{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:05:43Z","timestamp":1790237143521,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,1,2]],"date-time":"2017-01-02T00:00:00Z","timestamp":1483315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2017,1,2]],"date-time":"2017-01-02T00:00:00Z","timestamp":1483315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1038\/cmi.2016.59","type":"journal-article","created":{"date-parts":[[2017,1,2]],"date-time":"2017-01-02T09:40:56Z","timestamp":1483350056000},"page":"895-908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner"],"prefix":"10.1038","volume":"14","author":[{"given":"Kyung-Ah","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhwa","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Youn","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ha","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,2]]},"reference":[{"key":"BFcmi201659_CR1","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.jaci.2010.09.007","volume":"126","author":"D Gatto","year":"2010","unstructured":"Gatto D, Brink R . The germinal center reaction. J Allergy Clin Immunol 2010; 126: 898\u2013907.","journal-title":"J Allergy Clin Immunol"},{"key":"BFcmi201659_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1600-065X.2012.01124.x","volume":"247","author":"MJ Shlomchik","year":"2012","unstructured":"Shlomchik MJ, Weisel F . Germinal center selection and the development of memory B and plasma cells. Immunol Rev 2012; 247: 52\u201363.","journal-title":"Immunol Rev"},{"key":"BFcmi201659_CR3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","volume":"236","author":"LM Francisco","year":"2010","unstructured":"Francisco LM, Sage PT, Sharpe AH . The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010; 236: 219\u2013242.","journal-title":"Immunol Rev"},{"key":"BFcmi201659_CR4","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3109\/08916934.2012.665528","volume":"45","author":"D Luckey","year":"2012","unstructured":"Luckey D, Medina K, Taneja V . B cells as effectors and regulators of sex-biased arthritis. Autoimmunity 2012; 45: 364\u2013376.","journal-title":"Autoimmunity"},{"key":"BFcmi201659_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3899\/jrheum.111488","volume":"40","author":"A Vancsa","year":"2013","unstructured":"Vancsa A, Szab\u00f3 Z, Szamosi S, Bodn\u00e1r N, V\u00e9gh E, Gergely L et al. Longterm effects of rituximab on B cell counts and autoantibody production in rheumatoid arthritis: use of high-sensitivity flow cytometry for more sensitive assessment of B cell depletion. J Rheumatol 2013; 40: 565\u2013571.","journal-title":"J Rheumatol"},{"key":"BFcmi201659_CR6","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3389\/fimmu.2015.00425","volume":"6","author":"M Woods","year":"2015","unstructured":"Woods M, Zou YR, Davidson A . Defects in germinal center selection in SLE. Front Immunol 2015; 6: 425.","journal-title":"Front Immunol"},{"key":"BFcmi201659_CR7","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/nrrheum.2010.140","volume":"6","author":"C Mauri","year":"2010","unstructured":"Mauri C, Blair PA . Regulatory B cells in autoimmunity: developments and controversies. Nat Rev Rheumatol 2010; 6: 636\u2013643.","journal-title":"Nat Rev Rheumatol"},{"key":"BFcmi201659_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-immunol-020711-074934","volume":"30","author":"C Mauri","year":"2012","unstructured":"Mauri C, Bosma A . Immune regulatory function of B cells. Annu Rev Immunol 2012; 30: 221\u2013241.","journal-title":"Annu Rev Immunol"},{"key":"BFcmi201659_CR9","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/jid.2014.354","volume":"135","author":"AW Borkowski","year":"2015","unstructured":"Borkowski AW, Kuo IH, Bernard JJ, Yoshida T, Williams MR, Hung NJ et al. Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage. J Invest Dermatol 2015; 135: 569\u2013578.","journal-title":"J Invest Dermatol"},{"key":"BFcmi201659_CR10","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2177\/jsci.38.390","volume":"38","author":"T Miyagaki","year":"2015","unstructured":"Miyagaki T . Regulatory B cells in human autoimmune diseases. Nihon Rinsho Meneki Gakkai Kaishi 2015; 38: 390\u2013397.","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"key":"BFcmi201659_CR11","first-page":"1","volume":"8","author":"M Das","year":"2013","unstructured":"Das M, Sundell IB, Koka PS . Adult mesenchymal stem cells and their potency in the cell-based therapy. J Stem Cells 2013; 8: 1\u201316.","journal-title":"J Stem Cells"},{"key":"BFcmi201659_CR12","doi-asserted-by":"publisher","first-page":"574","DOI":"10.2174\/156652412800619950","volume":"12","author":"MP De Miguel","year":"2012","unstructured":"De Miguel MP, Fuentes-Juli\u00e1n S, Bl\u00e1zquez-Mart\u00ednez A, Pascual CY, Aller MA, Arias J et al. Immunosuppressive properties of mesenchymal stem cells: advances and applications. Curr Mol Med 2012; 12: 574\u2013591.","journal-title":"Curr Mol Med"},{"key":"BFcmi201659_CR13","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3109\/14653249.2012.706708","volume":"14","author":"KH Ryu","year":"2012","unstructured":"Ryu KH, Cho KA, Park HS, Kim JY, Woo SY, Jo I et al. Tonsil-derived mesenchymal stromal cells: evaluation of biologic, immunologic and genetic factors for successful banking. Cytotherapy 2012; 14: 1193\u20131202.","journal-title":"Cytotherapy"},{"key":"BFcmi201659_CR14","doi-asserted-by":"publisher","first-page":"106540","DOI":"10.1155\/2015\/106540","volume":"2015","author":"M Park","year":"2015","unstructured":"Park M, Kim YH, Ryu JH, Woo SY, Ryu KH . Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse bone-marrow-derived dendritic cells. Stem Cells Int 2015; 2015: 106540.","journal-title":"Stem Cells Int"},{"key":"BFcmi201659_CR15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.cyto.2015.02.028","volume":"73","author":"JH Ryu","year":"2015","unstructured":"Ryu JH, Park M, Kim BK, Ryu KH, Woo SY . Tonsil-derived mesenchymal stromal cells produce CXCR2-binding chemokines and acquire follicular dendritic cell-like phenotypes under TLR3 stimulation. Cytokine 2015; 73: 225\u2013235.","journal-title":"Cytokine"},{"key":"BFcmi201659_CR16","doi-asserted-by":"publisher","first-page":"J282","DOI":"10.1016\/j.jaut.2011.11.013","volume":"38","author":"LM Pennell","year":"2012","unstructured":"Pennell LM, Galligan CL, Fish EN . Sex affects immunity. J Autoimmun 2012; 38: J282\u2013J291.","journal-title":"J Autoimmun"},{"key":"BFcmi201659_CR17","doi-asserted-by":"publisher","first-page":"J109","DOI":"10.1016\/j.jaut.2011.10.003","volume":"38","author":"OL Quintero","year":"2012","unstructured":"Quintero OL, Amador-Patarroyo MJ, Montoya-Ortiz G, Rojas-Villarraga A, Anaya JM . Autoimmune disease and gender: plausible mechanisms for the female predominance of autoimmunity. J Autoimmun 2012; 38: J109\u2013J119.","journal-title":"J Autoimmun"},{"key":"BFcmi201659_CR18","doi-asserted-by":"publisher","first-page":"A422","DOI":"10.1016\/j.autrev.2011.11.020","volume":"11","author":"TP Lee","year":"2012","unstructured":"Lee TP, Chiang BL . Sex differences in spontaneous versus induced animal models of autoimmunity. Autoimmun Rev 2012; 11: A422\u2013A429.","journal-title":"Autoimmun Rev"},{"key":"BFcmi201659_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3109\/08916934.2012.748752","volume":"46","author":"E Incorvaia","year":"2013","unstructured":"Incorvaia E, Sicouri L, Petersen-Mahrt SK, Schmitz KM . Hormones and AID: balancing immunity and autoimmunity. Autoimmunity 2013; 46: 128\u2013137.","journal-title":"Autoimmunity"},{"key":"BFcmi201659_CR20","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.clim.2014.01.006","volume":"151","author":"NA Young","year":"2014","unstructured":"Young NA, Wu LC, Burd CJ, Friedman AK, Kaffenberger BH, Rajaram MV et al. Estrogen modulation of endosome-associated toll-like receptor 8: an IFNalpha-independent mechanism of sex-bias in systemic lupus erythematosus. Clin Immunol 2014; 151: 66\u201377.","journal-title":"Clin Immunol"},{"key":"BFcmi201659_CR21","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1084\/jem.20042309","volume":"201","author":"K Ingold","year":"2005","unstructured":"Ingold K, Zumsteg A, Tardivel A, Huard B, Steiner QG, Cachero TG et al. Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med 2005; 201: 1375\u20131383.","journal-title":"J Exp Med"},{"key":"BFcmi201659_CR22","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nri1886","volume":"6","author":"A Radbruch","year":"2006","unstructured":"Radbruch A, Muehlinghaus G, Luger EO, Inamine A, Smith KG, D\u00f6rner T et al. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol 2006; 6: 741\u2013750.