{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:03:43Z","timestamp":1791385423542,"version":"4.3.3"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Res"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1038\/cr.2017.11","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T12:37:19Z","timestamp":1484915839000},"page":"559-577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis"],"prefix":"10.1038","volume":"27","author":[{"given":"Chider","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Moshaverinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"BFcr201711_CR1","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"A Gabrielli","year":"2009","unstructured":"Gabrielli A, Avvedimento EV, Krieg T . Mechanisms of disease scleroderma. N Engl J Med 2009; 360:1989\u20132003.","journal-title":"N Engl J Med"},{"key":"BFcr201711_CR2","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.3899\/jrheum.130032","volume":"40","author":"MA Omair","year":"2013","unstructured":"Omair MA, Pagnoux C, McDonald-Blumer H, Johnson SR . Low bone density in systemic sclerosis. A systematic review. J Rheumatol 2013; 40:1881\u20131890.","journal-title":"J Rheumatol"},{"key":"BFcr201711_CR3","doi-asserted-by":"publisher","first-page":"e66991","DOI":"10.1371\/journal.pone.0066991","volume":"8","author":"M Atteritano","year":"2013","unstructured":"Atteritano M, Sorbara S, Bagnato G, et al. Bone mineral density, bone turnover markers and fractures in patients with systemic sclerosis: a case control study. PLoS One 2013; 8:e66991.","journal-title":"PLoS One"},{"key":"BFcr201711_CR4","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/1756-185X.12242","volume":"19","author":"G Kilic","year":"2016","unstructured":"Kilic G, Kilic E, Akgul O, Ozgocmen S . Increased risk for bone loss in women with systemic sclerosis: a comparative study with rheumatoid arthritis. Int J Rheum Dis 2016; 19:405\u2013411.","journal-title":"Int J Rheum Dis"},{"key":"BFcr201711_CR5","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.joms.2005.11.037","volume":"64","author":"H Mugino","year":"2006","unstructured":"Mugino H, Ikemura K . Progressive systemic sclerosis with spontaneous fracture due to resorption of the mandible: a case report. J Oral Maxillofac Surg 2006; 64:1137\u20131139.","journal-title":"J Oral Maxillofac Surg"},{"key":"BFcr201711_CR6","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1259\/dmfr\/14556986","volume":"34","author":"A Auluck","year":"2005","unstructured":"Auluck A, Pai KM, Shetty C, Shenoi SD . Mandibular resorption in progressive systemic sclerosis: a report of three cases. Dentomaxillofac Radiol 2005; 34:384\u2013386.","journal-title":"Dentomaxillofac Radiol"},{"key":"BFcr201711_CR7","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1080\/03009740600704296","volume":"35","author":"RB Souza","year":"2006","unstructured":"Souza RB, Borges CT, Takayama L, Aldrighi JM, Pereira RM . Systemic sclerosis and bone loss: the role of the disease and body composition. Scand J Rheumatol 2006; 35:384\u2013387.","journal-title":"Scand J Rheumatol"},{"key":"BFcr201711_CR8","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00223-007-9059-4","volume":"81","author":"T Barisic-Dujmovic","year":"2007","unstructured":"Barisic-Dujmovic T, Boban I, Adams DJ, Clark SH . Marfan-like skeletal phenotype in the tight skin (Tsk) mouse. Calcif Tissue Int 2007; 81:305\u2013315.","journal-title":"Calcif Tissue Int"},{"key":"BFcr201711_CR9","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nri1412","volume":"4","author":"TA Wynn","year":"2004","unstructured":"Wynn TA . Fibrotic disease and the T(H)1\/T(H)2 paradigm. Nat Rev Immunol 2004; 4:583\u2013594.","journal-title":"Nat Rev Immunol"},{"key":"BFcr201711_CR10","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1073\/pnas.052709999","volume":"99","author":"T Kodera","year":"2002","unstructured":"Kodera T, McGaha TL, Phelps R, Paul WE, Bona CA . Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts. Proc Natl Acad Sci USA 2002; 99:3800\u20133805.