{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:09:40Z","timestamp":1790100580043,"version":"4.0.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1038\/ctg.2016.67","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T10:41:43Z","timestamp":1483612903000},"page":"e212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Gastrointestinal Transcriptomic Response of Metabolic Vitamin B12 Pathways in Roux-en-Y Gastric Bypass"],"prefix":"10.14309","volume":"8","author":[{"given":"Priscila","family":"Sala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giliane","family":"Belarmino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel S","family":"Torrinhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha M","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle C","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziela R","family":"Ravacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson K","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael F M S","family":"Guarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo G","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A","family":"Santo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael D C G","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia C A","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela F","family":"Logullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Heymsfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Giannella-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan L","family":"Waitzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210317","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ncpcardio0349","article-title":"Therapy insight: weight loss surgery and major cardiovascular risk factors.","volume":"2","author":"Blackburn","year":"2005","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"R2-4-20210317","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1172\/JCI76305","article-title":"Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms.","volume":"125","author":"Manning","year":"2015","journal-title":"J Clin Invest"},{"key":"R3-4-20210317","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.soard.2014.08.007","article-title":"Self-report of gastrointestinal side effects after bariatric surgery.","volume":"10","author":"Kalarchian","year":"2014","journal-title":"Surg Obes Relat Dis"},{"key":"R4-4-20210317","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s11695-013-0919-x","article-title":"Screening and diagnosis of micronutrient deficiencies before and after bariatric surgery.","volume":"23","author":"Gudzune","year":"2013","journal-title":"Obes Surg"},{"key":"R5-4-20210317","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrgastro.2012.76","article-title":"Vitamin B12 transport from food to the bodys cellsa sophisticated, multistep pathway.","volume":"9","author":"Nielsen","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R6-4-20210317","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1177\/15648265080292S107","article-title":"Review of the magnitude of folate and vitamin B12 deficiencies worldwide.","volume":"29","author":"McLean","year":"2008","journal-title":"Food Nutr Bull"},{"key":"R7-4-20210317","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1381\/0960892053268264","article-title":"Nutritional deficiencies following bariatric surgery: what have we learned?","volume":"15","author":"Bloomberg","year":"2005","journal-title":"Obes Surg"},{"key":"R8-4-20210317","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00004836-200404000-00004","article-title":"Medical and gastroenterologic management of the post-bariatric surgery patient.","volume":"38","author":"Ukleja","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"R9-4-20210317","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1557-0843(10)80009-0","article-title":"Durable remission of diabetes after bariatric surgery: what is the underlying pathway?","volume":"5","author":"Wilson","year":"2010","journal-title":"Insulin"},{"key":"R10-4-20210317","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.med.051308.105148","article-title":"Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action.","volume":"61","author":"Rubino","year":"2010","journal-title":"Annu Rev Med"},{"key":"R11-4-20210317","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ajcn\/63.1.103","article-title":"Vitamin B-12 deficiency after gastric surgery for obesity.","volume":"63","author":"Rhode","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"R12-4-20210317","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mam.2005.12.003","article-title":"RNA integrity and the effect on the real-time qRT-PCR performance.","volume":"27","author":"Fleige","year":"2006","journal-title":"Mol Aspects Med"},{"key":"R13-4-20210317","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data.","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"R14-4-20210317","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods.","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"R15-4-20210317","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.febslet.2004.07.055","article-title":"Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments.","volume":"573","author":"Breitling","year":"2004","journal-title":"FEBS Lett"},{"key":"R16-4-20210317","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing.","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc B"},{"key":"R18-4-20210317","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s11695-012-0696-y","article-title":"Nutritional profile of patients before and after Roux-en-Y gastric bypass: 3-year follow-up.","volume":"22","author":"Blume","year":"2012","journal-title":"Obes Surg"},{"key":"R19-4-20210317","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/MCO.0b013e32832e1b14","article-title":"Endocrine and metabolic response to gastric bypass.","volume":"12","author":"Saliba","year":"2009","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"R20-4-20210317","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1251\/bpo126","article-title":"Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR.","volume":"8","author":"Morey","year":"2006","journal-title":"Biol Proced Online"},{"key":"R21-4-20210317","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1097\/MD.0000000000000169","article-title":"Optimization of vitamin supplementation after Roux-en-Y gastric bypass surgery can lower postoperative deficiencies: a randomized controlled trial.","volume":"93","author":"Dogan","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"R22-4-20210317","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00000658-199307000-00014","article-title":"Gastric