{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:18:43Z","timestamp":1777461523311,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1038\/ejcn.2015.143","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T10:01:54Z","timestamp":1441188114000},"page":"1346-1349","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Hypercarotenodermia in Zambia: which children turned orange during mango season?"],"prefix":"10.1038","volume":"69","author":[{"given":"S A","family":"Tanumihardjo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B M","family":"Gannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Kaliwile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Chileshe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"BFejcn2015143_CR1","unstructured":"WHO Global Prevalence of Vitamin A Deficiency in Populations at Risk 1995\u20132005 WHO Global Database on Vitamin A Deficiency. WHO: Geneva, Switzerland, 2009."},{"key":"BFejcn2015143_CR2","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.proche.2015.03.054","volume":"14","author":"SA Tanumihardjo","year":"2015","unstructured":"Tanumihardjo SA . Vitamin A fortification efforts require accurate monitoring of population vitamin A status to prevent excessive intakes. Proc Chem 2015; 14: 398\u2013407.","journal-title":"Proc Chem"},{"key":"BFejcn2015143_CR3","doi-asserted-by":"publisher","first-page":"972","DOI":"10.3945\/jn.114.192245","volume":"144","author":"K Bresnahan","year":"2014","unstructured":"Bresnahan K, Chileshe J, Arscott S, Nuss E, Surles R, Masi C et al. The acute phase response affected traditional measures of micronutrient status in rural Zambian children during a randomized, controlled feeding trial. J Nutr 2014; 144: 972\u2013978.","journal-title":"J Nutr"},{"key":"BFejcn2015143_CR4","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.3945\/ajcn.114.087379","volume":"100","author":"B Gannon","year":"2014","unstructured":"Gannon B, Kaliwile C, Arscott SA, Schmaelzle S, Chileshe J, Kalungwana N et al. Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a community-based, randomized placebo-controlled trial. Am J Clin Nutr 2014; 100: 1541\u20131550.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3945\/jn.113.182998","volume":"144","author":"S Pinkaew","year":"2014","unstructured":"Pinkaew S, Wegmuller R, Wasantwisut E, Winichagoon P, Hurrell RF, Tanumihardjo SA . Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children. J Nutr 2014; 144: 519\u2013524.","journal-title":"J Nutr"},{"key":"BFejcn2015143_CR6","unstructured":"Institute of Medicine Food and Nutrition Board Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academies Press: Washington, DC, USA, 2001; pp 82\u2013161."},{"key":"BFejcn2015143_CR7","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1017\/S1368980012000924","volume":"15","author":"C Hotz","year":"2012","unstructured":"Hotz C, Chileshe J, Siamusantu W, Palaniappan U, Kafwembe E . Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia. Public Health Nutr 2012; 15: 1688\u20131696.","journal-title":"Public Health Nutr"},{"key":"BFejcn2015143_CR8","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/ajcn\/76.6.1351","volume":"76","author":"CB Stephensen","year":"2002","unstructured":"Stephensen CB, Franchi LM, Hernandez H, Campos M, Colarossi A, Gilman RH et al. Assessment of vitamin A status with the relative-dose-response test in Peruvian children recovering from pneumonia. Am J Clin Nutr 2002; 76: 1351\u20131357.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR9","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1093\/jn\/131.10.3061","volume":"132","author":"FT Wieringa","year":"2002","unstructured":"Wieringa FT, Dijkhuizen MA, West CE, Northrop-Clewes CA, Muhilal . Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants. J Nutr 2002; 132: 3061\u20133066.","journal-title":"J Nutr"},{"key":"BFejcn2015143_CR10","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1177\/156482651203300106","volume":"33","author":"ET Nuss","year":"2012","unstructured":"Nuss ET, Arscott SA, Bresnahan K, Pixley KV, Rocheford T, Hotz C et al. Comparative intake of white- versus orange-colored maize by Zambian children in the context of promotion of biofortified maize. Food Nutr Bull 2012; 33: 63\u201371.","journal-title":"Food Nutr Bull"},{"key":"BFejcn2015143_CR11","doi-asserted-by":"publisher","first-page":"658S","DOI":"10.3945\/ajcn.110.005777","volume":"94","author":"SA Tanumihardjo","year":"2011","unstructured":"Tanumihardjo SA . Vitamin A: biomarkers of nutrition for development. Am J Clin Nutr 2011; 94: 658S\u2013665S.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/156482651403500108","volume":"35","author":"S Schmaelzle","year":"2014","unstructured":"Schmaelzle S, Kaliwile C, Arscott SA, Gannon B, Masi C, Tanumihardjo SA . Nutrient and non-traditional food intakes by Zambian children in a controlled feeding trial. Food Nutr Bull 2014; 35: 60\u201367.","journal-title":"Food Nutr Bull"},{"key":"BFejcn2015143_CR13","unstructured":"The World Bank Mortality rate, under-5 (per 1,000 live births). Available at http:\/\/data.worldbank.org\/indicator\/SH.DYN.MORT (last accessed 22 September 2014)."