{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:34:11Z","timestamp":1791941651909,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1038\/ejcn.2015.229","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T11:01:28Z","timestamp":1453892488000},"page":"918-924","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Maternal obesity during pregnancy is negatively associated with maternal and neonatal iron status"],"prefix":"10.1038","volume":"70","author":[{"given":"A D","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-p","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kaciroti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Lozoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,27]]},"reference":[{"key":"BFejcn2015229_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/ije\/dyi272","volume":"35","author":"AM Prentice","year":"2006","unstructured":"Prentice AM . The emerging epidemic of obesity in developing countries. Int J Epidemiol 2006; 35: 93\u201399.","journal-title":"Int J Epidemiol"},{"key":"BFejcn2015229_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/sj.ijo.0802824","volume":"29","author":"CM Doak","year":"2005","unstructured":"Doak CM, Adair LS, Bentley M, Monteiro C, Popkin BM . The dual burden household and the nutrition transition paradox. Int J Obes 2005; 29: 129\u2013136.","journal-title":"Int J Obes"},{"key":"BFejcn2015229_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/978-1-59745-112-3_20","volume-title":"Handbook of Nutrition and Pregnancy","author":"J Rozowski","year":"2008","unstructured":"Rozowski J, Parodi CG. Implications of the nutrition transition in the nutritional status on pregnant women. In: Lammi-Keefe C, Couch SC, Philipson E (eds). Handbook of Nutrition and Pregnancy. Humana Press: Totowa, NJ, USA, 2008, pp 307\u2013318."},{"key":"BFejcn2015229_CR4","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1038\/ijo.2008.43","volume":"32","author":"MB Zimmermann","year":"2008","unstructured":"Zimmermann MB, Zeder C, Muthayya S, Winichagoon P, Chaouki N, Aeberli I et al. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes 2008; 32: 1098\u20131104.","journal-title":"Int J Obes"},{"key":"BFejcn2015229_CR5","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/sj.ijo.0802224","volume":"27","author":"O Pinhas-Hamiel","year":"2003","unstructured":"Pinhas-Hamiel O, Newfield RS, Koren I, Agmon A, Lilos P, Phillip M . Greater prevalence of iron deficiency in overweight and obese children and adolescents. Int J Obes Relat Metab Disord 2003; 27: 416\u2013418.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFejcn2015229_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jada.2008.10.044","volume":"109","author":"LM Tussing-Humphreys","year":"2009","unstructured":"Tussing-Humphreys LM, Liang H, Nemeth E, Freels S, Braunschweig CA . Excess adiposity, inflammation, and iron-deficiency in female adolescents. J Am Diet Assoc 2009; 109: 297\u2013302.","journal-title":"J Am Diet Assoc"},{"key":"BFejcn2015229_CR7","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jada.2011.08.038","volume":"112","author":"L Tussing-Humphreys","year":"2012","unstructured":"Tussing-Humphreys L, Pusatcioglu C, Nemeth E, Braunschweig C . Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin. J Acad Nutr Diet 2012; 112: 391\u2013400.","journal-title":"J Acad Nutr Diet"},{"key":"BFejcn2015229_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1080\/07315724.2009.10719759","volume":"28","author":"JP Karl","year":"2009","unstructured":"Karl JP, Lieberman HR, Cable SJ, Williams KW, Glickman EL, Young AJ et al. Poor iron status is not associated with overweight or overfat in non-obese pre-menopausal women. J Am Coll Nutr 2009; 28: 37\u201342.","journal-title":"J Am Coll Nutr"},{"key":"BFejcn2015229_CR9","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1017\/S1368980014000755","volume":"18","author":"AS Wendt","year":"2015","unstructured":"Wendt AS, Jefferds ME, Perrine CG, Halleslevens P, Sullivan KM . Obese women less likely to have low serum ferritin, Nicaragua. Public Health Nutr 2015; 18: 736\u2013741.","journal-title":"Public