{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:55:49Z","timestamp":1791219349111,"version":"4.1.0"},"reference-count":122,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/cmi.2017.113","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T09:41:14Z","timestamp":1511170874000},"page":"206-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Th1 cytokines, true functional signatures for protective immunity against TB?"],"prefix":"10.1038","volume":"15","author":[{"given":"Gucheng","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"BFcmi2017113_CR1","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/iai.11.6.1174-1181.1975","volume":"11","author":"MJ Lefford","year":"1975","unstructured":"Lefford MJ . Transfer of adoptive immunity to tuberculosis in mice. Infect Immunity 1975; 11: 1174\u20131181.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1084\/jem.158.1.74","volume":"158","author":"IM Orme","year":"1983","unstructured":"Orme IM, Collins FM . Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients. J Exp Med 1983; 158: 74\u201383.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.021908.132703","volume":"27","author":"AM Cooper","year":"2009","unstructured":"Cooper AM . Cell-mediated immune responses in tuberculosis. Annu Rev Immunol 2009; 27: 393\u2013422.","journal-title":"Annu Rev Immunol"},{"key":"BFcmi2017113_CR4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4049\/jimmunol.138.1.293","volume":"138","author":"IM Orme","year":"1987","unstructured":"Orme IM . The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. J Immunol 1987; 138: 293\u2013298.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.193.3.271","volume":"193","author":"T Mogues","year":"2001","unstructured":"Mogues T, Goodrich ME, Ryan L, LaCourse R, North RJ . The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice. J Exp Med 2001; 193: 271\u2013280.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR6","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.4049\/jimmunol.1301373","volume":"192","author":"S Yao","year":"2014","unstructured":"Yao S, Huang D, Chen CY, Halliday L, Wang RC, Chen ZW . CD4+ T cells contain early extrapulmonary tuberculosis (TB) dissemination and rapid TB progression and sustain multieffector functions of CD8+ T and CD3- lymphocytes: mechanisms of CD4+ T cell immunity. J Immunol 2014; 192: 2120\u20132132.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1056\/NEJM199902043400507","volume":"340","author":"DV Havlir","year":"1999","unstructured":"Havlir DV, Barnes PF . Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med 1999; 340: 367\u2013373.","journal-title":"N Engl J Med"},{"key":"BFcmi2017113_CR8","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMra1405427","volume":"372","author":"H Getahun","year":"2015","unstructured":"Getahun H, Matteelli A, Chaisson RE, Raviglione M . Latent Mycobacterium tuberculosis infection. N Engl J Med 2015; 372: 2127\u20132135.","journal-title":"N Engl J Med"},{"key":"BFcmi2017113_CR9","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","volume":"178","author":"AM Cooper","year":"1993","unstructured":"Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM . Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 1993; 178: 2243\u20132247.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1084\/jem.186.1.39","volume":"186","author":"AM Cooper","year":"1997","unstructured":"Cooper AM, Magram J, Ferrante J, Orme IM . Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 1997; 186: 39\u201345.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR11","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","volume":"178","author":"JL Flynn","year":"1993","unstructured":"Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR . An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993; 178: 2249\u20132254.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR12","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1073\/pnas.94.10.5243","volume":"94","author":"JD MacMicking","year":"1997","unstructured":"MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF . Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci USA 1997; 94: 5243\u20135248.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi2017113_CR13","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1128\/IAI.68.3.1231-1234.2000","volume":"68","author":"AM Cooper","year":"2000","unstructured":"Cooper AM, Segal BH, Frank AA, Holland SM, Orme IM . Transient loss of resistance to pulmonary tuberculosis in p47(phox\u2212\/\u2212) mice. Infect Immunity 2000; 68: 1231\u20131234.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR14","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1128\/IAI.69.12.7711-7717.2001","volume":"69","author":"CA Scanga","year":"2001","unstructured":"Scanga CA, Mohan VP, Tanaka K, Alland D, Flynn JL, Chan J . The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice. Infect Immunity 2001; 69: 7711\u20137717.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR15","doi-asserted-by":"crossref","first-page":"854507","DOI":"10.1155\/2015\/854507","volume":"2015","author":"IV Lyadova","year":"2015","unstructured":"Lyadova IV, Panteleev AV . Th1 and Th17 cells in tuberculosis: protection, pathology, and biomarkers. Mediat Inflamm 2015; 2015: 854507.","journal-title":"Mediat Inflamm"},{"key":"BFcmi2017113_CR16","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.4049\/jimmunol.1001222","volume":"185","author":"G Du","year":"2010","unstructured":"Du G, Chen CY, Shen Y, Qiu L, Huang D, Wang R et al. TCR repertoire, clonal dominance, and pulmonary trafficking of mycobacterium-specific CD4+ and CD8+ T effector cells in immunity against tuberculosis. J Immunol 2010; 185: 3940\u20133947.