acid secretion and vitamin B12 absorption after vertical Roux-en-Y gastric bypass for morbid obesity.","volume":"218","author":"Smith","year":"1993","journal-title":"Ann Surg"},{"key":"R23-4-20210317","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/oby.20461","article-title":"Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient - 2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic Bariatric Surgery.","volume":"1","author":"Mechanick","year":"2013","journal-title":"Obesity"},{"key":"R24-4-20210317","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/fampra\/cml008","article-title":"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials.","volume":"23","author":"Butler","year":"2006","journal-title":"Fam Pract"},{"key":"R25-4-20210317","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3109\/00365528708991952","article-title":"Effect of gastric anacidity on the release of cobalamins from food and their subsequent binding to R-protein.","volume":"22","author":"Kittang","year":"1987","journal-title":"Scand J Gastroenterol"},{"key":"R26-4-20210317","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1136\/gut.30.12.1686","article-title":"Vitamin B12 absorption and malabsorption.","volume":"30","author":"Schjonsby","year":"1989","journal-title":"Gut"},{"key":"R27-4-20210317","first-page":"303","article-title":"Human gastric intrinsic factor expression is not restricted to parietal cells.","volume":"189","author":"Howard","year":"1996","journal-title":"J Anat"},{"key":"R28-4-20210317","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1007\/s10620-011-1738-3","article-title":"production of ectopic gastric intrinsic factor in gastric mucosa of humans with chronic gastritis.","volume":"56","author":"Shao","year":"2011","journal-title":"Dig Dis Sci"},{"key":"R29-4-20210317","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1172\/JCI108924","article-title":"Effect of proteolytic enzymes on the binding of cobalamin to R protein and intrinsic factor. In vitro evidence that a failure to partially degrade R protein is responsible for cobalamin malabsorption in pancreatic insufficiency.","volume":"61","author":"Allen","year":"1978","journal-title":"J Clin Invest"},{"key":"R30-4-20210317","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s11695-014-1441-5","article-title":"Effectiveness of B vitamin supplementation following bariatric surgery: rapid increases of serum vitamin B12.","volume":"25","author":"Moore","year":"2015","journal-title":"Obes Surg"},{"key":"R31-4-20210317","first-page":"79","article-title":"Vitamin B12 malabsorption after jejuno-ileal bypass surgery.","volume":"39","author":"Bero","year":"1982","journal-title":"Acta Med Acad Sci Hung"},{"key":"R32-4-20210317","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.soard.2013.12.005","article-title":"Anemia, iron and vitamin B12 deficiencies after sleeve gastrectomy compared to Roux-en-Y gastric bypass: a meta-analysis.","volume":"10","author":"Kwon","year":"2014","journal-title":"Surg Obes Relat Dis"},{"key":"R33-4-20210317","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.soard.2013.07.014","article-title":"Cross-sectional long-term micronutrient deficiencies after sleeve gastrectomy versus Roux-en-Y gastric bypass: a pilot study.","volume":"10","author":"Alexandrou","year":"2014","journal-title":"Surg Obes Relat Dis"},{"key":"R34-4-20210317","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4088\/PCC.08l00707","article-title":"Vitamin B12 deficiency and depression in the elderly: review and case report.","volume":"11","author":"Hanna","year":"2009","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"R35-4-20210317","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1515\/CCLM.2003.159","article-title":"A two-step method for the extraction of high-quality RNA from endoscopic biopsies.","volume":"41","author":"Wex","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"R36-4-20210317","doi-asserted-by":"crossref","first-page":"e21043","DOI":"10.1371\/journal.pone.0021043","article-title":"Formalin fixation at low temperature better preserves nucleic acid integrity.","volume":"6","author":"Bussolati","year":"2011","journal-title":"PLoS One"},{"key":"R37-4-20210317","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s12015-010-9197-3","article-title":"Human stem cell cultures from cleft lippalate patients show enrichment of transcripts involved in extracellular matrix modeling by comparison to controls.","volume":"7","author":"Bueno","year":"2011","journal-title":"Stem Cell Rev"},{"key":"R38-4-20210317","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/physiolgenomics.00058.2012","article-title":"Whole-blood genome-wide gene expression profile in males after prolonged wakefulness and sleep.","volume":"44","author":"Pellegrino","year":"2012","journal-title":"Physiol Genomics"},{"key":"R39-4-20210317","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/mp.2014.141","article-title":"Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons.","volume":"20","author":"Griesi-Oliveira","year":"2015","journal-title":"Mol Psychiatry"},{"key":"R40-4-20210317","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ymeth.2013.03.027","article-title":"On the importance of small changes in RNA expression.","volume":"63","author":"St Laurent","year":"2013","journal-title":"Methods"},{"key":"R41-4-20210317","doi-asserted-by":"crossref","first-page":"e52242","DOI":"10.1371\/journal.pone.0052242","article-title":"Cross-study homogeneity of psoriasis gene expression in skin across a large expression range.","volume":"8","author":"Bigler","year":"2013","journal-title":"PLoS One"},{"key":"R42-4-20210317","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrm778","article-title":"Megalin and cubilin: multifunctional endocytic receptors.","volume":"3","author":"Christensen","year":"2002","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Clinical and Translational Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ctg201667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ctg201667","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/01720094-201701000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/ctg201667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:15:01Z","timestamp":1786547701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01720094-201701000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1038\/ctg.2016.67","relation":{},"ISSN":["2155-384X"],"issn-type":[{"value":"2155-384X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}