{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:31:15Z","timestamp":1761964275890},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T00:00:00Z","timestamp":1279670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1038\/ejhg.2010.117","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T10:32:34Z","timestamp":1279708354000},"page":"1333-1338","source":"Crossref","is-referenced-by-count":11,"title":["Potential role of TCF7L2 gene variants on cardiac sympathetic\/parasympathetic activity"],"prefix":"10.1038","volume":"18","author":[{"given":"Virginia","family":"Boccardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immacolata","family":"Ambrosino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Papa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosaria","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Paolisso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelangela","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,21]]},"reference":[{"key":"BFejhg2010117_CR1","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1210\/me.2008-0135","volume":"22","author":"T Jin","year":"2008","unstructured":"Jin T, Liu L : The Wnt signalling pathway effector TCF7L2 and type II diabetes mellitus. Mol Endocrinol 2008; 22: 2383\u20132392.","journal-title":"Mol Endocrinol"},{"key":"BFejhg2010117_CR2","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1097\/00004872-200306000-00012","volume":"21","author":"M Yu","year":"2003","unstructured":"Yu M, Moreno C, Hoagland KM et al: Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats. J Hypertens 2003; 21: 1125\u20131135.","journal-title":"J Hypertens"},{"key":"BFejhg2010117_CR3","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ng1732","volume":"38","author":"SF Grant","year":"2006","unstructured":"Grant SF, Thorleifsson G, Reynisdottir I et al: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320\u2013323.","journal-title":"Nat Genet"},{"key":"BFejhg2010117_CR4","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.2337\/db06-0355","volume":"55","author":"CJ Groves","year":"2006","unstructured":"Groves CJ, Zeggini E, Minton J et al: Association analysis of 6736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006; 55: 2640\u20132644.","journal-title":"Diabetes"},{"key":"BFejhg2010117_CR5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1056\/NEJMoa062418","volume":"355","author":"JC Florez","year":"2006","unstructured":"Florez JC, Jablonski KA, Bayley N et al: TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006; 355: 241\u2013250.","journal-title":"N Engl J Med"},{"key":"BFejhg2010117_CR6","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.2337\/db06-0338","volume":"55","author":"CM Damcott","year":"2006","unstructured":"Damcott CM, Pollin TI, Reinhart LJ et al: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 2006; 55: 2654\u20132659.","journal-title":"Diabetes"},{"key":"BFejhg2010117_CR7","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.2337\/db06-0381","volume":"55","author":"R Saxena","year":"2006","unstructured":"Saxena R, Gianniny L, Burtt NP et al: Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 2006; 55: 2890\u20132895.","journal-title":"Diabetes"},{"key":"BFejhg2010117_CR8","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.2337\/db06-0643","volume":"55","author":"C Zhang","year":"2006","unstructured":"Zhang C, Qi L, Hunter DJ et al: Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes 2006; 55: 2645\u20132648.","journal-title":"Diabetes"},{"key":"BFejhg2010117_CR9","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.2337\/db06-0474","volume":"55","author":"S Cauchi","year":"2006","unstructured":"Cauchi S, Meyre D, Dina C et al: Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 2006; 55: 2903\u20132908.","journal-title":"Diabetes"},{"key":"BFejhg2010117_CR10","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.2337\/db06-0341","volume":"55","author":"LJ Scott","year":"2006","unstructured":"Scott LJ, Bonnycastle LL, Willer CJ et al: Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes 2006; 55: 2649\u20132653.","journal-title":"Diabetes"},{"key":"BFejhg2010117_CR11","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1007\/s00125-007-0753-6","volume":"50","author":"SA Schafer","year":"2007","unstructured":"Schafer SA, Tscritter O, Machicao F et al: Impaired glucagons-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 2007; 50: 2443\u20132450.","journal-title":"Diabetologia"},{"key":"BFejhg2010117_CR12","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1152\/ajpendo.00237.2004","volume":"287","author":"T Nystrom","year":"2004","unstructured":"Nystrom T, Gutniak MK, Zhang Q et al: Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004; 287: 1209\u20131215.