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR17","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1056\/NEJM199612263352602","volume":"335","author":"MJ Newport","year":"1996","unstructured":"Newport MJ, Huxley CM, Huston S, Hawrylowicz CM, Oostra BA, Williamson R et al. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med 1996; 335: 1941\u20131949.","journal-title":"N Engl J Med"},{"key":"BFcmi2017113_CR18","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1086\/340510","volume":"185","author":"H Elloumi-Zghal","year":"2002","unstructured":"Elloumi-Zghal H, Barbouche MR, Chemli J, Bejaoui M, Harbi A, Snoussi N et al. Clinical and genetic heterogeneity of inherited autosomal recessive susceptibility to disseminated Mycobacterium bovis bacille calmette-guerin infection. J Infect Dis 2002; 185: 1468\u20131475.","journal-title":"J Infect Dis"},{"key":"BFcmi2017113_CR19","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1182\/blood.V97.9.2688","volume":"97","author":"T Sakai","year":"2001","unstructured":"Sakai T, Matsuoka M, Aoki M, Nosaka K, Mitsuya H . Missense mutation of the interleukin-12 receptor beta1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection. Blood 2001; 97: 2688\u20132694.","journal-title":"Blood"},{"key":"BFcmi2017113_CR20","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tube.2007.01.002","volume":"87","author":"E Sahiratmadja","year":"2007","unstructured":"Sahiratmadja E, Alisjahbana B, Buccheri S, Di Liberto D, de Boer T, Adnan I et al. Plasma granulysin levels and cellular interferon-gamma production correlate with curative host responses in tuberculosis, while plasma interferon-gamma levels correlate with tuberculosis disease activity in adults. Tuberculosis 2007; 87: 312\u2013321.","journal-title":"Tuberculosis"},{"key":"BFcmi2017113_CR21","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1084\/jem.20110919","volume":"208","author":"B Nandi","year":"2011","unstructured":"Nandi B, Behar SM . Regulation of neutrophils by interferon-gamma limits lung inflammation during tuberculosis infection. J Exp Med 2011; 208: 2251\u20132262.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.it.2014.04.006","volume":"35","author":"P Andersen","year":"2014","unstructured":"Andersen P, Woodworth JS . Tuberculosis vaccines\u2014rethinking the current paradigm. Trends Immunol 2014; 35: 387\u2013395.","journal-title":"Trends Immunol"},{"key":"BFcmi2017113_CR23","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(13)60177-4","volume":"381","author":"MD Tameris","year":"2013","unstructured":"Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, Lockhart S et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet 2013; 381: 1021\u20131028.","journal-title":"Lancet"},{"key":"BFcmi2017113_CR24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ni.3048","volume":"16","author":"IM Orme","year":"2015","unstructured":"Orme IM, Robinson RT, Cooper AM . The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol 2015; 16: 57\u201363.","journal-title":"Nat Immunol"},{"key":"BFcmi2017113_CR25","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.coi.2009.06.004","volume":"21","author":"AM Cooper","year":"2009","unstructured":"Cooper AM . T cells in mycobacterial infection and disease. Curr Opin Immunol 2009; 21: 378\u2013384.","journal-title":"Curr Opin Immunol"},{"key":"BFcmi2017113_CR26","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.0801496105","volume":"105","author":"WW Reiley","year":"2008","unstructured":"Reiley WW, Calayag MD, Wittmer ST, Huntington JL, Pearl JE, Fountain JJ et al. ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes. Proc Natl Acad Sci USA 2008; 105: 10961\u201310966.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi2017113_CR27","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.4049\/jimmunol.179.4.2509","volume":"179","author":"AJ Wolf","year":"2007","unstructured":"Wolf AJ, Linas B, Trevejo-Nunez GJ, Kincaid E, Tamura T, Takatsu K et al. Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J Immunol 2007; 179: 2509\u20132519.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR28","first-page":"311","volume":"24","author":"A Poulsen","year":"1950","unstructured":"Poulsen A . Some clinical features of tuberculosis. 1. Incubation period. Acta tuberculosea Scandinavica 1950; 24: 311\u2013346.","journal-title":"Acta tuberculosea Scandinavica"},{"key":"BFcmi2017113_CR29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0041-3879(48)80033-4","volume":"29","author":"A Wallgren","year":"1948","unstructured":"Wallgren A . The time-table of tuberculosis. Tubercle 1948; 29: 245\u2013251.","journal-title":"Tubercle"},{"key":"BFcmi2017113_CR30","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.20091885","volume":"207","author":"S Shafiani","year":"2010","unstructured":"Shafiani S, Tucker-Heard G, Kariyone A, Takatsu K, Urdahl KB . Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med 2010; 207: 1409\u20131420.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR31","doi-asserted-by":"crossref","first-page":"e27477","DOI":"10.1371\/journal.pone.0027477","volume":"6","author":"EZ Tchilian","year":"2011","unstructured":"Tchilian EZ, Ronan EO, de Lara C, Lee LN, Franken KL, Vordermeier MH et al. Simultaneous immunization against tuberculosis. PLoS ONE 2011; 6: e27477.","journal-title":"PLoS ONE"},{"key":"BFcmi2017113_CR32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/mi.2013.99","volume":"7","author":"PC Beverley","year":"2014","unstructured":"Beverley PC, Sridhar S, Lalvani A, Tchilian EZ . Harnessing local and systemic immunity for vaccines against tuberculosis. Mucosal immunology 2014; 7: 20\u201326.","journal-title":"Mucosal immunology"},{"key":"BFcmi2017113_CR33","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1084\/jem.20050265","volume":"201","author":"YJ Jung","year":"2005","unstructured":"Jung YJ, Ryan L, LaCourse R, North RJ . Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice. J Exp Med 2005; 201: 1915\u20131924.","journal-title":"J Exp Med"},{"key":"BFcmi2017113_CR34","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1164\/rccm.200910-1583OC","volume":"181","author":"M Jeyanathan","year":"2010","unstructured":"Jeyanathan M, Mu J, McCormick S, Damjanovic D, Small CL, Shaler CR et al. Murine airway luminal antituberculosis memory CD8 T cells by mucosal immunization are maintained via antigen-driven in situ proliferation, independent of peripheral T cell recruitment. Am J Respir Crit Care Med 2010; 181: 862\u2013872.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFcmi2017113_CR35","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/eji.200940279","volume":"40","author":"LM Connor","year":"2010","unstructured":"Connor LM, Harvie MC, Rich FJ, Quinn KM, Brinkmann V, Le Gros G et al. A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination. Eur J Immunol 2010; 40: 2482\u20132492.","journal-title":"Eur J Immunol"},{"key":"BFcmi2017113_CR36","doi-asserted-by":"crossref","unstructured":"Perdomo C, Zedler U, Kuhl AA, Lozza L, Saikali P, Sander LE et al. Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis. mBio 2016; 7: pii: e01686-16.","DOI":"10.1128\/mBio.01686-16"},{"key":"BFcmi2017113_CR37","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni.1718","volume":"10","author":"T Gebhardt","year":"2009","unstructured":"Gebhardt T, Wakim LM, Eidsmo L, Reading PC, Heath WR, Carbone FR . Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol 2009; 10: 524\u2013530.","journal-title":"Nat Immunol"},{"key":"BFcmi2017113_CR38","doi-asserted-by":"crossref","first-page":"269rv261","DOI":"10.1126\/scitranslmed.3010641","volume":"7","author":"RA Clark","year":"2015","unstructured":"Clark RA . Resident memory T cells in human health and disease. Science translational medicine 2015; 7: 269rv261.","journal-title":"Science translational medicine"},{"key":"BFcmi2017113_CR39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","volume":"8","author":"SA Khader","year":"2007","unstructured":"Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 2007; 8: 369\u2013377.","journal-title":"Nat Immunol"},{"key":"BFcmi2017113_CR40","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","volume":"466","author":"MP Berry","year":"2010","unstructured":"Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 2010; 466: 973\u2013977.","journal-title":"Nature"},{"key":"BFcmi2017113_CR41","doi-asserted-by":"crossref","first-page":"e70630","DOI":"10.1371\/journal.pone.0070630","volume":"8","author":"CI Bloom","year":"2013","unstructured":"Bloom CI, Graham CM, Berry MP, Rozakeas F, Redford PS, Wang Y et al. Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS ONE 2013; 8: e70630.","journal-title":"PLoS ONE"},{"key":"BFcmi2017113_CR42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tube.2017.04.009","volume":"105","author":"MM Elnaggar","year":"2017","unstructured":"Elnaggar MM, Abdellrazeq GS, Elsisy A, Mahmoud AH, Shyboub A, Sester M et al. Evaluation of antigen specific interleukin-1beta as a biomarker to detect cattle infected with Mycobacterium bovis. Tuberculosis 2017; 105: 53\u201359.","journal-title":"Tuberculosis"},{"key":"BFcmi2017113_CR43","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cyto.2016.10.013","volume":"90","author":"GR Kathamuthu","year":"2017","unstructured":"Kathamuthu GR, Moideen K, Bhaskaran D, Sekar G, Sridhar R, Vidyajayanthi B et al. Reduced systemic and mycobacterial antigen-stimulated concentrations of IL-1beta and IL-18 in tuberculous lymphadenitis. Cytokine 2017; 90: 66\u201372.","journal-title":"Cytokine"},{"key":"BFcmi2017113_CR44","first-page":"426","volume":"29","author":"Y Wang","year":"2015","unstructured":"Wang Y, Hu C, Wang Z, Kong H, Xie W, Wang H . Serum IL-1beta and IL-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients. J Med Res 2015; 29: 426\u2013428.","journal-title":"J Med Res"},{"key":"BFcmi2017113_CR45","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.immuni.2011.12.002","volume":"35","author":"KD Mayer-Barber","year":"2011","unstructured":"Mayer-Barber KD, Andrade BB, Barber DL, Hieny S, Feng CG, Caspar P et al. Innate and adaptive interferons suppress IL-1alpha and IL-1beta production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity 2011; 35: 1023\u20131034.","journal-title":"Immunity"},{"key":"BFcmi2017113_CR46","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.4049\/jimmunol.0904189","volume":"184","author":"KD Mayer-Barber","year":"2010","unstructured":"Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A et al. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol 2010; 184: 3326\u20133330.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR47","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ebiom.2017.08.001","volume":"23","author":"S Hu","year":"2017","unstructured":"Hu S, He W, Du X, Yang J, Wen Q, Zhong XP et al. IL-17 production of neutrophils enhances antibacteria ability but promotes arthritis development during mycobacterium tuberculosis infection. EBioMedicine 2017; 23: 88\u201399.","journal-title":"EBioMedicine"},{"key":"BFcmi2017113_CR48","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1128\/IAI.01392-09","volume":"78","author":"TM Wozniak","year":"2010","unstructured":"Wozniak TM, Saunders BM, Ryan AA, Britton WJ . Mycobacterium bovis BCG-specific Th17 cells confer partial protection against Mycobacterium tuberculosis infection in the absence of gamma interferon. Infect Immunity 2010; 78: 4187\u20134194.