{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:24:30Z","timestamp":1767677070362},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1038\/ejhg.2010.33","type":"journal-article","created":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T11:25:22Z","timestamp":1269429922000},"page":"862-866","source":"Crossref","is-referenced-by-count":10,"title":["Usefulness of factor V Leiden mutation testing in clinical practice"],"prefix":"10.1038","volume":"18","author":[{"given":"Ellen \u00d8","family":"Blinkenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann-Helen","family":"Kristoffersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre","family":"Sandberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidar M","family":"Steen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Houge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,3,24]]},"reference":[{"key":"BFejhg201033_CR1","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00109-007-0203-4","volume":"85","author":"S Cauchi","year":"2007","unstructured":"Cauchi S, El Achhab Y, Choquet H et al: TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 2007; 85: 777\u2013782.","journal-title":"J Mol Med"},{"key":"BFejhg201033_CR2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/01.mol.0000217895.67444.de","volume":"17","author":"S Visvikis-Siest","year":"2006","unstructured":"Visvikis-Siest S, Marteau JB : Genetic variants predisposing to cardiovascular disease. Curr Opin Lipidol 2006; 17: 139\u2013151.","journal-title":"Curr Opin Lipidol"},{"key":"BFejhg201033_CR3","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/nrg1495","volume":"5","author":"W Burke","year":"2004","unstructured":"Burke W, Zimmern RL : Ensuring the appropriate use of genetic tests. Nat Rev Genet 2004; 5: 955\u2013959.","journal-title":"Nat Rev Genet"},{"key":"BFejhg201033_CR4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/00000441-200108000-00007","volume":"322","author":"R Lee","year":"2001","unstructured":"Lee R : Factor V Leiden: a clinical review. Am J Med Sci 2001; 322: 88\u2013102.","journal-title":"Am J Med Sci"},{"key":"BFejhg201033_CR5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.7326\/0003-4819-140-5-200403020-00008","volume":"140","author":"K Juul","year":"2004","unstructured":"Juul K, Tybjaerg-Hansen A, Schnohr P, Nordestgaard BG : Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med 2004; 140: 330\u2013337.","journal-title":"Ann Intern Med"},{"key":"BFejhg201033_CR6","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1001\/jama.1997.03540400055031","volume":"277","author":"PM Ridker","year":"1997","unstructured":"Ridker PM, Miletich JP, Hennekens CH, Buring JE : Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA 1997; 277: 1305\u20131307.","journal-title":"JAMA"},{"key":"BFejhg201033_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2796.1992.tb00565.x","volume":"232","author":"M Nordstrom","year":"1992","unstructured":"Nordstrom M, Lindblad B, Bergqvist D, Kjellstrom T : A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med 1992; 232: 155\u2013160.","journal-title":"J Intern Med"},{"key":"BFejhg201033_CR8","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0033-0620(94)80051-0","volume":"36","author":"CJ Carter","year":"1994","unstructured":"Carter CJ : The natural history and epidemiology of venous thrombosis. Prog Cardiovasc Dis 1994; 36: 423\u2013438.","journal-title":"Prog Cardiovasc Dis"},{"key":"BFejhg201033_CR9","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1001\/archinte.166.7.729","volume":"166","author":"WK Ho","year":"2006","unstructured":"Ho WK, Hankey GJ, Quinlan DJ, Eikelboom JW : Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic review. Arch Intern Med 2006; 166: 729\u2013736.","journal-title":"Arch Intern Med"},{"key":"BFejhg201033_CR10","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1001\/jama.296.4.397","volume":"296","author":"G Hron","year":"2006","unstructured":"Hron G, Kollars M, Binder BR, Eichinger S, Kyrle PA : Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation. JAMA 2006; 296: 397\u2013402.","journal-title":"JAMA"},{"key":"BFejhg201033_CR11","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1001\/jama.293.19.2352","volume":"293","author":"SC Christiansen","year":"2005","unstructured":"Christiansen SC, Cannegieter SC, Koster T, Vandenbroucke JP, Rosendaal FR : Thrombophilia, clinical factors, and recurrent venous thrombotic events. JAMA 2005; 293: 2352\u20132361.","journal-title":"JAMA"},{"key":"BFejhg201033_CR12","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.5858\/2002-126-1304-CUOFVL","volume":"126","author":"RD