{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:04:12Z","timestamp":1791896652138,"version":"4.3.4"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1038\/cmi.2015.43","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T13:56:23Z","timestamp":1432562183000},"page":"640-650","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["TSC1 controls IL-1\u03b2 expression in macrophages via mTORC1-dependent C\/EBP\u03b2 pathway"],"prefix":"10.1038","volume":"13","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxia","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongzhou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"BFcmi201543_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2174\/1568010054022024","volume":"4","author":"N Fujiwara","year":"2005","unstructured":"Fujiwara N, Kobayashi K . Macrophages in inflammation . Curr Drug Targets Inflamm Allergy 2005 ; 4 : 281 \u2013 286.","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"BFcmi201543_CR2","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/nri1733","volume":"5","author":"S Gordon","year":"2005","unstructured":"Gordon S, Taylor PR . Monocyte and macrophage heterogeneity . Nat Rev Immunol 2005 ; 5 : 953 \u2013 964.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201543_CR3","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nri2448","volume":"8","author":"DM Mosser","year":"2008","unstructured":"Mosser DM, Edwards JP . Exploring the full spectrum of macrophage activation . Nat Rev Immunol 2008 ; 8 : 958 \u2013 969.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201543_CR4","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1172\/JCI44490","volume":"121","author":"A Sindrilaru","year":"2011","unstructured":"Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H et al . An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice . J Clin Invest 2011 ; 121 : 985 \u2013 997.","journal-title":"J Clin Invest"},{"key":"BFcmi201543_CR5","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/cmi.2012.47","volume":"9","author":"X Hu","year":"2012","unstructured":"Hu X, Liu G, Hou Y, Shi J, Zhu L, Jin D et al . Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4(+)CD25(+) regulatory T cells . Cell Mol Immunol 2012 ; 9 : 464 \u2013 472.","journal-title":"Cell Mol Immunol"},{"key":"BFcmi201543_CR6","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.4049\/jimmunol.1201168","volume":"189","author":"H Qin","year":"2012","unstructured":"Qin H, Holdbrooks AT, Liu Y, Reynolds SL, Yanagisawa LL, Benveniste EN . SOCS3 deficiency promotes M1 macrophage polarization and inflammation . J Immunol 2012 ; 189 : 3439 \u2013 3448.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR7","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","volume":"27","author":"CA Dinarello","year":"2009","unstructured":"Dinarello CA . Immunological and inflammatory functions of the interleukin-1 family . Annu Rev Immunol 2009 ; 27 : 519 \u2013 550.","journal-title":"Annu Rev Immunol"},{"key":"BFcmi201543_CR8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s10555-006-9004-4","volume":"25","author":"RN Apte","year":"2006","unstructured":"Apte RN, Dotan S, Elkabets M, White MR, Reich E, Carmi Y et al . The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions . Cancer Metastasis Rev 2006 ; 25 : 387 \u2013 408.","journal-title":"Cancer Metastasis Rev"},{"key":"BFcmi201543_CR9","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1600-065X.2008.00615.x","volume":"222","author":"RN Apte","year":"2008","unstructured":"Apte RN, Voronov E . Is interleukin-1 a good or bad \u2018guy\u2019 in tumor immunobiology and immunotherapy? Immunol Rev 2008 ; 222 : 222 \u2013 241.","journal-title":"Immunol Rev"},{"key":"BFcmi201543_CR10","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.4049\/jimmunol.0901511","volume":"183","author":"Y Carmi","year":"2009","unstructured":"Carmi Y, Voronov E, Dotan S, Lahat N, Rahat MA, Fogel M et al . The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis . J Immunol 2009 ; 183 : 4705 \u2013 4714.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR11","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1073\/pnas.0437939100","volume":"100","author":"E Voronov","year":"2003","unstructured":"Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y et al . IL-1 is required for tumor invasiveness and angiogenesis . Proc Natl Acad Sci U S A 2003 ; 100 : 2645 \u2013 2650.