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We previously found a correlation between the maturation state of the NK cell compartment and a lower viral load by studying patients from the ANRS 147 Optiprim trial. We investigated here extensively the NKG2C<jats:sup>+<\/jats:sup> NK cells at the time of PHI and its evolution after 3 months of early antiretroviral therapy (combination antiretroviral therapy (cART)). Multiparametric cytometry combined with bioinformatics was used to determine subsets. NK<jats:sup>bright<\/jats:sup> NKG2C<jats:sup>+<\/jats:sup> progenitor, NK<jats:sup>dim<\/jats:sup> NKG2C<jats:sup>+<\/jats:sup> effector and NK<jats:sup>dim<\/jats:sup> NKG2C<jats:sup>+<\/jats:sup>CD57<jats:sup>+<\/jats:sup> memory\u2010like populations were identified. Two groups of patients were unraveled according to the distribution of the NKG2C<jats:sup>+<\/jats:sup> subsets skewed toward either progenitor\/effector or memory\u2010like phenotype. Patients with high NKG2C<jats:sup>+<\/jats:sup>CD57<jats:sup>+<\/jats:sup> NK cell frequencies showed lower HIV\u2010RNA, lower immune activation, higher pDC counts and reached more rapidly undetectable levels of HIV\u2010RNA at M1 under cART. NKG2C<jats:sup>+<\/jats:sup>CD57<jats:sup>+<\/jats:sup> NK cell frequency was the only factor strongly correlated to low viral load among other clinical features. While the patients were cytomegalovirus (CMV) infected, there was no sign of reactivation of CMV during PHI suggesting that memory\u2010like NK cells were already present at the time of HIV infection and constituted a preexisting immune response able to contribute to natural control of HIV. This parameter appears to be a good candidate in the search of predictive markers to monitor HIV remission.<\/jats:p>","DOI":"10.1038\/cti.2017.22","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T07:21:17Z","timestamp":1499412077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["NKG2C<sup>+<\/sup> memory\u2010like NK cells contribute to the control of HIV viremia during primary infection: Optiprim\u2010ANRS 147"],"prefix":"10.1002","volume":"6","author":[{"given":"Fran\u00e7oise","family":"Gondois\u2010Rey","sequence":"first","affiliation":[{"name":"Aix Marseille University, CNRS, Inserm, Institut Paoli\u2010Calmettes, CRCM, Department of Immunity and Cancer  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Ch\u00e9ret","sequence":"additional","affiliation":[{"name":"Department of Internal Medecine, H\u00f4pital 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