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EBV, a lymphocrytovirus and a member of the \u03b3\u2010herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8<jats:sup>+<\/jats:sup> T lymphocytes directed against EBV\u2010infected B cells. During convalescence, CD8<jats:sup>+<\/jats:sup> T cells return to normal levels and antibodies develop against EBV nuclear antigen\u20101. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV\u2010specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long\u2010term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti\u2010EBV drugs to treat infectious mononucleosis and other EBV\u2010spurred diseases.<\/jats:p>","DOI":"10.1038\/cti.2015.1","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T08:13:29Z","timestamp":1425024809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":221,"title":["Infectious mononucleosis"],"prefix":"10.1002","volume":"4","author":[{"suffix":"Jr","given":"Henry H","family":"Balfour","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota Medical School  Minneapolis MN USA"},{"name":"Department of Pediatrics, University of Minnesota Medical School  Minneapolis MN 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