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFcmi201543_CR12","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/ni.2711","volume":"14","author":"FJ Sheedy","year":"2013","unstructured":"Sheedy FJ, Moore KJ . IL-1 signaling in atherosclerosis: sibling rivalry . Nat Immunol 2013 ; 14 : 1030 \u2013 1032.","journal-title":"Nat Immunol"},{"key":"BFcmi201543_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3109\/08916934.2013.873413","volume":"47","author":"A Alghasham","year":"2014","unstructured":"Alghasham A, Rasheed Z . Therapeutic targets for rheumatoid arthritis: Progress and promises . Autoimmunity 2014 ; 47 : 77 \u2013 94.","journal-title":"Autoimmunity"},{"key":"BFcmi201543_CR14","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1074\/jbc.M412820200","volume":"280","author":"C Basak","year":"2005","unstructured":"Basak C, Pathak SK, Bhattacharyya A, Mandal D, Pathak S, Kundu M . NF-kappaB- and C\/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages . J Biol Chem 2005 ; 280 : 4279 \u2013 4288.","journal-title":"J Biol Chem"},{"key":"BFcmi201543_CR15","doi-asserted-by":"publisher","first-page":"461","DOI":"10.4049\/jimmunol.175.1.461","volume":"175","author":"C Chan","year":"2005","unstructured":"Chan C, Li L, McCall CE, Yoza BK . Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter . J Immunol 2005 ; 175 : 461 \u2013 468.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR16","doi-asserted-by":"publisher","first-page":"503","DOI":"10.4049\/jimmunol.181.1.503","volume":"181","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Saccani S, Shin H, Nikolajczyk BS . Dynamic protein associations define two phases of IL-1beta transcriptional activation . J Immunol 2008 ; 181 : 503 \u2013 512.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR17","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J . The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta . Mol Cell 2002 ; 10 : 417 \u2013 426.","journal-title":"Mol Cell"},{"key":"BFcmi201543_CR18","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.molcel.2012.06.009","volume":"47","author":"CC Dibble","year":"2012","unstructured":"Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM et al . TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 . Mol Cell 2012 ; 47 : 535 \u2013 546.","journal-title":"Mol Cell"},{"key":"BFcmi201543_CR19","doi-asserted-by":"publisher","first-page":"3658","DOI":"10.4049\/jimmunol.1102187","volume":"188","author":"H Pan","year":"2012","unstructured":"Pan H, O\u2019Brien TF, Zhang P, Zhong XP . The role of tuberous sclerosis complex 1 in regulating innate immunity . J Immunol 2012 ; 188 : 3658 \u2013 3666.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.it.2009.02.002","volume":"30","author":"T Weichhart","year":"2009","unstructured":"Weichhart T, Saemann MD . The multiple facets of mTOR in immunity . Trends Immunol 2009 ; 30 : 218 \u2013 226.","journal-title":"Trends Immunol"},{"key":"BFcmi201543_CR21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1182\/blood-2008-02-137430","volume":"112","author":"M Ohtani","year":"2008","unstructured":"Ohtani M, Nagai S, Kondo S, Mizuno S, Nakamura K, Tanabe M et al . Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells . Blood 2008 ; 112 : 635 \u2013 643.","journal-title":"Blood"},{"key":"BFcmi201543_CR22","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1002\/eji.200838761","volume":"38","author":"F Schmitz","year":"2008","unstructured":"Schmitz F, Heit A, Dreher S, Eisenacher K, Mages J, Haas T et al . Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells . Eur J Immunol 2008 ; 38 : 2981 \u2013 2992.","journal-title":"Eur J Immunol"},{"key":"BFcmi201543_CR23","doi-asserted-by":"publisher","first-page":"4696","DOI":"10.1038\/ncomms5696","volume":"5","author":"L Zhu","year":"2014","unstructured":"Zhu L, Yang T, Li L, Sun L, Hou Y, Hu X et al . TSC1 controls macrophage polarization to prevent inflammatory disease . Nat Commun 2014 ; 5 : 4696.","journal-title":"Nat Commun"},{"key":"BFcmi201543_CR24","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1038\/ncomms3834","volume":"4","author":"V Byles","year":"2013","unstructured":"Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T . The TSC-mTOR pathway regulates macrophage polarization . Nat Commun 2013 ; 4 : 2834.","journal-title":"Nat Commun"},{"key":"BFcmi201543_CR25","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1182\/blood-2010-09-310888","volume":"117","author":"T Weichhart","year":"2011","unstructured":"Weichhart T, Haidinger M, Katholnig K, Kopecky C, Poglitsch M, Lassnig C et al . Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells . Blood 2011 ; 117 : 4273 \u2013 4283.","journal-title":"Blood"},{"key":"BFcmi201543_CR26","doi-asserted-by":"publisher","first-page":"9587","DOI":"10.1074\/jbc.M110.202911","volume":"286","author":"J Harris","year":"2011","unstructured":"Harris J, Hartman M, Roche C, Zeng SG, O\u2019Shea A, Sharp FA et al . Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation . J Biol Chem 2011 ; 286 : 9587 \u2013 9597.","journal-title":"J Biol Chem"},{"key":"BFcmi201543_CR27","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1096\/fj.13-235408","volume":"27","author":"H Chen","year":"2013","unstructured":"Chen H, Zhang L, Zhang H, Xiao Y, Shao L, Li H et al . Disruption of TSC1\/2 signaling complex reveals a checkpoint governing thymic CD4+ CD25+ Foxp3+ regulatory T-cell development in mice . Faseb J 2013 ; 27 : 3979 \u2013 3990.","journal-title":"Faseb J"},{"key":"BFcmi201543_CR28","doi-asserted-by":"publisher","first-page":"e30592","DOI":"10.1371\/journal.pone.0030592","volume":"7","author":"L Zhang","year":"2012","unstructured":"Zhang L, Zhang H, Li L, Xiao Y, Rao E, Miao Z et al . TSC1\/2 signaling complex is essential for peripheral naive CD8+ T cell survival and homeostasis in mice . PLoS One 2012 ; 7 : e30592.","journal-title":"PLoS One"},{"key":"BFcmi201543_CR29","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/jcp.22891","volume":"227","author":"C Sun","year":"2012","unstructured":"Sun C, Sun L, Ma H, Peng J, Zhen Y, Duan K et al . The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term . J Cell Physiol 2012 ; 227 : 1670 \u2013 1679.","journal-title":"J Cell Physiol"},{"key":"BFcmi201543_CR30","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","volume":"176","author":"K Inaba","year":"1992","unstructured":"Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S et al . Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor . J Exp Med 1992 ; 176 : 1693 \u2013 1702.","journal-title":"J Exp Med"},{"key":"BFcmi201543_CR31","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1189\/jlb.1108702","volume":"86","author":"AJ Fleetwood","year":"2009","unstructured":"Fleetwood AJ, Dinh H, Cook AD, Hertzog PJ, Hamilton JA . GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling . J Leukoc Biol 2009 ; 86 : 411 \u2013 421.","journal-title":"J Leukoc Biol"},{"key":"BFcmi201543_CR32","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.4049\/jimmunol.1200068","volume":"189","author":"T Wu","year":"2012","unstructured":"Wu T, Sun C, Chen Z, Zhen Y, Peng J, Qi Z et al . Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway . J Immunol 2012 ; 189 : 4989 \u2013 5000.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR33","doi-asserted-by":"publisher","first-page":"30240","DOI":"10.1074\/jbc.M112.374405","volume":"287","author":"M Urbanska","year":"2012","unstructured":"Urbanska M, Gozdz A, Swiech LJ, Jaworski J . Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons . J Biol Chem 2012 ; 287 : 30240 \u2013 30256.","journal-title":"J Biol Chem"},{"key":"BFcmi201543_CR34","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1128\/MCB.00601-09","volume":"30","author":"LA Julien","year":"2010","unstructured":"Julien LA, Carriere A, Moreau J, Roux PP . mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling . Mol Cell Biol 2010 ; 30 : 908 \u2013 921.","journal-title":"Mol Cell Biol"},{"key":"BFcmi201543_CR35","doi-asserted-by":"publisher","first-page":"28745","DOI":"10.1074\/jbc.271.46.28745","volume":"271","author":"T Ishida","year":"1996","unstructured":"Ishida T, Mizushima S, Azuma S, Kobayashi N, Tojo T, Suzuki K et al . Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region . J Biol Chem 1996 ; 271 : 28745 \u2013 28748.","journal-title":"J Biol Chem"},{"key":"BFcmi201543_CR36","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S1074-7613(00)80402-1","volume":"7","author":"H Wesche","year":"1997","unstructured":"Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z . MyD88: an adapter that recruits IRAK to the IL-1 receptor complex . Immunity 1997 ; 7 : 837 \u2013 847.","journal-title":"Immunity"},{"key":"BFcmi201543_CR37","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1126\/science.278.5343.1612","volume":"278","author":"M Muzio","year":"1997","unstructured":"Muzio M, Ni J, Feng P, Dixit VM . IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling . Science 1997 ; 278 : 1612 \u2013 1615.","journal-title":"Science"},{"key":"BFcmi201543_CR38","doi-asserted-by":"publisher","first-page":"e73153","DOI":"10.1371\/journal.pone.0073153","volume":"8","author":"TY Lai","year":"2013","unstructured":"Lai TY, Wu SD, Tsai MH, Chuang EY, Chuang LL, Hsu LC, Lai LC . Transcription of Tnfaip3 is regulated by NF-kappaB and p38 via C\/EBPbeta in activated macrophages . PLoS One 2013 ; 8 : e73153.","journal-title":"PLoS One"},{"key":"BFcmi201543_CR39","doi-asserted-by":"publisher","first-page":"21272","DOI":"10.1074\/jbc.M000145200","volume":"275","author":"Z Yang","year":"2000","unstructured":"Yang Z, Wara-Aswapati N, Chen C, Tsukada J, Auron PE . NF-IL6 (C\/EBPbeta ) vigorously activates il1b gene expression via a Spi-1 (PU.1) protein-protein tether . J Biol Chem 2000 ; 275 : 21272 \u2013 21277.","journal-title":"J Biol Chem"},{"key":"BFcmi201543_CR40","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4049\/jimmunol.153.2.712","volume":"153","author":"JP Cogswell","year":"1994","unstructured":"Cogswell JP, Godlevski MM, Wisely GB, Clay WC, Leesnitzer LM, Ways JP, Gray JG . NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site . J Immunol 1994 ; 153 : 712 \u2013 723.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4049\/jimmunol.153.1.143","volume":"153","author":"SA Godambe","year":"1994","unstructured":"Godambe SA, Chaplin DD, Takova T, Bellone CJ . Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1 beta gene . J Immunol 1994 ; 153 : 143 \u2013 152.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR42","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1089\/dna.1994.13.561","volume":"13","author":"SA Godambe","year":"1994","unstructured":"Godambe SA, Chaplin DD, Takova T, Bellone CJ . An NFIL-6 sequence near the transcriptional initiation site is necessary for the lipopolysaccharide induction of murine interleukin-1 beta . DNA Cell Biol 1994 ; 13 : 561 \u2013 569.","journal-title":"DNA Cell Biol"},{"key":"BFcmi201543_CR43","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1006\/cyto.2000.0711","volume":"12","author":"TS Tengku-Muhammad","year":"2000","unstructured":"Tengku-Muhammad TS, Hughes TR, Ranki H, Cryer A, Ramji DP . Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokines . Cytokine 2000 ; 12 : 1430 \u2013 1436.","journal-title":"Cytokine"},{"key":"BFcmi201543_CR44","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.immuni.2008.08.012","volume":"29","author":"T Weichhart","year":"2008","unstructured":"Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM et al . The TSC-mTOR signaling pathway regulates the innate inflammatory response . Immunity 2008 ; 29 : 565 \u2013 577.","journal-title":"Immunity"},{"key":"BFcmi201543_CR45","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.4049\/jimmunol.1000296","volume":"185","author":"M Haidinger","year":"2010","unstructured":"Haidinger M, Poglitsch M, Geyeregger R, Kasturi S, Zeyda M, Zlabinger GJ et al . A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation . J Immunol 2010 ; 185 : 3919 \u2013 3931.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR46","doi-asserted-by":"publisher","first-page":"787","DOI":"10.4049\/jimmunol.0901363","volume":"183","author":"FG Bauernfeind","year":"2009","unstructured":"Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D et al . Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression . J Immunol 2009 ; 183 : 787 \u2013 791.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR47","doi-asserted-by":"publisher","first-page":"6263","DOI":"10.1158\/0008-5472.CAN-07-1232","volume":"67","author":"HC Dan","year":"2007","unstructured":"Dan HC, Adli M, Baldwin AS . Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha . Cancer Res 2007 ; 67 : 6263 \u2013 6269.","journal-title":"Cancer Res"},{"key":"BFcmi201543_CR48","doi-asserted-by":"publisher","first-page":"7582","DOI":"10.4049\/jimmunol.180.11.7582","volume":"180","author":"HC Dan","year":"2008","unstructured":"Dan HC, Baldwin AS . Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt . J Immunol 2008 ; 180 : 7582 \u2013 7589.","journal-title":"J Immunol"},{"key":"BFcmi201543_CR49","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.cell.2007.05.058","volume":"130","author":"DF Lee","year":"2007","unstructured":"Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y et al . IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway . Cell 2007 ; 130 : 440 \u2013 455.","journal-title":"Cell"},{"key":"BFcmi201543_CR50","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ni.1638","volume":"9","author":"MA Ermolaeva","year":"2008","unstructured":"Ermolaeva MA, Michallet MC, Papadopoulou N, Utermohlen O, Kranidioti K, Kollias G et al . Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses . Nat Immunol 2008 ; 9 : 1037 \u2013 1046.","journal-title":"Nat Immunol"},{"key":"BFcmi201543_CR51","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/ni.1639","volume":"9","author":"YL Pobezinskaya","year":"2008","unstructured":"Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z . The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors . Nat Immunol 2008 ; 9 : 1047 \u2013 1054.","journal-title":"Nat Immunol"},{"key":"BFcmi201543_CR52","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ccr.2006.08.007","volume":"10","author":"S Ghosh","year":"2006","unstructured":"Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P et al . Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival . Cancer Cell 2006 ; 10 : 215 \u2013 226.","journal-title":"Cancer Cell"},{"key":"BFcmi201543_CR53","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1158\/2159-8290.CD-11-0124","volume":"1","author":"K Tanaka","year":"2011","unstructured":"Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B et al . Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance . Cancer Discov 2011 ; 1 : 524 \u2013 538.","journal-title":"Cancer Discov"},{"key":"BFcmi201543_CR54","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ceb.2014.01.005","volume":"27","author":"M O\u2019Hayre","year":"2014","unstructured":"O\u2019Hayre M, Degese MS, Gutkind JS . Novel insights into G protein and G protein-coupled receptor signaling in cancer . Curr Opin Cell Biol 2014 ; 27 : 126 \u2013 135.","journal-title":"Curr Opin Cell Biol"},{"key":"BFcmi201543_CR55","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1128\/MCB.19.3.1695","volume":"19","author":"AL Welm","year":"1999","unstructured":"Welm AL, Timchenko NA, Darlington GJ . C\/EBPalpha regulates generation of C\/EBPbeta isoforms through activation of specific proteolytic cleavage . Mol Cell Biol 1999 ; 19 : 1695 \u2013 1704.","journal-title":"Mol Cell Biol"},{"key":"BFcmi201543_CR56","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/hep.20333","volume":"40","author":"T Luedde","year":"2004","unstructured":"Luedde T, Duderstadt M, Streetz KL, Tacke F, Kubicka S, Manns MP, Trautwein C . C\/EBP beta isoforms LIP and LAP modulate progression of the cell cycle in the regenerating mouse liver . Hepatology 2004 ; 40 : 356 \u2013 365.","journal-title":"Hepatology"},{"key":"BFcmi201543_CR57","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1182\/blood-2004-11-4513","volume":"106","author":"F Jundt","year":"2005","unstructured":"Jundt F, Raetzel N, Muller C, Calkhoven CF, Kley K, Mathas S et al . A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas . Blood 2005 ; 106 : 1801 \u2013 1807.","journal-title":"Blood"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201543","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cmi.2015.43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T11:09:49Z","timestamp":1672744189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["BFcmi201543"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2015.43","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,25]]},"assertion":[{"value":"3 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}