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFcr201711_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1084\/jem.20140643","volume":"212","author":"C Chen","year":"2014","unstructured":"Chen C, Akiyama K, Wang D, et al. IL4R\u03b1-mediated mTOR signaling determines mesenchymal stem cell lineage differentiation in fibrillin-1-mutant-induced osteopenia. J Exp Med 2014; 212:73\u201391.","journal-title":"J Exp Med"},{"key":"BFcr201711_CR12","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","volume":"363","author":"K Le Blanc","year":"2004","unstructured":"Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439\u20131441.","journal-title":"Lancet"},{"key":"BFcr201711_CR13","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/stem.68","volume":"27","author":"L Sun","year":"2009","unstructured":"Sun L, Akiyama K, Zhang H, et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009; 27:1421\u20131432.","journal-title":"Stem Cells"},{"key":"BFcr201711_CR14","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nrrheum.2010.80","volume":"6","author":"J Liang","year":"2010","unstructured":"Liang J, Gu F, Wang H, et al. Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE. Nat Rev Rheumatol 2010; 6:486\u2013489.","journal-title":"Nat Rev Rheumatol"},{"key":"BFcr201711_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/scrt446","volume":"5","author":"X Liu","year":"2014","unstructured":"Liu X, Zheng P, Wang X, et al. A preliminary evaluation of efficacy and safety of Wharton's jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cell Res Ther 2014; 5:57.","journal-title":"Stem Cell Res Ther"},{"key":"BFcr201711_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10067-011-1816-0","volume":"31","author":"J Liang","year":"2012","unstructured":"Liang J, Li X, Zhang H, et al. Allogenic mesenchymal stem cells transplantation in patients with refractory RA. Clin Rheumatol 2012; 31:157\u2013161.","journal-title":"Clin Rheumatol"},{"key":"BFcr201711_CR17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1161\/CIRCRESAHA.110.222703","volume":"107","author":"KE Hatzistergos","year":"2010","unstructured":"Hatzistergos KE, Quevedo H, Oskouei BN, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res 2010; 107:913\u2013922.","journal-title":"Circ Res"},{"key":"BFcr201711_CR18","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1002\/hep.20452","volume":"40","author":"I Sakaida","year":"2004","unstructured":"Sakaida I, Terai S, Yamamoto N, et al. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 2004; 40:1304\u20131311.","journal-title":"Hepatology"},{"key":"BFcr201711_CR19","first-page":"363","volume":"26","author":"Y Yamada","year":"2006","unstructured":"Yamada Y, Ueda M, Hibi H, Baba S . A novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: a clinical case report. Int J Periodontics Restorative Dent 2006; 26:363\u2013369.","journal-title":"Int J Periodontics Restorative Dent"},{"key":"BFcr201711_CR20","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1177\/1545968310369801","volume":"24","author":"NA Kishk","year":"2010","unstructured":"Kishk NA, Gabr H, Hamdy S, et al. Case control series of intrathecal autologus bone marrow mesenchymal stem cell therapy for chronic spinal cord injury. Neurorehabil Neural Repair 2010; 24:702\u2013708.","journal-title":"Neurorehabil Neural Repair"},{"key":"BFcr201711_CR21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jcyt.2012.09.005","volume":"15","author":"J Liu","year":"2013","unstructured":"Liu J, Han D, Wang Z, et al. Clinical analysis of the treatment of spinal cord injury with umbilical cord mesenchymal stem cells. Cytotherapy 2013; 15:185\u2013191.","journal-title":"Cytotherapy"},{"key":"BFcr201711_CR22","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1440-1711.2006.01458.x","volume":"84","author":"X Chen","year":"2006","unstructured":"Chen X, Armstrong MA, Li G . Mesenchymal stem cells in immunoregulation. Immunol Cell Biol 2006; 