{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:17:25Z","timestamp":1783689445493,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1038\/cmi.2016.33","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T09:07:44Z","timestamp":1467018464000},"page":"135-145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Shuxun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"BFcmi201633_CR1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nrm3660","volume":"14","author":"SM Doyle","year":"2013","unstructured":"Doyle SM, Genest O, Wickner S . Protein rescue from aggregates by powerful molecular chaperone machines. Nat Rev Mol Cell Biol 2013; 14: 617\u2013629.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcmi201633_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.physiol.67.040403.103635","volume":"67","author":"D K\u00fcltz","year":"2005","unstructured":"K\u00fcltz D . Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol 2005; 67: 225\u2013257.","journal-title":"Annu Rev Physiol"},{"key":"BFcmi201633_CR3","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrm3658","volume":"14","author":"H Saibil","year":"2013","unstructured":"Saibil H . Chaperone machines for protein folding, unfolding and disaggregation. Nat Rev Mol Cell Biol 2013; 14: 630\u2013642.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcmi201633_CR4","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrm2941","volume":"11","author":"HH Kampinga","year":"2010","unstructured":"Kampinga HH, Craig EA . The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol 2010; 11: 579\u2013592.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFcmi201633_CR5","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.4049\/jimmunol.172.7.4195","volume":"172","author":"JC Baker-LePain","year":"2004","unstructured":"Baker-LePain JC, Sarzotti M, Nicchitta CV . Glucose-regulated protein 94\/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. J Immunol 2004; 172: 4195\u20134203.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/cas.12570","volume":"106","author":"T Tanaka","year":"2015","unstructured":"Tanaka T, Okuya K, Kutomi G, Takaya A, Kajiwara T, Kanaseki T et al. Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells. Cancer Sci 2015; 106: 18\u201324.","journal-title":"Cancer Sci"},{"key":"BFcmi201633_CR7","doi-asserted-by":"publisher","first-page":"488","DOI":"10.4049\/jimmunol.0902255","volume":"184","author":"J Gong","year":"2010","unstructured":"Gong J, Zhang Y, Durfee J, Weng D, Liu C, Koido S et al. A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use. J Immunol 2010; 184: 488\u2013496.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR8","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.4049\/jimmunol.1400656","volume":"193","author":"ID Jung","year":"2014","unstructured":"Jung ID, Shin SJ, Lee MG, Kang TH, Han HD, Lee SJ et al. Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X. J Immunol 2014; 193: 1233\u20131245.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1189\/jlb.0807548","volume":"84","author":"B Valentinis","year":"2008","unstructured":"Valentinis B, Capobianco A, Esposito F, Bianchi A, Rovere-Querini P, Manfredi AA et al. Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity. J Leukoc Biol 2008; 84: 199\u2013206.","journal-title":"J Leukoc Biol"},{"key":"BFcmi201633_CR10","doi-asserted-by":"publisher","first-page":"5765","DOI":"10.4049\/jimmunol.1401417","volume":"193","author":"RJ Binder","year":"2014","unstructured":"Binder RJ . Functions of heat shock proteins in pathways of the innate and adaptive immune system. J Immunol 2014; 193: 5765\u20135771.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR11","doi-asserted-by":"publisher","first-page":"20847","DOI":"10.1074\/jbc.M200425200","volume":"277","author":"RM Vabulas","year":"2002","unstructured":"Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P et al. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2\/4 pathway. J Biol chem 2002; 277: 20847\u201320853.","journal-title":"J Biol chem"},{"key":"BFcmi201633_CR12","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1002\/eji.201445293","volume":"45","author":"K Saito","year":"2015","unstructured":"Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T et al. Heat shock protein 90 associates with Toll-like receptors 7\/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol 2015; 45: 2028\u20132041.","journal-title":"Eur J Immunol"},{"key":"BFcmi201633_CR13","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.4049\/jimmunol.0901235","volume":"183","author":"J Gong","year":"2009","unstructured":"Gong J, Zhu B, Murshid A, Adachi H, Song B, Lee A et al. T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1. J Immunol 2009; 183: 3092\u20133098.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR14","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1084\/jem.191.11.1965","volume":"191","author":"H Singh-Jasuja","year":"2000","unstructured":"Singh-Jasuja H, Toes RE, Spee P, M\u00fcnz C, Hilf N, Schoenberger SP et al. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis. J Exp Med 2000; 191: 1965\u20131974.","journal-title":"J Exp Med"},{"key":"BFcmi201633_CR15","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S1074-7613(01)00111-X","volume":"14","author":"S Basu","year":"2001","unstructured":"Basu S, Binder RJ, Ramalingam T, Srivastava PK . CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 2001; 14: 303\u2013313.","journal-title":"Immunity"},{"key":"BFcmi201633_CR16","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.4049\/jimmunol.0903214","volume":"185","author":"J Xie","year":"2010","unstructured":"Xie J, Zhu H, Guo L, Ruan Y, Wang L, Sun L et al. Lectin-like oxidized low-density lipoprotein receptor-1 delivers heat shock protein 60-fused antigen into the MHC class I presentation pathway. J Immunol 2010; 185: 2306\u20132313.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR17","doi-asserted-by":"publisher","first-page":"6819","DOI":"10.4049\/jimmunol.1000448","volume":"185","author":"AR Jockheck-Clark","year":"2010","unstructured":"Jockheck-Clark AR, Bowers EV, Totonchy MB, Neubauer J, Pizzo SV, Nicchitta CV . Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. J Immunol 2010; 185: 6819\u20136830.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR18","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/ncomms1524","volume":"2","author":"S Pawaria","year":"2011","unstructured":"Pawaria S, Binder RJ . CD91-dependent programming of T-helper cell responses following heat shock protein immunization. Nat Commun 2011; 2: 521.","journal-title":"Nat Commun"},{"key":"BFcmi201633_CR19","doi-asserted-by":"publisher","first-page":"16363","DOI":"10.1073\/pnas.1108372108","volume":"108","author":"T Imai","year":"2011","unstructured":"Imai T, Kato Y, Kajiwara C, Mizukami S, Ishige I, Ichiyanagi T et al. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci USA 2011; 108: 16363\u201316368.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201633_CR20","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.4049\/jimmunol.1000821","volume":"185","author":"T Ichiyanagi","year":"2010","unstructured":"Ichiyanagi T, Imai T, Kajiwara C, Mizukami S, Nakai A, Nakayama T et al. Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation. J Immunol 2010; 185: 2693\u20132700.","journal-title":"J Immunol"},{"key":"BFcmi201633_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s11060-015-1837-7","volume":"123","author":"L Ampie","year":"2015","unstructured":"Ampie L, Choy W, Lamano JB, Fakurnejad S, Bloch O, Parsa AT . Heat shock protein vaccines against glioblastoma: from bench to bedside. J Neurooncol 2015; 123: 441\u2013448.","journal-title":"J Neurooncol"},{"key":"BFcmi201633_CR22","doi-asserted-by":"publisher","first-page":"e0126075","DOI":"10.1371\/journal.pone.0126075","volume":"10","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Zhang Y, Chen J, Liu Y, Luo W . Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity. PLoS One 2015; 10: e0126075.","journal-title":"PLoS One"},{"key":"BFcmi201633_CR23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1089\/hum.2009.139","volume":"21","author":"L Zhou","year":"2010","unstructured":"Zhou L, Zhu T, Ye X, Yang L, Wang B, Liang X et al. Long-term protection against human papillomavirus e7-positive tumor by a single vaccination of adeno-associated virus vectors encoding a fusion protein of inactivated e7 of human papillomavirus 16\/18 and heat shock protein 70. Hum Gene Ther 2010; 21: 109\u2013119.","journal-title":"Hum Gene Ther"},{"key":"BFcmi201633_CR24","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1200\/JCO.2007.11.9941","volume":"26","author":"A Testori","year":"2008","unstructured":"Testori A, Richards J, Whitman E, Mann GB, Lutzky J, Camacho L et al. Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group. J Clin Oncol 2008; 26: 955\u2013962.","journal-title":"J Clin Oncol"},{"key":"BFcmi201633_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/1479-5876-9-175","volume":"9","author":"S Tischer","year":"2011","unstructured":"Tischer S, Basila M, Maecker-Kolhoff B, Immenschuh S, Oelke M, Blasczyk R et al. Heat shock protein 70\/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies. J Transl Med 2011; 9: 175.","journal-title":"J Transl Med"},{"key":"BFcmi201633_CR26","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1182\/blood-2013-08-520775","volume":"123","author":"RG Newman","year":"2014","unstructured":"Newman RG, Dee MJ, Malek TR, Podack ER, Levy RB . Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood 2014; 123: 3045\u20133055.","journal-title":"Blood"},{"key":"BFcmi201633_CR27","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00262-015-1709-1","volume":"64","author":"Y Maeda","year":"2015","unstructured":"Maeda Y, Yoshimura K, Matsui H, Shindo Y, Tamesa T, Tokumitsu Y et al. Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial. Cancer Immunol Immunother 2015; 64: 1047\u20131056.","journal-title":"Cancer Immunol Immunother"},{"key":"BFcmi201633_CR28","doi-asserted-by":"publisher","first-page":"10064","DOI":"10.1073\/pnas.0504400102","volume":"102","author":"H Otto","year":"2005","unstructured":"Otto H, Conz C, Maier P, W\u00f6lfle T, Suzuki CK, Jen\u00f6 P et al. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Proc Natl Acad Sci USA 2005; 102: 10064\u201310069.