{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:54:26Z","timestamp":1778903666408,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1038\/ejcn.2016.193","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T10:06:48Z","timestamp":1476871608000},"page":"259-266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Interactions between lifestyle and MTHFR polymorphisms on homocysteine concentrations in young adults belonging to the 1982 Pelotas Birth Cohort"],"prefix":"10.1038","volume":"71","author":[{"given":"I O","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L P","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O M","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J W","family":"Tessmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J V S","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F K","family":"Seixas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B L","family":"Horta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Gigante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"issue":"Suppl 6","key":"BFejcn2016193_CR1","doi-asserted-by":"publisher","first-page":"1636S","DOI":"10.1093\/jn\/136.6.1636S","volume":"136","author":"JT Brosnan","year":"2006","unstructured":"Brosnan JT, Brosnan ME . The sulfur-containing amino acids: an overview. J Nutr 2006; 136 (Suppl 6), 1636S\u20131640SS.","journal-title":"J Nutr"},{"key":"BFejcn2016193_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/ajcn\/67.2.263","volume":"67","author":"O Nygard","year":"1998","unstructured":"Nygard O, Refsum H, Ueland PM, Vollset SE . Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998; 67: 263\u2013270.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR3","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1093\/ajcn\/69.3.482","volume":"69","author":"PF Jacques","year":"1999","unstructured":"Jacques PF, Rosenberg IH, Rogers G, Selhub J, Bowman BA, Gunter EW et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 1999; 69: 482\u2013489.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/aje\/154.2.150","volume":"154","author":"A de Bree","year":"2001","unstructured":"de Bree A, Verschuren WM, Blom HJ, Kromhout D . Lifestyle factors and plasma homocysteine concentrations in a general population sample. Am J Epidemiol 2001; 154: 150\u2013154.","journal-title":"Am J Epidemiol"},{"key":"BFejcn2016193_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/S0100-879X2009007500021","volume":"43","author":"S Brustolin","year":"2010","unstructured":"Brustolin S, Giugliani R, Felix TM . Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res 2010; 43: 1\u20137.","journal-title":"Braz J Med Biol Res"},{"key":"BFejcn2016193_CR6","doi-asserted-by":"publisher","first-page":"755","DOI":"10.3945\/an.112.002758","volume":"3","author":"KL Schalinske","year":"2012","unstructured":"Schalinske KL, Smazal AL . Homocysteine imbalance: a pathological metabolic marker. Adv Nutr 2012; 3: 755\u2013762.","journal-title":"Adv Nutr"},{"key":"BFejcn2016193_CR7","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.clnu.2011.01.003","volume":"31","author":"T Huang","year":"2012","unstructured":"Huang T, Chen Y, Yang B, Yang J, Wahlqvist ML, Li D . Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. Clin Nutr 2012; 31: 448\u2013454.","journal-title":"Clin Nutr"},{"key":"BFejcn2016193_CR8","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.11.041","volume":"25","author":"Y Song","year":"2016","unstructured":"Song Y, Li B, Wang C, Wang P, Gao X, Liu G . Association between 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and risk of ischemic stroke: a meta-analysis. J Stroke Cerebrovasc Dis 2016; 25: 679\u2013687.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"BFejcn2016193_CR9","doi-asserted-by":"publisher","first-page":"363","DOI":"10.7326\/0003-4819-131-5-199909070-00008","volume":"131","author":"JW Eikelboom","year":"1999","unstructured":"Eikelboom JW, Lonn E, Genest Jr J, Hankey G, Yusuf S . Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med 1999; 131: 363\u2013375.","journal-title":"Ann Intern Med"},{"key":"BFejcn2016193_CR10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/ije\/31.1.59","volume":"31","author":"ES Ford","year":"2002","unstructured":"Ford ES, Smith SJ, Stroup DF, Steinberg KK, Mueller PW, Thacker SB . Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int J Epidemiol 2002; 31: 59\u201370.","journal-title":"Int J Epidemiol"},{"issue":"Suppl 7","key":"BFejcn2016193_CR11","first-page":"S59","volume":"52","author":"R Clarke","year":"2000","unstructured":"Clarke R . Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Indian Heart J 2000; 52 (Suppl 7), S59\u2013S64.","journal-title":"Indian Heart J"},{"key":"BFejcn2016193_CR12","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1093\/ajcn\/72.5.1156","volume":"72","author":"LB Rasmussen","year":"2000","unstructured":"Rasmussen LB, Ovesen L, Bulow I, Knudsen N, Laurberg P, Perrild H . Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women. Am J Clin Nutr 2000; 72: 1156\u20131163.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1017\/S0029665113003613","volume":"73","author":"R Reilly","year":"2014","unstructured":"Reilly R, McNulty H, Pentieva K, Strain JJ, Ward M . MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins? Proc Nutr Soc 2014; 73: 47\u201356.","journal-title":"Proc Nutr Soc"},{"key":"BFejcn2016193_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/ng0595-111","volume":"10","author":"P Frosst","year":"1995","unstructured":"Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111\u2013113.","journal-title":"Nat Genet"},{"key":"BFejcn2016193_CR15","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.ajhg.2009.02.011","volume":"84","author":"T Tanaka","year":"2009","unstructured":"Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet 2009; 84: 477\u2013482.","journal-title":"Am J Hum Genet"},{"key":"BFejcn2016193_CR16","doi-asserted-by":"publisher","first-page":"668","DOI":"10.3945\/ajcn.112.044545","volume":"98","author":"JB van Meurs","year":"2013","unstructured":"van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH et al. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr 2013; 98: 668\u2013676.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1161\/01.CIR.103.1.163","volume":"103","author":"LB Goldstein","year":"2001","unstructured":"Goldstein LB, Adams R, Becker K, Furberg CD, Gorelick PB, Hademenos G et al. Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Circulation 2001; 103: 163\u2013182.","journal-title":"Circulation"},{"key":"BFejcn2016193_CR18","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/ije\/dyi290","volume":"35","author":"CG Victora","year":"2006","unstructured":"Victora CG, Barros FC . Cohort profile: the 1982 Pelotas (Brazil) birth cohort study. Int J Epidemiol 2006; 35: 237\u2013242.","journal-title":"Int J Epidemiol"},{"issue":"Suppl 2","key":"BFejcn2016193_CR19","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1590\/S0034-89102008000900010","volume":"42","author":"MR Azevedo","year":"2008","unstructured":"Azevedo MR, Horta BL, Gigante DP, Victora CG, Barros FC . [Factors associated to leisure-time sedentary lifestyle in adults of 1982 birth cohort, Pelotas, Southern Brazil]. Rev Saude Publica 2008; 42 (Suppl 2), 70\u201377.","journal-title":"Rev Saude Publica"},{"key":"BFejcn2016193_CR20","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF . A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215.","journal-title":"Nucleic Acids Res"},{"key":"BFejcn2016193_CR21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12937-015-0006-3","volume":"14","author":"A Barnabe","year":"2015","unstructured":"Barnabe A, Alessio AC, Bittar LF, de Moraes Mazetto B, Bicudo AM, de Paula EV et al. Folate, vitamin B12 and homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center. Nutr J 2015; 14: 19.","journal-title":"Nutr J"},{"key":"BFejcn2016193_CR22","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1124\/pr.54.4.599","volume":"54","author":"A De Bree","year":"2002","unstructured":"De Bree A, Verschuren WM, Kromhout D, Kluijtmans LA, Blom HJ . Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 2002; 54: 599\u2013618.","journal-title":"Pharmacol Rev"},{"key":"BFejcn2016193_CR23","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1210\/jcem.83.2.4574","volume":"83","author":"EJ Giltay","year":"1998","unstructured":"Giltay EJ, Hoogeveen EK, Elbers JM, Gooren LJ, Asscheman H, Stehouwer CD . Effects of sex steroids on plasma total homocysteine levels: a study in transsexual males and females. J Clin Endocrinol Metab 1998; 83: 550\u2013553.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFejcn2016193_CR24","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1093\/jn\/133.8.2643","volume":"133","author":"A Must","year":"2003","unstructured":"Must A, Jacques PF, Rogers G, Rosenberg IH, Selhub J . Serum total homocysteine concentrations in children and adolescents: results from the third National Health and Nutrition Examination Survey (NHANES III). J Nutr 2003; 133: 2643\u20132649.","journal-title":"J Nutr"},{"key":"BFejcn2016193_CR25","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1373\/clinchem.2004.036194","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum H, Grindflek AW, Ueland PM, Fredriksen A, Meyer K, Ulvik A et al. Screening for serum total homocysteine in newborn children. Clin Chem 2004; 50: 1769\u20131784.","journal-title":"Clin Chem"},{"key":"BFejcn2016193_CR26","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.numecd.2006.03.006","volume":"17","author":"A Battezzati","year":"2007","unstructured":"Battezzati A, Bertoli S, San Romerio A, Testolin G . Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals. Nutr Metab Cardiovasc Dis 2007; 17: 525\u2013534.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"BFejcn2016193_CR27","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1001\/jama.1993.03510220049033","volume":"270","author":"J Selhub","year":"1993","unstructured":"Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH . Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270: 2693\u20132698.","journal-title":"JAMA"},{"key":"BFejcn2016193_CR28","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3945\/jn.108.092726","volume":"139","author":"V Ganji","year":"2009","unstructured":"Ganji V, Kafai MR . Demographic, lifestyle, and health characteristics and serum B vitamin status are determinants of plasma total homocysteine concentration in the post-folic acid fortification period, 1999-2004. J Nutr 2009; 139: 345\u2013352.","journal-title":"J Nutr"},{"key":"BFejcn2016193_CR29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1093\/ajcn\/73.3.613","volume":"73","author":"PF Jacques","year":"2001","unstructured":"Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J . Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 2001; 73: 613\u2013621.","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 8","key":"BFejcn2016193_CR30","doi-asserted-by":"publisher","first-page":"2367S","DOI":"10.1093\/jn\/132.8.2367S","volume":"132","author":"CH Halsted","year":"2002","unstructured":"Halsted CH, Villanueva JA, Devlin AM, Chandler CJ . Metabolic interactions of alcohol and folate. J Nutr 2002; 132 (Suppl 8), 2367S\u20132372SS.","journal-title":"J Nutr"},{"key":"BFejcn2016193_CR31","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1017\/S0007114514004218","volume":"113","author":"XD Liu","year":"2015","unstructured":"Liu XD, Gao B, Sun D, Shi M, Ma YY, Liu ZR et al. Prevalence of hyperhomocysteinaemia and some of its major determinants in Shaanxi Province, China: a cross-sectional study. Br J Nutr 2015; 113: 691\u2013698.","journal-title":"Br J Nutr"},{"key":"BFejcn2016193_CR32","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1017\/S1368980011000140","volume":"14","author":"T Huang","year":"2011","unstructured":"Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, Shen J et al. Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population. Public Health Nutr 2011; 14: 1805\u20131812.","journal-title":"Public Health Nutr"},{"key":"BFejcn2016193_CR33","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1017\/S0007114507280535","volume":"97","author":"JR Ruiz","year":"2007","unstructured":"Ruiz JR, Hurtig-Wennlof A, Ortega FB, Patterson E, Nilsson TK, Castillo MJ et al. Homocysteine levels in children and adolescents are associated with the methylenetetrahydrofolate reductase 677C&gt;T genotype, but not with physical activity, fitness or fatness: the European Youth Heart Study. Br J Nutr 2007; 97: 255\u2013262.","journal-title":"Br J Nutr"},{"key":"BFejcn2016193_CR34","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1161\/01.CIR.98.23.2520","volume":"98","author":"L Brattstrom","year":"1998","unstructured":"Brattstrom L, Wilcken DE, Ohrvik J, Brudin L . Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998; 98: 2520\u20132526.","journal-title":"Circulation"},{"key":"BFejcn2016193_CR35","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.atherosclerosis.2004.01.023","volume":"174","author":"KS Brown","year":"2004","unstructured":"Brown KS, Kluijtmans LA, Young IS, Murray L, McMaster D, Woodside JV et al. The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine. Atherosclerosis 2004; 174: 315\u2013322.","journal-title":"Atherosclerosis"},{"key":"BFejcn2016193_CR36","doi-asserted-by":"publisher","first-page":"e53322","DOI":"10.1371\/journal.pone.0053322","volume":"7","author":"M Linnebank","year":"2013","unstructured":"Linnebank M, Moskau S, Semmler A, Hoefgen B, Bopp G, Kallweit U et al. A possible genetic link between MTHFR genotype and smoking behavior. PLoS One 2013; 7: e53322.","journal-title":"PLoS One"},{"key":"BFejcn2016193_CR37","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/ajcn.83.3.708","volume":"83","author":"AM Devlin","year":"2006","unstructured":"Devlin AM, Clarke R, Birks J, Evans JG, Halsted CH . Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. Am J Clin Nutr 2006; 83: 708\u2013713.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR38","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3945\/ajcn.110.004671","volume":"93","author":"KS Crider","year":"2011","unstructured":"Crider KS, Zhu JH, Hao L, Yang QH, Yang TP, Gindler J et al. MTHFR 677C-&gt;T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Am J Clin Nutr 2011; 93: 1365\u20131372.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR39","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/ajcn\/73.2.232","volume":"73","author":"SM Saw","year":"2001","unstructured":"Saw SM, Yuan JM, Ong CN, Arakawa K, Lee HP, Coetzee GA et al. Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am J Clin Nutr 2001; 73: 232\u2013239.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR40","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/FPC.0b013e32834741ff","volume":"21","author":"P Nagele","year":"2011","unstructured":"Nagele P, Meissner K, Francis A, Fodinger M, Saccone NL . Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. Pharmacogenet Genomics 2011; 21: 426\u2013431.","journal-title":"Pharmacogenet Genomics"},{"key":"BFejcn2016193_CR41","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/ajcn\/82.1.155","volume":"82","author":"SE Chiuve","year":"2005","unstructured":"Chiuve SE, Giovannucci EL, Hankinson SE, Hunter DJ, Stampfer MJ, Willett WC et al. Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine. Am J Clin Nutr 2005; 82: 155\u2013162.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR42","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/ajcn\/88.1.232","volume":"88","author":"QH Yang","year":"2008","unstructured":"Yang QH, Botto LD, Gallagher M, Friedman JM, Sanders CL, Koontz D et al. Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank. Am J Clin Nutr 2008; 88: 232\u2013246.","journal-title":"Am J Clin Nutr"},{"key":"BFejcn2016193_CR43","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.alcohol.2005.03.012","volume":"35","author":"JB Mason","year":"2005","unstructured":"Mason JB, Choi SW . Effects of alcohol on folate metabolism: implications for carcinogenesis. Alcohol 2005; 35: 235\u2013241.","journal-title":"Alcohol"},{"key":"BFejcn2016193_CR44","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/gepi.10239","volume":"24","author":"LL Husemoen","year":"2003","unstructured":"Husemoen LL, Thomsen TF, Fenger M, Jorgensen HL, Jorgensen T . Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2). Genet Epidemiol 2003; 24: 322\u2013330.","journal-title":"Genet Epidemiol"},{"key":"BFejcn2016193_CR45","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/CIRCGENETICS.108.829804","volume":"2","author":"G Pare","year":"2009","unstructured":"Pare G, Chasman DI, Parker AN, Zee RR, Malarstig A, Seedorf U et al. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. Circ Cardiovasc Genet 2009; 2: 142\u2013150.","journal-title":"Circ Cardiovasc Genet"},{"key":"BFejcn2016193_CR46","doi-asserted-by":"publisher","first-page":"e17063","DOI":"10.1371\/journal.pone.0017063","volume":"6","author":"SD Pena","year":"2011","unstructured":"Pena SD, Di Pietro G, Fuchshuber-Moraes M, Genro JP, Hutz MH, Kehdy Fde S et al. The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected. PLoS One 2011; 6: e17063.","journal-title":"PLoS One"},{"key":"BFejcn2016193_CR47","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/S0140-6736(00)02172-3","volume":"355","author":"MS van der Gaag","year":"2000","unstructured":"van der Gaag MS, Ubbink JB, Sillanaukee P, Nikkari S, Hendriks HF . Effect of consumption of red wine, spirits, and beer on serum homocysteine. Lancet 2000; 355: 1522.","journal-title":"Lancet"}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejcn2016193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejcn2016193","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejcn2016193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:50:15Z","timestamp":1684417815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejcn2016193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,19]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["BFejcn2016193"],"URL":"https:\/\/doi.org\/10.1038\/ejcn.2016.193","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,19]]},"assertion":[{"value":"1 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}