{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:01:18Z","timestamp":1770415278149,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1038\/ejcn.2014.149","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T08:59:26Z","timestamp":1406710766000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Proposed ratios and cutoffs for the assessment of lipodystrophy in HIV-seropositive individuals"],"prefix":"10.1038","volume":"69","author":[{"given":"R A","family":"Beraldo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H S","family":"Vassimon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Aragon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F J","family":"Albuquerque de Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Foss-Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"BFejcn2014149_CR1","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1097\/00002030-200307250-00012","volume":"17","author":"JRP Marins","year":"2003","unstructured":"Marins JRP, Jamal LF, Chen SY, Barros MB, Hudes ES, Barbosa AA et al. Dramatic improvement in survival among adult Brazilian AIDS patients. AIDS 2003; 17: 1675\u20131682.","journal-title":"AIDS"},{"key":"BFejcn2014149_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1385\/CT:4:3:243","volume":"4","author":"B Boskurt","year":"2004","unstructured":"Boskurt B . Cardiovascular toxicity with highly active antiretroviral therapy: review of clinical study. Cardiovasc Toxicol 2004; 4: 243\u2013260.","journal-title":"Cardiovasc Toxicol"},{"key":"BFejcn2014149_CR3","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/01.qai.0000243052.73321.8e","volume":"43","author":"T Brown","year":"2006","unstructured":"Brown T, Wang Z, Chu H, Palela FJ, Kingsley L, Witt MD et al. Longitudinal anthropometric changes in HIV-infected and HIV-uninfected men. J Acquir Immune Defic Syndr 2006; 43: 356\u2013362.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"BFejcn2014149_CR4","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1152\/japplphysiol.00797.2005","volume":"100","author":"M Torriani","year":"2006","unstructured":"Torriani M, Thomas BJ, Barlow RB, Librizzi J, Dola NS, Grinspoon S . Increased intramyocellular lipid accumulation in HIV infected women with fat redistribution. Journal of applied physiology 2006; 100: 609\u20134.","journal-title":"Journal of applied physiology"},{"key":"BFejcn2014149_CR5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1155\/2005\/303141","volume":"16","author":"JG Baril","year":"2005","unstructured":"Baril JG, Junod G, Leblanc R, Dion H, Therrien R, Laplant F et al. HIV \u2013 associated lipodystrophy syndrome: a review of clinical aspects. J Infect Dis Med Microbiol 2005; 16: 233\u2013243.","journal-title":"J Infect Dis Med Microbiol"},{"key":"BFejcn2014149_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0021-9150(03)00246-6","volume":"174","author":"A Tershakovec","year":"2004","unstructured":"Tershakovec A, Frank I, Rader D . HIV-related lipodystrophy and related factors. Atherosclerosis 2004; 174: 1\u201310.","journal-title":"Atherosclerosis"},{"key":"BFejcn2014149_CR7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1385\/JCD:8:3:287","volume":"8","author":"E Bonnet","year":"2005","unstructured":"Bonnet E, Delpierre C, Sommet A, Mario-Latard F, Herv\u00e9 R, Aquilina C et al. Total body composition by DXA of 241 HIV-negative men and 162 HIV-infected men. J Clin Densitom 2005; 8: 287\u2013292.","journal-title":"J Clin Densitom"},{"key":"BFejcn2014149_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jocd.2010.01.005","volume":"13","author":"P Freitas","year":"2010","unstructured":"Freitas P, Santos AC, Carvalho D, Pereira J, Marques R, Martinez E et al. Fat mass ratio: an objective tool to define lipodystrophy in HIV-infected patients under antiretroviral. therapy. J Clin Densitom 2010; 13: 197\u2013203.","journal-title":"J Clin Densitom"},{"key":"BFejcn2014149_CR9","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","unstructured":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III \u2013 ATP III). JAMA 2001; 285: 2486\u20132497.","journal-title":"JAMA"},{"key":"BFejcn2014149_CR10","doi-asserted-by":"publisher","first-page":"E687","DOI":"10.1152\/ajpcell.00494.2006","volume":"292","author":"J Sutinen","year":"2007","unstructured":"Sutinen J, Yki-Jarvinen H . Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy. Am J Physiol End Met 2007; 292: E687\u2013E692.","journal-title":"Am J Physiol End Met"},{"key":"BFejcn2014149_CR11","volume-title":"Anthropometric standardization reference manual","author":"TG Lohman","year":"1988","unstructured":"Lohman TG, Roche AF, Martorell R Anthropometric standardization reference manual. Human Kinetics Books: Champaign, 1988."},{"key":"BFejcn2014149_CR12","first-page":"p","volume-title":"Anthropometric standardization reference manual: a bridged edition","author":"TG Lohman","year":"1991","unstructured":"Lohman TG, Roche AF, Martorell R Anthropometric standardization reference manual: a bridged edition. Human Kinetics Books: Champaign, 1991, p 90."