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFejhg2010117_CR13","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1161\/CIRCULATIONAHA.107.739938","volume":"117","author":"K Ban","year":"2008","unstructured":"Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M : Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008; 117: 2340\u20132350.","journal-title":"Circulation"},{"key":"BFejhg2010117_CR14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5","volume":"403","author":"I Merchenthaler","year":"1999","unstructured":"Merchenthaler I, Lane M, Shughrue P : Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 1999; 403: 261\u2013280.","journal-title":"J Comp Neurol"},{"key":"BFejhg2010117_CR15","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0014-5793(94)01430-9","volume":"358","author":"Y Wei","year":"1995","unstructured":"Wei Y, Mojsov S : Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 1995; 358: 219\u2013224.","journal-title":"FEBS Lett"},{"key":"BFejhg2010117_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1172\/JCI0215595","volume":"110","author":"H Yamamoto","year":"2002","unstructured":"Yamamoto H, Lee CE, Marcus JN et al: Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest 2002; 110: 43\u201352.","journal-title":"J Clin Invest"},{"key":"BFejhg2010117_CR17","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1523\/JNEUROSCI.23-07-02939.2003","volume":"23","author":"H Yamamoto","year":"2003","unstructured":"Yamamoto H, Kishi T, Lee CE et al: Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 2003; 23: 2939\u20132946.","journal-title":"J Neurosci"},{"key":"BFejhg2010117_CR18","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1152\/ajpregu.00153.2008","volume":"295","author":"AE Bharucha","year":"2008","unstructured":"Bharucha AE, Charkoudian N, Andrews CN et al: Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans. Am J Physiol Regul Integr Comp Physiol 2008; 295: 874\u2013880.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFejhg2010117_CR19","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","volume":"17","author":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Heart rate variability","year":"1996","unstructured":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Heart rate variability: Standards of measurements, physiological interpretation, and clinical use. Eur Heart J 1996; 17: 354\u2013381.","journal-title":"Eur Heart J"},{"key":"BFejhg2010117_CR20","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1161\/01.CIR.84.2.482","volume":"84","author":"A Malliani","year":"1991","unstructured":"Malliani A, Lombardi F, Pagani M, Cerutti S : Cardiovascular neural regulation explored in the frequency domain. Circulation 1991; 84: 1482\u20131492.","journal-title":"Circulation"},{"key":"BFejhg2010117_CR21","first-page":"471","volume":"273","author":"G Paolisso","year":"1997","unstructured":"Paolisso G, Manzella D, Ferrara N et al: Glucose ingestion affects cardiac ANS in healthy subjects with different amounts of body fat. Am J Physiol 1997; 273: 471\u2013478.","journal-title":"Am J Physiol"},{"key":"BFejhg2010117_CR22","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/S0026-0495(99)90176-2","volume":"48","author":"G Paolisso","year":"1999","unstructured":"Paolisso G, Manzella D, Tagliamonte MR, Rizzo MR, Gambardella A, Varricchio M : Effects of different insulin infusion rates on heart rate variability in lean and obese subjects. Metabolism 1999; 48: 755\u2013762.","journal-title":"Metabolism"},{"key":"BFejhg2010117_CR23","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"KGMM Aberti","year":"1998","unstructured":"Aberti KGMM, Zimmet PZ, for the WHO Consultation: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of WHO consultation. Diab Med 1998; 15: 539\u2013553.","journal-title":"Diab Med"},{"key":"BFejhg2010117_CR24","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1542-474X.2005.10101.x","volume":"10","author":"RE Kleiger","year":"2005","unstructured":"Kleiger RE, Stein PK, Bigger Jr JT : Heart rate variability: measurement and clinical utility. Ann Noninvasive Electrocardiol 2005; 10: 88\u2013101.","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"BFejhg2010117_CR25","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1190\/1.1440846","volume":"43","author":"SJ Jonsen","year":"1978","unstructured":"Jonsen SJ, Andersen N : On power estimation in maximum entropy spectral analysis. Geophysics 1978; 43: 681\u2013690.","journal-title":"Geophysics"},{"key":"BFejhg2010117_CR26","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1074\/jbc.M411487200","volume":"280","author":"F Yi","year":"2005","unstructured":"Yi F, Brubaker PL, Jin T : TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem 2005; 280: 1457\u20131464.","journal-title":"J Biol Chem"},{"key":"BFejhg2010117_CR27","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1210\/edrv-16-3-390","volume":"16","author":"HC Fehmann","year":"1995","unstructured":"Fehmann HC, Goke R, Goke B : Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr Rev 1995; 16: 390\u2013410.","journal-title":"Endocr Rev"},{"key":"BFejhg2010117_CR28","doi-asserted-by":"publisher","first-page":"276","DOI":"10.2337\/diabetes.53.2.276","volume":"53","author":"DR Seals","year":"2004","unstructured":"Seals DR, Bell C : Chronic sympathetic activation: consequence and cause of age-associated obesity? Diabetes 2004; 53: 276\u2013284.","journal-title":"Diabetes"},{"key":"BFejhg2010117_CR29","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.physbeh.2007.12.020","volume":"94","author":"A van Baak Marlen","year":"2007","unstructured":"van Baak Marlen A : Meal-induced activation of sympathetic nervous system and its cardiovascular and thermogenic effects in man. Physiol Behav 2007; 94: 178\u2013186.","journal-title":"Physiol Behav"},{"key":"BFejhg2010117_CR30","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1161\/01.CIR.90.2.878","volume":"90","author":"H Tsuji","year":"1994","unstructured":"Tsuji H, Venditti Jr FJ, Manders ES et al: Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 1994; 90: 878\u2013883.","journal-title":"Circulation"},{"key":"BFejhg2010117_CR31","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1097\/HJH.0b013e328048d004","volume":"25","author":"G Mancia","year":"2007","unstructured":"Mancia G, Bousquet P, Elghozi JL et al: The sympathetic nervous system and the metabolic syndrome. J Hypertens 2007; 25: 909\u2013920.","journal-title":"J Hypertens"},{"key":"BFejhg2010117_CR32","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM199602083340607","volume":"334","author":"GM Reaven","year":"1996","unstructured":"Reaven GM, Lithell H, Landsberg L : Hypertension and associated metabolic abnormalities\u2013the role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996; 334: 374\u2013381.","journal-title":"N Engl J Med"},{"key":"BFejhg2010117_CR33","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/BF00399935","volume":"35","author":"C Berne","year":"1992","unstructured":"Berne C, Fagius J, Pollare T, Hjemdahl P : The sympathetic response to euglycaemic hyperinsulinaemia. Evidence from microelectrode nerve recordings in healthy subjects. Diabetologia 1992; 35: 873\u2013879.","journal-title":"Diabetologia"},{"key":"BFejhg2010117_CR34","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1172\/JCI115260","volume":"87","author":"EA Anderson","year":"1991","unstructured":"Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL : Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 1991; 87: 2246\u20132252.","journal-title":"J Clin Invest"},{"key":"BFejhg2010117_CR35","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2337\/diacare.28.3.668","volume":"28","author":"EB Schroeder","year":"2005","unstructured":"Schroeder EB, Chambless LE, Liao D et al: Diabetes, glucose, insulin, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 2005; 28: 668\u2013674.","journal-title":"Diabetes Care"},{"key":"BFejhg2010117_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1042\/CS20040223","volume":"108","author":"D Manzella","year":"2005","unstructured":"Manzella D, Paolisso G : Cardiac autonomic activity and type II diabetes mellitus. Clinical Science 2005; 108: 93\u201399.","journal-title":"Clinical Science"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg2010117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2010117","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2010117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:59:44Z","timestamp":1684429184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg2010117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,21]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["BFejhg2010117"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2010.117","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,21]]}}}