{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:34:07Z","timestamp":1788910447566,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T00:00:00Z","timestamp":1270598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1038\/ejhg.2010.27","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T10:24:52Z","timestamp":1270635892000},"page":"838-843","source":"Crossref","is-referenced-by-count":68,"title":["Replication of the LINGO1 gene association with essential tremor in a North American population"],"prefix":"10.1038","volume":"18","author":[{"given":"Lorraine N","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Kisselev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan D","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,7]]},"reference":[{"key":"BFejhg201027_CR1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/ncpneuro0347","volume":"2","author":"J Benito-Leon","year":"2006","unstructured":"Benito-Leon J, Louis ED : Essential tremor: emerging views of a common disorder. Nat Clin Pract Neurol 2006; 2: 666\u2013678.","journal-title":"Nat Clin Pract Neurol"},{"key":"BFejhg201027_CR2","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1159\/000195691","volume":"32","author":"ED Louis","year":"2009","unstructured":"Louis ED, Thawani SP, Andrews HF : Prevalence of essential tremor in a multiethnic, community-based study in northern Manhattan, New York, NY. Neuroepidemiology 2009; 32: 208\u2013214.","journal-title":"Neuroepidemiology"},{"key":"BFejhg201027_CR3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/ng0997-84","volume":"17","author":"JR Gulcher","year":"1997","unstructured":"Gulcher JR, Jonsson P, Kong A et al: Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. Nat Genet 1997; 17: 84\u201387.","journal-title":"Nat Genet"},{"key":"BFejhg201027_CR4","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1002\/mds.870120605","volume":"12","author":"JJ Higgins","year":"1997","unstructured":"Higgins JJ, Pho LT, Nee LE : A gene (ETM) for essential tremor maps to chromosome 2p22-p25. Mov Disord 1997; 12: 859\u2013864.","journal-title":"Mov Disord"},{"key":"BFejhg201027_CR5","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1093\/brain\/awl120","volume":"129","author":"A Shatunov","year":"2006","unstructured":"Shatunov A, Sambuughin N, Jankovic J et al: Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23. Brain 2006; 129: 2318\u20132331.","journal-title":"Brain"},{"key":"BFejhg201027_CR6","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1212\/WNL.61.7.931","volume":"61","author":"ED Louis","year":"2003","unstructured":"Louis ED, Levy G, Mejia-Santana H et al: Risk of action tremor in relatives of tremor-dominant and postural instability gait disorder PD. Neurology 2003; 61: 931\u2013936.","journal-title":"Neurology"},{"key":"BFejhg201027_CR7","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1093\/brain\/awm266","volume":"130","author":"ED Louis","year":"2007","unstructured":"Louis ED, Faust PL, Vonsattel JP et al: Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 2007; 130: 3297\u20133307.","journal-title":"Brain"},{"key":"BFejhg201027_CR8","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1136\/jnnp.2008.147223","volume":"80","author":"J Benito-Leon","year":"2009","unstructured":"Benito-Leon J, Louis ED, Bermejo-Pareja F : Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study. J Neurol Neurosurg Psychiatry 2009; 80: 423\u2013425.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"BFejhg201027_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.neulet.2006.08.012","volume":"407","author":"H Deng","year":"2006","unstructured":"Deng H, Le W, Davidson AL, Xie W, Jankovic J : The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor. Neurosci Lett 2006; 407: 97\u2013100.","journal-title":"Neurosci Lett"},{"key":"BFejhg201027_CR10","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neulet.2007.04.026","volume":"419","author":"H Deng","year":"2007","unstructured":"Deng H, Le W, Huang M, Xie W, Pan T, Jankovic J : Genetic analysis of LRRK2 P755L variant in Caucasian patients with Parkinson's disease. Neurosci Lett 2007; 419: 104\u2013107.","journal-title":"Neurosci Lett"},{"key":"BFejhg201027_CR11","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.parkreldis.2007.12.003","volume":"14","author":"EK Tan","year":"2008","unstructured":"Tan EK, Lee J, Lim HQ, Yuen Y, Zhao Y : Essential tremor and the common LRRK2 G2385R variant. Parkinsonism Relat Disord 2008; 14: 569\u2013571.","journal-title":"Parkinsonism Relat Disord"},{"key":"BFejhg201027_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.parkreldis.2008.04.035","volume":"15","author":"C Vitale","year":"2009","unstructured":"Vitale C, Ciotti P, Gulli R et al: Common