{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:14:44Z","timestamp":1790428484418,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,4,6]],"date-time":"2010-04-06T00:00:00Z","timestamp":1270512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Res"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1038\/cr.2010.46","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T01:38:38Z","timestamp":1270604318000},"page":"676-687","source":"Crossref","is-referenced-by-count":91,"title":["Hypoxia induces PGC-1\u03b1 expression and mitochondrial biogenesis in the myocardium of TOF patients"],"prefix":"10.1038","volume":"20","author":[{"given":"Lingyun","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,6]]},"reference":[{"key":"BFcr201046_CR1","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/S0735-1097(98)00034-5","volume":"31","author":"AM Moran","year":"1998","unstructured":"Moran AM, Hornberger LK, Jonas RA, Keane JF . Development of a double-chambered right ventricle after repair of tetralogy of Fallot. J Am Coll Cardiol 1998; 31:1127\u20131133.","journal-title":"J Am Coll Cardiol"},{"key":"BFcr201046_CR2","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1161\/CIRCULATIONAHA.107.714428","volume":"117","author":"RJ Sommer","year":"2008","unstructured":"Sommer RJ, Hijazi ZM, Rhodes JF . Pathophysiology of congenital heart disease in the adult: part III: Complex congenital heart disease. Circulation 2008; 117:1340\u20131350.","journal-title":"Circulation"},{"key":"BFcr201046_CR3","first-page":"427","volume":"33","author":"T Tongsong","year":"2005","unstructured":"Tongsong T, Sittiwangkul R, Chanprapaph P, Sirichotiyakul S . Prenatal sonographic diagnosis of tetralogy of fallot. J Clin Ultrasound 2005; 33:427\u2013431.","journal-title":"J Clin Ultrasound"},{"key":"BFcr201046_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1136\/pgmj.2004.020172","volume":"81","author":"X Yang","year":"2005","unstructured":"Yang X, Freeman LJ, Ross C . Unoperated tetralogy of Fallot: case report of a natural survivor who died in his 73rd year; is it ever too late to operate? Postgrad Med J 2005; 81:133\u2013134.","journal-title":"Postgrad Med J"},{"key":"BFcr201046_CR5","doi-asserted-by":"publisher","first-page":"I37","DOI":"10.1161\/CIRCULATIONAHA.105.001248","volume":"114","author":"S Reddy","year":"2006","unstructured":"Reddy S, Osorio JC, Duque AM, et al. Failure of right ventricular adaptation in children with tetralogy of Fallot. Circulation 2006; 114:I37\u2013I42.","journal-title":"Circulation"},{"key":"BFcr201046_CR6","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.cardiores.2003.11.033","volume":"61","author":"NC Chi","year":"2004","unstructured":"Chi NC, Karliner JS . Molecular determinants of responses to myocardial ischemia\/reperfusion injury: focus on hypoxia-inducible and heat shock factors. Cardiovasc Res 2004; 61:437\u2013447.","journal-title":"Cardiovasc Res"},{"key":"BFcr201046_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/01.shk.0000170352.72694.36","volume":"24","author":"WJ Chen","year":"2005","unstructured":"Chen WJ, Chen HW, Yu SL, et al. Gene expression profiles in hypoxic preconditioning using cDNA microarray analysis: altered expression of an angiogenic factor, carcinoembryonic antigen-related cell adhesion molecule 1. Shock 2005; 24:124\u2013131.","journal-title":"Shock"},{"key":"BFcr201046_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2739\/kurumemedj.37.177","volume":"37","author":"T Isomura","year":"1990","unstructured":"Isomura T, Hisatomi K, Inuzuka H, et al. Ultrastructural alterations of right and left ventricular myocytes in tetralogy of Fallot. Kurume Med J 1990; 37:177\u2013183.","journal-title":"Kurume Med J"},{"key":"BFcr201046_CR9","first-page":"II63","volume":"17 Suppl 2","author":"AJ Moreno","year":"1998","unstructured":"Moreno AJ, Santos DJ, Palmeira CM . Ischemic heart disease: the role of mitochondria\u2014carvedilol prevents lipid peroxidation of mitochondrial membranes. Rev Port Cardiol 1998; 17 Suppl 2:II63\u2013II77.","journal-title":"Rev Port Cardiol"},{"key":"BFcr201046_CR10","first-page":"190","volume":"13","author":"S DiMauro","year":"1998","unstructured":"DiMauro S, Hirano M . Mitochondria and heart disease. Curr Opin Cardiol 1998; 13:190\u2013197.","journal-title":"Curr Opin Cardiol"},{"key":"BFcr201046_CR11","first-page":"S1","volume":"28","author":"R Ferrari","year":"1996","unstructured":"Ferrari R . The role of mitochondria in ischemic heart disease. J Cardiovasc