{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:54:05Z","timestamp":1791136445914,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T00:00:00Z","timestamp":1315353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T00:00:00Z","timestamp":1315353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1038\/ejhg.2011.160","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T10:42:11Z","timestamp":1315392131000},"page":"224-229","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Imaging genetics of FOXP2 in dyslexia"],"prefix":"10.1038","volume":"20","author":[{"given":"Arndt","family":"Wilcke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Ligges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfi","family":"Quente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ahnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"M\u00fcller-Myhsok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Cichon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Boltze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Kirsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,7]]},"reference":[{"key":"BFejhg2011160_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.conb.2004.03.014","volume":"14","author":"VS Mattay","year":"2004","unstructured":"Mattay VS, Goldberg TE : Imaging genetic influences in human brain function. Curr Opin Neurobiol 2004; 14: 239\u2013247.","journal-title":"Curr Opin Neurobiol"},{"key":"BFejhg2011160_CR2","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1126\/science.1071829","volume":"297","author":"AR Hariri","year":"2002","unstructured":"Hariri AR, Mattay VS, Tessitore A et al: Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400\u2013403.","journal-title":"Science"},{"key":"BFejhg2011160_CR3","doi-asserted-by":"publisher","first-page":"7406","DOI":"10.1073\/pnas.0732088100","volume":"100","author":"J Fan","year":"2003","unstructured":"Fan J, Fossella J, Sommer T, Wu Y, Posner MI : Mapping the genetic variation of executive attention onto brain activity. Proc Natl Acad Sci USA 2003; 100: 7406\u20137411.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg2011160_CR4","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.1073\/pnas.111134598","volume":"98","author":"MF Egan","year":"2001","unstructured":"Egan MF, Goldberg TE, Kolachana BS et al: Effect of COMT Val108\/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98: 6917\u20136922.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg2011160_CR5","first-page":"396","volume":"100","author":"G Schulte-K\u00f6rne","year":"2003","unstructured":"Schulte-K\u00f6rne G, Remschmidt H : Lese-Rechtschreibst\u00f6rung (Legasthenie) - Symptomatik, Diagnostik, Ursachen, Verlauf und Behandlung. Deutsches \u00c4rzteblatt 2003; 100: 396\u2013408.","journal-title":"Deutsches \u00c4rzteblatt"},{"key":"BFejhg2011160_CR6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1469-7610.2004.00358.x","volume":"46","author":"N Harlaar","year":"2005","unstructured":"Harlaar N, Spinath FM, Dale PS, Plomin R : Genetic influences on early word recognition abilities and disabilities: a study of 7-year-old twins. J Child Psychol Psychiatry 2005; 46: 373\u2013384.","journal-title":"J Child Psychol Psychiatry"},{"key":"BFejhg2011160_CR7","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1136\/jmg.40.5.340","volume":"40","author":"N Kaminen","year":"2003","unstructured":"Kaminen N, Hannula-Jouppi K, Kestila M et al: A genome scan for developmental dyslexia confirms linkage to chromosome 2p11 and suggests a new locus on 7q32. J Med Genet 2003; 40: 340\u2013345.","journal-title":"J Med Genet"},{"key":"BFejhg2011160_CR8","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/35097076","volume":"413","author":"CS Lai","year":"2001","unstructured":"Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP : A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 2001; 413: 519\u2013523.","journal-title":"Nature"},{"key":"BFejhg2011160_CR9","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/hbm.10093","volume":"18","author":"E Belton","year":"2003","unstructured":"Belton E, Salmond CH, Watkins KE, Vargha-Khadem F, Gadian DG : Bilateral brain abnormalities associated with dominantly inherited verbal and orofacial dyspraxia. Hum Brain Mapp 2003; 18: 194\u2013200.","journal-title":"Hum Brain Mapp"},{"key":"BFejhg2011160_CR10","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/nn1049","volume":"6","author":"F Li","year":"2003","unstructured":"Li F, Baldeweg T, Connelly A et al: Language fMRI abnormalities associated with FOXP2 gene mutation. Nat Neurosci 2003; 