mutations in the LRRK2 exon 41 are not responsible for essential tremor in Italian patients. Parkinsonism Relat Disord 2009; 15: 162\u2013163.","journal-title":"Parkinsonism Relat Disord"},{"key":"BFejhg201027_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.parkreldis.2009.05.008","volume":"16","author":"LN Clark","year":"2010","unstructured":"Clark LN, Kisselev S, Park N et al: Mutations in the Parkinson's disease genes, Leucine rich repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor. Parkinsonism Relat Disord 2010; 16: 132\u2013135.","journal-title":"Parkinsonism Relat Disord"},{"key":"BFejhg201027_CR14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/ng.299","volume":"41","author":"H Stefansson","year":"2009","unstructured":"Stefansson H, Steinberg S, Petursson H et al: Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet 2009; 41: 277\u2013279.","journal-title":"Nat Genet"},{"key":"BFejhg201027_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.parkreldis.2009.08.006","volume":"16","author":"C Vilari\u00f1o-G\u00fcell","year":"2010","unstructured":"Vilari\u00f1o-G\u00fcell C, Ross OA, Wider C et al: LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. Parkinsonism Relat Disord 2010; 16: 109\u2013111.","journal-title":"Parkinsonism Relat Disord"},{"key":"BFejhg201027_CR16","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1212\/WNL.0b013e3181bacfc9","volume":"73","author":"EK Tan","year":"2009","unstructured":"Tan EK, Teo YY, Prakash KM et al: LINGO1 variant increases risk of familial essential tremor. Neurology 2009; 73: 1161\u20131162.","journal-title":"Neurology"},{"key":"BFejhg201027_CR17","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1002\/1531-8257(200007)15:4<738::AID-MDS1024>3.0.CO;2-4","volume":"15","author":"ED Louis","year":"2000","unstructured":"Louis ED, Schonberger RB, Parides M, Ford B, Barnes LF : Test-retest reliability of patient information on age of onset in essential tremor. Mov Disord 2000; 15: 738\u2013741.","journal-title":"Mov Disord"},{"key":"BFejhg201027_CR18","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1159\/000111584","volume":"29","author":"ED Louis","year":"2007","unstructured":"Louis ED, Dogu O : Does age of onset in essential tremor have a bimodal distribution? Data from a tertiary referral setting and a population-based study. Neuroepidemiology 2007; 29: 208\u2013212.","journal-title":"Neuroepidemiology"},{"key":"BFejhg201027_CR19","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuro.2007.12.001","volume":"29","author":"ED Louis","year":"2008","unstructured":"Louis ED, Jiang W, Pellegrino KM et al: Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor. Neurotoxicology 2008; 29: 294\u2013300.","journal-title":"Neurotoxicology"},{"key":"BFejhg201027_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ : Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263\u2013265.","journal-title":"Bioinformatics"},{"key":"BFejhg201027_CR21","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1086\/338688","volume":"70","author":"DJ Schaid","year":"2002","unstructured":"Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA : Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002; 70: 425\u2013434.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201027_CR22","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s00401-009-0534-z","volume":"117","author":"ED Louis","year":"2009","unstructured":"Louis ED, Faust PL, Vonsattel JP, Erickson-Davis C : Purkinje cell axonal torpedoes are unrelated to advanced aging and likely reflect cerebellar injury. Acta Neuropathol 2009; 117: 719\u2013721.","journal-title":"Acta Neuropathol"},{"key":"BFejhg201027_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neulet.2008.11.043","volume":"450","author":"ED Louis","year":"2009","unstructured":"Louis ED, Yi H, Erickson-Davis C, Vonsattel JP, Faust PL : Structural study of Purkinje cell axonal torpedoes in essential tremor. Neurosci Lett 2009; 450: 287\u2013291.","journal-title":"Neurosci Lett"},{"key":"BFejhg201027_CR24","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/nm1664","volume":"13","author":"S Mi","year":"2007","unstructured":"Mi S, Hu B, Hahm K et al: LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med 2007; 13: 1228\u20131233.","journal-title":"Nat Med"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg201027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201027","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:01:29Z","timestamp":1684429289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg201027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["BFejhg201027"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2010.27","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,7]]}}}