{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:04:06Z","timestamp":1770289446057,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T00:00:00Z","timestamp":1314748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T00:00:00Z","timestamp":1314748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1038\/ejcn.2011.152","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T09:06:31Z","timestamp":1314781591000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population"],"prefix":"10.1038","volume":"66","author":[{"given":"K K","family":"Sukla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,31]]},"reference":[{"key":"BFejcn2011152_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/sj.ejcn.1601507","volume":"57","author":"H Alfthan","year":"2003","unstructured":"Alfthan H, Laurinen MS, Valsta LM, Pastinen T, Aro A (2003). Folate intake, plasma folate and homocysteine status in a random Finnish population. Eup J Clin Nutr 57, 81\u201388.","journal-title":"Eup J Clin Nutr"},{"key":"BFejcn2011152_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/gtmb.2008.0010","volume":"13","author":"A Ali","year":"2009","unstructured":"Ali A, Singh SK, Raman R (2009). MTHFR C677T alone and IRF6 820GG Together, with MTHFR 677CT, But not MTHFR A1298C, are risk for Nonsyndromic Cleft Lip with or without Cleft Palate in an Indian Population. Genet Test Mol Bioma 13, 1\u20136.","journal-title":"Genet Test Mol Bioma"},{"key":"BFejcn2011152_CR3","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/sj.ejcn.1602810","volume":"62","author":"PR Barbosa","year":"2008","unstructured":"Barbosa PR, Stabler SP, Machado ALK, Braga RC, Hirata MH, Sampaio-Neto LF et al. (2008). Association betwen decreased vitamin levels and MTHFR, MTR, and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. Eup J Clin Nutr 62, 1010\u20131021.","journal-title":"Eup J Clin Nutr"},{"key":"BFejcn2011152_CR4","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1093\/ajcn\/68.5.1104","volume":"6s","author":"A Bronstrup","year":"1998","unstructured":"Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K (1998). Effects of folic acid and combinations of folic acid and vitamin B-12 on plasma homocysteine concentrations in healthy, young women. Am J Clin Nutr 6s, 1104\u20131110.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR5","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1093\/humrep\/dem337","volume":"22","author":"G Callejon","year":"2007","unstructured":"Callejon G, Mayor-Olea A, Jimenez AJ, Gaitan MJ, Palomares AR, Martinez F et al. (2007). Genotypes of the C677T and A1298C polymorphisms of the MTHFR gene as a cause of human spontaneous embryo loss. Hum Reprod 22, 3249\u20133254.","journal-title":"Hum Reprod"},{"key":"BFejcn2011152_CR6","first-page":"62","volume":"2003","author":"R Carmel","year":"2003","unstructured":"Carmel R, Green R, Rosenblatt DS, Watkins D (2003). Update on cobalamin, Folate, and Homocysteine. Haematol 2003, 62\u201381.","journal-title":"Haematol"},{"key":"BFejcn2011152_CR7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1006\/mgme.2000.3034","volume":"70","author":"A Chango","year":"2000","unstructured":"Chango A, Filon NE, de Courcy GP, Lambert D, Pfister M, Rosenblatt DS et al. (2000). A Polymorphism (80G-> A) in the reduced folate carrier gene and its association with folate status and Homocysteinemia. Mol Gen Met 70, 310\u2013315.","journal-title":"Mol Gen Met"},{"key":"BFejcn2011152_CR8","first-page":"1","volume":"7933","author":"F Coppede","year":"2009","unstructured":"Coppede F (2009). The complex relationship between folate\/homoysteine metabolism and risk of Down syndrome. Mutat Res Rev 7933, 1\u201317.","journal-title":"Mutat Res Rev"},{"key":"BFejcn2011152_CR9","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.lfs.2006.05.009","volume":"79","author":"L Dufficy","year":"2006","unstructured":"Dufficy L, Naumovski N, Ng X, Blades B, Yates Z, Travers C et al. (2006). G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population. Life Sci 79, 957\u2013966.","journal-title":"Life Sci"},{"key":"BFejcn2011152_CR10","first-page":"1","volume":"25","author":"S Dutta","year":"2005","unstructured":"Dutta S, Sinha S, Chattopadhyay A, Gangopadhyay PK, Mukhopadhyay J, Singh M et al. (2005). Cystathionine beta synthase T833c\/844 INS 68 Polymorphism: a family- based study on mentally retarded children. Behav Brain Funct 25, 1\u20136.","journal-title":"Behav Brain Funct"},{"issue":"suppl","key":"BFejcn2011152_CR11","doi-asserted-by":"publisher","first-page":"1693s","DOI":"10.3945\/ajcn.2009.26736Y","volume":"89","author":"I Elmadfa","year":"2009","unstructured":"Elmadfa I, Singer I (2009). Vitamin B-12 and homocysteine status among vegetarians: a global perspective. Am J Clin Nutr 89 (suppl), 1693s\u20131698s.