},{"key":"BFejcn2015143_CR14","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3945\/ajcn.115.110973","volume":"102","author":"SA Tanumihardjo","year":"2015","unstructured":"Tanumihardjo SA, Gannon BM, Kaliwile C, Chileshe J . Reply to G Lietz et al.. Am J Clin Nutr 2015; 102: 521\u2013522.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR15","first-page":"61","volume":"45","author":"AM Vijayalakshmi","year":"2008","unstructured":"Vijayalakshmi AM . Carotenodermia. Indian Pediatr 2008; 45: 61.","journal-title":"Indian Pediatr"},{"key":"BFejcn2015143_CR16","doi-asserted-by":"publisher","first-page":"269S","DOI":"10.1093\/jn\/134.1.269S","volume":"134","author":"AC Ross","year":"2004","unstructured":"Ross AC, Zolfaghari R . Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. J Nutr 2004; 134: 269S\u2013275S.","journal-title":"J Nutr"},{"key":"BFejcn2015143_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/ajcn\/52.2.183","volume":"52","author":"JN Hathcock","year":"1990","unstructured":"Hathcock JN, Hattan DG, Jenkins MY, McDonald JT, Sundaresan PR, Wilkening VL . Evaluation of vitamin A toxicity. Am J Clin Nutr 1990; 52: 183\u2013202.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR18","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.jocd.2013.08.016","volume":"16","author":"SA Tanumihardjo","year":"2013","unstructured":"Tanumihardjo SA . Vitamin A and bone health: the balancing act. J Clin Densitom 2013; 16: 414\u2013419.","journal-title":"J Clin Densitom"},{"key":"BFejcn2015143_CR19","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3945\/ajcn.115.112383","volume":"102","author":"S Mondloch","year":"2015","unstructured":"Mondloch S, Gannon BM, Davis CR, Chileshe J, Kaliwile C, Masi C et al. High provitamin A carotenoid serum concentrations, elevated retinyl esters, and saturated retinol-binding protein in Zambian preschool children are consistent with the presence of high liver vitamin A stores. Am J Clin Nutr 2015; 102: 497\u2013504.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR20","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3945\/ajcn.113.063867","volume":"98","author":"AR Valentine","year":"2013","unstructured":"Valentine AR, Davis CR, Tanumihardjo SA . Vitamin A isotope dilution predicts liver stores in line with long-term vitamin A intake above the current Recommended Dietary Allowance for young adult women. Am J Clin Nutr 2013; 98: 1192\u20131199.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR21","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1093\/jn\/131.11.2904","volume":"131","author":"KL Penniston","year":"2001","unstructured":"Penniston KL, Tanumihardjo SA . Subtoxic hepatic vitamin A concentrations in captive rhesus monkeys (Macaca mulatta. J Nutr 2001; 131: 2904\u20132909.","journal-title":"J Nutr"},{"key":"BFejcn2015143_CR22","first-page":"101","volume-title":"Present Knowledge in Nutrition","author":"JA Olson","year":"1990","unstructured":"Olson JA . Vitamin A. In: Brown ML (ed). Present Knowledge in Nutrition, 6th edn. International Life Sciences Institute: Washington DC, USA, 1990, pp 101."},{"key":"BFejcn2015143_CR23","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1017\/S0007114513003851","volume":"111","author":"N Riabroy","year":"2014","unstructured":"Riabroy N, Dever J, Tanumihardjo SA . \u03b1-Retinol and 3,4-didehydroretinol support growth in rats when fed at equimolar amounts and \u03b1-retinol is not toxic after repeated administration of large doses. Br J Nutr 2014; 111: 1373\u20131381.","journal-title":"Br J Nutr"},{"key":"BFejcn2015143_CR24","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/ajcn\/83.2.191","volume":"83","author":"KL Penniston","year":"2006","unstructured":"Penniston KL, Tanumihardjo SA . The acute and chronic toxic effects of vitamin A. Am J Clin Nutr 2006; 83: 191\u2013201.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015143_CR25","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1056\/NEJM197604082941503","volume":"294","author":"FR Smith","year":"1976","unstructured":"Smith FR, Goodman DS . Vitamin A transport in human vitamin A toxicity. N Engl J Med 1976; 294: 805\u2013808.","journal-title":"N Engl J Med"},{"key":"BFejcn2015143_CR26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-2275(20)36724-9","volume":"16","author":"AK Mallia","year":"1975","unstructured":"Mallia AK, Smith JE, Goodman DS . Metabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat. J Lipid Res 1975; 16: 180\u2013188.","journal-title":"J Lipid Res"},{"key":"BFejcn2015143_CR27","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3945\/ajcn.114.086900","volume":"100","author":"L Jahns","year":"2014","unstructured":"Jahns L, Johnson LK, Mayne ST, Cartmel B, Picklo MJ Sr, Ermakov IV et al. Skin and plasma carotenoid response to a provided intervention diet high in vegetables and fruit: uptake and depletion kinetics. Am J Clin Nutr 2014; 100: 930\u2013937.","journal-title":"Am J Clin Nutr"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015143","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T14:12:28Z","timestamp":1648217548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,2]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["BFejcn2015143"],"URL":"https:\/\/doi.org\/10.1038\/ejcn.2015.143","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,2]]},"assertion":[{"value":"12 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}