b2 hydroxysteroid dehydrogenase autoantibodies in patients with idiopathic premature ovarian failure target N- and C-terminal epitopes. J Clin Endocrinol Metab 2001; 86: 5892\u20135897.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR29","first-page":"4439","volume":"81","author":"S Arif","year":"1996","unstructured":"Arif S, Vallian S, Farzaneh F, Zanone MM, James SL, Pietropaolo M et al. Identification of 3 beta-hydroxysteroid dehydrogenase as a novel target of steroid cell autoantibodies: association of autoantibodies with endocrine autoimmune disease. J Clin Endocrinol Metab 1996; 81: 4439\u20134445.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1365-2559.1991.tb00897.x","volume":"19","author":"RN Lonsdale","year":"1991","unstructured":"Lonsdale RN, Roberts PF, Trowell JE . Autoimmune oophoritis associated with polycystic ovaries. Histopathology 1991; 19: 77\u201381.","journal-title":"Histopathology"},{"key":"BFcmi201497_CR31","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1210\/jc.2004-1985","volume":"90","author":"C Welt","year":"2005","unstructured":"Welt C, Falorni A, Taylor A, Martin K, Hall J . Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels. J Clin Endocrinol Metab 2005; 90: 3069\u20133076.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR32","first-page":"107","volume":"18","author":"A Hoek","year":"1997","unstructured":"Hoek A, Schoemaker J, Drexhage HA . Premature ovarian failure and ovarian autoimmunity. Endocr Rev 1997; 18: 107\u2013134.","journal-title":"Endocr Rev"},{"key":"BFcmi201497_CR33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/ajcp\/81.1.105","volume":"81","author":"E Gloor","year":"1984","unstructured":"Gloor E, Hurlimann J . Autoimmune oophoritis. Am J Clin Pathol 1984; 81: 105\u2013109.","journal-title":"Am J Clin Pathol"},{"key":"BFcmi201497_CR34","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/GCO.0b013e32833b6c70","volume":"22","author":"A La Marca","year":"2010","unstructured":"La Marca A, Brozzetti A, Giovanna S, Stefania M, Annibale V, Alberto F . Primary ovarian insufficiency: autoimmune causes. Curr Opin Obstet Gynecol 2010; 22: 277\u2013282.","journal-title":"Curr Opin Obstet Gynecol"},{"key":"BFcmi201497_CR35","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1210\/jc.2007-1675","volume":"93","author":"A Tsigkou","year":"2008","unstructured":"Tsigkou A, Marzotti S, Borges L, Brozzetti A, Reis F, Candeloro P et al. High serum inhibin concentration discriminates autoimmune oophoritis from other forms of primary ovarian insufficiency. J Clin Endocrinol Metab 2008; 93: 1263\u20131269.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR36","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/0002-9378(88)90791-0","volume":"158","author":"FS Cowchock","year":"1988","unstructured":"Cowchock FS, McCabe JL, Montgomery BB . Pregnancy after corticosteroid administration in premature ovarian failure (polyglandular endocrinopathy syndrome). Am J Obstet Gynecol 1988; 158: 118\u2013119.","journal-title":"Am J Obstet Gynecol"},{"key":"BFcmi201497_CR37","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1093\/oxfordjournals.humrep.a136225","volume":"10","author":"P Barbarino-Monnier","year":"1995","unstructured":"Barbarino-Monnier P, Gobert B, Guillet-May F, B\u00e9n\u00e9 MC, Barbarino A, Foliguet B et al. Ovarian autoimmunity and corticotherapy in an in-vitro fertilization attempt. Hum Reprod 1995; 10: 2006\u20132007.","journal-title":"Hum Reprod"},{"key":"BFcmi201497_CR38","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/S0015-0282(16)55915-9","volume":"59","author":"B Corenblum","year":"1993","unstructured":"Corenblum B, Rowe T, Taylor PJ . High-dose, short-term glucocorticoids for the treatment of infertility resulting from premature ovarian failure. Fertil Steril 1993; 59: 988\u2013991.","journal-title":"Fertil Steril"},{"key":"BFcmi201497_CR39","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/S0015-0282(16)55854-3","volume":"59","author":"Z Blumenfeld","year":"1993","unstructured":"Blumenfeld Z, Halachmi S, Peretz BA, Shmuel Z, Golan D, Makler A et al. Premature ovarian failure\u2014the prognostic application of autoimmunity on conception after ovulation induction. Fertil Steril 1993; 59: 750\u2013755.","journal-title":"Fertil Steril"},{"key":"BFcmi201497_CR40","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/j.1365-2265.2012.04387.x","volume":"77","author":"A Falorni","year":"2012","unstructured":"Falorni A, Brozzetti A, Aglietti MC, Esposito R, Minarelli V, Tomaro ES et al. Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency. Clin Endocrinol 2012; 77: 453\u2013458.","journal-title":"Clin Endocrinol"},{"key":"BFcmi201497_CR41","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1210\/en.2006-1265","volume":"148","author":"JA Visser","year":"2007","unstructured":"Visser JA, Durlinger AL, Peters IJ, van den Heuvel ER, Rose UM, Kramer P et al. Increased oocyte degeneration and follicular atresia during the estrous cycle in anti-M\u00fcllerian hormone null mice. Endocrinology 2007; 148: 2301\u20132308.","journal-title":"Endocrinology"},{"key":"BFcmi201497_CR42","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3109\/09513599909167554","volume":"13","author":"L Falsetti","year":"1999","unstructured":"Falsetti L, Scalchi S, Villani MT, Bugari G . Premature ovarian failure. Gynecol Endocrinol 1999; 13: 189\u2013195.","journal-title":"Gynecol Endocrinol"},{"key":"BFcmi201497_CR43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1210\/edrv.23.3.0466","volume":"23","author":"C Betterle","year":"2002","unstructured":"Betterle C, Dal Pra C, Mantero F, Zanchetta R . Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 2002; 23: 327\u2013364.","journal-title":"Endocr Rev"},{"key":"BFcmi201497_CR44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/humupd\/dmh014","volume":"10","author":"T Forges","year":"2004","unstructured":"Forges T, Monnier-Barbarino P, Faure GC, Bene MC . Autoimmunity and antigenic targets in ovarian pathology. Hum Reprod Update 2004; 10: 163\u2013175.","journal-title":"Hum Reprod Update"},{"key":"BFcmi201497_CR45","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0029-7844(97)00077-X","volume":"89","author":"TJ Kim","year":"1997","unstructured":"Kim TJ, Anasti JN, Flack MR, Kimzey LM, Defensor RA, Nelson LM . Routine endocrine screening for patients with karyotypically normal spontaneous premature ovarian failure. Obstet Gynecol 1997; 89: 777\u2013779.","journal-title":"Obstet Gynecol"},{"key":"BFcmi201497_CR46","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/mus.20067","volume":"30","author":"MM Ryan","year":"2004","unstructured":"Ryan MM, Jones HR . Myasthenia gravis and premature ovarian failure. Muscle Nerve 2004; 30: 231\u2013233.","journal-title":"Muscle Nerve"},{"key":"BFcmi201497_CR47","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1210\/jc.2005-2611","volume":"91","author":"J Perheentupa","year":"2006","unstructured":"Perheentupa J . Autoimmune polyendocrinopathy\u2013candidiasis\u2013ectodermal dystrophy. J Clin Endocrinol Metab 2006; 91: 2843\u20132850.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR48","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1210\/jcem.83.4.4682","volume":"83","author":"C Betterle","year":"1998","unstructured":"Betterle C, Greggio NA, Volpato M . Clinical Review 93: autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metab 1998; 83: 1049\u20131055.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR49","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s10875-013-9938-6","volume":"33","author":"AS Wolff","year":"2013","unstructured":"Wolff AS, Sarkadi AK, Mar\u00f3di L, K\u00e4rner J, Orlova E, Oftedal BE et al. Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type I features in early childhood. J Clin Immunol 2013; 33: 1341\u20131348.","journal-title":"J Clin Immunol"},{"key":"BFcmi201497_CR50","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1210\/jc.2008-0935","volume":"93","author":"A Meloni","year":"2008","unstructured":"Meloni A, Furcas M, Cetani F, Marcocci C, Falorni A, Perniola R et al. Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 2008; 93: 4389\u20134397.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR51","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1056\/NEJM199006283222601","volume":"322","author":"P Ahonen","year":"1990","unstructured":"Ahonen P, Myll\u00e4rniemi S, Sipil\u00e4 I, Perheentupa J . Clinical variation of autoimmune polyendocrinopathy\u2013candidiasis\u2013ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med 1990; 322: 1829\u20131836.","journal-title":"N Engl J Med"},{"key":"BFcmi201497_CR52","first-page":"4434","volume":"85","author":"M Gylling","year":"2000","unstructured":"Gylling M, Tuomi T, Bjorses P, Kontiainen S, Prartanen J, Christie MR et al. SS-cell autoantibodies, human leukocyte Antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy\u2013candidiasis\u2013ectodermal dystrophy*. J Clin Endocrinol Metab 2000; 85: 4434\u20134440.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR53","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1210\/jcem.87.6.8564","volume":"87","author":"M Halonen","year":"2002","unstructured":"Halonen M, Eskelin P, Myher AG, Perheentupa J, Husebye ES, Kampe O et al. AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy\u2013candidiasis\u2013ectodermal dystrophy phenotype. J Clin Endocrinol Metab 2002; 87: 2568\u20132574.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFcmi201497_CR54","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0889-8529(01)00013-5","volume":"31","author":"J Perheentupa","year":"2002","unstructured":"Perheentupa J . APS-1\/APECED: the clinical disease and therapy. Endocrinol Metab Clin North Am 2002; 31: 295\u2013320.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"BFcmi201497_CR55","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/ng1297-393","volume":"17","author":"K Nagamine","year":"1997","unstructured":"Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M et al. Positional cloning of the APECED gene. Nat Genet 1997; 17: 393\u2013398.","journal-title":"Nat Genet"},{"key":"BFcmi201497_CR56","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/ng1297-399","volume":"17","author":"J Aaltonen","year":"1997","unstructured":"Aaltonen J, Bjorses P, Perheentupa J, Horelli-Kuitunen N, Palotie A, Peltonen L et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997; 17: 399\u2013403.","journal-title":"Nat Genet"},{"key":"BFcmi201497_CR57","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/humu.1176","volume":"18","author":"M Heino","year":"2001","unstructured":"Heino M, Peterson P, Kudoh J, Shimizu N, Antonarakis SE, Scott HS et al. APECED mutations in the autoimmune regulator (AIRE) gene. Hum Mutat 2001; 18: 205\u2013211.","journal-title":"Hum Mutat"},{"key":"BFcmi201497_CR58","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/nri2136","volume":"7","author":"D Mathis","year":"2007","unstructured":"Mathis D, Benoist C . A decade of AIRE. Nat Rev Immunol 2007; 7: 645\u2013650.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201497_CR59","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/ni723","volume":"2","author":"J Derbinski","year":"2001","unstructured":"Derbinski J, Schulte A, Kyewski B, Klein L . Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001; 2: 1032\u20131039.","journal-title":"Nat Immunol"},{"key":"BFcmi201497_CR60","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0065-2776(08)60404-6","volume":"71","author":"B Stockinger","year":"1999","unstructured":"Stockinger B . T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv Immunol 1999; 71: 229\u2013265.","journal-title":"Adv Immunol"},{"key":"BFcmi201497_CR61","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1600-065X.1993.tb01514.x","volume":"133","author":"JFAP Miller","year":"1993","unstructured":"Miller JFAP, Heath WR . Self-ignorance in the peripheral T-cell pool. Immunol Rev 1993; 133: 131\u2013150.","journal-title":"Immunol Rev"},{"key":"BFcmi201497_CR62","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.1073\/pnas.91.14.6707","volume":"91","author":"C Jolicoeur","year":"1994","unstructured":"Jolicoeur C, Hanahan D, Smith KM . T-cell tolerance in transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus. Proc Natl Acad Sci USA 1994; 91: 6707\u20136711.