{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T02:52:15Z","timestamp":1721875935715},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T00:00:00Z","timestamp":1283904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T00:00:00Z","timestamp":1283904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1038\/ejcn.2010.155","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T09:27:43Z","timestamp":1283938063000},"page":"1266-1271","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of folinic acid supplementation on homocysteine concentrations in newborns"],"prefix":"10.1038","volume":"64","author":[{"given":"M","family":"Hogeveen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"den Heijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Schonbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ijland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"van Oppenraaij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J K","family":"Gunnewiek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Blom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,9,8]]},"reference":[{"key":"BFejcn2010155_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0049-3848(01)00226-2","volume":"102","author":"N Akar","year":"2001","unstructured":"Akar N, Akar E, Ozel D, Deda G, Sipahi T (2001). Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res 102, 115\u2013120.","journal-title":"Thromb Res"},{"key":"BFejcn2010155_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/ajcn\/78.1.7","volume":"78","author":"AL Bjorke Monsen","year":"2003","unstructured":"Bjorke Monsen AL, Ueland PM (2003). Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence. Am J Clin Nutr 78, 7\u201321.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2010155_CR3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1542\/peds.108.3.624","volume":"108","author":"AL Bjorke Monsen","year":"2001","unstructured":"Bjorke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E et al. (2001). Determinants of cobalamin status in newborns. Pediatrics 108, 624\u2013630.","journal-title":"Pediatrics"},{"key":"BFejcn2010155_CR4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1542\/peds.2007-2716","volume":"122","author":"AL Bjorke-Monsen","year":"2008","unstructured":"Bjorke-Monsen AL, Torsvik I, Saetran H, Markestad T, Ueland PM (2008). Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation. Pediatrics 122, 83\u201391.","journal-title":"Pediatrics"},{"key":"BFejcn2010155_CR5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3109\/00365518809167487","volume":"48","author":"LE Brattstrom","year":"1988","unstructured":"Brattstrom LE, Israelsson B, Jeppsson JO, Hultberg BL (1988). Folic acid\u2014an innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest 48, 215\u2013221.","journal-title":"Scand J Clin Lab Invest"},{"key":"BFejcn2010155_CR6","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1159\/000046264","volume":"21","author":"G Buccianti","year":"2001","unstructured":"Buccianti G, Bamonti CF, Patrosso C, Corghi E, Novembrino C, Baragetti I et al. (2001). Reduction of the homocysteine plasma concentration by intravenously administered folinic acid and vitamin B(12) in uraemic patients on maintenance haemodialysis. Am J Nephrol 21, 294\u2013299.","journal-title":"Am J Nephrol"},{"key":"BFejcn2010155_CR7","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/sj.ejcn.1602528","volume":"61","author":"FD Couto","year":"2007","unstructured":"Couto FD, Moreira LM, Dos Santos DB, Reis MG, Goncalves MS (2007). Folate, vitamin B12 and total homocysteine levels in neonates from Brazil. Eur J Clin Nutr 61, 382\u2013386.","journal-title":"Eur J Clin Nutr"},{"key":"BFejcn2010155_CR8","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1055\/s-0037-1615380","volume":"80","author":"M den Heijer","year":"1998","unstructured":"den Heijer M, Rosendaal FR, Blom HJ, Gerrits WB, Bos GM (1998). Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb Haemost 80, 874\u2013877.","journal-title":"Thromb Haemost"},{"key":"BFejcn2010155_CR9","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/ndt\/17.5.865","volume":"17","author":"D Ducloux","year":"2002","unstructured":"Ducloux D, Aboubakr A, Motte G, Toubin G, Fournier V, Chalopin JM et al. (2002). Hyperhomocysteinaemia therapy in haemodialysis patients: folinic versus folic acid in combination with vitamin B6 and B12. Nephrol Dial Transplant 17, 865\u2013870.","journal-title":"Nephrol Dial Transplant"},{"key":"BFejcn2010155_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/j.1651-2227.2002.tb03268.x","volume":"91","author":"MR Fokkema","year":"2002","unstructured":"Fokkema MR, Woltil HA, van Beusekom CM, Schaafsma A, Dijck-Brouwer DA, Muskiet FA (2002). Plasma total homocysteine increases from day 20 to 40 in breastfed but not formula-fed low-birthweight infants. Acta Paediatr 91, 507\u2013511.","journal-title":"Acta Paediatr"},{"key":"BFejcn2010155_CR11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/BF02073891","volume":"151","author":"NJ Fuller","year":"1992","unstructured":"Fuller NJ, Bates CJ, Cole TJ, Lucas A (1992). Plasma folate levels in preterm infants, with and without a 1\u2009mg daily folate supplement. Eur J Pediatr 151, 48\u201350.","journal-title":"Eur J Pediatr"},{"key":"BFejcn2010155_CR12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1055\/s-2005-872396","volume":"5","author":"H Gellekink","year":"2005","unstructured":"Gellekink H, den Heijer M, Heil SG, Blom HJ (2005). Genetic determinants of plasma total homocysteine. Semin Vasc Med 5, 98\u2013109.","journal-title":"Semin Vasc Med"},{"key":"BFejcn2010155_CR13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1053\/j.semperi.2007.06.001","volume":"31","author":"EF Grabowski","year":"2007","unstructured":"Grabowski EF, Buonanno FS, Krishnamoorthy K (2007). Prothrombotic risk factors in the evaluation and management of perinatal stroke. Semin Perinatol 31, 243\u2013249.","journal-title":"Semin Perinatol"},{"key":"BFejcn2010155_CR14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1471-0528.2002.01307.x","volume":"109","author":"EM Guerra-Shinohara","year":"2002","unstructured":"Guerra-Shinohara EM, Paiva AA, Rondo PH, Yamasaki K, Terzi CA, D\u2019Almeida V (2002). Relationship between total homocysteine and folate levels in pregnant women and their newborn babies according to maternal serum levels of vitamin B12. BJOG 109, 784\u2013791.","journal-title":"BJOG"},{"key":"BFejcn2010155_CR15","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/S0272-6386(01)80125-6","volume":"37","author":"AC Hauser","year":"2001","unstructured":"Hauser AC, Hagen W, Rehak PH, Buchmayer H, Fodinger M, Papagiannopoulos M et al. (2001). Efficacy of folinic versus folic acid for the correction of hyperhomocysteinemia in hemodialysis patients. Am J Kidney Dis 37, 758\u2013765.","journal-title":"Am J Kidney Dis"},{"key":"BFejcn2010155_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2174\/138920007779315008","volume":"8","author":"W Herrmann","year":"2007","unstructured":"Herrmann W, Herrmann M, Obeid R (2007). Hyperhomocysteinaemia: a critical review of old and new aspects. Curr Drug Metab 8, 17\u201331.","journal-title":"Curr Drug Metab"},{"key":"BFejcn2010155_CR17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1067\/mpd.2002.126598","volume":"141","author":"M Hogeveen","year":"2002","unstructured":"Hogeveen M, Blom HJ, Van Amerongen M, Boogmans B, van Beynum I, van de Bor M (2002). Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants. J Pediatr 141, 429\u2013431.","journal-title":"J Pediatr"},{"key":"BFejcn2010155_CR18","first-page":"S59","volume":"52","author":"Homocysteine Lowering Trialists\u2019 Collaboration","year":"2000","unstructured":"Homocysteine Lowering Trialists\u2019 Collaboration (2000). Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Indian Heart J 52, S59\u2013S64.","journal-title":"Indian Heart J"},{"key":"BFejcn2010155_CR19","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/ajcn\/82.4.806","volume":"82","author":"Homocysteine Lowering Trialists\u2019 Collaboration","year":"2005","unstructured":"Homocysteine Lowering Trialists\u2019 Collaboration (2005). Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 82, 806\u2013812.