{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:14:12Z","timestamp":1786662852351,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/cmi.2016.57","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T09:41:17Z","timestamp":1483954877000},"page":"260-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-\u03b3 production by CD4+ T cells"],"prefix":"10.1038","volume":"15","author":[{"given":"Chenhong","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"BFcmi201657_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1478-3231.2011.02654.x","volume":"32","author":"DC dos Santos","year":"2012","unstructured":"dos Santos DC, Neves PC, Azeredo EL, Pelajo-Machado M, Martinho JM, Pacheco-Moreira LF et al. Activated lymphocytes and high liver expression of IFN-gamma are associated with fulminant hepatic failure in patients. Liver Int 2012; 32: 147\u2013157.","journal-title":"Liver Int"},{"key":"BFcmi201657_CR2","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/hep.27991","volume":"62","author":"K Beland","year":"2015","unstructured":"Beland K, Marceau G, Labardy A, Bourbonnais S, Alvarez F . Depletion of B cells induces remission of autoimmune hepatitis in mice through reduced antigen presentation and help to T cells. Hepatology 2015; 62: 1511\u20131523.","journal-title":"Hepatology"},{"key":"BFcmi201657_CR3","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1056\/NEJM199604043341406","volume":"334","author":"EL Krawitt","year":"1996","unstructured":"Krawitt EL . Autoimmune hepatitis. N Engl J Med 1996; 334: 897\u2013903.","journal-title":"N Engl J Med"},{"key":"BFcmi201657_CR4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.14218\/JCTH.2014.00032","volume":"3","author":"R Liberal","year":"2015","unstructured":"Liberal R, Vergani D, Mieli-Vergani G . Update on autoimmune hepatitis. J Clin Transl Hepatol 2015; 3: 42\u201352.","journal-title":"J Clin Transl Hepatol"},{"issue":"1 Suppl","key":"BFcmi201657_CR5","doi-asserted-by":"publisher","first-page":"S100","DOI":"10.1016\/j.jhep.2015.03.005","volume":"62","author":"MP Manns","year":"2015","unstructured":"Manns MP, Lohse AW, Vergani D . Autoimmune hepatitis\u2014update 2015. J Hepatol 2015; 62 (1 Suppl): S100\u2013S111.","journal-title":"J Hepatol"},{"key":"BFcmi201657_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/cmi.2016.3","volume":"13","author":"MW Robinson","year":"2016","unstructured":"Robinson MW, Harmon C, O'Farrelly C . Liver immunology and its role in inflammation and homeostasis. Cell Mol Immunol 2016; 13: 267\u2013276.","journal-title":"Cell Mol Immunol"},{"key":"BFcmi201657_CR7","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/cmi.2016.4","volume":"13","author":"Z Shuai","year":"2016","unstructured":"Shuai Z, Leung MW, He X, Zhang W, Yang G, Leung PS et al. Adaptive immunity in the liver. Cell Mol Immunol 2016; 13: 354\u2013368.","journal-title":"Cell Mol Immunol"},{"key":"BFcmi201657_CR8","doi-asserted-by":"publisher","first-page":"5498","DOI":"10.1073\/pnas.040566697","volume":"97","author":"K Takeda","year":"2000","unstructured":"Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, Okumura K . Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci USA 2000; 97: 5498\u20135503.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201657_CR9","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/hep.22034","volume":"47","author":"B Gao","year":"2008","unstructured":"Gao B, Jeong WI, Tian Z . Liver: an organ with predominant innate immunity. Hepatology 2008; 47: 729\u2013736.","journal-title":"Hepatology"},{"key":"BFcmi201657_CR10","first-page":"255","volume":"18","author":"JL Baier","year":"2014","unstructured":"Baier JL, Mattner J . Mechanisms of autoimmune liver disease. Discov Med 2014; 18: 255\u2013263.","journal-title":"Discov Med"},{"key":"BFcmi201657_CR11","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1084\/jem.179.5.1529","volume":"179","author":"H Mizuhara","year":"1994","unstructured":"Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 1994; 179: 1529\u20131537.","journal-title":"J Exp Med"},{"key":"BFcmi201657_CR12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3109\/08916934.2011.616559","volume":"45","author":"S Iwamoto","year":"2012","unstructured":"Iwamoto S, Kido M, Aoki N, Nishiura H, Maruoka R, Ikeda A et al. IFN-gamma is reciprocally involved in the concurrent development of organ-specific autoimmunity in the liver and stomach. Autoimmunity 2012; 45: 186\u2013198.","journal-title":"Autoimmunity"},{"key":"BFcmi201657_CR13","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/j.1478-3231.2011.02487.x","volume":"31","author":"Y