{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:01:26Z","timestamp":1790028086013,"version":"4.0.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1038\/cmi.2017.147","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T16:25:07Z","timestamp":1517847907000},"page":"126-137","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell\/IL-13\/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis"],"prefix":"10.1038","volume":"16","author":[{"given":"Yuejin","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denley Ming Kee","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuliang","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakari","family":"Kwota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Soong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaren","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"132_CR1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJM199608293350904","volume":"335","author":"P Farci","year":"1996","unstructured":"Farci P, Alter HJ, Shimoda A, Govindarajan S, Cheung LC, Melpolder JC et al. Hepatitis C virus-associated fulminant hepatic failure. N Engl J Med 1996; 335: 631\u2013634.","journal-title":"N Engl J Med"},{"key":"132_CR2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/hep.27323","volume":"61","author":"B Rehermann","year":"2015","unstructured":"Rehermann B, Bertoletti A. Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology 2015; 61: 712\u2013721.","journal-title":"Hepatology"},{"key":"132_CR3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nri.2016.69","volume":"16","author":"EC Shin","year":"2016","unstructured":"Shin EC, Sung PS, Park SH. Immune responses and immunopathology in acute and chronic viral hepatitis. Nat Rev Immunol 2016; 16: 509\u2013523.","journal-title":"Nat Rev Immunol"},{"key":"132_CR4","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nri911","volume":"2","author":"JA Trapani","year":"2002","unstructured":"Trapani JA, Smyth MJ. Functional significance of the perforin\/granzyme cell death pathway. Nat Rev Immunol 2002; 2: 735\u2013747.","journal-title":"Nat Rev Immunol"},{"key":"132_CR5","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1128\/JVI.78.4.2152-2157.2004","volume":"78","author":"C Gremion","year":"2004","unstructured":"Gremion C, Grabscheid B, Wolk B, Moradpour D, Reichen J, Pichler W et al. Cytotoxic T lymphocytes derived from patients with chronic hepatitis C virus infection kill bystander cells via Fas-FasL interaction. J Virol 2004; 78: 2152\u20132157.","journal-title":"J Virol"},{"key":"132_CR6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","volume":"23","author":"J Schmitz","year":"2005","unstructured":"Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005; 23: 479\u2013490.","journal-title":"Immunity"},{"key":"132_CR7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","volume":"16","author":"FY Liew","year":"2016","unstructured":"Liew FY, Girard JP, Turnquist HR. Interleukin-33 in health and disease. Nat Rev Immunol 2016; 16: 676\u2013689.","journal-title":"Nat Rev Immunol"},{"key":"132_CR8","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1002\/eji.201141629","volume":"41","author":"Q Yang","year":"2011","unstructured":"Yang Q, Li G, Zhu Y, Liu L, Chen E, Turnquist H et al. IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells. Eur J Immunol 2011; 41: 3351\u20133360.","journal-title":"Eur J Immunol"},{"key":"132_CR9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/imm.12483","volume":"146","author":"T Gajardo","year":"2015","unstructured":"Gajardo T, Morales RA, Campos-Mora M, Campos-Acuna J, Pino-Lagos K. Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3(+) regulatory T cells in skin-transplanted mice. Immunology 2015; 146: 81\u201388.","journal-title":"Immunology"},{"key":"132_CR10","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.4049\/jimmunol.1100519","volume":"187","author":"HR Turnquist","year":"2011","unstructured":"Turnquist HR, Zhao Z, Rosborough BR, Liu Q, Castellaneta A, Isse K et al. IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol 2011; 187: 4598\u20134610.","journal-title":"J Immunol"},{"key":"132_CR11","doi-asserted-by":"crossref","unstructured":"Chen CC, Kobayashi T, Iijima K, Hsu FC, Kita H. IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs. J Allergy Clin Immunol 2017.","DOI":"10.1016\/j.jaci.2017.01.015"},{"key":"132_CR12","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.1215418","volume":"335","author":"WV Bonilla","year":"2012","unstructured":"Bonilla WV, Frohlich A, Senn K, Kallert S, Fernandez M, Johnson