Health Nutr"},{"key":"BFejcn2015229_CR10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3945\/jn.112.167767","volume":"143","author":"K Kordas","year":"2013","unstructured":"Kordas K, Fonseca Centeno ZY, Pachon H, Jimenez Soto AZ . Being overweight or obese is associated with lower prevalence of anemia among Colombian women of reproductive age. J Nutr 2013; 143: 175\u2013181.","journal-title":"J Nutr"},{"key":"BFejcn2015229_CR11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/jp.2012.81","volume":"33","author":"MC Dao","year":"2013","unstructured":"Dao MC, Sen S, Iyer C, Klebenov D, Meydani SN . Obesity during pregnancy and fetal iron status: Is hepcidin the link? J Perinatol 2013; 33: 177\u2013181.","journal-title":"J Perinatol"},{"key":"BFejcn2015229_CR12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/jp.2014.42","volume":"34","author":"A Phillips","year":"2014","unstructured":"Phillips A, Roy S, Lundberg R, Guilbert T, Auger A, Blohowiak S et al. Neonatal iron status is impaired by maternal obesity and excessive weight gain during pregnancy. J Perinatol 2014; 34: 513\u2013518.","journal-title":"J Perinatol"},{"key":"BFejcn2015229_CR13","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/ijo.2015.3","volume":"39","author":"L Garcia-Valdes","year":"2015","unstructured":"Garcia-Valdes L, Campoy C, Hayes H, Florido J, Rusanova I, Miranda MT et al. The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy. Int J Obes 2015; 39: 571\u2013578.","journal-title":"Int J Obes"},{"key":"BFejcn2015229_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000332138","volume":"59","author":"M Domellof","year":"2011","unstructured":"Domellof M . Iron requirements in infancy. Ann Nutr Metab 2011; 59: 59\u201363.","journal-title":"Ann Nutr Metab"},{"key":"BFejcn2015229_CR15","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.spen.2006.08.004","volume":"13","author":"B Lozoff","year":"2006","unstructured":"Lozoff B, Georgieff MK . Iron deficiency and brain development. Semin Pediatr Neurol 2006; 13: 158\u2013165.","journal-title":"Semin Pediatr Neurol"},{"key":"BFejcn2015229_CR16","doi-asserted-by":"publisher","first-page":"c3428","DOI":"10.1136\/bmj.c3428","volume":"341","author":"SD McDonald","year":"2010","unstructured":"McDonald SD, Han Z, Mulla S, Beyene J . Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses. BMJ 2010; 341: c3428.","journal-title":"BMJ"},{"key":"BFejcn2015229_CR17","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.3945\/jn.114.208678","volume":"145","author":"G Zhao","year":"2015","unstructured":"Zhao G, Xu G, Zhou M, Jiang Y, Richards B, Clark KM et al. Prenatal iron supplementation reduces maternal anemia, iron deficiency, and iron deficiency anemia in a randomized clinical trial in rural China, but iron deficiency remains widespread in mothers and neonates. J Nutr 2015; 145: 1916\u20131923.","journal-title":"J Nutr"},{"key":"BFejcn2015229_CR18","unstructured":"Institute of Medicine, National Research Council Weight Gain During Pregnancy: Reexamining the Guidelines. National Academies Press: Washington, DC, USA, 2009."},{"key":"BFejcn2015229_CR19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0308-2261(21)00338-6","volume":"11","author":"M Worwood","year":"1982","unstructured":"Worwood M . Ferritin in human tissues and serum. Clin Haematol 1982; 11: 275\u2013307.","journal-title":"Clin Haematol"},{"key":"BFejcn2015229_CR20","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/ajcn\/54.6.1077","volume":"54","author":"MT Carriaga","year":"1991","unstructured":"Carriaga MT, Skikne BS, Finley B, Cutler B, Cook JD . Serum transferrin receptor for the detection of iron deficiency in pregnancy. Am J Clin Nutr 1991; 54: 1077\u20131081.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015229_CR21","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/ajcn\/81.3.615","volume":"81","author":"MB Zimmermann","year":"2005","unstructured":"Zimmermann MB, Molinari L, Staubli-Asobayire F, Hess SY, Chaouki N, Adou P et al. Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children. Am J Clin Nutr 2005; 81: 615\u2013623.