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR12","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1002\/humu.20522","volume":"28","author":"A Fredriksen","year":"2007","unstructured":"Fredriksen A, Meyer K, Ueland PM, Vollset SE, Grotmol T, Schneede J (2007). Large Scale Population-Based Metabolic Phenotyping of Thirteen Genetic Polymorphisms Related to One-Carbon Metabolism. Hum Mut 28, 856\u2013865.","journal-title":"Hum Mut"},{"key":"BFejcn2011152_CR13","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1093\/ajcn\/81.6.1372","volume":"81","author":"MV Gamble","year":"2005","unstructured":"Gamble MV, Ahsan H, Liu X, Factor-Litvak P, Llievski V, Slavkovich V et al. (2005). Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh. Am J Clin Nutr 81, 1372\u20131377.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR14","doi-asserted-by":"publisher","first-page":"R113","DOI":"10.1093\/hmg\/ddp347","volume":"18","author":"NDE Greene","year":"2009","unstructured":"Greene NDE, Stainer P, Copp AJ (2009). Genetics of human neural tube defects. Hum Mol Genet 18, R113\u2013R129.","journal-title":"Hum Mol Genet"},{"key":"BFejcn2011152_CR15","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/ajcn.83.3.701","volume":"83","author":"RM Gueant-Rodriguez","year":"2006","unstructured":"Gueant-Rodriguez RM, Gueant JL, Debard R, Thirion S, Hong LX, Bronowicki JP et al. (2006). Prevalence of methylentetrahydrofolate reductase 677T and 1298C alleles and folate status: a compatative study in Mexican, West African and European populations. Am J Clin Nutr 83, 701\u2013707.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR16","first-page":"536","volume":"54","author":"MR Harshman","year":"2008","unstructured":"Harshman MR, Aldoori W (2008). Vitamin B12 and health. Can Fam Physician 54, 536\u2013541.","journal-title":"Can Fam Physician"},{"key":"BFejcn2011152_CR17","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1086\/513520","volume":"80","author":"S Hustad","year":"2007","unstructured":"Hustad S, Midttum O, Schneede J, Vollset SE, Grotmol T, Ueland PM (2007). The Methylenetetrahydofolate reductase 677C-T Polymorphisms has a Modulator of a B Vitamin Network with Major Effects on Homocysteine Metabolism. Am J Hum Genet 80, 846\u2013855.","journal-title":"Am J Hum Genet"},{"key":"BFejcn2011152_CR18","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/ajcn\/70.4.495","volume":"70","author":"SJ James","year":"1999","unstructured":"James SJ, Pogribna M, Pogribny IP, Melnyk S, Hine RJ, Gibson JB et al. (1999). Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr 70, 495\u2013501.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR19","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1182\/blood.V101.7.2483","volume":"101","author":"LAJ Kluijtmans","year":"2003","unstructured":"Kluijtmans LAJ, Young IS, Boreham CA, Murray L, McMaster D, McNulty H et al. (2003). Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 101, 2483\u20132488.","journal-title":"Blood"},{"key":"BFejcn2011152_CR20","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1017\/S0007114507691788","volume":"98","author":"VS Konstantinova","year":"2007","unstructured":"Konstantinova VS, Vollset ES, Berstad P, Ueland PM, Drevon CA, Refsum H et al. (2007). Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study. Br J Nutr 98, 201\u2013210.","journal-title":"Br J Nutr"},{"key":"BFejcn2011152_CR21","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s10038-005-0313-1","volume":"50","author":"J Kumar","year":"2005","unstructured":"Kumar J, Das SK, Sharma P, Karthikeyan G, Ramakrishnan L, Sengupta S (2005). Homocysteine levels are associated with MTHFR A1298C polymorphisms in Indian population. J Hum Genet 50, 655\u2013663.","journal-title":"J Hum Genet"},{"key":"BFejcn2011152_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3109\/13547501003658106","volume":"15","author":"J Kumar","year":"2010","unstructured":"Kumar J, Garg G, Karthikeyan G, Sengupta S (2010). Cystathionine \u03b2-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population. Biomarkers 15, 283\u2013287.","journal-title":"Biomarkers"},{"key":"BFejcn2011152_CR23","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1161\/CIRCGENETICS.108.841411","volume":"2","author":"J Kumar","year":"2009","unstructured":"Kumar J, Garg