{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:54:43Z","timestamp":1779378883020,"version":"3.53.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Mol Immunol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1038\/cmi.2017.160","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T09:40:59Z","timestamp":1520242859000},"page":"154-164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Siglec genes confer resistance to systemic lupus erythematosus in humans and mice"],"prefix":"10.1038","volume":"16","author":[{"given":"Rhonda","family":"Flores","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"144_CR1","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1056\/NEJMra1100359","volume":"365","author":"GC Tsokos","year":"2011","unstructured":"Tsokos GC. Systemic lupus erythematosus. N Engl J Med 2011; 365: 2110\u20132121.","journal-title":"N Engl J Med"},{"key":"144_CR2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1126\/science.126.3265.162","volume":"126","author":"HR Holman","year":"1957","unstructured":"Holman HR, Kunkel HG. Affinity between the lupus erythematosus serum factor and cell nuclei and nucleoprotein. Science 1957; 126: 162\u2013163.","journal-title":"Science"},{"key":"144_CR3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.autrev.2010.08.015","volume":"10","author":"LE Munoz","year":"2010","unstructured":"Munoz LE, Janko C, Schulze C, Schorn C, Sarter K, Schett G et al. Autoimmunity and chronic inflammation\u2014two clearance-related steps in the etiopathogenesis of SLE. Autoimmun Rev 2010; 10: 38\u201342.","journal-title":"Autoimmun Rev"},{"key":"144_CR4","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1016\/j.febslet.2010.10.046","volume":"584","author":"MT Silva","year":"2010","unstructured":"Silva MT. Secondary necrosis: the natural outcome of the complete apoptotic program. FEBS Lett 2010; 584: 4491\u20134499.","journal-title":"FEBS Lett"},{"key":"144_CR5","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/nature05245","volume":"443","author":"K Kawane","year":"2006","unstructured":"Kawane K, Ohtani M, Miwa K, Kizawa T, Kanbara Y, Yoshioka Y et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 2006; 443: 998\u20131002.","journal-title":"Nature"},{"key":"144_CR6","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1084\/jem.20081165","volume":"205","author":"V Urbonaviciute","year":"2008","unstructured":"Urbonaviciute V, Furnrohr BG, Meister S, Munoz L, Heyder P, De Marchis F et al. Induction of inflammatory and immune responses by HMGB1\u2013nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med 2008; 205: 3007\u20133018.","journal-title":"J Exp Med"},{"key":"144_CR7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.cell.2013.01.011","volume":"152","author":"W Chen","year":"2013","unstructured":"Chen W, Han C, Xie B, Hu X, Yu Q, Shi L et al. Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell 2013; 152: 467\u2013478.","journal-title":"Cell"},{"key":"144_CR8","doi-asserted-by":"publisher","first-page":"7703","DOI":"10.4049\/jimmunol.0902780","volume":"183","author":"CR Boyd","year":"2009","unstructured":"Boyd CR, Orr SJ, Spence S, Burrows JF, Elliott J, Carroll HP et al. Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production. J Immunol 2009; 183: 7703\u20137709.","journal-title":"J Immunol"},{"key":"144_CR9","first-page":"v","volume":"8","author":"PR Crocker","year":"1998","unstructured":"Crocker PR, Clark EA, Filbin M, Gordon S, Jones Y, Kehrl JH et al. Siglecs: a family of sialic-acid binding lectins. Glycobiology 1998; 8: v.","journal-title":"Glycobiology"},{"key":"144_CR10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nri2056","volume":"7","author":"PR Crocker","year":"2007","unstructured":"Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol 2007; 7: 255\u2013266.","journal-title":"Nat Rev Immunol"},{"key":"144_CR11","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/nature05816","volume":"446","author":"A Varki","year":"2007","unstructured":"Varki A. Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins. Nature 2007; 446: 1023\u20131029.","journal-title":"Nature"},{"key":"144_CR12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.bcp.2011.05.018","volume":"82","author":"C Jandus","year":"2011","unstructured":"Jandus C, Simon HU, von Gunten S. Targeting siglecs\u2014a novel pharmacological strategy for immuno- and glycotherapy. Biochem Pharmacol 2011; 82: 323\u2013332.","journal-title":"Biochem Pharmacol"},{"key":"144_CR13","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1126\/science.1168988","volume":"323","author":"GY Chen","year":"2009","unstructured":"Chen GY, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science (New York, NY) 2009; 323: 1722\u20131725.","journal-title":"Science (New York, NY)"},{"key":"144_CR14","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.it.2009.09.006","volume":"30","author":"Y Liu","year":"2009","unstructured":"Liu Y, Chen GY, Zheng P. CD24-Siglec G\/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol 2009; 30: 557\u2013561.","journal-title":"Trends Immunol"},{"key":"144_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.coi.2010.10.004","volume":"23","author":"Y Liu","year":"2011","unstructured":"Liu Y, Chen GY, Zheng P. Sialoside-based pattern recognitions discriminating infections from tissue injuries. Curr Opin Immunol 2011; 23: 41\u201345.","journal-title":"Curr Opin Immunol"},{"key":"144_CR16","doi-asserted-by":"publisher","first-page":"6324","DOI":"10.1074\/jbc.M110146200","volume":"277","author":"T Yamaji","year":"2002","unstructured":"Yamaji T, Teranishi T, Alphey MS, Crocker PR, Hashimoto Y. A small region of the natural killer cell receptor, Siglec-7, is responsible for its preferred binding to alpha 2,8-disialyl and branched alpha 2,6-sialyl residues. A comparison with Siglec-9. J Biol Chem 2002; 277: 6324\u20136332.","journal-title":"J Biol Chem"},{"key":"144_CR17","doi-asserted-by":"publisher","first-page":"14451","DOI":"10.1074\/jbc.M011650200","volume":"276","author":"T Ulyanova","year":"2001","unstructured":"Ulyanova T, Shah DD, Thomas ML. Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2. J Biol Chem 2001; 276: 14451\u201314458.","journal-title":"J Biol Chem"},{"key":"144_CR18","doi-asserted-by":"publisher","first-page":"e04066","DOI":"10.7554\/eLife.04066","volume":"3","author":"GY Chen","year":"2014","unstructured":"Chen GY, Brown NK, Wu W, Khedri Z, Yu H, Chen X et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. eLife 2014; 3: e04066.","journal-title":"eLife"},{"key":"144_CR19","first-page":"97","volume":"61","author":"YH Lee","year":"2015","unstructured":"Lee YH, Bae SC. Association between functional CD24 polymorphisms and susceptibility to autoimmune diseases: a meta-analysis. Cell Mol Biol (Noisy-le-grand) 2015; 61: 97\u2013104.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"144_CR20","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/j.1399-0039.2010.01447.x","volume":"75","author":"P Piotrowski","year":"2010","unstructured":"Piotrowski P, Lianeri M, Wudarski M, Lacki JK, Jagodzinski PP. CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus. Tissue Antigens 2010; 75: 696\u2013700.","journal-title":"Tissue Antigens"},{"key":"144_CR21","doi-asserted-by":"publisher","first-page":"3080","DOI":"10.1002\/art.22871","volume":"56","author":"E Sanchez","year":"2007","unstructured":"Sanchez E, Abelson AK, Sabio JM, Gonz\u00e1lez-Gay MA, Ortego-Centeno N, Jim\u00e9nez-Alonso J et al. Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus. Arthritis Rheum 2007; 56: 3080\u20133086.","journal-title":"Arthritis Rheum"},{"key":"144_CR22","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1371\/journal.pgen.0030049","volume":"3","author":"L Wang","year":"2007","unstructured":"Wang L, Lin S, Rammohan K, Liu Z, Liu JQ, Liu RH et al. A di-nucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genet 2007; 3: e49.","journal-title":"PLoS Genet"},{"key":"144_CR23","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nbt.1846","volume":"29","author":"GY Chen","year":"2011","unstructured":"Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X et al. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol 2011; 29: 428\u2013435.","journal-title":"Nat Biotechnol"},{"key":"144_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1365-2796.2011.02432.x","volume":"270","author":"V Urbonaviciute","year":"2011","unstructured":"Urbonaviciute V, Voll RE. High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus. J Intern Med 2011; 270: 309\u2013318.","journal-title":"J Intern Med"},{"key":"144_CR25","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.4049\/jimmunol.1303367","volume":"192","author":"S Bokers","year":"2014","unstructured":"Bokers S, Urbat A, Daniel C, Amann K, Smith KG, Esp\u00e9li M et al. Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL\/lpr mice. J Immunol 2014; 192: 2994\u20133002.","journal-title":"J Immunol"},{"key":"144_CR26","doi-asserted-by":"publisher","first-page":"e997","DOI":"10.1371\/journal.pone.0000997","volume":"2","author":"C Ding","year":"2007","unstructured":"Ding C, Liu Y, Wang Y, Park BK, Wang CY, Zheng P et al. Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation. PLoS One 2007; 2: e997.","journal-title":"PLoS One"},{"key":"144_CR27","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/ni1480","volume":"8","author":"A Hoffmann","year":"2007","unstructured":"Hoffmann A, Kerr S, Jellusova J, Zhang J, Weisel F, Wellmann U et al. Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol 2007; 8: 695\u2013704.","journal-title":"Nat Immunol"},{"key":"144_CR28","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.4049\/jimmunol.0902711","volume":"184","author":"J Jellusova","year":"2010","unstructured":"Jellusova J, Wellmann U, Amann K, Winkler TH, Nitschke L. CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. J Immunol (Baltimore, Md: 1950) 2010; 184: 3618\u20133637.","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"key":"144_CR29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature09115","volume":"466","author":"I Surolia","year":"2010","unstructured":"Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J et al. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 2010; 466: 243\u2013247.","journal-title":"Nature"},{"key":"144_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ng.3496","volume":"48","author":"C Sun","year":"2016","unstructured":"Sun C, Molineros JE, Looger LL, Zhou XJ, Kim K, Okada Y et al. High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry. Nat Genet 2016; 48: 323\u2013330.","journal-title":"Nat Genet"},{"key":"144_CR31","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbs017","volume":"14","author":"H Thorvaldsdottir","year":"2013","unstructured":"Thorvaldsdottir H, Robinson JT, Mesirov JP. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform 2013; 14: 178\u2013192.","journal-title":"Brief Bioinform"},{"key":"144_CR32","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/acr.20683","volume":"64","author":"RW Jakes","year":"2012","unstructured":"Jakes RW, Bae SC, Louthrenoo W, Mok CC, Navarra SV, Kwon N. Systematic review of the epidemiology of systemic lupus erythematosus in the Asia-Pacific region: prevalence, incidence, clinical features, and mortality. Arthritis Care Res (Hoboken) 2012; 64: 159\u2013168.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"144_CR33","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","volume":"28","author":"AA Shabalin","year":"2012","unstructured":"Shabalin AA. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics 2012; 28: 1353\u20131358.","journal-title":"Bioinformatics"},{"key":"144_CR34","doi-asserted-by":"publisher","first-page":"23816","DOI":"10.1074\/jbc.M102394200","volume":"276","author":"Z Yu","year":"2001","unstructured":"Yu Z, Lai CM, Maoui M, Banville D, Shen SH. Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs. J Biol Chem 2001; 276: 23816\u201323824.","journal-title":"J Biol Chem"},{"key":"144_CR35","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.4049\/jimmunol.162.11.6492","volume":"162","author":"C Mohan","year":"1999","unstructured":"Mohan C, Yu Y, Morel L, Yang P, Wakeland EK. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J Immunol 1999; 162: 6492\u20136502.","journal-title":"J Immunol"},{"key":"144_CR36","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.4049\/jimmunol.158.12.6019","volume":"158","author":"L Morel","year":"1997","unstructured":"Morel L, Mohan C, Yu Y, Croker BP, Tian N, Deng A et al. Functional dissection of systemic lupus erythematosus using congenic mouse strains. J Immunol 1997; 158: 6019\u20136028.","journal-title":"J Immunol"},{"key":"144_CR37","doi-asserted-by":"publisher","first-page":"45128","DOI":"10.1074\/jbc.M108573200","volume":"276","author":"T Angata","year":"2001","unstructured":"Angata T, Hingorani R, Varki NM, Varki A. Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. J Biol Chem 2001; 276: 45128\u201345136.","journal-title":"J Biol Chem"},{"key":"144_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature10558","volume":"479","author":"N Kayagaki","year":"2011","unstructured":"Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J et al. Non-canonical inflammasome activation targets caspase-11. Nature 2011; 479: 117\u2013121.","journal-title":"Nature"},{"key":"144_CR39","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1002\/art.1780400910","volume":"40","author":"W Emlen","year":"1997","unstructured":"Emlen W, O'Neill L. Clinical significance of antinuclear antibodies: comparison of detection with immunofluorescence and enzyme-linked immunosorbent assays. Arthritis Rheum 1997; 40: 1612\u20131618.","journal-title":"Arthritis Rheum"},{"key":"144_CR40","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s12016-013-8402-y","volume":"47","author":"Y Liu","year":"2014","unstructured":"Liu Y, Yin H, Zhao M, Lu Q. TLR2 and TLR4 in autoimmune diseases: a comprehensive review. Clin Rev Allergy Immunol 2014; 47: 136\u2013147.","journal-title":"Clin Rev Allergy Immunol"},{"key":"144_CR41","doi-asserted-by":"publisher","first-page":"23003","DOI":"10.1074\/jbc.M111.244152","volume":"286","author":"N Mitra","year":"2011","unstructured":"Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J et al. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. J Biol Chem 2011; 286: 23003\u201323011.","journal-title":"J Biol Chem"},{"key":"144_CR42","doi-asserted-by":"crossref","unstructured":"Schwarz F, Pearce OM, Wang X, Samraj AN, L\u00e4ubli H, Garcia JO et al. Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife 2015; 4.","DOI":"10.7554\/eLife.06184"},{"key":"144_CR43","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1182\/blood-2012-08-449983","volume":"121","author":"SJ McMillan","year":"2013","unstructured":"McMillan SJ, Sharma RS, McKenzie EJ, Richards HE, Zhang J, Prescott A et al. Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signaling. Blood 2013; 121: 2084\u20132094.","journal-title":"Blood"},{"key":"144_CR44","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/sj.gene.6364335","volume":"7","author":"Y Heidari","year":"2006","unstructured":"Heidari Y, Bygrave AE, Rigby RJ, Rose KL, Walport MJ, Cook HT et al. Identification of chromosome intervals from 129 and C57BL\/6 mouse strains linked to the development of systemic lupus erythematosus. Genes Immun 2006; 7: 592\u2013599.","journal-title":"Genes Immun"},{"key":"144_CR45","doi-asserted-by":"publisher","first-page":"6207","DOI":"10.4049\/jimmunol.0803219","volume":"183","author":"A Lartigue","year":"2009","unstructured":"Lartigue A, Colliou N, Calbo S, Fran\u00e7ois A, Jacquot S, Arnoult C et al. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. J Immunol 2009; 183: 6207\u20136216.","journal-title":"J Immunol"},{"key":"144_CR46","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jaut.2010.05.004","volume":"35","author":"SA Summers","year":"2010","unstructured":"Summers SA, Hoi A, Steinmetz OM, O'Sullivan KM, Ooi JD, Odobasic D et al. TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy. J Autoimmun 2010; 35: 291\u2013298.","journal-title":"J Autoimmun"},{"key":"144_CR47","doi-asserted-by":"publisher","first-page":"6880","DOI":"10.4049\/jimmunol.177.10.6880","volume":"177","author":"B Liu","year":"2006","unstructured":"Liu B, Yang Y, Dai J, Medzhitov R, Freudenberg MA, Zhang PL et al. TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol 2006; 177: 6880\u20136888.","journal-title":"J Immunol"}],"container-title":["Cellular & Molecular Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cmi2017160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cmi2017160","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/cmi.2017.160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/cmi2017160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:55:26Z","timestamp":1693569326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cmi2017160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["144"],"URL":"https:\/\/doi.org\/10.1038\/cmi.2017.160","relation":{},"ISSN":["1672-7681","2042-0226"],"issn-type":[{"value":"1672-7681","type":"print"},{"value":"2042-0226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]},"assertion":[{"value":"15 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}