},{"key":"BFejcn2014149_CR13","first-page":"121e131","volume":"40","author":"P Bacchetti","year":"2005","unstructured":"Bacchetti P, Gripshover B, Grunfeld C, Heymsfield S, McCreath H, Osmond D et al. From the Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM). Fat distribution in men with HIV Infection. J Acquir Immune Defic Syndr 2005; 40: 121e131.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"BFejcn2014149_CR14","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1177\/1545109708328931","volume":"7","author":"RJ Bedimo","year":"2008","unstructured":"Bedimo RJ . Body-Fat Abnormalities in Patients With HIV: Progress and Challenges. J Int Assoc Physicians AIDS Care 2008; 7: 292\u2013305.","journal-title":"J Int Assoc Physicians AIDS Care"},{"key":"BFejcn2014149_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1046\/j.1468-1293.2003.00151.x","volume":"4","author":"L Kosmiski","year":"2003","unstructured":"Kosmiski L, Kuritzkes D, Hamilton J, Sharp T, Lichtenstien K, Hill J et al. Fat distribution is altered in HIV-infected men without clinical evidence of the HIV lipodystrophy syndrome. HIV Med 2003; 4: 235\u2013240.","journal-title":"HIV Med"},{"key":"BFejcn2014149_CR16","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1093\/jac\/dki165","volume":"56","author":"A Milinkovic","year":"2005","unstructured":"Milinkovic A, Martinez E . Current perspectives on HIV-associated lipodystrophy syndrome. J Antimicrob Chemother 2005; 56: 6\u20139.","journal-title":"J Antimicrob Chemother"},{"key":"BFejcn2014149_CR17","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0140-6736(03)12656-6","volume":"361","author":"A Carr","year":"2003","unstructured":"Carr A, Emery S, Law MG, Puls R, Lundgren JD, Powderly W . An objective case definition of lipodystrophy in HIV-infected adults: a case-control study. HIV Lipodystrophy Case Definition Study Group. Lancet 2003; 361: 726\u2013735.","journal-title":"Lancet"},{"key":"BFejcn2014149_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/00002030-199807000-00003","volume":"12","author":"A Carr","year":"1998","unstructured":"Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm DJ et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998; 12: 51\u201358.","journal-title":"AIDS"},{"key":"BFejcn2014149_CR19","first-page":"615","volume":"52","author":"P Massip","year":"1997","unstructured":"Massip P, Marchou B, Bonnet E, Cuzin L, Montastruc JL . Lipodystrophy with protease inhibitors in HIV patients. Therapie 1997; 52: 615.","journal-title":"Therapie"},{"key":"BFejcn2014149_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/00002030-199806000-00001","volume":"12","author":"R Viraben","year":"1998","unstructured":"Viraben R, Aquilina C . Indinavir-associated lipodystrophy. AIDS 1998; 12: 37\u201339.","journal-title":"AIDS"},{"key":"BFejcn2014149_CR21","doi-asserted-by":"publisher","first-page":"404","DOI":"10.4067\/S0717-75182011000400002","volume":"38","author":"RA Beraldo","year":"2011","unstructured":"Beraldo RA, Vassimon HS, Jord\u00e3o J. AA, Albuquerque FJ, Machado AM, Foss-Freitas MC et al. Anthropometry and bioelectrical impedance analysis compared to dual-photon absorptiometry for the assessment of body composition of hiv-seropositive patients. Rev Chil Nutr 2011; 38: 404\u2013413.","journal-title":"Rev Chil Nutr"},{"key":"BFejcn2014149_CR22","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1152\/ajpregu.2000.279.3.R936","volume":"279","author":"RV Weber","year":"2000","unstructured":"Weber RV, Buckley MC, Fried SK, Kral JG . Subcutaneous lipectomy causes a metabolic syndrome in hamsters. Am J Physiol Regul Integr Comp Physiol 2000; 279: 936\u2013943.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFejcn2014149_CR23","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1086\/317541","volume":"32","author":"C Hadigan","year":"2001","unstructured":"Hadigan C, Meigs JB, Corcoran C, Rietschel P, Piecuch S, Basgoz N et al. Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy. Clin Infect Dis 2001; 32: 130\u2013139.","journal-title":"Clin Infect Dis"},{"key":"BFejcn2014149_CR24","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1590\/S0066-782X2002000600012","volume":"78","author":"SG Barroso","year":"2002","unstructured":"Barroso SG, Abreu VG, Francischetti EA . A Participa\u00e7\u00e3o do Tecido Adiposo Visceral na G\u00eanese da Hipertens\u00e3o e Doen\u00e7a Cardiovascular Aterog\u00eanica. Um Conceito Emergente. Arq Bras Cardiol 2002; 78: 618\u2013630.","journal-title":"Arq Bras Cardiol"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ejcn2014149","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2014149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2014149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T13:02:50Z","timestamp":1648213370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejcn2014149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["BFejcn2014149"],"URL":"https:\/\/doi.org\/10.1038\/ejcn.2014.149","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,30]]},"assertion":[{"value":"23 June 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}