S et al. The alarmin interleukin-33 drives protective antiviral CD8 T cell responses. Science 2012; 335: 984\u2013989.","journal-title":"Science"},{"key":"132_CR13","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.4049\/jimmunol.1300117","volume":"190","author":"Y Liang","year":"2013","unstructured":"Liang Y, Jie Z, Hou L, Aguilar-Valenzuela R, Vu D, Soong L et al. IL-33 induces nuocytes and modulates liver injury in viral hepatitis. J Immunol 2013; 190: 5666\u20135675.","journal-title":"J Immunol"},{"key":"132_CR14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.4VMR1114-555R","volume":"98","author":"IE Galani","year":"2015","unstructured":"Galani IE, Andreakos E. Neutrophils in viral infections: current concepts and caveats. J Leukoc Biol 2015; 98: 557\u2013564.","journal-title":"J Leukoc Biol"},{"key":"132_CR15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2012.10.022","volume":"38","author":"BA Norris","year":"2013","unstructured":"Norris BA, Uebelhoer LS, Nakaya HI, Price AA, Grakoui A, Pulendran B. Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity 2013; 38: 309\u2013321.","journal-title":"Immunity"},{"key":"132_CR16","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1007\/s10620-009-0969-z","volume":"55","author":"G Alvarez-Uria","year":"2010","unstructured":"Alvarez-Uria G, Day JN, Nasir AJ, Russell SK, Vilar FJ. Reduction in neutrophil count during hepatitis C treatment: drug toxicity or predictor of good response? Dig Dis Sci 2010; 55: 2058\u20132062.","journal-title":"Dig Dis Sci"},{"key":"132_CR17","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2016-01-688887","volume":"127","author":"C Silvestre-Roig","year":"2016","unstructured":"Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood 2016; 127: 2173\u20132181.","journal-title":"Blood"},{"key":"132_CR18","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1007\/s00018-013-1286-4","volume":"70","author":"J Pillay","year":"2013","unstructured":"Pillay J, Tak T, Kamp VM, Koenderman L. Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences. Cell Mol Life Sci 2013; 70: 3813\u20133827.","journal-title":"Cell Mol Life Sci"},{"key":"132_CR19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","volume":"522","author":"SB Coffelt","year":"2015","unstructured":"Coffelt SB, Kersten K, Doornebal CW, Weiden J, Vrijland K, Hau CS et al. IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Nature 2015; 522: 345\u2013348.","journal-title":"Nature"},{"key":"132_CR20","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nm.2156","volume":"16","author":"JC Alves-Filho","year":"2010","unstructured":"Alves-Filho JC, Sonego F, Souto FO, Freitas A, Verri WA Jr., Auxiliadora-Martins M et al. Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med 2010; 16: 708\u2013712.","journal-title":"Nat Med"},{"key":"132_CR21","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/ard.2009.122655","volume":"69","author":"WA Verri Jr.","year":"2010","unstructured":"Verri WA Jr., Souto FO, Vieira SM, Almeida SC, Fukada SY, Xu D et al. IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy. Ann Rheum Dis 2010; 69: 1697\u20131703.","journal-title":"Ann Rheum Dis"},{"key":"132_CR22","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.1182\/blood-2010-06-287839","volume":"116","author":"SL Highfill","year":"2010","unstructured":"Highfill SL, Rodriguez PC, Zhou Q, Goetz CA, Koehn BH, Veenstra R et al. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 2010; 116: 5738\u20135747.","journal-title":"Blood"},{"key":"132_CR23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1172\/JCI57990","volume":"122","author":"J Pillay","year":"2012","unstructured":"Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW et al. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest 2012; 122: 327\u2013336.","journal-title":"J Clin Invest"},{"key":"132_CR24","first-page":"263","volume":"70","author":"J Lohler","year":"1994","unstructured":"Lohler J, Gossmann J, Kratzberg T, Lehmann-Grube F. Murine hepatitis caused by lymphocytic choriomeningitis virus. I. The hepatic lesions. Lab Invest 1994; 70: 263\u2013278.","journal-title":"Lab Invest"},{"key":"132_CR25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1084\/jem.164.4.1075","volume":"164","author":"RM Zinkernagel","year":"1986","unstructured":"Zinkernagel RM, Haenseler E, Leist T, Cerny A, Hengartner H, Althage A. T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay? J Exp Med 1986; 164: 1075\u20131092.","journal-title":"J Exp Med"},{"key":"132_CR26","doi-asserted-by":"crossref","first-page":"e0166094","DOI":"10.1371\/journal.pone.0166094","volume":"11","author":"MD van de Garde","year":"2016","unstructured":"van de Garde MD, Movita D, van der Heide M, Herschke F, De Jonghe S, Gama L et al. Liver monocytes and kupffer cells remain transcriptionally distinct during chronic viral infection. PLoS One 2016; 11: e0166094.","journal-title":"PLoS One"},{"key":"132_CR27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1189\/jlb.0407247","volume":"83","author":"JM Daley","year":"2008","unstructured":"Daley JM, Thomay AA, Connolly MD, Reichner JS, Albina JE. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J Leukoc Biol 2008; 83: 64\u201370.","journal-title":"J Leukoc Biol"},{"key":"132_CR28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","volume":"1","author":"RG Knodell","year":"1981","unstructured":"Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431\u2013435.","journal-title":"Hepatology"},{"key":"132_CR29","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.4049\/jimmunol.1303281","volume":"192","author":"Z Jie","year":"2014","unstructured":"Jie Z, Liang Y, Hou L, Dong C, Iwakura Y, Soong L et al. Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection. J Immunol 2014; 192: 3289\u20133300.","journal-title":"J Immunol"},{"key":"132_CR30","doi-asserted-by":"crossref","first-page":"Unit 15A 11","DOI":"10.1002\/9780471729259.mc15a01s8","volume":"Chapter 15","author":"RM Welsh","year":"2008","unstructured":"Welsh RM, Seedhom MO. Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage. Curr Protoc Microbiol 2008; Chapter 15: Unit 15A 11.","journal-title":"Curr Protoc Microbiol"},{"key":"132_CR31","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1189\/jlb.0612273","volume":"92","author":"VM Kamp","year":"2012","unstructured":"Kamp VM, Pillay J, Lammers JW, Pickkers P, Ulfman LH, Koenderman L. Human suppressive neutrophils CD16bright\/CD62Ldim exhibit decreased adhesion. J Leukoc Biol 2012; 92: 1011\u20131020.","journal-title":"J Leukoc Biol"},{"key":"132_CR32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jhep.2011.03.022","volume":"56","author":"V Volarevic","year":"2012","unstructured":"Volarevic V, Mitrovic M, Milovanovic M, Zelen I, Nikolic I, Mitrovic S et al. Protective role of IL-33\/ST2 axis in Con A-induced hepatitis. J Hepatol 2012; 56: 26\u201333.","journal-title":"J Hepatol"},{"key":"132_CR33","doi-asserted-by":"crossref","first-page":"31222","DOI":"10.1074\/jbc.273.47.31222","volume":"273","author":"A Lischke","year":"1998","unstructured":"Lischke A, Moriggl R, Brandlein S, Berchtold S, Kammer W, Sebald W et al. The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain. J Biol Chem 1998; 273: 31222\u201331229.","journal-title":"J Biol Chem"},{"key":"132_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2012.10.553","volume":"54","author":"A Bhattacharjee","year":"2013","unstructured":"Bhattacharjee A, Shukla M, Yakubenko VP, Mulya A, Kundu S, Cathcart MK. IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes\/macrophages. Free Radic Biol Med 2013; 54: 1\u201316.","journal-title":"Free Radic Biol Med"},{"key":"132_CR35","doi-asserted-by":"crossref","first-page":"C248","DOI":"10.1152\/ajpcell.2000.279.1.C248","volume":"279","author":"LH Wei","year":"2000","unstructured":"Wei LH, Jacobs AT, Morris SM Jr., Ignarro LJ. IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK\/STAT6 pathways in vascular smooth muscle cells. Am J Physiol Cell Physiol 2000; 279: C248\u2013C256.","journal-title":"Am J Physiol Cell Physiol"},{"key":"132_CR36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 2013; 13: 159\u2013175.","journal-title":"Nat Rev Immunol"},{"key":"132_CR37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","volume":"11","author":"A Mantovani","year":"2011","unstructured":"Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011; 11: 519\u2013531.","journal-title":"Nat Rev Immunol"},{"key":"132_CR38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.it.2015.07.007","volume":"36","author":"ND Kim","year":"2015","unstructured":"Kim ND, Luster AD. The role of tissue resident cells in neutrophil recruitment. Trends Immunol 2015; 36: 547\u2013555.","journal-title":"Trends Immunol"},{"key":"132_CR39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000345943","volume":"5","author":"J Rossaint","year":"2013","unstructured":"Rossaint J, Zarbock A. Tissue-specific neutrophil recruitment into the lung, liver, and kidney. J Innate Immun 2013; 5: 348\u2013357.","journal-title":"J Innate Immun"},{"key":"132_CR40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cmi.2016.45","volume":"14","author":"Y Li","year":"2017","unstructured":"Li Y, Zhu L, Chu Z, Yang T, Sun HX, Yang F et al. Characterization and biological significance of IL-23-induced neutrophil polarization. Cell Mol Immunol 2017; 14: 1\u201313.","journal-title":"Cell Mol Immunol"},{"key":"132_CR41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chom.2013.01.005","volume":"13","author":"CN Jenne","year":"2013","unstructured":"Jenne CN, Wong CH, Zemp FJ, McDonald B, Rahman MM, Forsyth PA et al. Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps. Cell Host Microbe 2013; 13: 169\u2013180.","journal-title":"Cell Host Microbe"},{"key":"132_CR42","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/657416","volume":"202","author":"F Bai","year":"2010","unstructured":"Bai F, Kong KF, Dai J, Qian F, Zhang L, Brown CR et al. A paradoxical role for neutrophils in the pathogenesis of West Nile virus. J Infect Dis 2010; 202: 1804\u20131812.","journal-title":"J Infect Dis"},{"key":"132_CR43","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.immuni.2016.06.002","volume":"44","author":"M Pingen","year":"2016","unstructured":"Pingen M, Bryden SR, Pondeville E, Schnettler E, Kohl A, Merits A et al. Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity 2016; 44: 1455\u20131469.","journal-title":"Immunity"},{"key":"132_CR44","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ni.3370","volume":"17","author":"NT Martin","year":"2016","unstructured":"Martin NT, Martin MU. Interleukin 33 is a guardian of barriers and a local alarmin. Nat Immunol 2016; 17: 122\u2013131.","journal-title":"Nat Immunol"},{"key":"132_CR45","doi-asserted-by":"crossref","first-page":"1359064","DOI":"10.1155\/2017\/1359064","volume":"2017","author":"V Carriere","year":"2017","unstructured":"Carriere V, Arshad MI, Le Seyec J, Lefevre B, Farooq M, Jan A et al. Endogenous IL-33 deficiency exacerbates liver injury and increases hepatic influx of neutrophils in acute murine viral hepatitis. Mediators Inflamm 2017; 2017: 1359064.","journal-title":"Mediators Inflamm"},{"key":"132_CR46","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molimm.2016.03.004","volume":"72","author":"F Lan","year":"2016","unstructured":"Lan F, Yuan B, Liu T, Luo X, Huang P, Liu Y et al. Interleukin-33 facilitates neutrophil recruitment and bacterial clearance in S. aureus-caused peritonitis. Mol Immunol 2016; 72: 74\u201380.","journal-title":"Mol Immunol"},{"key":"132_CR47","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4049\/jimmunol.1103564","volume":"189","author":"HT Le","year":"2012","unstructured":"Le HT, Tran VG, Kim W, Kim J, Cho HR, Kwon B. IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals. J Immunol 2012; 189: 287\u2013295.","journal-title":"J Immunol"},{"key":"132_CR48","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","volume":"167","author":"R Geiger","year":"2016","unstructured":"Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T et al. L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity. Cell 2016; 167: 829\u2013842 e813.","journal-title":"Cell"},{"key":"132_CR49","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","volume":"5","author":"V Bronte","year":"2005","unstructured":"Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 2005; 5: 641\u2013654.","journal-title":"Nat Rev Immunol"},{"key":"132_CR50","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood-2006-11-010389","volume":"108","author":"M Munder","year":"2006","unstructured":"Munder M, Schneider H, Luckner C, Giese T, Langhans CD, Fuentes JM et al. Suppression of T-cell functions by human granulocyte arginase. Blood 2006; 108: 1627\u20131634.","journal-title":"Blood"},{"key":"132_CR51","doi-asserted-by":"crossref","first-page":"14919","DOI":"10.1038\/ncomms14919","volume":"8","author":"DC Nascimento","year":"2017","unstructured":"Nascimento DC, Melo PH, Pineros AR, Ferreira RG, Colon DF, Donate PB et al. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. Nat Commun 2017; 8: 14919.","journal-title":"Nat Commun"},{"key":"132_CR52","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1476-5381.2009.00291.x","volume":"158","author":"M Munder","year":"2009","unstructured":"Munder M. Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol 2009; 158: 638\u2013651.","journal-title":"Br J Pharmacol"},{"key":"132_CR53","doi-asserted-by":"crossref","first-page":"e480","DOI":"10.1371\/journal.pntd.0000480","volume":"3","author":"M Modolell","year":"2009","unstructured":"Modolell M, Choi BS, Ryan RO, Hancock M, Titus RG, Abebe T et al. Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis. PLoS Negl Trop Dis 2009; 3: e480.","journal-title":"PLoS Negl Trop Dis"},{"key":"132_CR54","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.4049\/jimmunol.1303432","volume":"193","author":"X Kong","year":"2014","unstructured":"Kong X, Sun R, Chen Y, Wei H, Tian Z. gammadeltaT cells drive myeloid-derived suppressor cell-mediated CD8+ T cell exhaustion in hepatitis B virus-induced immunotolerance. J Immunol 2014; 193: 1645\u20131653.","journal-title":"J Immunol"},{"key":"132_CR55","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/mi.2016.10","volume":"9","author":"D Croxatto","year":"2016","unstructured":"Croxatto D, Micheletti A, Montaldo E, Orecchia P, Loiacono F, Canegallo F et al. Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua. Mucosal Immunol 2016; 9: 1372\u20131383.","journal-title":"Mucosal Immunol"},{"key":"132_CR56","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1182\/blood-2010-02-271981","volume":"116","author":"S Huber","year":"2012","unstructured":"Huber S, Hoffmann R, Muskens F, Voehringer D. Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 2012; 116: 3311\u20133320.","journal-title":"Blood"},{"key":"132_CR57","doi-asserted-by":"crossref","unstructured":"Gieseck RL 3rd, Wilson MS, Wynn TA. Type 2 immunity in tissue repair and fibrosis. Nat Rev Immunol 2017.","DOI":"10.1038\/nri.2017.90"},{"key":"132_CR58","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1002\/eji.201545696","volume":"45","author":"Y Liang","year":"2015","unstructured":"Liang Y, Jie Z, Hou L, Yi P, Wang W, Kwota Z et al. IL-33 promotes innate IFN-gamma production and modulates dendritic cell response in LCMV-induced hepatitis in mice. Eur J Immunol 2015; 45: 3052\u20133063.","journal-title":"Eur J Immunol"},{"key":"132_CR59","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.immuni.2015.05.019","volume":"43","author":"AB Molofsky","year":"2015","unstructured":"Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J et al. Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune perturbation. Immunity 2015; 43: 161\u2013174.","journal-title":"Immunity"},{"key":"132_CR60","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1067\/mai.2000.107604","volume":"105","author":"H Jiang","year":"2000","unstructured":"Jiang H, Harris MB, Rothman P. IL-4\/IL-13 signaling beyond JAK\/STAT. J Allergy Clin Immunol 2000; 105: 1063\u20131070.","journal-title":"J Allergy Clin Immunol"},{"key":"132_CR61","doi-asserted-by":"crossref","first-page":"e1002365","DOI":"10.1371\/journal.pmed.1002365","volume":"14","author":"J Xu","year":"2017","unstructured":"Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y et al. IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translateon study from a human cohort to a mouse trauma model. PLoS Med 2017; 14: e1002365.","journal-title":"PLoS Med"},{"key":"132_CR62","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1084\/jem.20170051","volume":"214","author":"C Schwartz","year":"2017","unstructured":"Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR et al. ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control. J Exp Med 2017; 214: 2507\u20132521.","journal-title":"J Exp Med"},{"key":"132_CR63","doi-asserted-by":"crossref","first-page":"e1003993","DOI":"10.1371\/journal.ppat.1003993","volume":"10","author":"NL Bowers","year":"2014","unstructured":"Bowers NL, Helton ES, Huijbregts RP, Goepfert PA, Heath SL, Hel Z. Immune suppression by neutrophils in HIV-1 infection: role of PD-L1\/PD-1 pathway. PLoS Pathog 2014; 10: e1003993.","journal-title":"PLoS Pathog"},{"key":"132_CR64","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature13577","volume":"513","author":"C Schiering","year":"2014","unstructured":"Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert EA et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature 2014; 513: 564\u2013568.","journal-title":"Nature"}],"container-title":["Cellular &amp; Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cmi2017147","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cmi2017147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cmi.2017.147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/cmi2017147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:19:17Z","timestamp":1684415957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi2017147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["132"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2017.147","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]},"assertion":[{"value":"14 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}