{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:39:02Z","timestamp":1791275942457,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1038\/cmi.2015.70","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T08:41:07Z","timestamp":1437381667000},"page":"240-250","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-\u03baB pathways"],"prefix":"10.1038","volume":"13","author":[{"given":"Xiaojun","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuh","family":"Narumiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"BFcmi201570_CR1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.20041257","volume":"201","author":"CL Langrish","year":"2005","unstructured":"Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005; 201: 233\u2013240.","journal-title":"J Exp Med"},{"key":"BFcmi201570_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","volume":"31","author":"CE Sutton","year":"2009","unstructured":"Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH . Interleukin-1 and IL-23 induce innate IL-17 production from \u03b3\u03b4 T cells, amplifying Th17 responses and autoimmunity. Immunity 2009; 31: 331\u2013341.","journal-title":"Immunity"},{"key":"BFcmi201570_CR3","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1146\/annurev-immunol-020711-075053","volume":"30","author":"H Spits","year":"2012","unstructured":"Spits H, Cupedo T . Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol 2012; 30: 647\u2013675.","journal-title":"Annu Rev Immunol"},{"key":"BFcmi201570_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nri3365","volume":"13","author":"H Spits","year":"2013","unstructured":"Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G et al. Innate lymphoid cells \u2013 a proposal for uniform nomenclature. Nat Rev Immunol 2013; 13: 145\u2013149.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201570_CR5","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.chom.2012.10.003","volume":"12","author":"ED Tait Wojno","year":"2012","unstructured":"Tait Wojno ED, Artis D . Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine. Cell Host Microbe 2012; 12: 445\u2013457.","journal-title":"Cell Host Microbe"},{"key":"BFcmi201570_CR6","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/bjd.12663","volume":"170","author":"J Schmitt","year":"2013","unstructured":"Schmitt J, Rosumeck S, Thomaschewski G, Sporbeck B, Haufe E, Nast A . Efficacy and safety of systemic treatments for moderate-to-severe psoriasis: meta-analysis of randomized controlled trials. Br J Dermatol 2013; 170: 274\u2013303.","journal-title":"Br J Dermatol"},{"key":"BFcmi201570_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1136\/annrheumdis-2012-201601","volume":"72","author":"MC Genovese","year":"2013","unstructured":"Genovese MC, Durez P, Richards HB, Supronik J, Dokoupilova E, Mazurov V et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann Rheum Dis 2013; 72: 863\u2013869.","journal-title":"Ann Rheum Dis"},{"key":"BFcmi201570_CR8","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1016\/S0140-6736(13)61134-4","volume":"382","author":"D Baeten","year":"2013","unstructured":"Baeten D, Baraliakos X, Braun J, Sieper J, Emery P, van der Heijde D et al. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Lancet 2013; 382: 1705\u20131713.","journal-title":"Lancet"},{"key":"BFcmi201570_CR9","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/S0140-6736(08)60725-4","volume":"371","author":"CL Leonardi","year":"2008","unstructured":"Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y et al. Efficacy and safety of ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008; 371: 1665\u20131674.","journal-title":"Lancet"},{"key":"BFcmi201570_CR10","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/S0140-6736(08)60726-6","volume":"371","author":"KA Papp","year":"2008","unstructured":"Papp KA, Langley RG, Lebwohl M, Krueger GG, Szapary P, Yeilding N et al. Efficacy and safety of ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008; 371: 1675\u20131684.","journal-title":"Lancet"},{"key":"BFcmi201570_CR11","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1056\/NEJMoa1203572","volume":"367","author":"WJ Sandborn","year":"2012","unstructured":"Sandborn WJ, Gasink C, Gao LL, Blank MA, Johanns J, Guzzo C et al. Ustekinumab induction and maintenance therapy in refractory Crohn\u2019s disease. N Engl J Med 2012; 367: 1519\u20131528.","journal-title":"N Engl J Med"},{"key":"BFcmi201570_CR12","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature14175","volume":"521","author":"T Kopp","year":"2015","unstructured":"Kopp T, Riedl E, Bangert C, Bowman EP, Greisenegger E, Horowitz A et al. Clinical improvement in psoriasis with specific targeting of interleukin-23. Nature 2015; 521: 222\u2013226.","journal-title":"Nature"},{"key":"BFcmi201570_CR13","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","volume":"13","author":"B Oppmann","year":"2000","unstructured":"Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13: 715\u2013725.","journal-title":"Immunity"},{"key":"BFcmi201570_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1172\/JCI200113416","volume":"108","author":"SL Tilley","year":"2001","unstructured":"Tilley SL, Coffman TM, Koller BH . Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 2001; 108: 15\u201323.","journal-title":"J Clin Invest"},{"key":"BFcmi201570_CR15","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1096\/fj.11-0302ufm","volume":"25","author":"S Narumiya","year":"2011","unstructured":"Narumiya S, Furuyashiki T . Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years. FASEB J 2011; 25: 813\u2013818.","journal-title":"FASEB J"},{"key":"BFcmi201570_CR16","doi-asserted-by":"publisher","first-page":"6209","DOI":"10.1021\/cr200010h","volume":"111","author":"T Hirata","year":"2011","unstructured":"Hirata T, Narumiya S . Prostanoid receptors. Chem Rev 2011; 111: 6209\u20136230.","journal-title":"Chem Rev"},{"key":"BFcmi201570_CR17","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1096\/fj.03-1367fje","volume":"18","author":"AF Sheibanie","year":"2004","unstructured":"Sheibanie AF, Tadmori I, Jing H, Vassiliou E, Ganea D . Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J 2004; 18: 1318\u20131320.","journal-title":"FASEB J"},{"key":"BFcmi201570_CR18","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nm.1968","volume":"15","author":"C Yao","year":"2009","unstructured":"Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K et al. Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med 2009; 15: 633\u2013640.","journal-title":"Nat Med"},{"key":"BFcmi201570_CR19","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","volume":"176","author":"K Inaba","year":"1992","unstructured":"Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693\u20131702.","journal-title":"J Exp Med"},{"key":"BFcmi201570_CR20","doi-asserted-by":"publisher","first-page":"6454","DOI":"10.4049\/jimmunol.1002672","volume":"186","author":"X Qian","year":"2011","unstructured":"Qian X, Ning H, Zhang J, Hoft DF, Stumpo DJ, Blackshear PJ et al. Posttranscriptional regulation of IL-23 expression by IFN-\u03b3 through tristetraprolin. J Immunol 2011; 186: 6454\u20136464.","journal-title":"J Immunol"},{"key":"BFcmi201570_CR21","doi-asserted-by":"publisher","first-page":"e23239","DOI":"10.1371\/journal.pone.0023239","volume":"6","author":"Z Song","year":"2011","unstructured":"Song Z, Jin R, Yu S, Rivet JJ, Smyth SS, Nanda A et al. CD40 is essential in the upregulation of TRAF proteins and NF-\u03baB-dependent proinflammatory gene expression after arterial injury. PLoS One 2011; 6: e23239.","journal-title":"PLoS One"},{"key":"BFcmi201570_CR22","doi-asserted-by":"publisher","first-page":"11613","DOI":"10.1074\/jbc.R600038200","volume":"282","author":"Y Sugimoto","year":"2007","unstructured":"Sugimoto Y, Narumiya S . Prostaglandin E receptors. J Biol Chem 2007; 282: 11613\u201311617.","journal-title":"J Biol Chem"},{"key":"BFcmi201570_CR23","doi-asserted-by":"publisher","first-page":"6596","DOI":"10.4049\/jimmunol.179.10.6596","volume":"179","author":"S Mise-Omata","year":"2007","unstructured":"Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS . A proximal \u03baB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription. J Immunol 2007; 179: 6596\u20136603.","journal-title":"J Immunol"},{"key":"BFcmi201570_CR24","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4049\/jimmunol.178.1.186","volume":"178","author":"RJ Carmody","year":"2007","unstructured":"Carmody RJ, Ruan Q, Liou HC, Chen YH . Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells. J Immunol 2007; 178: 186\u2013191.","journal-title":"J Immunol"},{"key":"BFcmi201570_CR25","doi-asserted-by":"publisher","first-page":"36922","DOI":"10.1074\/jbc.M112.402958","volume":"287","author":"VP Kocieda","year":"2012","unstructured":"Kocieda VP, Adhikary S, Emig F, Yen JH, Toscano MG, Ganea D . Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C\/AATT enhancer-binding protein beta in bone marrow-derived dendritic cells. J Biol Chem 2012; 287: 36922\u201336935.","journal-title":"J Biol Chem"},{"key":"BFcmi201570_CR26","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/ncomms2684","volume":"4","author":"C Yao","year":"2013","unstructured":"Yao C, Hirata T, Soontrapa K, Ma X, Takemori H, Narumiya S . Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase. Nat Commun 2013; 4: 1685.","journal-title":"Nat Commun"},{"key":"BFcmi201570_CR27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0026-895X(25)09407-6","volume":"50","author":"N Nishigaki","year":"1996","unstructured":"Nishigaki N, Negishi M, Ichikawa A . Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol Pharmacol 1996; 50: 1031\u20131037.","journal-title":"Mol Pharmacol"},{"key":"BFcmi201570_CR28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.molimm.2012.12.010","volume":"54","author":"NJ Poloso","year":"2013","unstructured":"Poloso NJ, Urquhart P, Nicolaou A, Wang J, Woodward DF . PGE2 differentially regulates monocyte-derived dendritic cell cytokine responses depending on receptor usage (EP2\/EP4). Mol Immunol 2013; 54: 284\u2013295.","journal-title":"Mol Immunol"},{"key":"BFcmi201570_CR29","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.molimm.2012.08.014","volume":"53","author":"KW Kalim","year":"2013","unstructured":"Kalim KW, Groettrup M . Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. Mol Immunol 2013; 53: 274\u2013282.","journal-title":"Mol Immunol"},{"key":"BFcmi201570_CR30","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/jlb.63.4.418","volume":"63","author":"MF Mackey","year":"1998","unstructured":"Mackey MF, Barth RJ, Jr., Noelle RJ . The role of CD40\/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells. J Leukoc Biol 1998; 63: 418\u2013428.","journal-title":"J Leukoc Biol"},{"key":"BFcmi201570_CR31","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1084\/jem.180.4.1263","volume":"180","author":"C Caux","year":"1994","unstructured":"Caux C, Massacrier C, Vanbervliet B, Dubois B, Van Kooten C, Durand I et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994; 180: 1263\u20131272.","journal-title":"J Exp Med"},{"key":"BFcmi201570_CR32","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1084\/jem.179.4.1109","volume":"179","author":"F Sallusto","year":"1994","unstructured":"Sallusto F, Lanzavecchia A . Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte\/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994; 179: 1109\u20131118.","journal-title":"J Exp Med"},{"key":"BFcmi201570_CR33","doi-asserted-by":"publisher","first-page":"12233","DOI":"10.1073\/pnas.0915112107","volume":"107","author":"Y Esaki","year":"2010","unstructured":"Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T et al. Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2010; 107: 12233\u201312238.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201570_CR34","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1476-5381.2010.00647.x","volume":"160","author":"Q Chen","year":"2010","unstructured":"Chen Q, Muramoto K, Masaaki N, Ding Y, Yang H, Mackey M et al. A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br J Pharmacol 2010; 160: 292\u2013310.","journal-title":"Br J Pharmacol"},{"key":"BFcmi201570_CR35","doi-asserted-by":"publisher","first-page":"e52873","DOI":"10.1371\/journal.pone.0052873","volume":"7","author":"J Glas","year":"2012","unstructured":"Glas J, Seiderer J, Czamara D, Pasciuto G, Diegelmann J, Wetzke M et al. PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn\u2019s disease and affect NF-\u03baB and XBP1 binding sites. PLoS One 2012; 7: e52873.","journal-title":"PLoS One"},{"key":"BFcmi201570_CR36","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature10251","volume":"476","author":"C International Multiple Sclerosis Ge","year":"2011","unstructured":"International Multiple Sclerosis Genetics C, Wellcome Trust Case Control C, Sawcer S, Hellenthal G, Pirinen M, Spencer CC et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011; 476: 214\u2013219.","journal-title":"Nature"},{"key":"BFcmi201570_CR37","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/ng.2686","volume":"45","author":"DA Hinds","year":"2013","unstructured":"Hinds DA, McMahon G, Kiefer AK, Do CB, Eriksson N, Evans DM et al. A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. Nat Genet 2013; 45: 907\u2013911.","journal-title":"Nat Genet"},{"key":"BFcmi201570_CR38","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature13835","volume":"518","author":"KK Farh","year":"2015","unstructured":"Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 2015; 518: 337\u2013343.","journal-title":"Nature"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201570","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T12:31:23Z","timestamp":1748521883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,20]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["BFcmi201570"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2015.70","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,20]]},"assertion":[{"value":"7 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}