G, Kuamar A, Sundaramoorthy E, Sanapala KR, Ghosh S et al. (2009a). Single Nucleotide Polymorphisms in Homocysteine Metabolism Pathway Genes: Association of CHDH A119C and MTHFR C677T with Hyperhomocysteinemia. Circ Cardiovasc Genet 2, 599\u2013606.","journal-title":"Circ Cardiovasc Genet"},{"key":"BFejcn2011152_CR24","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1515\/CCLM.2009.074","volume":"47","author":"J Kumar","year":"2009","unstructured":"Kumar J, Garg G, Sundaramoorthy E, Prasad PV, Karthikeyan G, Ramakrishnan L et al. (2009b). Vitamin B12 deficiency is associated with coronary artery disease in an Indian population. Clin Chem Lab Med 47, 334\u2013338.","journal-title":"Clin Chem Lab Med"},{"key":"BFejcn2011152_CR25","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.ymgme.2009.06.004","volume":"98","author":"F Li","year":"2009","unstructured":"Li F, Watkins D, Rosenblatt DS (2009). Vitamin B12 and birth defects. Mol Genet Met 98, 166\u2013172.","journal-title":"Mol Genet Met"},{"key":"BFejcn2011152_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev.med.60.041807.123308","volume":"60","author":"AB Maron","year":"2009","unstructured":"Maron AB, Loscalzo J (2009). The treatment of hyperhomocysteinemia. Annu Rev Med 60, 39\u201354.","journal-title":"Annu Rev Med"},{"key":"BFejcn2011152_CR27","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/ajmg.a.31203","volume":"140A","author":"ML Martinez-Frias","year":"2006","unstructured":"Martinez-Frias ML, Perez B, Desviat LR, Castro M, Leal F, Rodriguez L et al. (2006) Maternal polymorphisms 677C-T and A1298C of MTHFR, and 66A-G MTRR Genes: Is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk of having a child with Down Syndrome. Am J Med Genet 140A, 987\u2013997.","journal-title":"Am J Med Genet"},{"key":"BFejcn2011152_CR28","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1002\/ajmg.a.32308","volume":"146A","author":"ML Martinez-frias","year":"2008","unstructured":"Martinez-frias ML (2008). The Biochemical Structure and Function of Methylenetetrahydrofolate Reductase Provide the Rationale to Interpret the Epidemiological Results on the Risk of Infants with Down Syndrome. Am J Med Genet 146A, 1477\u20131482.","journal-title":"Am J Med Genet"},{"issue":"Suppl","key":"BFejcn2011152_CR29","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1177\/15648265080292S107","volume":"29","author":"E McLean","year":"2008","unstructured":"McLean E, Benoist B, Allen LH (2008). Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr Bull 29 (Suppl), S38\u2013S51.","journal-title":"Food Nutr Bull"},{"key":"BFejcn2011152_CR30","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1006\/mgme.2001.3197","volume":"73","author":"PL Rady","year":"2001","unstructured":"Rady PL, Szucs S, Matalon RK, Grady J, Hudnall SD, Kellner LH et al. (2001). Genetic Polymorphism (G80A) of Reduced Folate Carrier Gene in Ethnic Populations. Mol Genet Met 73, 285\u2013286.","journal-title":"Mol Genet Met"},{"key":"BFejcn2011152_CR31","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s10038-005-0356-3","volume":"51","author":"AK Rai","year":"2006","unstructured":"Rai AK, Singh S, Mehta S, Kumar A, Pandey LK, Raman R (2006). MTHFR C677T and A1298C are risk factors for Down's syndrome in Indian mothers. J Hum Genet 51, 278\u2013283.","journal-title":"J Hum Genet"},{"key":"BFejcn2011152_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J et al. (2004). Facts and recommendations about total homocysteine determinations: An Expert Opinion. Clin Chem 50, 3\u201332.","journal-title":"Clin Chem"},{"key":"BFejcn2011152_CR33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/ajcn\/74.2.233","volume":"74","author":"H Refsum","year":"2001","unstructured":"Refsum H, Yajnik CS, Gadkari M, Schneede J, Vollset SE, Orning L et al. (2001). Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am J Clin Nutr 74, 233\u2013241.