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201497_CR63","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1084\/jem.191.5.761","volume":"191","author":"AC Anderson","year":"2000","unstructured":"Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK . High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J Exp Med 2000; 191: 761\u2013770.","journal-title":"J Exp Med"},{"key":"BFcmi201497_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/71540","volume":"6","author":"L Klein","year":"2000","unstructured":"Klein L, Klugmann M, Nave KA, Tuohy VK, Kyewski B . Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat Med 2000; 6: 56\u201361.","journal-title":"Nat Med"},{"key":"BFcmi201497_CR65","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1002\/1521-4141(200108)31:8<2476::AID-IMMU2476>3.0.CO;2-T","volume":"31","author":"L Klein","year":"2001","unstructured":"Klein L, Roettinger B, Kyewski B . Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur J Immunol 2001; 31: 2476\u20132486.","journal-title":"Eur J Immunol"},{"key":"BFcmi201497_CR66","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1126\/science.1075958","volume":"298","author":"MS Anderson","year":"2002","unstructured":"Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 2002; 298: 1395\u20131401.","journal-title":"Science"},{"key":"BFcmi201497_CR67","first-page":"33","volume":"202","author":"J Derbinski","year":"2005","unstructured":"Derbinski J, Gabler J, Brors B, Tierling S, Jonnakuty S, Hergenhahn M et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Immunol 2005; 202: 33\u201345.","journal-title":"J Immunol"},{"key":"BFcmi201497_CR68","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1084\/jem.20031677","volume":"199","author":"J Gotter","year":"2004","unstructured":"Gotter J, Brors B, Hergenhahn M, Kyewski B . Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med 2004; 199: 155\u2013166.","journal-title":"J Exp Med"},{"key":"BFcmi201497_CR69","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/hmg\/11.4.397","volume":"11","author":"C Ramsey","year":"2002","unstructured":"Ramsey C, Winqvist O, Puhakka L, Halonen M, Moro A, Kampe O et al. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 2002; 11: 397\u2013409.","journal-title":"Hum Mol Genet"},{"key":"BFcmi201497_CR70","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1084\/jem.20061864","volume":"203","author":"J DeVoss","year":"2006","unstructured":"DeVoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med 2006; 203: 2727\u20132735.","journal-title":"J Exp Med"},{"key":"BFcmi201497_CR71","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1038\/emboj.2009.212","volume":"28","author":"Y Fan","year":"2009","unstructured":"Fan Y, Rudert WA, Grupillo M, He J, Sisino G, Trucco M . Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 2009; 28: 2812\u20132824.","journal-title":"EMBO J"},{"key":"BFcmi201497_CR72","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1073\/pnas.0700259104","volume":"104","author":"I Gavanescu","year":"2007","unstructured":"Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D . Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad Sci USA 2007; 104: 4583\u20134587.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201497_CR73","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1196\/annals.1405.026","volume":"1132","author":"B Kyewski","year":"2008","unstructured":"Kyewski B, Taubert R . How promiscuity promotes tolerance: the case of myasthenia gravis. Ann NY Acad Sci 2008; 1132: 157\u2013162.","journal-title":"Ann NY Acad Sci"},{"key":"BFcmi201497_CR74","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/nri2450","volume":"8","author":"P Peterson","year":"2008","unstructured":"Peterson P, Org T, Rebane A . Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol 2008; 8: 948\u2013957.