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015229_CR22","unstructured":"Centers for Disease Control and Prevention. Recommendations to prevent and control iron deficiency in the United States. MMWR Recomm Rep 1998; 47: 1\u201329."},{"key":"BFejcn2015229_CR23","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1016\/S2214-109X(13)70001-9","volume":"1","author":"GA Stevens","year":"2013","unstructured":"Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995\u20132011: a systematic analysis of population-representative data. Lancet Glob Health 2013; 1: e16\u2013e25.","journal-title":"Lancet Glob Health"},{"key":"BFejcn2015229_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1600-0609.2005.00515.x","volume":"75","author":"G Metzgeroth","year":"2005","unstructured":"Metzgeroth G, Adelberger V, Dorn-Beineke A, Kuhn C, Schatz M, Maywald O et al. Soluble transferrin receptor and zinc protoporphyrin\u2014competitors or efficient partners? Eur J Haematol 2005; 75: 309\u2013317.","journal-title":"Eur J Haematol"},{"key":"BFejcn2015229_CR25","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1182\/blood-2002-10-3071","volume":"101","author":"JD Cook","year":"2003","unstructured":"Cook JD, Flowers CH, Skikne BS . The quantitative assessment of body iron. Blood 2003; 101: 3359\u20133364.","journal-title":"Blood"},{"key":"BFejcn2015229_CR26","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/0929-693X(96)81129-8","volume":"2","author":"I Diagne","year":"1995","unstructured":"Diagne I, Archambeaud MP, Diallo D, d'Oiron R, Yvart J, Tchernia G . [Erythrocyte indices and iron stores in cord blood]. Arch Pediatr 1995; 2: 208\u2013214.","journal-title":"Arch Pediatr"},{"key":"BFejcn2015229_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000204454","volume":"90","author":"GS Paterakis","year":"1993","unstructured":"Paterakis GS, Lykopoulou L, Papassotiriou J, Stamulakatou A, Kattamis C, Loukopoulos D . Flow-cytometric analysis of reticulocytes in normal cord blood. Acta Haematol 1993; 90: 182\u2013185.","journal-title":"Acta Haematol"},{"key":"BFejcn2015229_CR28","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.3945\/jn.112.162362","volume":"142","author":"J Shao","year":"2012","unstructured":"Shao J, Lou J, Rao R, Georgieff MK, Kaciroti N, Felt BT et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr 2012; 142: 2004\u20132009.","journal-title":"J Nutr"},{"key":"BFejcn2015229_CR29","doi-asserted-by":"crossref","DOI":"10.1201\/9780429258411","volume-title":"Bayesian Data Analysis","author":"A Gelman","year":"1995","unstructured":"Gelman A, Carlin JB, Stern HS, Rubin DB . Bayesian Data Analysis. Chapman and Hall: London, UK, 1995."},{"key":"BFejcn2015229_CR30","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","volume":"117","author":"T Ganz","year":"2011","unstructured":"Ganz T . Hepcidin and iron regulation, 10 years later. Blood 2011; 117: 4425\u20134433.","journal-title":"Blood"},{"key":"BFejcn2015229_CR31","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3945\/an.113.004424","volume":"4","author":"MC Dao","year":"2013","unstructured":"Dao MC, Meydani SN . Iron biology, immunology, aging, and obesity: four fields connected by the small peptide hormone hepcidin. Adv Nutr 2013; 4: 602\u2013617.","journal-title":"Adv Nutr"},{"key":"BFejcn2015229_CR32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/j.1651-2227.2002.tb02917.x","volume":"91","author":"R Rao","year":"2002","unstructured":"Rao R, Georgieff MK . Perinatal aspects of iron metabolism. Acta Paediatr 2002; 91: 124\u2013129.","journal-title":"Acta Paediatr"},{"key":"BFejcn2015229_CR33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000100807","volume":"92","author":"KJ Kleven","year":"2007","unstructured":"Kleven KJ, Blohowiak SE, Kling PJ . Zinc protoporphyrin\/heme in large-for-gestation newborns. Neonatology 2007; 92: 91\u201395.","journal-title":"Neonatology"},{"key":"BFejcn2015229_CR34","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/jp.2009.182","volume":"30","author":"M Schmatz","year":"2010","unstructured":"Schmatz M, Madan J, Marino T, Davis J . Maternal obesity: the interplay