{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:14:12Z","timestamp":1791386052376,"version":"4.3.3"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T00:00:00Z","timestamp":1289865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Res"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1038\/cr.2010.159","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T11:41:39Z","timestamp":1289907699000},"page":"169-182","source":"Crossref","is-referenced-by-count":305,"title":["Role of NF-\u03baB in the skeleton"],"prefix":"10.1038","volume":"21","author":[{"given":"Deborah Veis","family":"Novack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,16]]},"reference":[{"key":"BFcr2010159_CR1","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","volume":"11","author":"G Franzoso","year":"1997","unstructured":"Franzoso G, Carlson L, Xing L, et al. Requirement for NF-\u03baB in osteoclast and B-cell development. Genes Dev 1997; 11:3482\u20133496.","journal-title":"Genes Dev"},{"key":"BFcr2010159_CR2","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/nm1197-1285","volume":"3","author":"V Iotsova","year":"1997","unstructured":"Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R . Osteopetrosis in mice lacking NF-\u03baB1 and NF-\u03baB2. Nat Med 1997; 3:1285\u20131289.","journal-title":"Nat Med"},{"key":"BFcr2010159_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1172\/JCI200419657","volume":"114","author":"F Ikeda","year":"2004","unstructured":"Ikeda F, Nishimura R, Matsubara T, et al. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 2004; 114:475\u2013484.","journal-title":"J Clin Invest"},{"key":"BFcr2010159_CR4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1126\/science.7939685","volume":"266","author":"AE Grigoriadis","year":"1994","unstructured":"Grigoriadis AE, Wang Z-Q, Cecchini MG, et al. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 1994; 266:443\u2013448.","journal-title":"Science"},{"issue":"1","key":"BFcr2010159_CR5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.arr.2009.09.005","volume":"10","author":"Deborah V. Novack","year":"2011","unstructured":"Novack DV, Faccio R . Osteoclast motility: Putting the brakes on bone resorption. Ageing Res Rev 2009 Sep 27; doi:10.1016\/j.arr.2009.09.005.","journal-title":"Ageing Research Reviews"},{"key":"BFcr2010159_CR6","doi-asserted-by":"publisher","first-page":"20551","DOI":"10.1074\/jbc.273.32.20551","volume":"273","author":"BG Darnay","year":"1998","unstructured":"Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB . Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem 1998; 273:20551\u201320555.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR7","doi-asserted-by":"publisher","first-page":"54759","DOI":"10.1074\/jbc.M404687200","volume":"279","author":"W Liu","year":"2004","unstructured":"Liu W, Xu D, Yang H, et al. Functional identification of three receptor activator of NF-\u03baB cytoplasmic motifs mediating osteoclast differentiation and function. J Biol Chem 2004; 279:54759\u201354769.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR8","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.bbrc.2007.06.017","volume":"359","author":"B Lamothe","year":"2007","unstructured":"Lamothe B, Webster WK, Gopinathan A, Besse A, Campos AD, Darnay BG . TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Biochem Biophys Res Commun 2007; 359:1044\u20131049.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcr2010159_CR9","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S1534-5807(03)00403-9","volume":"6","author":"A Duran","year":"2004","unstructured":"Duran A, Serrano M, Leitges M, et al. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell 2004; 6:303\u2013309.","journal-title":"Dev Cell"},{"key":"BFcr2010159_CR10","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1172\/JCI34257","volume":"118","author":"W Jin","year":"2008","unstructured":"Jin W, Chang M, Paul EM, et al. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest 2008; 118:1858\u20131866.","journal-title":"J Clin Invest"},{"key":"BFcr2010159_CR11","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1359\/jbmr.2003.18.2.260","volume":"18","author":"L Xing","year":"2003","unstructured":"Xing L, Carlson L, Story B, et al. Expression of either NF-\u03baB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption. J Bone Miner Res 2003; 18:260\u2013269.