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR34","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S1474-4422(06)70598-1","volume":"5","author":"E Reynolds","year":"2006","unstructured":"Reynolds E (2006). Vitamin B12, folic acid, and the nervous system. Lancet Neurol 5, 949\u2013960.","journal-title":"Lancet Neurol"},{"key":"BFejcn2011152_CR35","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1086\/338932","volume":"70","author":"N Rosenberg","year":"2002","unstructured":"Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E et al. (2002). The Frequent 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphism is associated with a common haplotype in whites, Japanese and Africans. Am J Hum Genet 70, 758\u2013762.","journal-title":"Am J Hum Genet"},{"key":"BFejcn2011152_CR36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","volume":"19","author":"J Selhub","year":"1999","unstructured":"Selhub J (1999). Homocysteine Metabolism. Annu Rev Nutr 19, 217\u2013246.","journal-title":"Annu Rev Nutr"},{"issue":"suppl","key":"BFejcn2011152_CR37","doi-asserted-by":"publisher","first-page":"S116","DOI":"10.1177\/15648265080292S116","volume":"29","author":"J Selhub","year":"2008","unstructured":"Selhub J (2008). Public health significance of elevated homocysteine. Food Nutr Bull 29 (suppl), S116\u2013S125.","journal-title":"Food Nutr Bull"},{"key":"BFejcn2011152_CR38","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1365-2605.2004.00513.x","volume":"28","author":"K Singh","year":"2005","unstructured":"Singh K, Singh S K, Sah R, Singh I, Raman R (2005). Mutation C677T in the Methylenetetrahydrofolate Reductase gene is associated with male infertility in an Indian Population. Int J Androl 28, 115\u2013119.","journal-title":"Int J Androl"},{"key":"BFejcn2011152_CR39","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1093\/ajcn\/86.5.1302","volume":"86","author":"S Taneja","year":"2007","unstructured":"Taneja S, Bhandari N, Strand TA, Sommerfelt H, Refsum H, Ueland PM et al. (2007). Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Am J Clin Nutr 86, 1302\u20131309.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR40","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1017\/S0007114509992947","volume":"103","author":"BH Thuesen","year":"2010","unstructured":"Thuesen BH, Husemoen LLN, Oversen L, Jorgensen T, Fenger M, Linneberg A (2010). Life style and genetic determinants of folate and vitamin B12 levels in a general adult population. Br J Nutr 103, 1195\u20131204.","journal-title":"Br J Nutr"},{"key":"BFejcn2011152_CR41","first-page":"275","volume":"68","author":"A Waskiewicz","year":"2010","unstructured":"Waskiewicz A, Sygnowska E, Broda G (2010). Dietary intake of vitamins B6, B12 and folate in relation to homocysteine serum concentration in the adult Polish population\u2014WOBASZ Project. Kardiol Pol, 68, 275\u2013282.","journal-title":"Kardiol Pol"},{"key":"BFejcn2011152_CR42","unstructured":"World Bank report on malnourishment (2009): www.worldbank.org."},{"key":"BFejcn2011152_CR43","first-page":"775","volume":"54","author":"CS Yajnik","year":"2006","unstructured":"Yajnik CS, Deshpande SS, Lubree HG, Naik SS, Bhat DS, Uradey BS et al. (2006). Vitamin B12 Deficiency and Hyperhomocysteinemia in Rural and Urban Indians. JAPI 54, 775\u2013782.","journal-title":"JAPI"},{"key":"BFejcn2011152_CR44","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/ajcn\/88.1.232","volume":"88","author":"QH Yang","year":"2008","unstructured":"Yang QH, Botto LD, Gallagher M, Friedman JM, Sanders CL, Koontz D et al. (2008). Prevalence and effects of gene-gene and gene-nutrient interactions on serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am J Clin Nutr 88, 232\u2013246.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2011152_CR45","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1016\/j.lfs.2005.02.029","volume":"77","author":"Z Yates","year":"2005","unstructured":"Yates Z, Lucock M (2005). G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism. Life Sci 77, 2735\u20132742.","journal-title":"Life Sci"},{"key":"BFejcn2011152_CR46","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1373\/clinchem.2006.083881","volume":"53","author":"RYL Zee","year":"2007","unstructured":"Zee RYL, Mora S, Cheng S, Erlich HA, Lindpaintner K, Rifai N et al. (2007). Homocysteine, 5,10-Methylenetetrahydrofolate Reductase C677T polymorphism, nutrient Intake and incidence of cardiovascular disease in 24968 Initially Healthy Woman. Clin Chem 53, 845\u2013851.","journal-title":"Clin Chem"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ejcn2011152.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2011152","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2011152.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T12:52:11Z","timestamp":1648212731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejcn2011152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,31]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["BFejcn2011152"],"URL":"https:\/\/doi.org\/10.1038\/ejcn.2011.152","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,31]]},"assertion":[{"value":"29 March 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}