Pharmacol 1996; 28 Suppl 1:S1\u2013S10.","journal-title":"J Cardiovasc Pharmacol"},{"key":"BFcr201046_CR12","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/BF00252828","volume":"72","author":"I Maurer","year":"1994","unstructured":"Maurer I, Zierz S . Mitochondrial respiratory chain enzyme activities in tetralogy of Fallot. Clin Investig 1994; 72:358\u2013363.","journal-title":"Clin Investig"},{"key":"BFcr201046_CR13","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.cca.2006.09.011","volume":"377","author":"SB Shinde","year":"2007","unstructured":"Shinde SB, Save VC, Patil ND, Mishra KP, Tendolkar AG . Impairment of mitochondrial respiratory chain enzyme activities in tetralogy of Fallot. Clin Chim Acta 2007; 377:138\u2013143.","journal-title":"Clin Chim Acta"},{"key":"BFcr201046_CR14","first-page":"23","volume":"41","author":"GD Kniazeva","year":"1979","unstructured":"Kniazeva GD, Sheremet'eva GF, Konstantinov BA, Kostriukov BM, Liubarskaia AD . (Intraoperative damage to the myocardium and heart failure upon radical correction of the tetralogy of Fallot). Arkh Patol 1979; 41:23\u201329.","journal-title":"Arkh Patol"},{"key":"BFcr201046_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/BF00734511","volume":"411","author":"M Toussaint","year":"1987","unstructured":"Toussaint M, Planche C, Duboc D, et al. Left ventricular ultrastructure in pulmonary stenosis and in tetralogy of Fallot. Virchows Arch A Pathol Anat Histopathol 1987; 411:33\u201338.","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"BFcr201046_CR16","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","volume":"92","author":"P Puigserver","year":"1998","unstructured":"Puigserver P, Wu Z, Park CW, et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92:829\u2013839.","journal-title":"Cell"},{"key":"BFcr201046_CR17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1210\/er.2002-0012","volume":"24","author":"P Puigserver","year":"2003","unstructured":"Puigserver P, Spiegelman BM . Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 2003; 24:78\u201390.","journal-title":"Endocr Rev"},{"key":"BFcr201046_CR18","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","volume":"1","author":"J Lin","year":"2005","unstructured":"Lin J, Handschin C, Spiegelman BM . Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 2005; 1:361\u2013370.","journal-title":"Cell Metab"},{"key":"BFcr201046_CR19","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","volume":"98","author":"Z Wu","year":"1999","unstructured":"Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98:115\u2013124.","journal-title":"Cell"},{"key":"BFcr201046_CR20","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1161\/CIRCULATIONAHA.107.670588","volume":"115","author":"BN Finck","year":"2007","unstructured":"Finck BN, Kelly DP . Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 2007; 115:2540\u20132548.","journal-title":"Circulation"},{"key":"BFcr201046_CR21","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cmet.2005.03.002","volume":"1","author":"Z Arany","year":"2005","unstructured":"Arany Z, He H, Lin J, et al. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab 2005; 1:259\u2013271.","journal-title":"Cell Metab"},{"key":"BFcr201046_CR22","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1172\/JCI24405","volume":"115","author":"JM Huss","year":"2005","unstructured":"Huss JM, Kelly DP . Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest 2005; 115:547\u2013555.","journal-title":"J Clin Invest"},{"key":"BFcr201046_CR23","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/nm778","volume":"8","author":"M Sano","year":"2002","unstructured":"Sano M, Abdellatif M, Oh H, et al. Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nat Med 2002; 8:1310\u20131317.","journal-title":"Nat Med"},{"key":"BFcr201046_CR24","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1172\/JCI10268","volume":"106","author":"JJ Lehman","year":"2000","unstructured":"Lehman JJ, Barger PM, Kovacs A, et al. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 2000; 106:847\u2013856.","journal-title":"J Clin Invest"},{"key":"BFcr201046_CR25","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00109-008-0385-4","volume":"86","author":"H Witt","year":"2008","unstructured":"Witt H, Schubert C, Jaekel J, et al. Sex-specific pathways in early cardiac response to pressure overload in mice. J Mol Med 2008; 86:1013\u20131024.","journal-title":"J Mol Med"},{"key":"BFcr201046_CR26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1046\/j.1440-1681.2002.03655.x","volume":"29","author":"JJ Lehman","year":"2002","unstructured":"Lehman JJ, Kelly DP . Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol 2002; 29:339\u2013345.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFcr201046_CR27","doi-asserted-by":"publisher","first-page":"27186","DOI":"10.1074\/jbc.270.45.27186","volume":"270","author":"SA Hawley","year":"1995","unstructured":"Hawley SA, Selbert MA, Goldstein EG, et al. 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+\/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem 1995; 270:27186\u201327191.","journal-title":"J Biol Chem"},{"key":"BFcr201046_CR28","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1161\/01.RES.0000258446.23525.37","volume":"100","author":"M Arad","year":"2007","unstructured":"Arad M, Seidman CE, Seidman JG . AMP-activated protein kinase in the heart: role during health and disease. Circ Res 2007; 100:474\u2013488.","journal-title":"Circ Res"},{"key":"BFcr201046_CR29","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nature00904","volume":"418","author":"J Lin","year":"2002","unstructured":"Lin J, Wu H, Tarr PT, et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002; 418:797\u2013801.","journal-title":"Nature"},{"key":"BFcr201046_CR30","doi-asserted-by":"publisher","first-page":"e4182","DOI":"10.1371\/journal.pone.0004182","volume":"4","author":"L Zhu","year":"2009","unstructured":"Zhu L, Sun G, Zhang H, et al. PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS One 2009; 4:e4182.","journal-title":"PLoS One"},{"key":"BFcr201046_CR31","doi-asserted-by":"publisher","first-page":"e1137","DOI":"10.1371\/journal.pone.0001137","volume":"2","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Liu C, Zhu L, et al. PGC-1alpha inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells. PLoS One 2007; 2:e1137.","journal-title":"PLoS One"},{"key":"BFcr201046_CR32","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/nature06613","volume":"451","author":"Z Arany","year":"2008","unstructured":"Arany Z, Foo SY, Ma Y, et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 2008; 451:1008\u20131012.","journal-title":"Nature"},{"key":"BFcr201046_CR33","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1523\/JNEUROSCI.5654-07.2008","volume":"28","author":"DR Gutsaeva","year":"2008","unstructured":"Gutsaeva DR, Carraway MS, Suliman HB, et al. Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci 2008; 28:2015\u20132024.","journal-title":"J Neurosci"},{"key":"BFcr201046_CR34","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1161\/STROKEAHA.108.520114","volume":"39","author":"W Yin","year":"2008","unstructured":"Yin W, Signore AP, Iwai M, et al. Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury. Stroke 2008; 39:3057\u20133063.","journal-title":"Stroke"},{"key":"BFcr201046_CR35","doi-asserted-by":"publisher","first-page":"41970","DOI":"10.1074\/jbc.M302403200","volume":"278","author":"S Horman","year":"2003","unstructured":"Horman S, Beauloye C, Vertommen D, et al. Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2. J Biol Chem 2003; 278:41970\u201341976.","journal-title":"J Biol Chem"},{"key":"BFcr201046_CR36","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1074\/jbc.M410213200","volume":"280","author":"J Yang","year":"2005","unstructured":"Yang J, Holman GD . Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes. J Biol Chem 2005; 280:4070\u20134078.","journal-title":"J Biol Chem"},{"key":"BFcr201046_CR37","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1096\/fj.04-3144fje","volume":"19","author":"SB Jorgensen","year":"2005","unstructured":"Jorgensen SB, Wojtaszewski JF, Viollet B, et al. Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J 2005; 19:1146\u20131148.","journal-title":"FASEB J"},{"key":"BFcr201046_CR38","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.bbrc.2005.12.011","volume":"340","author":"WJ Lee","year":"2006","unstructured":"Lee WJ, Kim M, Park HS, et al. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem Biophys Res Commun 2006; 340:291\u2013295.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFcr201046_CR39","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1161\/01.RES.0000117088.36577.EB","volume":"94","author":"LK Russell","year":"2004","unstructured":"Russell LK, Mansfield CM, Lehman JJ, et al. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1\u03b1 promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res 2004; 94:525\u2013533.","journal-title":"Circ Res"},{"key":"BFcr201046_CR40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cell.2007.01.047","volume":"129","author":"R Fukuda","year":"2007","unstructured":"Fukuda R, Zhang H, Kim JW, et al. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007; 129:111\u2013122.","journal-title":"Cell"},{"key":"BFcr201046_CR41","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/cr.2007.11","volume":"17","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Ba Y, Liu C, et al. PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res 2007; 17:363\u2013373.","journal-title":"Cell Res"},{"key":"BFcr201046_CR42","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/jemt.1070270403","volume":"27","author":"CA Mannella","year":"1994","unstructured":"Mannella CA, Marko M, Penczek P, Barnard D, Frank J . The internal compartmentation of rat-liver mitochondria: tomographic study using the high-voltage transmission electron microscope. Microsc Res Tech 1994; 27:278\u2013283.","journal-title":"Microsc Res Tech"},{"key":"BFcr201046_CR43","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1006\/dbio.1999.9524","volume":"216","author":"PB Burton","year":"1999","unstructured":"Burton PB, Raff MC, Kerr P, Yacoub MH, Barton PJ . An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes. Dev Biol 1999; 216:659\u2013670.","journal-title":"Dev Biol"},{"key":"BFcr201046_CR44","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1128\/MCB.16.8.4043","volume":"16","author":"DL Disch","year":"1996","unstructured":"Disch DL, Rader TA, Cresci S, et al. Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression. Mol Cell Biol 1996; 16:4043\u20134051.","journal-title":"Mol Cell Biol"},{"key":"BFcr201046_CR45","doi-asserted-by":"publisher","first-page":"27605","DOI":"10.1074\/jbc.M100277200","volume":"276","author":"JM Huss","year":"2001","unstructured":"Huss JM, Levy FH, Kelly DP . Hypoxia inhibits the peroxisome proliferator-activated receptor alpha\/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation. J Biol Chem 2001; 276:27605\u201327612.","journal-title":"J Biol Chem"},{"key":"BFcr201046_CR46","doi-asserted-by":"publisher","first-page":"L836","DOI":"10.1152\/ajpcell.1998.275.2.C440","volume":"275","author":"HR Wong","year":"1998","unstructured":"Wong HR, Menendez IY, Ryan MA, Denenberg AG, Wispe JR . Increased expression of heat shock protein-70 protects A549 cells against hyperoxia. Am J Physiol 1998; 275:L836\u2013L841.","journal-title":"Am J Physiol"},{"key":"BFcr201046_CR47","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1007\/s00125-005-1713-7","volume":"48","author":"D Konrad","year":"2005","unstructured":"Konrad D, Rudich A, Bilan PJ, et al. Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells. Diabetologia 2005; 48:954\u2013966.","journal-title":"Diabetologia"},{"key":"BFcr201046_CR48","doi-asserted-by":"publisher","first-page":"E1334","DOI":"10.1152\/ajpendo.00516.2001","volume":"282","author":"J Li","year":"2002","unstructured":"Li J, Yu X, Pan W, Unger RH . Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity. Am J Physiol Endocrinol Metab 2002; 282:E1334\u2013E1341.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFcr201046_CR49","doi-asserted-by":"crossref","unstructured":"Lebrecht D, Kirschner J, Geist A, Haberstroh J, Walker UA . Respiratory chain deficiency precedes the disrupted calcium homeostasis in chronic doxorubicin cardiomyopathy. Cardiovasc Pathol 2009 Sep 9. doi:10.1016\/j.carpath.2009.06.006.","DOI":"10.1016\/j.carpath.2009.06.006"},{"key":"BFcr201046_CR50","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1007\/s00125-008-1054-4","volume":"51","author":"LM Cree","year":"2008","unstructured":"Cree LM, Patel SK, Pyle A, et al. Age-related decline in mitochondrial DNA copy number in isolated human pancreatic islets. Diabetologia 2008; 51:1440\u20131443.","journal-title":"Diabetologia"}],"container-title":["Cell Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cr201046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cr201046","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cr201046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:28:15Z","timestamp":1684416495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cr201046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["BFcr201046"],"URL":"https:\/\/doi.org\/10.1038\/cr.2010.46","relation":{},"ISSN":["1001-0602","1748-7838"],"issn-type":[{"value":"1001-0602","type":"print"},{"value":"1748-7838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,6]]}}}