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR12","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1084\/jem.20042081","volume":"201","author":"MG Ruocco","year":"2005","unstructured":"Ruocco MG, Maeda S, Park JM, et al. I\u03baB kinase (IKK)\u03b2, but not IKK\u03b1, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med 2005; 201:1677\u20131687.","journal-title":"J Exp Med"},{"key":"BFcr2010159_CR13","doi-asserted-by":"publisher","first-page":"24546","DOI":"10.1074\/jbc.M800434200","volume":"283","author":"JE Otero","year":"2008","unstructured":"Otero JE, Dai S, Foglia D, et al. Defective osteoclastogenesis by IKK\u03b2-null precursors is a result of receptor activator of NF-\u03baB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation. J Biol Chem 2008; 283:24546\u201324553.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR14","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nm1054","volume":"10","author":"E Jimi","year":"2004","unstructured":"Jimi E, Aok K, Saito H, et al. Selective inhibition of NF-\u03baB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004; 10:617\u2013624.","journal-title":"Nat Med"},{"key":"BFcr2010159_CR15","doi-asserted-by":"publisher","first-page":"37219","DOI":"10.1074\/jbc.C400258200","volume":"279","author":"S Dai","year":"2004","unstructured":"Dai S, Hirayama T, Abbas S, Abu-Amer Y . The I\u03baB Kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J Biol Chem 2004; 279:37219\u201337222.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR16","first-page":"2088","volume":"118","author":"S Vaira","year":"2008","unstructured":"Vaira S, Alhawagri M, Anwisye I, Kitaura H, Faccio R, Novack DV . RelA\/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J Clin Invest 2008; 118:2088\u20132097.","journal-title":"J Clin Invest"},{"key":"BFcr2010159_CR17","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/35104560","volume":"414","author":"E De Smaele","year":"2001","unstructured":"De Smaele E, Zazzeroni F, Papa S, et al. Induction of gadd45b by NF-kB downregulates pro-apoptotic JNK signalling. Nature 2001; 414:308\u2013313.","journal-title":"Nature"},{"key":"BFcr2010159_CR18","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2004.12.041","volume":"120","author":"H Kamata","year":"2005","unstructured":"Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M . Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120:649\u2013661.","journal-title":"Cell"},{"key":"BFcr2010159_CR19","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.1242\/jcs.01483","volume":"117","author":"S Papa","year":"2004","unstructured":"Papa S, Zazzeroni F, Pham CG, Bubici C, Franzoso G . Linking JNK signaling to NF-\u03baB: a key to survival. J Cell Sci 2004; 117:5197\u20135208.","journal-title":"J Cell Sci"},{"key":"BFcr2010159_CR20","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1073\/pnas.0500187102","volume":"102","author":"J Hauer","year":"2005","unstructured":"Hauer J, Puschner S, Ramakrishnan P, et al. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2\/5-mediated activation of the noncanonical NF-\u03baB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci USA 2005; 102:2874\u20132879.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcr2010159_CR21","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1084\/jem.20030116","volume":"198","author":"DV Novack","year":"2003","unstructured":"Novack DV, Yin L, Hagen-Stapleton A, et al. The I\u03baB function of NF-\u03baB2 p100 controls stimulated osteoclastogenesis. J Exp Med 2003; 198:771\u2013781.","journal-title":"J Exp Med"},{"key":"BFcr2010159_CR22","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1073\/pnas.0708576105","volume":"105","author":"S Vaira","year":"2008","unstructured":"Vaira S, Johnson T, Hirbe AC, et al. RelB is the NF-\u03baB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci USA 2008; 105:3897\u20133902.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcr2010159_CR23","doi-asserted-by":"publisher","first-page":"54841","DOI":"10.1074\/jbc.M406392200","volume":"279","author":"ML Chaisson","year":"2004","unstructured":"Chaisson ML, Branstetter DG, Derry JM, et al. Osteoclast differentiation is impaired in the absence of inhibitor of \u03baB kinase \u03b1. J Biol Chem 2004; 279:54841\u201354848.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR24","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1359\/jbmr.091030","volume":"25","author":"NS Soysa","year":"2010","unstructured":"Soysa NS, Alles N, Weih D, et al. The pivotal role of the alternative NF-\u03baB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res 2010; 25:809\u2013818.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR25","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1359\/jbmr.091032","volume":"25","author":"T Maruyama","year":"2010","unstructured":"Maruyama T, Fukushima H, Nakao K, et al. Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation. J Bone Miner Res 2010; 25:1058\u20131067.