between inflammation, mother and fetus. J Perinatol 2010; 30: 441\u2013446.","journal-title":"J Perinatol"},{"key":"BFejcn2015229_CR35","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/j.1753-4887.2008.00145.x","volume":"67","author":"JP McClung","year":"2009","unstructured":"McClung JP, Karl JP . Iron deficiency and obesity: the contribution of inflammation and diminished iron absorption. Nutr Rev 2009; 67: 100\u2013104.","journal-title":"Nutr Rev"},{"key":"BFejcn2015229_CR36","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1600-0609.2010.01479.x","volume":"85","author":"M Rehu","year":"2010","unstructured":"Rehu M, Punnonen K, Ostland V, Heinonen S, Westerman M, Pulkki K et al. Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol 2010; 85: 345\u2013352.","journal-title":"Eur J Haematol"},{"key":"BFejcn2015229_CR37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3945\/jn.111.145961","volume":"142","author":"MF Young","year":"2012","unstructured":"Young MF, Griffin I, Pressman E, McIntyre AW, Cooper E, McNanley T et al. Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources. J Nutr 2012; 142: 33\u201339.","journal-title":"J Nutr"},{"key":"BFejcn2015229_CR38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ejogrb.2009.08.012","volume":"147","author":"M Ervasti","year":"2009","unstructured":"Ervasti M, Sankilampi U, Luukkonen S, Heinonen S, Punnonen K . Maternal pro-hepcidin at term correlates with cord blood pro-hepcidin at birth. Eur J Obstet Gynecol Reprod Biol 2009; 147: 161\u2013165.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"BFejcn2015229_CR39","doi-asserted-by":"publisher","first-page":"R1063","DOI":"10.1152\/ajpregu.90793.2008","volume":"296","author":"L Gambling","year":"2009","unstructured":"Gambling L, Czopek A, Andersen HS, Holtrop G, Srai SK, Krejpcio Z et al. Fetal iron status regulates maternal iron metabolism during pregnancy in the rat. Am J Physiol Regul Integr Comp Physiol 2009; 296: R1063\u2013R1070.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFejcn2015229_CR40","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1182\/blood-2006-06-027631","volume":"108","author":"DM Wrighting","year":"2006","unstructured":"Wrighting DM, Andrews NC . Interleukin-6 induces hepcidin expression through STAT3. Blood 2006; 108: 3204\u20133209.","journal-title":"Blood"},{"key":"BFejcn2015229_CR41","first-page":"63","volume-title":"Priorities in the assessment of vitamin A and iron status in populations, Panama City, Panama, 15-17 September 2010","author":"DI Thurnham","year":"2012","unstructured":"Thurnham DI, McCabe GP. Influence of infection and inflammation on biomarkers of nutritional status with an emphasis on vitamin A and iron. In: Priorities in the assessment of vitamin A and iron status in populations, Panama City, Panama, 15-17 September 2010. World Health Organization: Geneva, Switzerland, 2012, pp 63\u201380."},{"key":"BFejcn2015229_CR42","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3945\/ajcn.2010.29284","volume":"92","author":"DI Thurnham","year":"2010","unstructured":"Thurnham DI, McCabe LD, Haldar S, Wieringa FT, Northrop-Clewes CA, McCabe GP . Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis. Am J Clin Nutr 2010; 92: 546\u2013555.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2015229_CR43","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1126\/science.1241244","volume":"341","author":"RS Ahima","year":"2013","unstructured":"Ahima RS, Lazar MA . The health risk of obesity\u2014better metrics imperative. Science 2013; 341: 856\u2013858.","journal-title":"Science"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015229","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T13:40:10Z","timestamp":1648215610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejcn2015229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,27]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["BFejcn2015229"],"URL":"https:\/\/doi.org\/10.1038\/ejcn.2015.229","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,27]]},"assertion":[{"value":"19 August 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}