Press","year":"2002","unstructured":"Press RD, Bauer KA, Kujovich JL, Heit JA : Clinical utility of factor V leiden (R506Q) testing for the diagnosis and management of thromboembolic disorders. Arch Pathol Lab Med 2002; 126: 1304\u20131318.","journal-title":"Arch Pathol Lab Med"},{"key":"BFejhg201033_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00125817-200103000-00009","volume":"3","author":"WW Grody","year":"2001","unstructured":"Grody WW, Griffin JH, Taylor AK, Korf BR, Heit JA : American College of Medical Genetics consensus statement on factor V Leiden mutation testing. Genet Med 2001; 3: 139\u2013148.","journal-title":"Genet Med"},{"key":"BFejhg201033_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/00033197050560i101","volume":"24","author":"AN Nicolaides","year":"2005","unstructured":"Nicolaides AN, Breddin HK, Carpenter P et al: Thrombophilia and venous thromboembolism. International consensus statement. Guidelines according to scientific evidence. Int Angiol 2005; 24: 1\u201326.","journal-title":"Int Angiol"},{"key":"BFejhg201033_CR15","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1097\/01.GIM.0000172641.57755.3A","volume":"7","author":"EB Spector","year":"2005","unstructured":"Spector EB, Grody WW, Matteson CJ et al: Technical standards and guidelines: venous thromboembolism (Factor V Leiden and prothrombin 20210G>A testing): a disease-specific supplement to the standards and guidelines for clinical genetics laboratories. Genet Med 2005; 7: 444\u2013453.","journal-title":"Genet Med"},{"key":"BFejhg201033_CR16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1093\/aje\/kwf055","volume":"156","author":"W Burke","year":"2002","unstructured":"Burke W, Atkins D, Gwinn M et al: Genetic test evaluation: information needs of clinicians, policy makers, and the public. Am J Epidemiol 2002; 156: 311\u2013318.","journal-title":"Am J Epidemiol"},{"key":"BFejhg201033_CR17","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/GIM.0b013e318156e45b","volume":"9","author":"W Burke","year":"2007","unstructured":"Burke W, Zimmern RL, Kroese M : Defining purpose: a key step in genetic test evaluation. Genet Med 2007; 9: 675\u2013681.","journal-title":"Genet Med"},{"key":"BFejhg201033_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1001\/archinternmed.2008.517","volume":"169","author":"LA Hindorff","year":"2009","unstructured":"Hindorff LA, Burke W, Laberge AM et al: Motivating factors for physician ordering of factor V Leiden genetic tests. Arch Intern Med 2009; 169: 68\u201374.","journal-title":"Arch Intern Med"},{"key":"BFejhg201033_CR19","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1001\/archinternmed.2008.589","volume":"169","author":"ID Bezemer","year":"2009","unstructured":"Bezemer ID, van der Meer FJ, Eikenboom JC, Rosendaal FR, Doggen CJ : The value of family history as a risk indicator for venous thrombosis. Arch Intern Med 2009; 169: 610\u2013615.","journal-title":"Arch Intern Med"},{"key":"BFejhg201033_CR20","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1160\/TH06-06-0328","volume":"96","author":"F Couturaud","year":"2006","unstructured":"Couturaud F, Kearon C, Leroyer C et al: Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost 2006; 96: 744\u2013749.","journal-title":"Thromb Haemost"},{"key":"BFejhg201033_CR21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1477-9560-3-8","volume":"3","author":"M Spannagl","year":"2005","unstructured":"Spannagl M, Heinemann LA, Dominh T, Assmann A, Schramm W, Schurmann R : Comparison of incidence\/risk of venous thromboembolism (VTE) among selected clinical and hereditary risk markers: a community-based cohort study. Thromb J 2005; 3: 8.","journal-title":"Thromb J"},{"key":"BFejhg201033_CR22","doi-asserted-by":"publisher","first-page":"5314","DOI":"10.1182\/blood-2008-10-184879","volume":"113","author":"WM Lijfering","year":"2009","unstructured":"Lijfering WM, Brouwer JL, Veeger NJ et al: Selective testing for thrombophilia in patients with first venous thrombosis. Results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. Blood 2009; 113: 5314\u20135322.","journal-title":"Blood"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg201033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201033","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:01:33Z","timestamp":1684429293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg201033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,24]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["BFejhg201033"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2010.33","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,24]]}}}