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR26","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1074\/jbc.M109619200","volume":"277","author":"NJ Solan","year":"2002","unstructured":"Solan NJ, Miyoshi H, Carmona EM, Bren GD, Paya CV . RelB cellular regulation and trancriptional activity are regulated by p100. J Biol Chem 2002; 277:1405\u20131418.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR27","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1002\/jbmr.4","volume":"25","author":"JE Otero","year":"2010","unstructured":"Otero JE, Dai S, Alhawagri MA, Darwech I, Abu-Amer Y . IKK\u03b2 activation is sufficient for RANK-independent osteoclast differentiation and osteolysis. J Bone Miner Res 2010; 25:1282\u20131294.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR28","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/jcb.1202","volume":"83","author":"W Zou","year":"2001","unstructured":"Zou W, Hakim I, Tschoep K, Endres S, Bar-Shavit Z . Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism. J Cell Biochem 2001; 83:70\u201383.","journal-title":"J Cell Biochem"},{"key":"BFcr2010159_CR29","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/S8756-3282(01)00420-3","volume":"28","author":"M Komine","year":"2001","unstructured":"Komine M, Kukita A, Kukita T, Ogata Y, Hotokebuchi T, Kohashi O . Tumor necrosis factor-\u03b1 cooperates with receptor activator of nuclear factor \u03baB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture. Bone 2001; 28:474\u2013483.","journal-title":"Bone"},{"key":"BFcr2010159_CR30","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1172\/JCI11176","volume":"106","author":"J Lam","year":"2000","unstructured":"Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL . TNF-\u03b1 induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000; 106:1481\u20131488.","journal-title":"J Clin Invest"},{"key":"BFcr2010159_CR31","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1084\/jem.191.2.275","volume":"191","author":"K Kobayashi","year":"2000","unstructured":"Kobayashi K, Takahashi N, Jimi E, et al. Tumor necrosis factor \u03b1 stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction. J Exp Med 2000; 191:275\u2013285.","journal-title":"J Exp Med"},{"key":"BFcr2010159_CR32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0736-0266(02)00106-7","volume":"21","author":"A Sabokbar","year":"2003","unstructured":"Sabokbar A, Kudo O, Athanasou NA . Two distinct cellular mechanisms of osteoclast formation and bone resorption in periprosthetic osteolysis. J Orthop Res 2003; 21:73\u201380.","journal-title":"J Orthop Res"},{"key":"BFcr2010159_CR33","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1074\/jbc.275.7.4858","volume":"275","author":"Y Azuma","year":"2000","unstructured":"Azuma Y, Kaji K, Katogi R, Takeshita S, Kudo A . Tumor necrosis factor-\u03b1 induces differentiation of and bone resorption by osteoclasts. J Biol Chem 2000; 275:4858\u20134864.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR34","doi-asserted-by":"publisher","first-page":"18245","DOI":"10.1074\/jbc.M610701200","volume":"282","author":"T Yamashita","year":"2007","unstructured":"Yamashita T, Yao Z, Li F, et al. NF-\u03baB p50 and p52 regulate receptor activator of NF-\u03baB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem 2007; 282:18245\u201318253.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR35","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1172\/JCI23763","volume":"115","author":"K Aya","year":"2005","unstructured":"Aya K, Alhawagri M, Hagen-Stapleton A, Kitaura H, Kanagawa O, Novack DV . NF-\u03baB-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis. J Clin Invest 2005; 115:1848\u20131854.","journal-title":"J Clin Invest"},{"key":"BFcr2010159_CR36","doi-asserted-by":"publisher","first-page":"23278","DOI":"10.1074\/jbc.M300106200","volume":"278","author":"E Derudder","year":"2003","unstructured":"Derudder E, Dejardin E, Pritchard LL, Green DR, Korner M, Baud V . RelB\/p50 dimers are differentially regulated by tumor necrosis factor-{alpha} and lymphotoxin-{beta} receptor activation: CRITICAL ROLES FOR p100. J Biol Chem 2003; 278:23278\u201323284.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR37","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1172\/JCI38716","volume":"119","author":"Z Yao","year":"2009","unstructured":"Yao Z, Xing L, Boyce BF . NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism. J Clin Invest 2009; 119:3024\u20133034.","journal-title":"J Clin Invest"},{"key":"BFcr2010159_CR38","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.4049\/jimmunol.173.8.4838","volume":"173","author":"H Kitaura","year":"2004","unstructured":"Kitaura H, Sands MS, Aya K, et al. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-\u03b1-induced osteoclastogenesis in vivo. J Immunol 2004; 173:4838\u20134846.","journal-title":"J Immunol"},{"key":"BFcr2010159_CR39","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jdsr.2009.10.003","volume":"46","author":"E Jimi","year":"2010","unstructured":"Jimi E, Hirata S, Shin M, Yamazaki M, Fukushima H . Molecular mechanisms of BMP-induced bone formation: cross-talk between BMP and NF-\u03baB signaling pathways in osteoblastogenesis. Jpn Dent Sci Rev 2010; 46:33\u201342.","journal-title":"Jpn Dent Sci Rev"},{"key":"BFcr2010159_CR40","doi-asserted-by":"publisher","first-page":"E1011","DOI":"10.1152\/ajpendo.00534.2004","volume":"288","author":"LC Gilbert","year":"2005","unstructured":"Gilbert LC, Rubin J, Nanes MS . The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis. Am J Physiol Endocrinol Metab 2005; 288:E1011\u20131018.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFcr2010159_CR41","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1359\/jbmr.070121","volume":"22","author":"Y Li","year":"2007","unstructured":"Li Y, Li A, Strait K, Zhang H, Nanes MS, Weitzmann MN . Endogenous TNF\u03b1 lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-\u03baB. J Bone Miner Res 2007; 22:646\u2013655.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR42","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.yexcr.2005.09.016","volume":"312","author":"RA Eliseev","year":"2006","unstructured":"Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN . Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Exp Cell Res 2006; 312:40\u201350.","journal-title":"Exp Cell Res"},{"key":"BFcr2010159_CR43","doi-asserted-by":"publisher","first-page":"35987","DOI":"10.1074\/jbc.M109.070540","volume":"284","author":"M Yamazaki","year":"2009","unstructured":"Yamazaki M, Fukushima H, Shin M, et al. Tumor necrosis factor \u03b1 represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-\u03baB. J Biol Chem 2009; 284:35987\u201335995.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR44","doi-asserted-by":"publisher","first-page":"6297","DOI":"10.1074\/jbc.M507804200","volume":"281","author":"X Lu","year":"2006","unstructured":"Lu X, Gilbert L, He X, Rubin J, Nanes MS . Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem 2006; 281:6297\u20136306.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR45","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nm.1954","volume":"15","author":"J Chang","year":"2009","unstructured":"Chang J, Wang Z, Tang E, et al. Inhibition of osteoblastic bone formation by nuclear factor-\u03baB. Nat Med 2009; 15:682\u2013689.","journal-title":"Nat Med"},{"key":"BFcr2010159_CR46","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1096\/fj.02-0901fje","volume":"17","author":"S Agarwal","year":"2003","unstructured":"Agarwal S, Long P, Seyedain A, Piesco N, Shree A, Gassner R . A central role for the nuclear factor-\u03baB pathway in anti-inflammatory and proinflammatory actions of mechanical strain. FASEB J 2003; 17:899\u2013901.","journal-title":"FASEB J"},{"key":"BFcr2010159_CR47","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.molmed.2009.03.001","volume":"15","author":"KK Papachroni","year":"2009","unstructured":"Papachroni KK, Karatzas DN, Papavassiliou KA, Basdra EK, Papavassiliou AG . Mechanotransduction in osteoblast regulation and bone disease. Trends Mol Med 2009; 15:208\u2013216.","journal-title":"Trends Mol Med"},{"key":"BFcr2010159_CR48","doi-asserted-by":"publisher","first-page":"041005","DOI":"10.1115\/1.4001162","volume":"132","author":"MJ Barron","year":"2010","unstructured":"Barron MJ, Tsai CJ, Donahue SW . Mechanical stimulation mediates gene expression in MC3T3 osteoblastic cells differently in 2D and 3D environments. J Biomech Eng 2010; 132:041005.","journal-title":"J Biomech Eng"},{"key":"BFcr2010159_CR49","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bone.2010.03.014","volume":"47","author":"SR Young","year":"2010","unstructured":"Young SR, Gerard-O'Riley R, Harrington M, Pavalko FM . Activation of NF-\u03baB by fluid shear stress, but not TNF-\u03b1, requires focal adhesion kinase in osteoblasts. Bone 2010; 47:74\u201382.","journal-title":"Bone"},{"key":"BFcr2010159_CR50","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1359\/jbmr.091032","volume":"25","author":"T Maruyama","year":"2010","unstructured":"Maruyama T, Fukushima H, Nakao K, et al. Processing of the NF-\u03baB2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation. J Bone Miner Res 2010; 25:1058\u20131067.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR51","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.cmet.2007.05.001","volume":"5","author":"S Tatsumi","year":"2007","unstructured":"Tatsumi S, Ishii K, Amizuka N, et al. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab 2007; 5:464\u2013475.","journal-title":"Cell Metab"},{"key":"BFcr2010159_CR52","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s12195-009-0068-4","volume":"2","author":"J Litzenberger","year":"2009","unstructured":"Litzenberger J, Tang W, Castillo A, Jacobs C . Deletion of \u03b21 integrins from cortical osteocytes reduces load-induced bone formation. Cell Mol Bioeng 2009; 2:416\u2013424.","journal-title":"Cell Mol Bioeng"},{"key":"BFcr2010159_CR53","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/jcp.21021","volume":"212","author":"DC Genetos","year":"2007","unstructured":"Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ . Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol 2007; 212:207\u2013214.","journal-title":"J Cell Physiol"},{"key":"BFcr2010159_CR54","doi-asserted-by":"publisher","first-page":"33698","DOI":"10.1074\/jbc.M702991200","volume":"282","author":"S Wu","year":"2007","unstructured":"Wu S, Flint JK, Rezvani G, De Luca F . Nuclear factor-\u03baB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis. J Biol Chem 2007; 282:33698\u201333706.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR55","doi-asserted-by":"publisher","first-page":"34037","DOI":"10.1074\/jbc.M803754200","volume":"283","author":"S Wu","year":"2008","unstructured":"Wu S, Fadoju D, Rezvani G, De Luca F . Stimulatory effects of insulin-like growth factor-I on growth plate chondrogenesis are mediated by nuclear factor-\u03baB p65. J Biol Chem 2008; 283:34037\u201334044.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR56","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1126\/science.284.5412.313","volume":"284","author":"K Takeda","year":"1999","unstructured":"Takeda K, Takeuchi O, Tsujimura T, et al. Limb and skin abnormalities in mice lacking IKK\u03b1. Science 1999; 284:313\u2013316.","journal-title":"Science"},{"key":"BFcr2010159_CR57","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1101\/gad.13.10.1322","volume":"13","author":"Q Li","year":"1999","unstructured":"Li Q, Lu Q, Hwang JY, et al. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev 1999; 13:1322\u20131328.","journal-title":"Genes Dev"},{"key":"BFcr2010159_CR58","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature02421","volume":"428","author":"AK Sil","year":"2004","unstructured":"Sil AK, Maeda S, Sano Y, Roop DR, Karin M . I\u03baB kinase-\u03b1 acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 2004; 428:660\u2013664.","journal-title":"Nature"},{"key":"BFcr2010159_CR59","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/rheumatology\/kem298","volume":"47","author":"RE Simmonds","year":"2008","unstructured":"Simmonds RE, Foxwell BM . Signalling, inflammation and arthritis: NF-\u03baB and its relevance to arthritis and inflammation. Rheumatology (Oxford) 2008; 47:584\u2013590.","journal-title":"Rheumatology (Oxford)"},{"key":"BFcr2010159_CR60","doi-asserted-by":"publisher","first-page":"5547","DOI":"10.4049\/jimmunol.171.10.5547","volume":"171","author":"JC Clohisy","year":"2003","unstructured":"Clohisy JC, Roy BC, Biondo C, et al. Direct inhibition of NF-\u03baB blocks bone erosion associated with inflammatory arthritis. J Immunol 2003; 171:5547\u20135553.","journal-title":"J Immunol"},{"key":"BFcr2010159_CR61","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1002\/art.11131","volume":"48","author":"KW McIntyre","year":"2003","unstructured":"McIntyre KW, Shuster DJ, Gillooly KM, et al. A highly selective inhibitor of I\u03baB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum 2003; 48:2652\u20132659.","journal-title":"Arthritis Rheum"},{"key":"BFcr2010159_CR62","doi-asserted-by":"publisher","first-page":"6603","DOI":"10.1182\/blood-2008-12-192914","volume":"113","author":"W Jin","year":"2009","unstructured":"Jin W, Zhou XF, Yu J, Cheng X, Sun SC . Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood 2009; 113:6603\u20136610.","journal-title":"Blood"},{"key":"BFcr2010159_CR63","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1002\/art.22117","volume":"54","author":"TP van Staa","year":"2006","unstructured":"van Staa TP, Geusens P, Bijlsma JW, Leufkens HG, Cooper C . Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum 2006; 54:3104\u20133112.","journal-title":"Arthritis Rheum"},{"key":"BFcr2010159_CR64","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1136\/ard.2005.044198","volume":"65","author":"M Vis","year":"2006","unstructured":"Vis M, Havaardsholm EA, Haugeberg G, et al. Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NF\u03baB ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis. Ann Rheum Dis 2006; 65:1495\u20131499.","journal-title":"Ann Rheum Dis"},{"key":"BFcr2010159_CR65","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1359\/jbmr.090320","volume":"24","author":"NC Walsh","year":"2009","unstructured":"Walsh NC, Reinwald S, Manning CA, et al. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res 2009; 24:1572\u20131585.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR66","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1002\/art.21021","volume":"52","author":"G Schett","year":"2005","unstructured":"Schett G, Middleton S, Bolon B, et al. Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models. Arthritis Rheum 2005; 52:1604\u20131611.","journal-title":"Arthritis Rheum"},{"key":"BFcr2010159_CR67","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.0105-2896.2009.00857.x","volume":"233","author":"NC Walsh","year":"2010","unstructured":"Walsh NC, Gravallese EM . Bone remodeling in rheumatic disease: a question of balance. Immunol Rev 2010; 233:301\u2013312.","journal-title":"Immunol Rev"},{"key":"BFcr2010159_CR68","doi-asserted-by":"publisher","first-page":"24793","DOI":"10.1074\/jbc.M110.110320","volume":"285","author":"P Wang","year":"2010","unstructured":"Wang P, Zhu F, Lee NH, Konstantopoulos K . Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP\/protein kinase A- and PI3-K\/Akt-dependent NF-kappaB activation. J Biol Chem 2010; 285:24793\u201324804.","journal-title":"J Biol Chem"},{"key":"BFcr2010159_CR69","doi-asserted-by":"publisher","first-page":"5781","DOI":"10.4049\/jimmunol.174.9.5781","volume":"174","author":"JI Pulai","year":"2005","unstructured":"Pulai JI, Chen H, Im HJ, et al. NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol 2005; 174:5781\u20135788.","journal-title":"J Immunol"},{"key":"BFcr2010159_CR70","doi-asserted-by":"publisher","first-page":"R82","DOI":"10.1186\/ar3009","volume":"12","author":"TT Chowdhury","year":"2010","unstructured":"Chowdhury TT, Schulz RM, Rai SS, et al. Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte\/agarose constructs. Arthritis Res Ther 2010; 12:R82.","journal-title":"Arthritis Res Ther"},{"key":"BFcr2010159_CR71","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/art.24096","volume":"61","author":"X Chevalier","year":"2009","unstructured":"Chevalier X, Goupille P, Beaulieu AD, et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 2009; 61:344\u2013352.","journal-title":"Arthritis Rheum"},{"key":"BFcr2010159_CR72","first-page":"1323","volume":"34","author":"MD Magnano","year":"2007","unstructured":"Magnano MD, Chakravarty EF, Broudy C, et al. A pilot study of tumor necrosis factor inhibition in erosive\/inflammatory osteoarthritis of the hands. J Rheumatol 2007; 34:1323\u20131327.","journal-title":"J Rheumatol"},{"key":"BFcr2010159_CR73","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2174\/138945010791011938","volume":"11","author":"KB Marcu","year":"2010","unstructured":"Marcu KB, Otero M, Olivotto E, Borzi RM, Goldring MB . NF-\u03baB signaling: multiple angles to target OA. Curr Drug Targets 2010; 11:599\u2013613.","journal-title":"Curr Drug Targets"},{"key":"BFcr2010159_CR74","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1016\/j.joca.2008.04.027","volume":"16","author":"LJ Sandell","year":"2008","unstructured":"Sandell LJ, Xing X, Franz C, Davies S, Chang LW, Patra D . Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. Osteoarthritis Cartilage 2008; 16:1560\u20131571.","journal-title":"Osteoarthritis Cartilage"},{"key":"BFcr2010159_CR75","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.4049\/jimmunol.171.8.4406","volume":"171","author":"D Merz","year":"2003","unstructured":"Merz D, Liu R, Johnson K, Terkeltaub R . IL-8\/CXCL8 and growth-related oncogene \u03b1\/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol 2003; 171:4406\u20134415.","journal-title":"J Immunol"},{"key":"BFcr2010159_CR76","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.joca.2007.06.006","volume":"16","author":"LX Chen","year":"2008","unstructured":"Chen LX, Lin L, Wang HJ, et al. Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-\u03baBp65-specific siRNA. Osteoarthritis Cartilage 2008; 16:174\u2013184.","journal-title":"Osteoarthritis Cartilage"},{"key":"BFcr2010159_CR77","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cell.2007.07.025","volume":"130","author":"T Nakamura","year":"2007","unstructured":"Nakamura T, Imai Y, Matsumoto T, et al. Estrogen prevents bone loss via estrogen receptor \u03b1 and induction of Fas ligand in osteoclasts. Cell 2007; 130:811\u2013823.","journal-title":"Cell"},{"key":"BFcr2010159_CR78","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1210\/me.2009-0354","volume":"24","author":"M Martin-Millan","year":"2010","unstructured":"Martin-Millan M, Almeida M, Ambrogini E, et al. The estrogen receptor-\u03b1 in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol 2010; 24:323\u2013334.","journal-title":"Mol Endocrinol"},{"key":"BFcr2010159_CR79","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.tem.2005.01.004","volume":"16","author":"D Kalaitzidis","year":"2005","unstructured":"Kalaitzidis D, Gilmore TD . Transcription factor cross-talk: the estrogen receptor and NF-\u03baB. Trends Endocrinol Metab 2005; 16:46\u201352.","journal-title":"Trends Endocrinol Metab"},{"key":"BFcr2010159_CR80","doi-asserted-by":"publisher","first-page":"8918","DOI":"10.1158\/0008-5472.CAN-09-2608","volume":"69","author":"J Frasor","year":"2009","unstructured":"Frasor J, Weaver A, Pradhan M, et al. Positive cross-talk between estrogen receptor and NF-\u03baB in breast cancer. Cancer Res 2009; 69:8918\u20138925.","journal-title":"Cancer Res"},{"key":"BFcr2010159_CR81","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1359\/jbmr.070207","volume":"22","author":"N Charatcharoenwitthaya","year":"2007","unstructured":"Charatcharoenwitthaya N, Khosla S, Atkinson EJ, McCready LK, Riggs BL . Effect of blockade of TNF-\u03b1 and interleukin-1 action on bone resorption in early postmenopausal women. J Bone Miner Res 2007; 22:724\u2013729.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR82","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1172\/JCI200523394","volume":"115","author":"S Wei","year":"2005","unstructured":"Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL . IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest 2005; 115:282\u2013290.","journal-title":"J Clin Invest"},{"key":"BFcr2010159_CR83","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1136\/jcp.2009.064428","volume":"63","author":"A Goode","year":"2010","unstructured":"Goode A, Layfield R . Recent advances in understanding the molecular basis of Paget disease of bone. J Clin Pathol 2010; 63:199\u2013203.","journal-title":"J Clin Pathol"},{"key":"BFcr2010159_CR84","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1359\/jbmr.081204","volume":"24","author":"D Najat","year":"2009","unstructured":"Najat D, Garner T, Hagen T, et al. Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone. J Bone Miner Res 2009; 24:632\u2013642.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR85","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1359\/jbmr.090214","volume":"24","author":"SL Rea","year":"2009","unstructured":"Rea SL, Walsh JP, Ward L, et al. Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype\/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-\u03baB signaling without loss of ubiquitin binding. J Bone Miner Res 2009; 24:1216\u20131223.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR86","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1210\/me.2009-0066","volume":"23","author":"E Chamoux","year":"2009","unstructured":"Chamoux E, Couture J, Bisson M, Morissette J, Brown JP, Roux S . The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts. Mol Endocrinol 2009; 23:1668\u20131680.","journal-title":"Mol Endocrinol"},{"key":"BFcr2010159_CR87","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1093\/hmg\/ddn266","volume":"17","author":"Y Hiruma","year":"2008","unstructured":"Hiruma Y, Kurihara N, Subler MA, et al. A SQSTM1\/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment. Hum Mol Genet 2008; 17:3708\u20133719.","journal-title":"Hum Mol Genet"},{"key":"BFcr2010159_CR88","doi-asserted-by":"publisher","first-page":"P55","DOI":"10.1359\/jbmr.06s210","volume":"21 Suppl 2","author":"N Kurihara","year":"2006","unstructured":"Kurihara N, Zhou H, Reddy SV, et al. Experimental models of Paget's disease. J Bone Miner Res 2006; 21 Suppl 2:P55\u201357.","journal-title":"J Bone Miner Res"},{"key":"BFcr2010159_CR89","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.1182\/blood-2006-09-048686","volume":"109","author":"AC Hirbe","year":"2007","unstructured":"Hirbe AC, Uluckan O, Morgan EA, et al. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner. Blood 2007; 109:3424\u20133431.","journal-title":"Blood"},{"key":"BFcr2010159_CR90","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s10585-007-9127-1","volume":"25","author":"JR Canon","year":"2008","unstructured":"Canon JR, Roudier M, Bryant R, et al. Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin Exp Metastasis 2008; 25:119\u2013129.","journal-title":"Clin Exp Metastasis"},{"key":"BFcr2010159_CR91","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.0.CO;2-Z","volume":"88","author":"A Lipton","year":"2000","unstructured":"Lipton A, Theriault RL, Hortobagyi GN . Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases: long term follow-up of two randomized, placebo-controlled trials. Cancer 2000; 88:1082\u20131090.","journal-title":"Cancer"},{"key":"BFcr2010159_CR92","doi-asserted-by":"publisher","first-page":"4431","DOI":"10.1200\/JCO.2007.11.8604","volume":"25","author":"A Lipton","year":"2007","unstructured":"Lipton A, Steger GG, Figueroa J, et al. Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases. J Clin Oncol 2007; 25:4431\u20134437.","journal-title":"J Clin Oncol"},{"key":"BFcr2010159_CR93","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/ncb1559","volume":"9","author":"X Wang","year":"2007","unstructured":"Wang X, Belguise K, Kersual N, et al. Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol 2007; 9:470\u2013478.","journal-title":"Nat Cell Biol"},{"key":"BFcr2010159_CR94","doi-asserted-by":"publisher","first-page":"14205","DOI":"10.1073\/pnas.2234372100","volume":"100","author":"SJ Bakewell","year":"2003","unstructured":"Bakewell SJ, Nestor P, Prasad S, et al. Platelet and osteoclast \u03b23 integrins are critical for bone metastasis. Proc Natl Acad Sci USA 2003; 100:14205\u201314210.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcr2010159_CR95","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.bone.2009.01.010","volume":"44","author":"AC Hirbe","year":"2009","unstructured":"Hirbe AC, Roelofs AJ, Floyd DH, et al. The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone 2009; 44:908\u2013916.","journal-title":"Bone"},{"key":"BFcr2010159_CR96","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ccr.2007.07.004","volume":"12","author":"CM Annunziata","year":"2007","unstructured":"Annunziata CM, Davis RE, Demchenko Y, et al. Frequent engagement of the classical and alternative NF-\u03baB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007; 12:115\u2013130.","journal-title":"Cancer Cell"},{"key":"BFcr2010159_CR97","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ccr.2007.07.003","volume":"12","author":"JJ Keats","year":"2007","unstructured":"Keats JJ, Fonseca R, Chesi M, et al. Promiscuous mutations activate the noncanonical NF-\u03baB pathway in multiple myeloma. Cancer Cell 2007; 12:131\u2013144.","journal-title":"Cancer Cell"},{"key":"BFcr2010159_CR98","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1038\/sj.leu.2404806","volume":"21","author":"I von Metzler","year":"2007","unstructured":"von Metzler I, Krebbel H, Hecht M, et al. Bortezomib inhibits human osteoclastogenesis. Leukemia 2007; 21:2025\u20132034.","journal-title":"Leukemia"},{"key":"BFcr2010159_CR99","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.leukres.2008.07.028","volume":"33","author":"H Hongming","year":"2009","unstructured":"Hongming H, Jian H . Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6. Leuk Res 2009; 33:115\u2013122.","journal-title":"Leuk Res"},{"key":"BFcr2010159_CR100","doi-asserted-by":"publisher","first-page":"5228","DOI":"10.1182\/blood-2008-06-161505","volume":"113","author":"T Hideshima","year":"2009","unstructured":"Hideshima T, Chauhan D, Kiziltepe T, et al. Biologic sequelae of I\u03baB kinase (IKK) inhibition in multiple myeloma: therapeutic implications. Blood 2009; 113:5228\u20135236.","journal-title":"Blood"},{"key":"BFcr2010159_CR101","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1365-2141.2007.06629.x","volume":"138","author":"M Jourdan","year":"2007","unstructured":"Jourdan M, Moreaux J, Vos JD, et al. Targeting NF-\u03baB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth. Br J Haematol 2007; 138:160\u2013168.","journal-title":"Br J Haematol"},{"key":"BFcr2010159_CR102","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1158\/1541-7786.MCR-08-0108","volume":"6","author":"S Markovina","year":"2008","unstructured":"Markovina S, Callander NS, O'Connor SL, et al. Bortezomib-resistant nuclear factor-\u03baB activity in multiple myeloma cells. Mol Cancer Res 2008; 6:1356\u20131364.","journal-title":"Mol Cancer Res"}],"container-title":["Cell Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cr2010159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cr2010159","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cr2010159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:53:39Z","timestamp":1711958019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cr2010159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,16]]},"references-count":102,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["BFcr2010159"],"URL":"https:\/\/doi.org\/10.1038\/cr.2010.159","relation":{},"ISSN":["1001-0602","1748-7838"],"issn-type":[{"value":"1001-0602","type":"print"},{"value":"1748-7838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,16]]}}}