Zhao","year":"2011","unstructured":"Zhao Y, Zhang Y, Liu YM, Liu Y, Feng X, Liao HY et al. Identification of T cell epitopes on soluble liver antigen in Chinese patients with auto-immune hepatitis. Liver Int 2011; 31: 721\u2013729.","journal-title":"Liver Int"},{"key":"BFcmi201657_CR14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fimmu.2014.00221","volume":"5","author":"N Nakamoto","year":"2014","unstructured":"Nakamoto N, Kanai T . Role of toll-like receptors in immune activation and tolerance in the liver. Front Immunol 2014; 5: 221.","journal-title":"Front Immunol"},{"key":"BFcmi201657_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00441-010-1058-5","volume":"343","author":"PM Kowalewska","year":"2011","unstructured":"Kowalewska PM, Patrick AL, Fox-Robichaud AE . Innate immunity of the liver microcirculation. Cell Tissue Res 2011; 343: 85\u201396.","journal-title":"Cell Tissue Res"},{"key":"BFcmi201657_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1172\/JCI115836","volume":"90","author":"G Tiegs","year":"1992","unstructured":"Tiegs G, Hentschel J, Wendel AA . T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992; 90: 196\u2013203.","journal-title":"J Clin Invest"},{"issue":"suppl 1","key":"BFcmi201657_CR17","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1177\/0023677215572841","volume":"49","author":"F Heymann","year":"2015","unstructured":"Heymann F, Hamesch K, Weiskirchen R, Tacke F . The concanavalin A model of acute hepatitis in mice. Lab Anim 2015; 49 (suppl 1): 12\u201320.","journal-title":"Lab Anim"},{"key":"BFcmi201657_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s12016-015-8470-2","volume":"50","author":"Y Tan","year":"2016","unstructured":"Tan Y, Zhao M, Xiang B, Chang C, Lu Q . CD24: from a hematopoietic differentiation antigen to a genetic risk factor for multiple autoimmune diseases. Clin Rev Allergy Immunol 2016; 50: 70\u201383.","journal-title":"Clin Rev Allergy Immunol"},{"key":"BFcmi201657_CR19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/hep.25983","volume":"57","author":"D Zuo","year":"2013","unstructured":"Zuo D, Yu X, Guo C, Wang H, Qian J, Yi H et al. Scavenger receptor A restrains T-cell activation and protects against concanavalin A-induced hepatic injury. Hepatology 2013; 57: 228\u2013238.","journal-title":"Hepatology"},{"key":"BFcmi201657_CR20","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/imm.12201","volume":"141","author":"Y Chen","year":"2014","unstructured":"Chen Y, Peng H, Chen Y, Wei H, Sun R, Tian Z . CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production. Immunology 2014; 141: 388\u2013400.","journal-title":"Immunology"},{"key":"BFcmi201657_CR21","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.it.2009.09.006","volume":"30","author":"Y Liu","year":"2009","unstructured":"Liu Y, Chen GY, Zheng P . CD24-Siglec G\/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol 2009; 30: 557\u2013561.","journal-title":"Trends Immunol"},{"key":"BFcmi201657_CR22","first-page":"6714","volume":"60","author":"J Friederichs","year":"2000","unstructured":"Friederichs J, Zeller Y, Hafezi-Moghadam A, Grone HJ, Ley K, Altevogt P . The CD24\/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells. Cancer Res 2000; 60: 6714\u20136722.","journal-title":"Cancer Res"},{"key":"BFcmi201657_CR23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/sj.embor.7400759","volume":"7","author":"HE Harris","year":"2006","unstructured":"Harris HE, Raucci A . Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep 2006; 7: 774\u2013778.","journal-title":"EMBO Rep"},{"key":"BFcmi201657_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.it.2007.05.001","volume":"28","author":"Y Liu","year":"2007","unstructured":"Liu Y, Zheng P . CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases. Trends Immunol 2007; 28: 315\u2013320.","journal-title":"Trends Immunol"},{"key":"BFcmi201657_CR25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jns.2011.05.032","volume":"307","author":"SJ Gonzalez","year":"2011","unstructured":"Gonzalez SJ, Rojas JI, Redal MA, Patrucco L, Correale J, Argibay PF et al. CD24 as a genetic modifier of disease progression in multiple sclerosis in Argentinean patients. J Neurol Sci 2011; 307: 18\u201321.","journal-title":"J Neurol Sci"},{"key":"BFcmi201657_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1089\/dna.2015.3046","volume":"35","author":"M Chen","year":"2016","unstructured":"Chen M, Zhang L, Ren Y, Zhang K, Yang Y, Fang Y et al. Defective function of CD24(+)CD38(+) regulatory B cells in ankylosing spondylitis. DNA Cell Biol 2016; 35: 88\u201395.","journal-title":"DNA Cell Biol"},{"key":"BFcmi201657_CR27","doi-asserted-by":"publisher","first-page":"15041","DOI":"10.1073\/pnas.2533866100","volume":"100","author":"Q Zhou","year":"2003","unstructured":"Zhou Q, Rammohan K, Lin S, Robinson N, Li O, Liu X et al. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci USA 2003; 100: 15041\u201315046.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201657_CR28","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1371\/journal.pgen.0030049","volume":"3","author":"L Wang","year":"2007","unstructured":"Wang L, Lin S, Rammohan KW, Liu Z, Liu JQ, Liu RH et al. A dinucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genet 2007; 3: e49.","journal-title":"PLoS Genet"},{"key":"BFcmi201657_CR29","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1172\/JCI9012","volume":"105","author":"XF Bai","year":"2000","unstructured":"Bai XF, Liu JQ, Liu X, Guo Y, Cox K, Wen J et al. The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J Clin Invest 2000; 105: 1227\u20131232.","journal-title":"J Clin Invest"},{"key":"BFcmi201657_CR30","doi-asserted-by":"publisher","first-page":"6227","DOI":"10.4049\/jimmunol.178.10.6227","volume":"178","author":"JQ Liu","year":"2007","unstructured":"Liu JQ, Carl Jr JW, Joshi PS, RayChaudhury A, Pu XA, Shi FD et al. CD24 on the resident cells of the central nervous system enhances experimental autoimmune encephalomyelitis. J Immunol 2007; 178: 6227\u20136235.","journal-title":"J Immunol"},{"key":"BFcmi201657_CR31","first-page":"Unit14.4","volume":"Chapter 14","author":"M Froh","year":"2003","unstructured":"Froh M, Konno A, Thurman RG . Isolation of liver Kupffer cells. Curr Protoc Toxicol 2003; Chapter 14: Unit14.4.","journal-title":"Curr Protoc Toxicol"},{"key":"BFcmi201657_CR32","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1002\/hep.25906","volume":"56","author":"K Jung","year":"2012","unstructured":"Jung K, Kang M, Park C, Hyun Choi Y, Jeon Y, Park SH et al. Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and natural killer T-cells. Hepatology 2012; 56: 1838\u20131848.","journal-title":"Hepatology"},{"key":"BFcmi201657_CR33","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1002\/hep.26748","volume":"59","author":"HJ Kwon","year":"2014","unstructured":"Kwon HJ, Won YS, Park O, Feng D, Gao B . Opposing effects of prednisolone treatment on T\/NKT cell- and hepatotoxin-mediated hepatitis in mice. Hepatology 2014; 59: 1094\u20131106.","journal-title":"Hepatology"},{"key":"BFcmi201657_CR34","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1002\/eji.201343531","volume":"43","author":"M Higashimoto","year":"2013","unstructured":"Higashimoto M, Sakai Y, Takamura M, Usui S, Nasti A, Yoshida K et al. Adipose tissue derived stromal stem cell therapy in murine ConA-derived hepatitis is dependent on myeloid-lineage and CD4+ T-cell suppression. Eur J Immunol 2013; 43: 2956\u20132968.","journal-title":"Eur J Immunol"},{"key":"BFcmi201657_CR35","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1002\/hep.26471","volume":"58","author":"H Wang","year":"2013","unstructured":"Wang H, Feng D, Park O, Yin S, Gao B . Invariant NKT cell activation induces neutrophil accumulation and hepatitis: opposite regulation by IL-4 and IFN-gamma. Hepatology 2013; 58: 1474\u20131485.","journal-title":"Hepatology"},{"key":"BFcmi201657_CR36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1084\/jem.191.1.105","volume":"191","author":"Y Kaneko","year":"2000","unstructured":"Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, Gejyo F et al. Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 2000; 191: 105\u2013114.","journal-title":"J Exp Med"},{"key":"BFcmi201657_CR37","first-page":"93","volume":"22","author":"SI Grivennikov","year":"2005","unstructured":"Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, Shakhov AN et al. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages\/neutrophils: protective and deleterious effects. Immunity 2005; 22: 93\u2013104.","journal-title":"Immunity"},{"key":"BFcmi201657_CR38","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jhep.2012.01.029","volume":"57","author":"B Gao","year":"2012","unstructured":"Gao B, Wang H, Lafdil F, Feng D . STAT proteins - key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver. J Hepatol 2012; 57: 430\u2013441.","journal-title":"J Hepatol"},{"key":"BFcmi201657_CR39","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1084\/jem.20040779","volume":"200","author":"O Li","year":"2004","unstructured":"Li O, Zheng P, Liu Y . CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med 2004; 200: 1083\u20131089.","journal-title":"J Exp Med"},{"key":"BFcmi201657_CR40","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1084\/jem.175.2.437","volume":"175","author":"Y Liu","year":"1992","unstructured":"Liu Y, Jones B, Aruffo A, Sullivan KM, Linsley PS, Janeway CA Jr . Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med 1992; 175: 437\u2013445.","journal-title":"J Exp Med"},{"key":"BFcmi201657_CR41","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/0003-9861(92)90274-Z","volume":"299","author":"D Loganathan","year":"1992","unstructured":"Loganathan D, Osborne SE, Glick GD, Goldstein IJ . Synthesis of high-affinity, hydrophobic monosaccharide derivatives and study of their interaction with concanavalin A, the pea, the lentil, and fava bean lectins. Arch Biochem Biophys 1992; 299: 268\u2013274.","journal-title":"Arch Biochem Biophys"},{"key":"BFcmi201657_CR42","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1084\/jem.20040131","volume":"200","author":"XF Bai","year":"2004","unstructured":"Bai XF, Li O, Zhou Q, Zhang H, Joshi PS, Zheng X et al. CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis. J Exp Med 2004; 200: 447\u2013458.","journal-title":"J Exp Med"},{"key":"BFcmi201657_CR43","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/eji.1830250505","volume":"25","author":"YC Wang","year":"1995","unstructured":"Wang YC, Zhu L, McHugh R, Sell KW, Selvaraj P . Expression of heat-stable antigen on tumor cells provides co-stimulation for tumor-specific T cell proliferation and cytotoxicity in mice. Eur J Immunol 1995; 25: 1163\u20131167.","journal-title":"Eur J Immunol"},{"key":"BFcmi201657_CR44","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/eji.201142024","volume":"42","author":"X Zhang","year":"2012","unstructured":"Zhang X, Liu JQ, Shi Y, Reid HH, Boyd RL, Khattabi M et al. CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes. Eur J Immunol 2012; 42: 924\u2013935.","journal-title":"Eur J Immunol"},{"key":"BFcmi201657_CR45","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.4049\/jimmunol.1302755","volume":"192","author":"JE Thaxton","year":"2014","unstructured":"Thaxton JE, Liu B, Zheng P, Liu Y, Li Z . Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells. J Immunol 2014; 192: 5679\u20135686.","journal-title":"J Immunol"},{"key":"BFcmi201657_CR46","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1006\/bbrc.1997.6639","volume":"234","author":"M Sammar","year":"1997","unstructured":"Sammar M, Gulbins E, Hilbert K, Lang F, Altevogt P . Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem Biophys Res Commun 1997; 234: 330\u2013334.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcmi201657_CR47","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.4049\/jimmunol.166.9.5567","volume":"166","author":"T Suzuki","year":"2001","unstructured":"Suzuki T, Kiyokawa N, Taguchi T, Sekino T, Katagiri YU, Fujimoto J . CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains\/rafts-mediated signaling system. J Immunol 2001; 166: 5567\u20135577.","journal-title":"J Immunol"},{"key":"BFcmi201657_CR48","doi-asserted-by":"publisher","first-page":"428","DOI":"10.4161\/epi.6.4.14515","volume":"6","author":"H Hernandez-Vargas","year":"2011","unstructured":"Hernandez-Vargas H, Ouzounova M, Le Calvez-Kelm F, Lambert MP, McKay-Chopin S, Tavtigian SV et al. Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells. Epigenetics 2011; 6: 428\u2013439.","journal-title":"Epigenetics"},{"key":"BFcmi201657_CR49","doi-asserted-by":"publisher","first-page":"6624","DOI":"10.4049\/jimmunol.1001232","volume":"185","author":"R Berga-Bolanos","year":"2010","unstructured":"Berga-Bolanos R, Drews-Elger K, Aramburu J, Lopez-Rodriguez C . NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologic hypernatremia. J Immunol 2010; 185: 6624\u20136635.","journal-title":"J Immunol"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cmi201657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cmi201657","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cmi.2016.57","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/cmi201657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:19:02Z","timestamp":1684415942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["BFcmi201657"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2016.57","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,9]]},"assertion":[{"value":"4 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}