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi201659_CR23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.cytogfr.2015.07.013","volume":"26","author":"CE Egwuagu","year":"2015","unstructured":"Egwuagu CE, Yu CR, Sun L, Wang R . Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases. Cytokine Growth Factor Rev 2015; 26: 587\u2013593.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFcmi201659_CR24","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature06306","volume":"450","author":"LW Collison","year":"2007","unstructured":"Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007; 450: 566\u2013569.","journal-title":"Nature"},{"key":"BFcmi201659_CR25","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nm.3554","volume":"20","author":"RX Wang","year":"2014","unstructured":"Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska MB, Sergeev YV et al. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat Med 2014; 20: 633\u2013641.","journal-title":"Nat Med"},{"key":"BFcmi201659_CR26","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.immuni.2008.03.017","volume":"28","author":"K Yanaba","year":"2008","unstructured":"Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF . A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008; 28: 639\u2013650.","journal-title":"Immunity"},{"key":"BFcmi201659_CR27","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1182\/blood-2010-07-294249","volume":"117","author":"Y Iwata","year":"2011","unstructured":"Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011; 117: 530\u2013541.","journal-title":"Blood"},{"key":"BFcmi201659_CR28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jneuroim.2016.02.009","volume":"293","author":"G Benedek","year":"2016","unstructured":"Benedek G, Zhang J, Bodhankar S, Nguyen H, Kent G, Jordan K et al. Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis. J Neuroimmunol 2016; 293: 45\u201353.","journal-title":"J Neuroimmunol"},{"key":"BFcmi201659_CR29","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1002\/eji.201040992","volume":"41","author":"S Bodhankar","year":"2011","unstructured":"Bodhankar S, Wang C, Vandenbark AA, Offner H . Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells. Eur J Immunol 2011; 41: 1165\u20131175.","journal-title":"Eur J Immunol"},{"key":"BFcmi201659_CR30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jneuroim.2015.06.002","volume":"285","author":"J Zhang","year":"2015","unstructured":"Zhang J, Benedek G, Bodhankar S, Lapato A, Vandenbark AA, Offner H . IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice. J Neuroimmunol 2015; 285: 129\u2013136.","journal-title":"J Neuroimmunol"},{"key":"BFcmi201659_CR31","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3109\/14653240903502712","volume":"12","author":"SY Joo","year":"2010","unstructured":"Joo SY, Cho KA, Jung YJ, Kim HS, Park SY, Choi YB et al. Mesenchymal stromal cells inhibit graft-versus-host disease of mice in a dose-dependent manner. Cytotherapy 2010; 12: 361\u2013370.","journal-title":"Cytotherapy"},{"key":"BFcmi201659_CR32","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.imlet.2015.06.003","volume":"168","author":"W Cao","year":"2015","unstructured":"Cao W, Cao K, Cao J, Wang Y, Shi Y . Mesenchymal stem cells and adaptive immune responses. Immunol Lett 2015; 168: 147\u2013153.","journal-title":"Immunol Lett"},{"key":"BFcmi201659_CR33","doi-asserted-by":"publisher","first-page":"526","DOI":"10.4252\/wjsc.v6.i5.526","volume":"6","author":"JD Glenn","year":"2014","unstructured":"Glenn JD, Whartenby KA . Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy. World J Stem Cells 2014; 6: 526\u2013539.","journal-title":"World J Stem Cells"},{"key":"BFcmi201659_CR34","doi-asserted-by":"publisher","first-page":"8616","DOI":"10.1038\/srep08616","volume":"5","author":"M Park","year":"2015","unstructured":"Park M, Kim YH, Woo SY, Lee HJ, Yu Y, Kim HS et al. Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation. Sci Rep 2015; 5: 8616.","journal-title":"Sci Rep"},{"key":"BFcmi201659_CR35","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.yexcr.2014.06.007","volume":"326","author":"KH Ryu","year":"2014","unstructured":"Ryu KH, Kim SY, Kim YR, Woo SY, Sung SH, Kim HS et al. Tonsil-derived mesenchymal stem cells alleviate concanavalin A-induced acute liver injury. Exp Cell Res 2014; 326: 143\u2013154.","journal-title":"Exp Cell Res"},{"issue":"5","key":"BFcmi201659_CR36","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/cmi.2015.89","volume":"14","author":"Dandan Wang","year":"2015","unstructured":"Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G et al. The regulation of the Treg\/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus. Cell Mol Immunol, e-pub ahead of print 5 October 2015 doi:10.1038\/cmi.2015.89.","journal-title":"Cellular & Molecular Immunology"},{"key":"BFcmi201659_CR37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.autrev.2009.10.001","volume":"9","author":"A Rojas-Villarraga","year":"2010","unstructured":"Rojas-Villarraga A, Toro CE, Espinosa G, Rodr\u00edguez-Velosa Y, Duarte-Rey C, Mantilla RD et al. Factors influencing polyautoimmunity in systemic lupus erythematosus. Autoimmun Rev 2010; 9: 229\u2013232.","journal-title":"Autoimmun Rev"},{"key":"BFcmi201659_CR38","doi-asserted-by":"publisher","first-page":"A377","DOI":"10.1016\/j.autrev.2011.11.001","volume":"11","author":"U Nussinovitch","year":"2012","unstructured":"Nussinovitch U, Shoenfeld Y . The role of gender and organ specific autoimmunity. Autoimmun Rev 2012; 11: A377\u2013A385.","journal-title":"Autoimmun Rev"},{"key":"BFcmi201659_CR39","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.3727\/096368914X685645","volume":"24","author":"MJ Park","year":"2015","unstructured":"Park MJ, Kwok SK, Lee SH, Kim EK, Park SH, Cho ML . Adipose tissue-derived mesenchymal stem cells induce expansion of interleukin-10-producing regulatory B cells and ameliorate autoimmunity in a murine model of systemic lupus erythematosus. Cell Transplant 2015; 24: 2367\u20132377.","journal-title":"Cell Transplant"},{"key":"BFcmi201659_CR40","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.autrev.2015.08.001","volume":"14","author":"RR Meka","year":"2015","unstructured":"Meka RR, Venkatesha SH, Dudics S, Acharya B, Moudgil KD . IL-27-induced modulation of autoimmunity and its therapeutic potential. Autoimmun Rev 2015; 14: 1131\u20131141.","journal-title":"Autoimmun Rev"},{"key":"BFcmi201659_CR41","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/nature12979","volume":"507","author":"P Shen","year":"2014","unstructured":"Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E et al. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature 2014; 507: 366\u2013370.","journal-title":"Nature"},{"key":"BFcmi201659_CR42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12185-015-1918-6","volume":"103","author":"N Kim","year":"2016","unstructured":"Kim N, Cho SG . Overcoming immunoregulatory plasticity of mesenchymal stem cells for accelerated clinical applications. Int J Hematol 2016; 103: 129\u2013137.","journal-title":"Int J Hematol"},{"key":"BFcmi201659_CR43","doi-asserted-by":"publisher","first-page":"14723","DOI":"10.1073\/pnas.0507223102","volume":"102","author":"O Thaunat","year":"2005","unstructured":"Thaunat O, Field AC, Dai J, Louedec L, Patey N, Bloch MF et al. Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response. Proc Natl Acad Sci USA 2005; 102: 14723\u201314728.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi201659_CR44","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.coi.2006.07.006","volume":"18","author":"O Thaunat","year":"2006","unstructured":"Thaunat O, Patey N, Morelon E, Michel JB, Nicoletti A . Lymphoid neogenesis in chronic rejection: the murderer is in the house. Curr Opin Immunol 2006; 18: 576\u2013579.","journal-title":"Curr Opin Immunol"},{"key":"BFcmi201659_CR45","doi-asserted-by":"publisher","first-page":"678180","DOI":"10.1155\/2013\/678180","volume":"2013","author":"RR Correa","year":"2013","unstructured":"Correa RR, Machado JR, da Silva MV, Helmo FR, Guimar\u00e3es CS, Rocha LP et al. The importance of C4d in biopsies of kidney transplant recipients. Clin Dev Immunol 2013; 2013: 678180.","journal-title":"Clin Dev Immunol"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi201659.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201659","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi201659.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T11:07:32Z","timestamp":1672744052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi201659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,2]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["BFcmi201659"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2016.59","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,2]]},"assertion":[{"value":"30 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}