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EBV vaccines to prevent primary infection or disease, or therapeutic vaccines to treat EBV malignancies have not been licensed. Most efforts to develop prophylactic vaccines have focused on EBV gp350, which is the major target of neutralizing antibody. A single phase 2 trial of an EBV gp350 vaccine has been reported; the vaccine reduced the rate of IM but not virus infection. The observation that infusion of EBV\u2010specific T cells can reduce disease due to Hodgkin lymphoma and nasopharyngeal carcinoma provides a proof of principle that a therapeutic vaccine for these and other EBV\u2010associated malignancies might be effective. Most therapeutic vaccines have targeted EBV LMP2 and EBV nuclear antigen\u20101. As EBV is associated with nearly 200 000 new malignancies each year worldwide, an EBV vaccine to prevent these diseases is needed.<\/jats:p>","DOI":"10.1038\/cti.2014.27","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T08:14:05Z","timestamp":1422000845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Epstein\u2013barr virus vaccines"],"prefix":"10.1002","volume":"4","author":[{"given":"Jeffrey I","family":"Cohen","sequence":"first","affiliation":[{"name":"Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health  Bethesda MD 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