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201633_CR29","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1128\/MCB.00986-10","volume":"31","author":"H Jaiswal","year":"2011","unstructured":"Jaiswal H, Conz C, Otto H, W\u00f6lfle T, Fitzke E, Mayer MP et al. The chaperone network connected to human ribosome-associated complex. Mol Cell Biol 2011; 31: 1160\u20131173.","journal-title":"Mol Cell Biol"},{"key":"BFcmi201633_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nsmb.2447","volume":"20","author":"C Leidig","year":"2013","unstructured":"Leidig C, Bange G, Kopp J, Amlacher S, Aravind A, Wickles S et al. Structural characterization of a eukaryotic chaperone\u2014the ribosome-associated complex. Nat Struct Mol Biol 2013; 20: 23\u201328.","journal-title":"Nat Struct Mol Biol"},{"key":"BFcmi201633_CR31","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1182\/blood-2003-08-2828","volume":"103","author":"T Wan","year":"2004","unstructured":"Wan T, Zhou X, chen G, An H, chen T, Zhang W et al. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. Blood 2004; 103: 1747\u20131754.","journal-title":"Blood"},{"key":"BFcmi201633_CR32","doi-asserted-by":"publisher","first-page":"30393","DOI":"10.1074\/jbc.M111.266528","volume":"286","author":"H Fang","year":"2011","unstructured":"Fang H, Wu Y, Huang X, Wang W, Ang B, Cao X et al. Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response. J Biol chem 2011; 286: 30393\u201330400.","journal-title":"J Biol chem"},{"key":"BFcmi201633_CR33","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/cmi.2011.21","volume":"8","author":"Q Fu","year":"2011","unstructured":"Fu Q, Wu Y, Yan F, Wang N, Wang W, Cao X et al. Efficient induction of a Her2-specific anti-tumor response by dendritic cells pulsed with a Hsp70L1-Her2(341-456) fusion protein. Cell Mol Immunol 2011; 8: 424\u2013432.","journal-title":"Cell Mol Immunol"},{"key":"BFcmi201633_CR34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/cmi.2013.59","volume":"11","author":"H Fang","year":"2014","unstructured":"Fang H, Ang B, Xu X, Huang X, Wu Y, Sun Y et al. TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells. Cell Mol Immunol 2014; 11: 150\u2013159.","journal-title":"Cell Mol Immunol"},{"key":"BFcmi201633_CR35","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.1158\/0008-5472.CAN-04-3912","volume":"65","author":"Y Wu","year":"2005","unstructured":"Wu Y, Wan T, Zhou X, Wang B, Yang F, Li N et al. Hsp70-like protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD8+ CTL response by dendritic cell vaccine. Cancer Res 2005; 65: 4947\u20134954.","journal-title":"Cancer Res"},{"key":"BFcmi201633_CR36","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1128\/JVI.02702-13","volume":"88","author":"E Lam","year":"2014","unstructured":"Lam E, Stein S, Falck-Pedersen E . Adenovirus detection by the cGAS\/STING\/TBK1 DNA sensing cascade. J Virol 2014; 88: 974\u2013981.","journal-title":"J Virol"},{"key":"BFcmi201633_CR37","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1038\/onc.2014.286","volume":"34","author":"V De Simone","year":"2015","unstructured":"De Simone V, Franz\u00e8 E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D et al. Th17-type cytokines, IL-6 and TNF-\u03b1 synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene 2015; 34: 3493\u20133503.","journal-title":"Oncogene"},{"key":"BFcmi201633_CR38","doi-asserted-by":"publisher","first-page":"42667","DOI":"10.18632\/oncotarget.5626","volume":"6","author":"D Malanga","year":"2015","unstructured":"Malanga D, De Marco C, Guerriero I, Colelli F, Rinaldo N, Scrima M et al. The Akt1\/IL-6\/STAT3 pathway regulates growth of lung tumor initiating cells. Oncotarget 2015; 6: 42667\u201342686.","journal-title":"Oncotarget"},{"key":"BFcmi201633_CR39","doi-asserted-by":"publisher","first-page":"6956","DOI":"10.1038\/ncomms7956","volume":"6","author":"Z Deng","year":"2015","unstructured":"Deng Z, Mu J, Tseng M, Wattenberg B, Zhuang X, Egilmez NK et al. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. Nat Commun 2015; 6: 6956.","journal-title":"Nat Commun"},{"key":"BFcmi201633_CR40","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1084\/jem.20150204","volume":"212","author":"L Wu","year":"2015","unstructured":"Wu L, Chen X, Zhao J, Martin B, Zepp JA, Ko JS et al. A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis. J Exp Med 2015; 212: 1571\u20131587.","journal-title":"J Exp Med"}],"updated-by":[{"DOI":"10.1038\/s41423-019-0335-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000}}],"container-title":["Cellular &amp; Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201633.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201633","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cmi.2016.33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201633.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T11:25:24Z","timestamp":1672745124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,27]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["BFcmi201633"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2016.33","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41423-019-0335-9","asserted-by":"object"}]},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,27]]},"assertion":[{"value":"2 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2019","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"\"An amendment to this paper has been published and can be accessed via a link at the top of the paper.\"","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}