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201497_CR75","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1093\/hmg\/11.26.3299","volume":"11","author":"C Ramsey","year":"2002","unstructured":"Ramsey C, Bukrinsky A, Peltonen L . Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting. Hum Mol Genet 2002; 11: 3299\u20133308.","journal-title":"Hum Mol Genet"},{"key":"BFcmi201497_CR76","doi-asserted-by":"publisher","first-page":"41357","DOI":"10.1074\/jbc.M104898200","volume":"276","author":"PG Kumar","year":"2001","unstructured":"Kumar PG, Laloraya M, Wang CY, Ruan QG, Davoodi-Semiromi A, Kao KJ et al. The autoimmune regulator (AIRE) is a DNA-binding protein. J Biol Chem 2001; 276: 41357\u201341364.","journal-title":"J Biol Chem"},{"key":"BFcmi201497_CR77","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1146\/annurev.immunol.25.022106.141532","volume":"27","author":"D Mathis","year":"2009","unstructured":"Mathis D, Benoist C . Aire. Annu Rev Immunol 2009; 27: 287\u2013312.","journal-title":"Annu Rev Immunol"},{"key":"BFcmi201497_CR78","doi-asserted-by":"publisher","first-page":"8815","DOI":"10.1128\/MCB.01085-07","volume":"27","author":"I Oven","year":"2007","unstructured":"Oven I, Brdi\u010dkov\u00e1 N, Kohoutek J, Vaupoti\u010d T, Narat M, Peterlin BM . AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol 2007; 27: 8815\u20138823.","journal-title":"Mol Cell Biol"},{"key":"BFcmi201497_CR79","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.molimm.2007.10.045","volume":"45","author":"T Ilmarinen","year":"2008","unstructured":"Ilmarinen T, Kangas H, Kyt\u00f6maa T, Eskelin P, Saharinen J, Seeler JS et al. Functional interaction of AIRE with PIAS1 in transcriptional regulation. Mol Immunol 2008; 45: 1847\u20131862.","journal-title":"Mol Immunol"},{"key":"BFcmi201497_CR80","doi-asserted-by":"publisher","first-page":"13012","DOI":"10.1074\/jbc.M109.037747","volume":"285","author":"A Meloni","year":"2010","unstructured":"Meloni A, Fiorillo E, Corda D, Incani F, Serra ML, Contini A et al. DAXX I is a new AIRE-interacting protein. J Biol Chem 2010; 285: 13012\u201313021.","journal-title":"J Biol Chem"},{"key":"BFcmi201497_CR81","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/embor.2008.11","volume":"9","author":"T Org","year":"2008","unstructured":"Org T, Chignola F, Het\u00e9nyi C, Gaetani M, Rebane A, Liiv I et al. The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep 2008; 9: 370\u2013376.","journal-title":"EMBO Rep"},{"key":"BFcmi201497_CR82","doi-asserted-by":"publisher","first-page":"4699","DOI":"10.1093\/hmg\/ddp433","volume":"18","author":"T Org","year":"2009","unstructured":"Org T, Rebane A, Kisand K, Laan M, Haljasorg U, Andreson R et al. AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum Mol Genet 2009; 18: 4699\u20134710.","journal-title":"Hum Mol Genet"},{"key":"BFcmi201497_CR83","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1128\/MCB.06359-11","volume":"32","author":"K \u017dumer","year":"2012","unstructured":"\u017dumer K, Low AK, Jiang H, Saksela K, Peterlin BM . Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes. Mol Cell Biol 2012; 32: 1354\u20131362.","journal-title":"Mol Cell Biol"},{"key":"BFcmi201497_CR84","doi-asserted-by":"publisher","first-page":"7233","DOI":"10.1073\/pnas.0502670102","volume":"102","author":"JB Johnnidis","year":"2005","unstructured":"Johnnidis JB, Venanzi ES, Taxman DJ, Ting JP, Benoist CO, Mathis DJ . Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci USA 2005; 102: 7233\u20137238.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201497_CR85","doi-asserted-by":"publisher","first-page":"15854","DOI":"10.1073\/pnas.0808069105","volume":"105","author":"J Villase\u00f1or","year":"2008","unstructured":"Villase\u00f1or J, Besse W, Benoist C, Mathis D . Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci USA 2008; 105: 15854\u201315859.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201497_CR86","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1073\/pnas.0707486105","volume":"105","author":"J Derbinski","year":"2008","unstructured":"Derbinski J, Pinto S, R\u00f6sch S, Hexel K, Kyewski B . Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc Natl Acad Sci USA 2008; 105: 657\u2013662.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201497_CR87","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/hmg\/8.2.277","volume":"8","author":"C Rinderle","year":"1999","unstructured":"Rinderle C, Christensen HM, Schweiger S, Lehrach H, Yaspo ML . AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers. Hum Mol Genet 1999; 8: 277\u2013290.","journal-title":"Hum Mol Genet"},{"key":"BFcmi201497_CR88","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.immuni.2005.07.005","volume":"23","author":"MS Anderson","year":"2005","unstructured":"Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D . The cellular mechanism of Aire control of T cell tolerance. Immunity 2005; 23: 227\u2013239.","journal-title":"Immunity"},{"key":"BFcmi201497_CR89","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1182\/blood-2010-06-286393","volume":"118","author":"FX Hubert","year":"2011","unstructured":"Hubert FX, Kinkel SA, Davey GM, Phipson B, Mueller SN, Liston A et al. Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood 2011; 118: 2462\u20132472.","journal-title":"Blood"},{"key":"BFcmi201497_CR90","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ni906","volume":"4","author":"A Liston","year":"2003","unstructured":"Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC . Aire regulates negative selection of organ-specific T cells. Nat Immunol 2003; 4: 350\u2013354.","journal-title":"Nat Immunol"},{"key":"BFcmi201497_CR91","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/ni1444","volume":"8","author":"K Aschenbrenner","year":"2007","unstructured":"Aschenbrenner K, D'Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, Swee LK et al. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol 2007; 8: 351\u2013358.","journal-title":"Nat Immunol"},{"key":"BFcmi201497_CR92","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000179665","volume":"16","author":"I Hansenne","year":"2009","unstructured":"Hansenne I, Louis C, Martens H, Dorban G, Charlet-Renard C, Peterson P et al. Aire and Foxp3 expression in a particular microenvironment for T cell differentiation. Neuroimmunomodulation 2009; 16: 35\u201344.","journal-title":"Neuroimmunomodulation"},{"key":"BFcmi201497_CR93","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1126\/science.1233913","volume":"339","author":"S Malchow","year":"2013","unstructured":"Malchow S, Leventhal DS, Nishi S, Fischer BI, Shen L, Paner GP et al. Aire-dependent thymic development of tumor-associated regulatory T cells. Science 2013; 339: 1219\u20131224.","journal-title":"Science"},{"key":"BFcmi201497_CR94","doi-asserted-by":"publisher","first-page":"4072","DOI":"10.4049\/jimmunol.181.6.4072","volume":"181","author":"JJ Devoss","year":"2008","unstructured":"Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P et al. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 2008; 181: 4072\u20134079.","journal-title":"J Immunol"},{"key":"BFcmi201497_CR95","doi-asserted-by":"publisher","first-page":"13009","DOI":"10.1073\/pnas.0806874105","volume":"105","author":"I Gavanescu","year":"2008","unstructured":"Gavanescu I, Benoist C, Mathis D . B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: a therapeutic approach for APECED patients. Proc Natl Acad Sci USA 2008; 105: 13009\u201313014.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"BFcmi201497_CR96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nri2136-c1","volume":"7","author":"Eliisa Kek\u00e4l\u00e4inen","year":"2007","unstructured":"Kekalainen E, Miettinen A, Arstila TP . Does the deficiency of Aire in mice really resemble human APECED? Nat Rev Immunol 2007; 7 : 1.","journal-title":"Nature Reviews Immunology"},{"key":"BFcmi201497_CR97","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1084\/jem.20050693","volume":"202","author":"W Jiang","year":"2005","unstructured":"Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C . Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 2005; 202: 805\u2013815.","journal-title":"J Exp Med"},{"key":"BFcmi201497_CR98","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1095\/biolreprod.111.097501","volume":"86","author":"S Jasti","year":"2012","unstructured":"Jasti S, Warren BD, McGinnis LK, Kinsey WH, Petroff BK, Petroff MG . The autoimmune regulator prevents premature reproductive senescence in female mice. Biol Reprod 2012; 86: 110.","journal-title":"Biol Reprod"},{"key":"BFcmi201497_CR99","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1095\/biolreprod56.3.764","volume":"56","author":"H Bagavant","year":"1997","unstructured":"Bagavant H, Fusi FM, Baisch J, Kurth B, David CS, Tung KS . Immunogenicity and contraceptive potential of a human zona pellucida 3 peptide vaccine. Biol Reprod 1997; 56: 764\u2013770.","journal-title":"Biol Reprod"},{"issue":"Meeting Abstrac","key":"BFcmi201497_CR100","doi-asserted-by":"crossref","first-page":"44.41","DOI":"10.4049\/jimmunol.186.Supp.44.41","volume":"186","author":"M Cheng","year":"2011","unstructured":"Cheng M, Fan U, Johannes K, Anderson MS . Antigenic targets in Aire-mediated ovarian autoimmunity. J Immunol 2011; 186 ( Meeting Abstract Supplement): 44.41.","journal-title":"J Immunol"},{"key":"BFcmi201497_CR101","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1084\/jem.161.1.72","volume":"161","author":"S Sakaguchi","year":"1985","unstructured":"Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T . Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985; 161: 72\u201387.","journal-title":"J Exp Med"},{"key":"BFcmi201497_CR102","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1084\/jem.184.2.387","volume":"184","author":"M Asano","year":"1996","unstructured":"Asano M, Toda M, Sakaguchi N, Sakaguchi S . Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. j Exp Med 1996; 184: 387\u2013396.","journal-title":"j Exp Med"},{"key":"BFcmi201497_CR103","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1084\/jem.20041033","volume":"202","author":"ET Samy","year":"2005","unstructured":"Samy ET, Parker LA, Sharp CP, Tung KS . Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node. J Exp Med 2005; 202: 771\u2013781.","journal-title":"J Exp Med"},{"key":"BFcmi201497_CR104","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1210\/endo.140.8.6911","volume":"140","author":"ZB Tong","year":"1999","unstructured":"Tong ZB, Nelson LM . A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure. Endocrinology 1999; 140: 3720\u20133726.","journal-title":"Endocrinology"},{"key":"BFcmi201497_CR105","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/81547","volume":"26","author":"ZB Tong","year":"2000","unstructured":"Tong ZB, Gold L, Pfeifer KE, Dorward H, Lee E, Bondy CA et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet 2000; 26: 267\u2013268.","journal-title":"Nat Genet"},{"key":"BFcmi201497_CR106","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1056\/NEJMoa0706487","volume":"358","author":"M Alimohammadi","year":"2008","unstructured":"Alimohammadi M, Bj\u00f6rklund P, Hallgren \u00c5, P\u00f6ntynen N, Szinnai G, Shikama N et al. Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med 2008; 358: 1018\u20131028.","journal-title":"N Engl J Med"},{"key":"BFcmi201497_CR107","first-page":"2031","volume":"119","author":"Y Hou","year":"2009","unstructured":"Hou Y, DeVoss J, Dao V, Kwek S, Simko JP, McNeel DG et al. An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans. J Clin Invest 2009; 119: 2031\u20132041.","journal-title":"J Clin Invest"}],"container-title":["Cellular &amp; Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201497","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T11:35:21Z","timestamp":1672745721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,20]]},"references-count":107,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["BFcmi201497"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2014.97","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,20]]},"assertion":[{"value":"19 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}