84:413\u2013421.","journal-title":"Immunol Cell Biol"},{"key":"BFcr201711_CR23","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3727\/096368912X639017","volume":"22","author":"N Scuderi","year":"2013","unstructured":"Scuderi N, Ceccarelli S, Onesti MG, et al. Human adipose-derived stem cells for cell-based therapies in the treatment of systemic sclerosis. Cell Transplant 2013; 22:779\u2013795.","journal-title":"Cell Transplant"},{"key":"BFcr201711_CR24","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","volume":"2","author":"G Ren","year":"2008","unstructured":"Ren G, Zhang L, Zhao X, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2:141\u2013150.","journal-title":"Cell Stem Cell"},{"key":"BFcr201711_CR25","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1182\/blood-2010-12-327353","volume":"118","author":"H Choi","year":"2011","unstructured":"Choi H, Lee RH, Bazhanov N, Oh JY, Prockop DJ . Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2\/NF-kappaB signaling in resident macrophages. Blood 2011; 118:330\u2013338.","journal-title":"Blood"},{"key":"BFcr201711_CR26","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1182\/blood-2003-11-3909","volume":"103","author":"R Meisel","year":"2004","unstructured":"Meisel R, Zibert A, Laryea M, Gobel U, Daubeber W, Dilloo D . Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103:4619\u20134621.","journal-title":"Blood"},{"key":"BFcr201711_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nm.1905","volume":"15","author":"K Nemeth","year":"2009","unstructured":"Nemeth K, Leelahavanichkul A, Yuen PS, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15:42\u201349.","journal-title":"Nat Med"},{"key":"BFcr201711_CR28","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.stem.2012.03.007","volume":"10","author":"K Akiyama","year":"2012","unstructured":"Akiyama K, Chen C, Wang D, et al. Mesenchymal-stem -cell-induced immunoregulation involves FAS-ligand-\/FAS-mediated T cell apoptosis. Cell Stem Cell 2012; 10:544\u2013555.","journal-title":"Cell Stem Cell"},{"key":"BFcr201711_CR29","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/emmm.201303000","volume":"6","author":"C Chen","year":"2014","unstructured":"Chen C, Akiyama K, Yamaza T, et al. Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression. EMBO Mol Med 2014; 6:322\u2013334.","journal-title":"EMBO Mol Med"},{"key":"BFcr201711_CR30","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2014.06.005","volume":"20","author":"J Hayes","year":"2014","unstructured":"Hayes J, Peruzzi PP, Lawler S . MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med 2014; 20:460\u2013469.","journal-title":"Trends Mol Med"},{"key":"BFcr201711_CR31","first-page":"Unit3.22","volume":"Chapter 3","author":"C Thery","year":"2006","unstructured":"Thery C, Amigorena S, Raposo G, Clayton A . Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol 2006; Chapter 3:Unit3.22.","journal-title":"Curr Protoc Cell Biol"},{"key":"BFcr201711_CR32","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.chom.2012.08.010","volume":"12","author":"M Dreux","year":"2012","unstructured":"Dreux M, Garaigorta U, Boyd B, et al. Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Cell Host Microbe 2012; 12:558\u2013570.","journal-title":"Cell Host Microbe"},{"key":"BFcr201711_CR33","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/ni.2647","volume":"14","author":"J Li","year":"2013","unstructured":"Li J, Liu K, Liu Y, et al. Exosomes mediate the cell-to cell transmission of IFN-\u03b1-induced antiviral activity. Nat Immunol 2013; 14:793\u2013803.","journal-title":"Nat Immunol"},{"key":"BFcr201711_CR34","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.cell.2012.11.024","volume":"151","author":"V Luga","year":"2012","unstructured":"Luga V, Zhang L, Viloria-Petit AM, et al. Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 2012; 151:1542\u20131556.","journal-title":"Cell"},{"key":"BFcr201711_CR35","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.cell.2014.09.051","volume":"159","author":"MC Boelens","year":"2014","unstructured":"Boelens MC, Wu TJ, Nabet BY, et al. Exosome transfer from stromal to breast cancer cells regulates therapy resisitance pathways. Cell 2014; 159:499\u2013513.","journal-title":"Cell"},{"key":"BFcr201711_CR36","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.cmet.2015.08.018","volume":"22","author":"S Liu","year":"2015","unstructured":"Liu S, Liu D, Chen C, et al. MSC transplantation improves osteopenia via epigenetic regulation of Notch signaling in lupus. Cell Metab 2015; 22:606\u2013618.","journal-title":"Cell Metab"},{"key":"BFcr201711_CR37","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1177\/0022034514552675","volume":"93","author":"Y Liu","year":"2014","unstructured":"Liu Y, Wang L, Liu S, et al. Transplantation of SHED prevents bone loss in the early phase of ovariectomy-induced osteoporosis. J Dent Res 2014; 93:1124\u201332.","journal-title":"J Dent Res"},{"key":"BFcr201711_CR38","doi-asserted-by":"publisher","first-page":"ra63","DOI":"10.1126\/scisignal.2005231","volume":"7","author":"M Ono","year":"2014","unstructured":"Ono M, Kosaka N, Tominaga N, et al. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal 2014; 7:ra63.","journal-title":"Sci Signal"},{"key":"BFcr201711_CR39","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s13287-015-0116-z","volume":"6","author":"SR Baglio","year":"2015","unstructured":"Baglio SR, Rooijers K, Koppers-Lalic D, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther 2015; 6:127.","journal-title":"Stem Cell Res Ther"},{"key":"BFcr201711_CR40","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/mt.2016.90","volume":"24","author":"B Wang","year":"2016","unstructured":"Wang B, Yao K, Huuskes BM, et al. Mesenchymal stem cells deliver exogenous microRNA-let7c via exosomes to attenuate renal fibrosis. Mol Ther 2016; 24:1290\u20131301.","journal-title":"Mol Ther"},{"key":"BFcr201711_CR41","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1038\/sj.mt.6300311","volume":"15","author":"HS Soifer","year":"2007","unstructured":"Soifer HS, Rossi JJ, Saetrom P . MicroRNAs in disease and potential therapeutic applications. Mol Ther 2007; 15:2070\u20132079.","journal-title":"Mol Ther"},{"key":"BFcr201711_CR42","doi-asserted-by":"publisher","first-page":"jev.v2i0.20360","DOI":"10.3402\/jev.v2i0.20360","volume":"2","author":"KW Witwer","year":"2013","unstructured":"Witwer KW, Buzas EI, Bemis LT, et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles 2013; 2:jev.v2i0.20360.","journal-title":"J Extracell Vesicles"},{"key":"BFcr201711_CR43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ncb2000","volume":"12","author":"M Ostrowski","year":"2010","unstructured":"Ostrowski M, Carmo NB, Krumeich S, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 2010; 12:19\u201330.","journal-title":"Nat Cell Biol"},{"key":"BFcr201711_CR44","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1182\/blood-2007-02-069716","volume":"110","author":"AJ Nauta","year":"2007","unstructured":"Nauta AJ, Fibbe WE . Immunomodulatory properties of mesenchymal stem cells. Blood 2007; 110:3499\u20133506.","journal-title":"Blood"},{"key":"BFcr201711_CR45","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","volume":"8","author":"A Uccelli","year":"2008","unstructured":"Uccelli A, Moretta L, Pistoia V . Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008; 8:726\u2013736.","journal-title":"Nat Rev Immunol"},{"key":"BFcr201711_CR46","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1749-6632.2009.04607.x","volume":"1176","author":"ME Bernardo","year":"2009","unstructured":"Bernardo ME, Locatelli F, Fibbe WE . Mesenchymal stromal cells. Ann NY Acad Sci 2009; 1176:101\u2013117.","journal-title":"Ann NY Acad Sci"},{"key":"BFcr201711_CR47","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/art.39477","volume":"68","author":"AT Maria","year":"2016","unstructured":"Maria AT, Toupet K, Bony C, et al. Antifibrotic, Antioxidant, and