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2010155_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000014143","volume":"76","author":"P Hongsprabhas","year":"1999","unstructured":"Hongsprabhas P, Saboohi F, Aranda JV, Bardin CL, Kovacs LB, Papageorgiou AN et al. (1999). Plasma homocysteine concentrations of preterm infants. Biol Neonate 76, 65\u201371.","journal-title":"Biol Neonate"},{"key":"BFejcn2010155_CR21","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1159\/000103745","volume":"92","author":"S Jyothi","year":"2007","unstructured":"Jyothi S, Misra I, Morris G, Benton A, Griffin D, Allen S (2007). Red cell folate and plasma homocysteine in preterm infants. Neonatology 92, 264\u2013268.","journal-title":"Neonatology"},{"key":"BFejcn2010155_CR22","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1177\/147323000703500313","volume":"35","author":"F Karademir","year":"2007","unstructured":"Karademir F, Suleymanoglu S, Ersen A, Aydinoz S, Gultepe M, Meral C et al. (2007). Vitamin B12, folate, homocysteine and urinary methylmalonic acid levels in infants. J Int Med Res 35, 384\u2013388.","journal-title":"J Int Med Res"},{"key":"BFejcn2010155_CR23","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/ajcn\/72.3.751","volume":"72","author":"JC Minet","year":"2000","unstructured":"Minet JC, Bisse E, Aebischer CP, Beil A, Wieland H, Lutschg J (2000). Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates. Am J Clin Nutr 72, 751\u2013757.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2010155_CR24","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1067\/mob.2002.121105","volume":"186","author":"AM Molloy","year":"2002","unstructured":"Molloy AM, Mills JL, McPartlin J, Kirke PN, Scott JM, Daly S (2002). Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C-->T variant. Am J Obstet Gynecol 186, 499\u2013503.","journal-title":"Am J Obstet Gynecol"},{"key":"BFejcn2010155_CR25","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1542\/peds.2007-0336","volume":"120","author":"TN Raju","year":"2007","unstructured":"Raju TN, Nelson KB, Ferriero D, Lynch JK (2007). Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics 120, 609\u2013616.","journal-title":"Pediatrics"},{"key":"BFejcn2010155_CR26","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1373\/clinchem.2004.036194","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum H, Grindflek AW, Ueland PM, Fredriksen A, Meyer K, Ulvik A et al. (2004). Screening for serum total homocysteine in newborn children. Clin Chem 50, 1769\u20131784.","journal-title":"Clin Chem"},{"key":"BFejcn2010155_CR27","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1365-277X.2004.00550.x","volume":"17","author":"K Schulpis","year":"2004","unstructured":"Schulpis K, Spiropoulos A, Gavrili S, Karikas G, Grigori C, Vlachos G et al. (2004). Maternal\u2014neonatal folate and vitamin B12 serum concentrations in Greeks and in Albanian immigrants. J Hum Nutr Diet 17, 443\u2013448.","journal-title":"J Hum Nutr Diet"},{"key":"BFejcn2010155_CR28","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1097\/MPH.0b013e31802d3e8a","volume":"28","author":"N Sirachainan","year":"2006","unstructured":"Sirachainan N, Tapanapruksakul P, Visudtibhan A, Chuansumrit A, Cheeramakara C, Atamasirikul K et al. (2006). Homocysteine, MTHFR C677 T, vitamin B12, and folate levels in Thai children with ischemic stroke: a case-control study. J Pediatr Hematol Oncol 28, 803\u2013808.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"Part 2","key":"BFejcn2010155_CR29","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1177\/000456329503200218","volume":"32","author":"MT te Poele-Pothoff","year":"1995","unstructured":"te Poele-Pothoff MT, van den Berg M, Franken DG, Boers GH, Jakobs C, de Kroon I et al. (1995). Three different methods for the determination of total homocysteine in plasma. Ann Clin Biochem 32 (Part 2), 218\u2013220.","journal-title":"Ann Clin Biochem"},{"key":"BFejcn2010155_CR30","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1046\/j.1523-1755.1999.00792.x","volume":"56","author":"M Touam","year":"1999","unstructured":"Touam M, Zingraff J, Jungers P, Chadefaux-Vekemans B, Drueke T, Massy ZA (1999). Effective correction of hyperhomocysteinemia in hemodialysis patients by intravenous folinic acid and pyridoxine therapy. Kidney Int 56, 2292\u20132296.","journal-title":"Kidney Int"},{"key":"BFejcn2010155_CR31","first-page":"473","volume":"114","author":"PM Ueland","year":"1989","unstructured":"Ueland PM, Refsum H (1989). Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy. J Lab Clin Med 114, 473\u2013501.","journal-title":"J Lab Clin Med"},{"key":"BFejcn2010155_CR32","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1093\/ajcn\/81.5.1110","volume":"81","author":"I van Beynum","year":"2005","unstructured":"van Beynum I, den Heijer M, Thomas CM, Afman L, van Oppenraay ED, Blom HJ (2005). Total homocysteine and its predictors in Dutch children. Am J Clin Nutr 81, 1110\u20131116.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2010155_CR33","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1161\/01.CIR.99.16.2070","volume":"99","author":"I van Beynum","year":"1999","unstructured":"van Beynum I, Smeitink JA, den Heijer M, te Poele Pothoff MT, Blom HJ (1999). Hyperhomocysteinemia: a risk factor for ischemic stroke in children. Circulation 99, 2070\u20132072.","journal-title":"Circulation"},{"key":"BFejcn2010155_CR34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1079\/PNS2006495","volume":"65","author":"I van der Linden","year":"2006","unstructured":"van der Linden I, Afman LA, Heil SG, Blom HJ (2006). Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc Nutr Soc 65, 204\u2013215.","journal-title":"Proc Nutr Soc"},{"key":"BFejcn2010155_CR35","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1093\/ajcn\/77.5.1318","volume":"77","author":"FV van Oort","year":"2003","unstructured":"van Oort FV, Melse-Boonstra A, Brouwer IA, Clarke R, West CE, Katan MB et al. (2003). Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. Am J Clin Nutr 77, 1318\u20131323.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2010155_CR36","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1055\/s-2005-872397","volume":"5","author":"P Verhoef","year":"2005","unstructured":"Verhoef P, de Groot LC (2005). Dietary determinants of plasma homocysteine concentrations. Semin Vasc Med 5, 110\u2013123.","journal-title":"Semin Vasc Med"},{"key":"BFejcn2010155_CR37","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1016\/S0140-6736(07)60854-X","volume":"369","author":"X Wang","year":"2007","unstructured":"Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y et al. (2007). Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 369, 1876\u20131882.","journal-title":"Lancet"},{"key":"BFejcn2010155_CR38","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/0026-0495(88)90093-5","volume":"37","author":"DE Wilcken","year":"1988","unstructured":"Wilcken DE, Dudman NP, Tyrrell PA, Robertson MR (1988). Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease. Metabolism 37, 697\u2013701.","journal-title":"Metabolism"},{"key":"BFejcn2010155_CR39","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1046\/j.1523-1755.2001.00507.x","volume":"59","author":"A Yango","year":"2001","unstructured":"Yango A, Shemin D, Hsu N, Jacques PF, Dworkin L, Selhub J et al. (2001). Rapid communication: L-folinic acid versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients. Kidney Int 59, 324\u2013327.","journal-title":"Kidney Int"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ejcn2010155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2010155","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2010155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T12:48:05Z","timestamp":1648212485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejcn2010155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,8]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["BFejcn2010155"],"URL":"https:\/\/doi.org\/10.1038\/ejcn.2010.155","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,8]]},"assertion":[{"value":"6 October 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}