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR49","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1016\/j.vaccine.2017.07.073","volume":"35","author":"M Ahmed","year":"2017","unstructured":"Ahmed M, Smith DM, Hamouda T, Rangel-Moreno J, Fattom A, Khader SA . A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice. Vaccine 2017; 35: 4983\u20134989.","journal-title":"Vaccine"},{"key":"BFcmi2017113_CR50","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/jam.13449","volume":"122","author":"VB Pereira","year":"2017","unstructured":"Pereira VB, da Cunha VP, Preisser TM, Souza BM, Turk MZ, De Castro CP et al. Lactococcus lactis carrying a DNA vaccine coding for the ESAT-6 antigen increases IL-17 cytokine secretion and boosts the BCG vaccine immune response. J Appl Microbiol 2017; 122: 1657\u20131662.","journal-title":"J Appl Microbiol"},{"key":"BFcmi2017113_CR51","first-page":"844","volume":"19","author":"F Heidarnezhad","year":"2016","unstructured":"Heidarnezhad F, Asnaashari A, Rezaee SA, Ghezelsofla R, Ghazvini K, Valizadeh N et al. Evaluation of Interleukin17and Interleukin 23 expression in patients with active and latent tuberculosis infection. Iran J Basic Med Sci 2016; 19: 844\u2013850.","journal-title":"Iran J Basic Med Sci"},{"key":"BFcmi2017113_CR52","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tube.2016.04.009","volume":"99","author":"E You","year":"2016","unstructured":"You E, Kim MH, Lee WI, Kang SY . Evaluation of IL-2, IL-10, IL-17 and IP-10 as potent discriminative markers for active tuberculosis among pulmonary tuberculosis suspects. Tuberculosis 2016; 99: 100\u2013108.","journal-title":"Tuberculosis"},{"key":"BFcmi2017113_CR53","doi-asserted-by":"crossref","first-page":"28586","DOI":"10.1038\/srep28586","volume":"6","author":"M Wang","year":"2016","unstructured":"Wang M, Xu G, Lu L, Xu K, Chen Y, Pan H et al. Genetic polymorphisms of IL-17A, IL-17F, TLR4 and miR-146a in association with the risk of pulmonary tuberculosis. Sci Rep 2016; 6: 28586.","journal-title":"Sci Rep"},{"key":"BFcmi2017113_CR54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12967-016-0909-6","volume":"14","author":"L Xu","year":"2016","unstructured":"Xu L, Cui G, Jia H, Zhu Y, Ding Y, Chen J et al. Decreased IL-17 during treatment of sputum smear-positive pulmonary tuberculosis due to increased regulatory T cells and IL-10. J Transl Med 2016; 14: 179.","journal-title":"J Transl Med"},{"key":"BFcmi2017113_CR55","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00408-016-9860-9","volume":"194","author":"J Zhao","year":"2016","unstructured":"Zhao J, Wen C, Li M . Association analysis of interleukin-17 gene polymorphisms with the risk susceptibility to tuberculosis. Lung 2016; 194: 459\u2013467.","journal-title":"Lung"},{"key":"BFcmi2017113_CR56","doi-asserted-by":"crossref","first-page":"e1004099","DOI":"10.1371\/journal.ppat.1004099","volume":"10","author":"R Gopal","year":"2014","unstructured":"Gopal R, Monin L, Slight S, Uche U, Blanchard E, Fallert Junecko BA et al. Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection. PLoS Pathog 2014; 10: e1004099.","journal-title":"PLoS Pathog"},{"key":"BFcmi2017113_CR57","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/mi.2017.15","volume":"10","author":"P Treerat","year":"2017","unstructured":"Treerat P, Prince O, Cruz-Lagunas A, Munoz-Torrico M, Salazar-Lezama MA, Selman M et al. Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection. Mucosal Immunol 2017; 10: 1069\u20131081.","journal-title":"Mucosal Immunol"},{"key":"BFcmi2017113_CR58","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1073\/pnas.1424302112","volume":"112","author":"X Bai","year":"2015","unstructured":"Bai X, Shang S, Henao-Tamayo M, Basaraba RJ, Ovrutsky AR, Matsuda JL et al. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2015; 112: 5111\u20135116.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi2017113_CR59","doi-asserted-by":"crossref","first-page":"250ra114","DOI":"10.1126\/scitranslmed.3009546","volume":"6","author":"D Montoya","year":"2014","unstructured":"Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P et al. IL-32 is a molecular marker of a host defense network in human tuberculosis. Sci Transl Med 2014; 6: 250ra114.","journal-title":"Sci Transl Med"},{"key":"BFcmi2017113_CR60","doi-asserted-by":"crossref","first-page":"13402","DOI":"10.1073\/pnas.1007394107","volume":"107","author":"E Lazar-Molnar","year":"2010","unstructured":"Lazar-Molnar E, Chen B, Sweeney KA, Wang EJ, Liu W, Lin J et al. Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis. Proc Natl Acad Sci USA 2010; 107: 13402\u201313407.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi2017113_CR61","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.4049\/jimmunol.1003304","volume":"186","author":"DL Barber","year":"2011","unstructured":"Barber DL, Mayer-Barber KD, Feng CG, Sharpe AH, Sher A . CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. J Immunol 2011; 186: 1598\u20131607.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR62","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/j.jtho.2016.07.006","volume":"11","author":"K Fujita","year":"2016","unstructured":"Fujita K, Terashima T, Mio T . Anti-PD1 antibody treatment and the development of acute pulmonary tuberculosis. J Thorac Oncol 2016; 11: 2238\u20132240.","journal-title":"J Thorac Oncol"},{"key":"BFcmi2017113_CR63","doi-asserted-by":"crossref","first-page":"e1005667","DOI":"10.1371\/journal.ppat.1005667","volume":"12","author":"S Sakai","year":"2016","unstructured":"Sakai S, Kauffman KD, Sallin MA, Sharpe AH, Young HA, Ganusov VV et al. CD4 T cell-derived ifn-gamma plays a minimal role in control of pulmonary mycobacterium tuberculosis infection and must be actively repressed by PD-1 to prevent lethal disease. PLoS Pathog 2016; 12: e1005667.","journal-title":"PLoS Pathog"},{"key":"BFcmi2017113_CR64","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/imm.12371","volume":"144","author":"JM Guerra-Laso","year":"2015","unstructured":"Guerra-Laso JM, Raposo-Garcia S, Garcia-Garcia S, Diez-Tascon C, Rivero-Lezcano OM . Microarray analysis of Mycobacterium tuberculosis-infected monocytes reveals IL26 as a new candidate gene for tuberculosis susceptibility. Immunology 2015; 144: 291\u2013301.","journal-title":"Immunology"},{"key":"BFcmi2017113_CR65","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1164\/rccm.201404-0689OC","volume":"190","author":"KF Che","year":"2014","unstructured":"Che KF, Tengvall S, Levanen B, Silverpil E, Smith ME, Awad M et al. Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization. Am J Respir Crit Care Med 2014; 190: 1022\u20131031.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFcmi2017113_CR66","doi-asserted-by":"crossref","first-page":"e88149","DOI":"10.1371\/journal.pone.0088149","volume":"9","author":"AS Wareham","year":"2014","unstructured":"Wareham AS, Tree JA, Marsh PD, Butcher PD, Dennis M, Sharpe SA . Evidence for a role for interleukin-17, Th17 cells and iron homeostasis in protective immunity against tuberculosis in cynomolgus macaques. PLoS One 2014; 9: e88149.","journal-title":"PLoS One"},{"key":"BFcmi2017113_CR67","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1128\/IAI.68.5.2962-2970.2000","volume":"68","author":"MJ Maeurer","year":"2000","unstructured":"Maeurer MJ, Trinder P, Hommel G, Walter W, Freitag K, Atkins D et al. Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Infect Immunity 2000; 68: 2962\u20132970.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR68","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1086\/653827","volume":"202","author":"V Singh","year":"2010","unstructured":"Singh V, Gowthaman U, Jain S, Parihar P, Banskar S, Gupta P et al. Coadministration of interleukins 7 and 15 with bacille Calmette-Guerin mounts enduring T cell memory response against Mycobacterium tuberculosis. J Infect Dis 2010; 202: 480\u2013489.","journal-title":"J Infect Dis"},{"key":"BFcmi2017113_CR69","doi-asserted-by":"crossref","first-page":"e1006425","DOI":"10.1371\/journal.ppat.1006425","volume":"13","author":"C Lundtoft","year":"2017","unstructured":"Lundtoft C, Afum-Adjei Awuah A, Rimpler J, Harling K, Nausch N, Kohns M et al. Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis. PLoS Pathog 2017; 13: e1006425.","journal-title":"PLoS Pathog"},{"key":"BFcmi2017113_CR70","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/gene.2011.29","volume":"12","author":"L Rane","year":"2011","unstructured":"Rane L, Rahman S, Magalhaes I, Ahmed R, Spangberg M, Kondova I et al. Increased (6 exon) interleukin-7 production after M. tuberculosis infection and soluble interleukin-7 receptor expression in lung tissue. Genes and immunity 2011; 12: 513\u2013522.","journal-title":"Genes and immunity"},{"key":"BFcmi2017113_CR71","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1128\/IAI.73.5.2910-2922.2005","volume":"73","author":"V Lazarevic","year":"2005","unstructured":"Lazarevic V, Yankura DJ, DiVito SJ, Flynn JL . Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice. Infect Immunity 2005; 73: 2910\u20132922.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR72","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.4049\/jimmunol.176.4.2496","volume":"176","author":"K Saito","year":"2006","unstructured":"Saito K, Yajima T, Kumabe S, Doi T, Yamada H, Sad S et al. Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice. J Immunol 2006; 176: 2496\u20132504.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR73","doi-asserted-by":"crossref","first-page":"946","DOI":"10.4049\/jimmunol.167.2.946","volume":"167","author":"M Umemura","year":"2001","unstructured":"Umemura M, Nishimura H, Hirose K, Matsuguchi T, Yoshikai Y . Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guerin infection via augmentation of NK and T cytotoxic 1 responses. J Immunol 2001; 167: 946\u2013956.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR74","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cyto.2016.02.003","volume":"81","author":"S Chandrashekara","year":"2016","unstructured":"Chandrashekara S, Anupama KR, Sambarey A, Chandra N . High IL-6 and low IL-15 levels mark the presence of TB infection: A preliminary study. Cytokine 2016; 81: 57\u201362.","journal-title":"Cytokine"},{"key":"BFcmi2017113_CR75","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tube.2010.12.003","volume":"91","author":"SS Pydi","year":"2011","unstructured":"Pydi SS, Bandaru AR, Venkatasubramanian S, Jonnalagada S, Valluri VL . Vaccine for tuberculosis: up-regulation of IL-15 by Ag85A and not by ESAT-6. Tuberculosis 2011; 91: 136\u2013139.","journal-title":"Tuberculosis"},{"key":"BFcmi2017113_CR76","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.1601340","volume":"199","author":"L Moreira-Teixeira","year":"2017","unstructured":"Moreira-Teixeira L, Redford PS, Stavropoulos E, Ghilardi N, Maynard CL, Weaver CT et al. T Cell-Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection. J Immunol 2017; 199: 613\u2013623.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR77","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.4049\/jimmunol.169.11.6343","volume":"169","author":"J Turner","year":"2002","unstructured":"Turner J, Gonzalez-Juarrero M, Ellis DL, Basaraba RJ, Kipnis A, qOrme IM et al. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL\/6 mice. J Immunol 2002; 169: 6343\u20136351.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR78","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.4049\/jimmunol.1202722","volume":"190","author":"JC Cyktor","year":"2013","unstructured":"Cyktor JC, Carruthers B, Kominsky RA, Beamer GL, Stromberg P, Turner J . IL-10 inhibits mature fibrotic granuloma formation during Mycobacterium tuberculosis infection. J Immunol 2013; 190: 2778\u20132790.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR79","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.4049\/jimmunol.181.8.5545","volume":"181","author":"GL Beamer","year":"2008","unstructured":"Beamer GL, Flaherty DK, Assogba BD, Stromberg P, Gonzalez-Juarrero M, de Waal Malefyt R et al. Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA\/J mice. J Immunol 2008; 181: 5545\u20135550.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR80","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1128\/iai.61.8.3482-3489.1993","volume":"61","author":"PF Barnes","year":"1993","unstructured":"Barnes PF, Lu S, Abrams JS, Wang E, Yamamura M, Modlin RL . Cytokine production at the site of disease in human tuberculosis. Infect Immunity 1993; 61: 3482\u20133489.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR81","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1128\/IAI.71.12.6871-6883.2003","volume":"71","author":"RC Huard","year":"2003","unstructured":"Huard RC, Chitale S, Leung M, Lazzarini LC, Zhu H, Shashkina E et al. The Mycobacterium tuberculosis complex-restricted gene cfp32 encodes an expressed protein that is detectable in tuberculosis patients and is positively correlated with pulmonary interleukin-10. Infect Immunity 2003; 71: 6871\u20136883.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR82","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4049\/jimmunol.0801212","volume":"183","author":"AS Almeida","year":"2009","unstructured":"Almeida AS, Lago PM, Boechat N, Huard RC, Lazzarini LC, Santos AR et al. Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity. J Immunol 2009; 183: 718\u2013731.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR83","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1128\/IAI.72.5.2628-2634.2004","volume":"72","author":"MG Bonecini-Almeida","year":"2004","unstructured":"Bonecini-Almeida MG, Ho JL, Boechat N, Huard RC, Chitale S, Doo H et al. Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis. Infect Immunity 2004; 72: 2628\u20132634.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR84","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/eji.201141569","volume":"42","author":"R Gopal","year":"2012","unstructured":"Gopal R, Lin Y, Obermajer N, Slight S, Nuthalapati N, Ahmed M et al. IL-23-dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccination. Eur J Immunol 2012; 42: 364\u2013373.","journal-title":"Eur J Immunol"},{"key":"BFcmi2017113_CR85","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4049\/jimmunol.175.2.788","volume":"175","author":"SA Khader","year":"2005","unstructured":"Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM et al. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol 2005; 175: 788\u2013795.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR86","doi-asserted-by":"crossref","first-page":"e1002052","DOI":"10.1371\/journal.ppat.1002052","volume":"7","author":"AM Gallegos","year":"2011","unstructured":"Gallegos AM, van Heijst JW, Samstein M, Su X, Pamer EG, Glickman MS . A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo. PLoS Pathog 2011; 7: e1002052.","journal-title":"PLoS Pathog"},{"key":"BFcmi2017113_CR87","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1164\/rccm.200909-1463OC","volume":"181","author":"X Chen","year":"2010","unstructured":"Chen X, Zhang M, Liao M, Graner MW, Wu C, Yang Q et al. Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T Cells. Am J Respir Crit Care Med 2010; 181: 734\u2013742.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFcmi2017113_CR88","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrmicro3230","volume":"12","author":"C Nunes-Alves","year":"2014","unstructured":"Nunes-Alves C, Booty MG, Carpenter SM, Jayaraman P, Rothchild AC, Behar SM . In search of a new paradigm for protective immunity to TB. Nat Reviews Microbiol 2014; 12: 289\u2013299.","journal-title":"Nat Reviews Microbiol"},{"key":"BFcmi2017113_CR89","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/infdis\/jit206","volume":"208","author":"A Singh","year":"2013","unstructured":"Singh A, Mohan A, Dey AB, Mitra DK . Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon gamma-producing T cells from apoptosis in patients with pulmonary tuberculosis. J Infect Dis 2013; 208: 603\u2013615.","journal-title":"J Infect Dis"},{"key":"BFcmi2017113_CR90","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4049\/jimmunol.181.1.116","volume":"181","author":"JO Jurado","year":"2008","unstructured":"Jurado JO, Alvarez IB, Pasquinelli V, Martinez GJ, Quiroga MF, Abbate E et al. Programmed death (PD)-1:PD-ligand 1\/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis. J Immunol 2008; 181: 116\u2013125.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR91","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1183\/13993003.00235-2016","volume":"48","author":"L Gao","year":"2016","unstructured":"Gao L, Bai L, Liu J, Lu W, Wang X, Li X et al. Annual risk of tuberculosis infection in rural China: a population-based prospective study. Eur Respir J 2016; 48: 168\u2013178.","journal-title":"Eur Respir J"},{"key":"BFcmi2017113_CR92","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1128\/JCM.01646-16","volume":"55","author":"MA De Groote","year":"2017","unstructured":"De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG et al. Highly multiplexed proteomic analysis of quantiferon supernatants to identify biomarkers of latent tuberculosis infection. J Clin Microbiol 2017; 55: 391\u2013402.","journal-title":"J Clin Microbiol"},{"key":"BFcmi2017113_CR93","doi-asserted-by":"crossref","first-page":"e38080","DOI":"10.1371\/journal.pone.0038080","volume":"7","author":"G Sandhu","year":"2012","unstructured":"Sandhu G, Battaglia F, Ely BK, Athanasakis D, Montoya R, Valencia T et al. Discriminating active from latent tuberculosis in patients presenting to community clinics. PLoS ONE 2012; 7: e38080.","journal-title":"PLoS ONE"},{"key":"BFcmi2017113_CR94","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cca.2013.04.010","volume":"423","author":"N Che","year":"2013","unstructured":"Che N, Cheng J, Li H, Zhang Z, Zhang X, Ding Z et al. Decreased serum 5-oxoproline in TB patients is associated with pathological damage of the lung. Clin Chim Acta 2013; 423: 5\u20139.","journal-title":"Clin Chim Acta"},{"key":"BFcmi2017113_CR95","doi-asserted-by":"crossref","first-page":"e40221","DOI":"10.1371\/journal.pone.0040221","volume":"7","author":"J Weiner 3rd","year":"2012","unstructured":"Weiner J 3rd, Parida SK, Maertzdorf J, Black GF, Repsilber D, Telaar A et al. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PLoS ONE 2012; 7: e40221.","journal-title":"PLoS ONE"},{"key":"BFcmi2017113_CR96","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1378\/chest.111.3.606","volume":"111","author":"CK Lai","year":"1997","unstructured":"Lai CK, Ho S, Chan CH, Chan J, Choy D, Leung R et al. Cytokine gene expression profile of circulating CD4+ T cells in active pulmonary tuberculosis. Chest 1997; 111: 606\u2013611.","journal-title":"Chest"},{"key":"BFcmi2017113_CR97","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.4049\/jimmunol.1300283","volume":"192","author":"JS Woodworth","year":"2014","unstructured":"Woodworth JS, Aagaard CS, Hansen PR, Cassidy JP, Agger EM, Andersen P . Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation. J Immunol 2014; 192: 3247\u20133258.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR98","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.0900947","volume":"183","author":"CS Aagaard","year":"2009","unstructured":"Aagaard CS, Hoang TT, Vingsbo-Lundberg C, Dietrich J, Andersen P . Quality and vaccine efficacy of CD4+ T cell responses directed to dominant and subdominant epitopes in ESAT-6 from Mycobacterium tuberculosis. J Immunol 2009; 183: 2659\u20132668.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR99","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","volume":"8","author":"RA Seder","year":"2008","unstructured":"Seder RA, Darrah PA, Roederer M . T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 2008; 8: 247\u2013258.","journal-title":"Nat Rev Immunol"},{"key":"BFcmi2017113_CR100","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nm.2299","volume":"17","author":"A Harari","year":"2011","unstructured":"Harari A, Rozot V, Bellutti Enders F, Perreau M, Stalder JM, Nicod LP et al. Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. Nat Med 2011; 17: 372\u2013376.","journal-title":"Nat Med"},{"key":"BFcmi2017113_CR101","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1128\/IAI.00480-13","volume":"82","author":"YH Jeong","year":"2014","unstructured":"Jeong YH, Jeon BY, Gu SH, Cho SN, Shin SJ, Chang J et al. Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection. Infect Immunity 2014; 82: 132\u2013139.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR102","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jinf.2013.02.004","volume":"66","author":"E Petruccioli","year":"2013","unstructured":"Petruccioli E, Petrone L, Vanini V, Sampaolesi A, Gualano G, Girardi E et al. IFNgamma\/TNFalpha specific-cells and effector memory phenotype associate with active tuberculosis. J Infect 2013; 66: 475\u2013486.","journal-title":"J Infect"},{"key":"BFcmi2017113_CR103","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.4049\/jimmunol.1101122","volume":"187","author":"CL Day","year":"2011","unstructured":"Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, O'Rie T et al. Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J Immunol 2011; 187: 2222\u20132232.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR104","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/srep00216","volume":"2","author":"Z Qiu","year":"2012","unstructured":"Qiu Z, Zhang M, Zhu Y, Zheng F, Lu P, Liu H et al. Multifunctional CD4 T cell responses in patients with active tuberculosis. Sci Rep 2012; 2: 216.","journal-title":"Sci Rep"},{"key":"BFcmi2017113_CR105","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/eji.200838693","volume":"39","author":"JS Sutherland","year":"2009","unstructured":"Sutherland JS, Adetifa IM, Hill PC, Adegbola RA, Ota MO . Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease. Eur J Immunol 2009; 39: 723\u2013729.","journal-title":"Eur J Immunol"},{"key":"BFcmi2017113_CR106","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/eji.201040455","volume":"40","author":"N Caccamo","year":"2010","unstructured":"Caccamo N, Guggino G, Joosten SA, Gelsomino G, Di Carlo P, Titone L et al. Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection. Eur J Immunol 2010; 40: 2211\u20132220.","journal-title":"Eur J Immunol"},{"key":"BFcmi2017113_CR107","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.1117194109","volume":"109","author":"Q Han","year":"2012","unstructured":"Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC . Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci USA 2012; 109: 1607\u20131612.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcmi2017113_CR108","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/bfgp\/elt025","volume":"12","author":"CM Evans","year":"2013","unstructured":"Evans CM, Jenner RG . Transcription factor interplay in T helper cell differentiation. Brief Funct Genomics 2013; 12: 499\u2013511.","journal-title":"Brief Funct Genomics"},{"key":"BFcmi2017113_CR109","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1189\/jlb.1211619","volume":"91","author":"JO Jurado","year":"2012","unstructured":"Jurado JO, Pasquinelli V, Alvarez IB, Pena D, Rovetta AI, Tateosian NL et al. IL-17 and IFN-gamma expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease. J Leukoc Biol 2012; 91: 991\u20131002.","journal-title":"J Leukoc Biol"},{"key":"BFcmi2017113_CR110","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.4049\/jimmunol.1401151","volume":"193","author":"CL Arlehamn","year":"2014","unstructured":"Arlehamn CL, Seumois G, Gerasimova A, Huang C, Fu Z, Yue X et al. Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features. J Immunol 2014; 193: 2931\u20132940.","journal-title":"J Immunol"},{"key":"BFcmi2017113_CR111","doi-asserted-by":"crossref","first-page":"e1003130","DOI":"10.1371\/journal.ppat.1003130","volume":"9","author":"CS Lindestam Arlehamn","year":"2013","unstructured":"Lindestam Arlehamn CS, Gerasimova A, Mele F, Henderson R, Swann J, Greenbaum JA et al. Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset. PLoS Pathog 2013; 9: e1003130.","journal-title":"PLoS Pathog"},{"key":"BFcmi2017113_CR112","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.1260668","volume":"347","author":"S Becattini","year":"2015","unstructured":"Becattini S, Latorre D, Mele F, Foglierini M, De Gregorio C, Cassotta A et al. T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines. Science 2015; 347: 400\u2013406.","journal-title":"Science"},{"key":"BFcmi2017113_CR113","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2016.08.072","volume":"167","author":"LL Lu","year":"2016","unstructured":"Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS et al. A functional role for antibodies in tuberculosis. Cell 2016; 167: 433\u2013443 e414.","journal-title":"Cell"},{"key":"BFcmi2017113_CR114","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.femsim.2004.01.004","volume":"41","author":"MA Chambers","year":"2004","unstructured":"Chambers MA, Gavier-Widen D, Hewinson RG . Antibody bound to the surface antigen MPB83 of Mycobacterium bovis enhances survival against high dose and low dose challenge. FEMS Immunol Med Microbiology 2004; 41: 93\u2013100.","journal-title":"FEMS Immunol Med Microbiology"},{"key":"BFcmi2017113_CR115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2249.2004.02593.x","volume":"138","author":"B Hamasur","year":"2004","unstructured":"Hamasur B, Haile M, Pawlowski A, Schroder U, Kallenius G, Svenson SB . A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab') fragment prolong survival of mice infected with Mycobacterium tuberculosis. Clin Exp Immunol 2004; 138: 30\u201338.","journal-title":"Clin Exp Immunol"},{"key":"BFcmi2017113_CR116","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijmm.2008.10.007","volume":"299","author":"Y Lopez","year":"2009","unstructured":"Lopez Y, Yero D, Falero-Diaz G, Olivares N, Sarmiento ME, Sifontes S et al. Induction of a protective response with an IgA monoclonal antibody against Mycobacterium tuberculosis 16kDa protein in a model of progressive pulmonary infection. Int J Med Microbiol 2009; 299: 447\u2013452.","journal-title":"Int J Med Microbiol"},{"key":"BFcmi2017113_CR117","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-2567.2004.01809.x","volume":"111","author":"A Williams","year":"2004","unstructured":"Williams A, Reljic R, Naylor I, Clark SO, Falero-Diaz G, Singh M et al. Passive protection with immunoglobulin A antibodies against tuberculous early infection of the lungs. Immunology 2004; 111: 328\u2013333.","journal-title":"Immunology"},{"key":"BFcmi2017113_CR118","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1128\/IAI.73.9.6101-6109.2005","volume":"73","author":"E Roy","year":"2005","unstructured":"Roy E, Stavropoulos E, Brennan J, Coade S, Grigorieva E, Walker B et al. Therapeutic efficacy of high-dose intravenous immunoglobulin in Mycobacterium tuberculosis infection in mice. Infect Immunity 2005; 73: 6101\u20136109.","journal-title":"Infect Immunity"},{"key":"BFcmi2017113_CR119","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.micinf.2005.12.004","volume":"8","author":"E Guirado","year":"2006","unstructured":"Guirado E, Amat I, Gil O, Diaz J, Arcos V, Caceres N et al. Passive serum therapy with polyclonal antibodies against Mycobacterium tuberculosis protects against post-chemotherapy relapse of tuberculosis infection in SCID mice. Microbes Infect 2006; 8: 1252\u20131259.","journal-title":"Microbes Infect"},{"key":"BFcmi2017113_CR120","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tube.2006.01.006","volume":"86","author":"N Olivares","year":"2006","unstructured":"Olivares N, Leon A, Lopez Y, Puig A, Cadiz A, Falero G et al. The effect of the administration of human gamma globulins in a model of BCG infection in mice. Tuberculosis 2006; 86: 268\u2013272.","journal-title":"Tuberculosis"},{"key":"BFcmi2017113_CR121","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.15252\/emmm.201606330","volume":"8","author":"N Zimmermann","year":"2016","unstructured":"Zimmermann N, Thormann V, Hu B, Kohler AB, Imai-Matsushima A, Locht C et al. Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis. EMBO Mol Med 2016; 8: 1325\u20131339.","journal-title":"EMBO Mol Med"},{"key":"BFcmi2017113_CR122","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1073\/pnas.1611776114","volume":"114","author":"H Li","year":"2017","unstructured":"Li H, Wang XX, Wang B, Fu L, Liu G, Lu Y et al. Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2017; 114: 5023\u20135028.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Cellular &amp; Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/cmi2017113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/cmi2017113","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cmi.2017.113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/cmi2017113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T15:10:06Z","timestamp":1672758606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi2017113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":122,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["BFcmi2017113"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2017.113","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,20]]},"assertion":[{"value":"26 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}