immunomodulatory effects of mesenchymal stem cells in HOCl-induced systemic sclerosis. Arthritis Rheumatol 2016; 68:1013\u20131025.","journal-title":"Arthritis Rheumatol"},{"key":"BFcr201711_CR48","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jaut.2016.03.013","volume":"70","author":"AT Maria","year":"2016","unstructured":"Maria AT, Toupet K, Maumus M, et al. Human adipose mesenchymal stem cells as potent anti-fibrosis for systemic sclerosis. J Autoimmun 2016; 70:31\u201339.","journal-title":"J Autoimmun"},{"key":"BFcr201711_CR49","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1002\/art.38674","volume":"66","author":"D Wang","year":"2014","unstructured":"Wang D, Feng X, Lu L, et al. A CD8 T cell\/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus. Arthritis Rheumatol 2014; 66:2234\u20132245.","journal-title":"Arthritis Rheumatol"},{"key":"BFcr201711_CR50","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1152\/physrev.00019.2015","volume":"96","author":"S Golpanian","year":"2016","unstructured":"Golpanian S, Wolf A, Hatzistergos KE, Hare JM . Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue. Physiol Rev 2016; 96:1127\u20131168.","journal-title":"Physiol Rev"},{"key":"BFcr201711_CR51","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3109\/02699052.2015.1053525","volume":"29","author":"I Mastro-Martinez","year":"2015","unstructured":"Mastro-Martinez I, Perez-Suarez E, Melen G, et al. Effects of local administration of allogenic adipose tissue-derived mesenchymal stem cells on functional recovery in experimental traumatic brain injury. Brain Inj 2015; 29:1497\u20131510.","journal-title":"Brain Inj"},{"key":"BFcr201711_CR52","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1182\/blood-2011-02-338004","volume":"119","author":"A Montecalvo","year":"2012","unstructured":"Montecalvo A, Larregina AT, Shufesky WJ, et al. Mechanism of transfer of functional microRNAs between mouse dentritic cells via exosomes. Blood 2012; 119:756\u2013766.","journal-title":"Blood"},{"key":"BFcr201711_CR53","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1038\/jcbfm.2013.152","volume":"33","author":"H Xin","year":"2013","unstructured":"Xin H, Li Y, Cui Y, Yang JJ, Zhang ZG, Chopp M . Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 2013; 33:1711\u20131715.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFcr201711_CR54","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1089\/scd.2012.0395","volume":"15","author":"T Li","year":"2013","unstructured":"Li T, Yan Y, Wang B, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cell Dev 2013; 15:845\u2013854.","journal-title":"Stem Cell Dev"},{"key":"BFcr201711_CR55","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2217\/rme.11.35","volume":"6","author":"RC Lai","year":"2011","unstructured":"Lai RC, Chen TS, Lim SK . Mesenchymal stem cell exosome: a novel stem cell therapy for cardiovascular disease. Regen Med 2011; 6:481\u2013492.","journal-title":"Regen Med"},{"key":"BFcr201711_CR56","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.addr.2012.07.001","volume":"65","author":"RW Yeo","year":"2013","unstructured":"Yeo RW, Lai RC, Zhang B, et al. Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. Adv Drug Deliv Rev 2013; 65:336\u2013341.","journal-title":"Adv Drug Deliv Rev"},{"key":"BFcr201711_CR57","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/gene.2014.44","volume":"15","author":"M Ciechomska","year":"2014","unstructured":"Ciechomska M, van Laar JM, O'Reilly S . Emerging role of epigenetics in systemic sclerosis pathogenesis. Genes Immun 2014; 15:433\u2013439.","journal-title":"Genes Immun"},{"key":"BFcr201711_CR58","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.autrev.2013.04.004","volume":"12","author":"SA Jimenes","year":"2013","unstructured":"Jimenes SA, Piera-Velazquez S . Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of systemic sclerosis and Sjogern's syndrome. Autoimmun Rev 2013; 12:1046\u20131051.","journal-title":"Autoimmun Rev"},{"key":"BFcr201711_CR59","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.gpb.2015.07.001","volume":"13","author":"Y Li","year":"2015","unstructured":"Li Y, Huang J, Guo M, Zuo X . MicroRNAs regulating signaling pathways: potential biomarkers in systemic sclerosis. Genomics Proteomics Bioinformatics 2015; 13:234\u2013241.","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"BFcr201711_CR60","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/stem.1623","volume":"32","author":"EA Clark","year":"2014","unstructured":"Clark EA, Kalomoiris S, Nolta JA, Fierro FA . Concise review: microRNA function in multipotent mesenchymal stem cells. Stem Cells 2014; 32:1074\u20131082.","journal-title":"Stem Cells"},{"key":"BFcr201711_CR61","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1172\/JCI77716","volume":"125","author":"CJ Li","year":"2015","unstructured":"Li CJ, Cheng P, Liang MK, et al. MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest 2015; 125:1509\u20131522.","journal-title":"J Clin Invest"},{"key":"BFcr201711_CR62","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/gt.2011.50","volume":"18","author":"JA Broderick","year":"2011","unstructured":"Broderick JA, Zamore PD . MicroRNA therapeutics. Gene Therapy 2011; 18:1104\u20131110.","journal-title":"Gene Therapy"},{"key":"BFcr201711_CR63","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/nm.1880","volume":"14","author":"D Bonci","year":"2008","unstructured":"Bonci D, Coppola V, Musumeci M, et al. The miR15a-miR16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 2008; 14:1271\u20137.","journal-title":"Nat Med"},{"key":"BFcr201711_CR64","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nprot.2009.238","volume":"5","author":"H Zhu","year":"2010","unstructured":"Zhu H, Guo ZK, Jiang XX, et al. A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc 2010; 5:550\u2013560.","journal-title":"Nat Protoc"},{"key":"BFcr201711_CR65","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nprot.2008.221","volume":"4","author":"M Soleimani","year":"2009","unstructured":"Soleimani M, Nadri S . A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protoc 2009; 4:102\u2013106.","journal-title":"Nat Protoc"},{"key":"BFcr201711_CR66","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1634\/stemcells.2005-0403","volume":"24","author":"M Miura","year":"2006","unstructured":"Miura M, Miura Y, Padilla-Nash HM, et al. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 2006; 24:1095\u20131103.","journal-title":"Stem Cells"},{"key":"BFcr201711_CR67","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/stem.1069","volume":"30","author":"SV Boregowda","year":"2012","unstructured":"Boregowda SV, Krishnappa V, Chambers JW, et al. Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: implications for long-term culture expansion. Stem Cells 2012; 30:975\u2013987.","journal-title":"Stem Cells"},{"key":"BFcr201711_CR68","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1002\/jcb.24166","volume":"113","author":"DG Phinney","year":"2012","unstructured":"Phinney DG . Functional heterogeneity of mesenchymal stem cells: implications for cell therapy. J Cell Biochem 2012; 113:2806\u20132812.","journal-title":"J Cell Biochem"}],"container-title":["Cell Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/cr201711.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cr201711","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/cr201711.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:39:10Z","timestamp":1684417150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/cr201711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,20]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["BFcr201711"],"URL":"https:\/\/doi.org\/10.1038\/cr.2017.11","relation":{},"ISSN":["1001-0602","1748-7838"],"issn-type":[{"value":"1001-0602","type":"print"},{"value":"1748-7838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,20]]},"assertion":[{"value":"11 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}