6: 1230\u20131237.","journal-title":"Nat Neurosci"},{"key":"BFejhg2011160_CR11","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/ilar.51.4.362","volume":"51","author":"MS Fee","year":"2010","unstructured":"Fee MS, Scharff C : The songbird as a model for the generation and learning of complex sequential behaviors. ILAR J 2010; 51: 362\u2013377.","journal-title":"ILAR J"},{"key":"BFejhg2011160_CR12","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.tig.2009.03.002","volume":"25","author":"SE Fisher","year":"2009","unstructured":"Fisher SE, Scharff C : FOXP2 as a molecular window into speech and language. Trends Genet 2009; 25: 166\u2013177.","journal-title":"Trends Genet"},{"key":"BFejhg2011160_CR13","first-page":"113","volume":"88","author":"DW Frayer","year":"2010","unstructured":"Frayer DW, Fiore I, Lalueza-Fox C, Radovcic J, Bondioli L : Right handed Neandertals: Vindija and beyond. J Anthropol Sci 2010; 88: 113\u2013127.","journal-title":"J Anthropol Sci"},{"key":"BFejhg2011160_CR14","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.cell.2009.03.041","volume":"137","author":"W Enard","year":"2009","unstructured":"Enard W, Gehre S, Hammerschmidt K et al: A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 2009; 137: 961\u2013971.","journal-title":"Cell"},{"key":"BFejhg2011160_CR15","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1056\/NEJMoa0802828","volume":"359","author":"SC Vernes","year":"2008","unstructured":"Vernes SC, Newbury DF, Abrahams BS et al: A functional genetic link between distinct developmental language disorders. N Engl J Med 2008; 359: 2337\u20132345.","journal-title":"N Engl J Med"},{"key":"BFejhg2011160_CR16","doi-asserted-by":"publisher","first-page":"12695","DOI":"10.1073\/pnas.95.21.12695","volume":"95","author":"F Vargha-Khadem","year":"1998","unstructured":"Vargha-Khadem F, Watkins KE, Price CJ et al: Neural basis of an inherited speech and language disorder. Proc Natl Acad Sci USA 1998; 95: 12695\u201312700.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg2011160_CR17","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1073\/pnas.95.5.2636","volume":"95","author":"SE Shaywitz","year":"1998","unstructured":"Shaywitz SE, Shaywitz BA, Pugh KR et al: Functional disruption in the organization of the brain for reading in dyslexia. Proc Natl Acad Sci USA 1998; 95: 2636\u20132641.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg2011160_CR18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1024\/1422-4917.35.2.107","volume":"35","author":"C Ligges","year":"2007","unstructured":"Ligges C, Blanz B : [Survey of fMRI results regarding a phonological deficit in children and adults with dyslexia: fundamental deficit or indication of compensation?]. Z Kinder Jugendpsychiatr Psychother 2007; 35: 107\u2013115.","journal-title":"Z Kinder Jugendpsychiatr Psychother"},{"key":"BFejhg2011160_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1196\/annals.1416.024","volume":"1145","author":"JM Maisog","year":"2008","unstructured":"Maisog JM, Einbinder ER, Flowers DL, Turkeltaub PE, Eden GF : A meta-analysis of functional neuroimaging studies of dyslexia. Ann NY Acad Sci 2008; 1145: 237\u2013259.","journal-title":"Ann NY Acad Sci"},{"key":"BFejhg2011160_CR20","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1126\/science.1057179","volume":"291","author":"E Paulesu","year":"2001","unstructured":"Paulesu E, Demonet JF, Fazio F et al: Dyslexia: cultural diversity and biological unity. Science 2001; 291: 2165\u20132167.","journal-title":"Science"},{"key":"BFejhg2011160_CR21","volume-title":"The d2 test of attention","author":"R Brickenkamp","year":"2002","unstructured":"Brickenkamp R, Zillmer E : The d2 test of attention. G\u00f6ttingen: Hogrefe, 2002."},{"key":"BFejhg2011160_CR22","volume-title":"Knuspels Leseaufgaben (KNUSPEL-L)","author":"H Marx","year":"1998","unstructured":"Marx H : Knuspels Leseaufgaben (KNUSPEL-L). G\u00f6ttingen: Hogrefe, 1998."},{"key":"BFejhg2011160_CR23","volume-title":"Grundintelligenztest Skala 2","author":"RH Weiss","year":"1998","unstructured":"Weiss RH : Grundintelligenztest Skala 2. G\u00f6ttingen: Hogrefe, 1998."},{"key":"BFejhg2011160_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11881-008-0020-7","volume":"59","author":"A Wilcke","year":"2009","unstructured":"Wilcke A, Weissfuss J, Kirsten H et al: The role of gene DCDC2 in German dyslexics. Ann Dyslexia 2009; 59: 1\u201311.","journal-title":"Ann Dyslexia"},{"key":"BFejhg2011160_CR25","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1081\/NCN-120023038","volume":"22","author":"T Wenzel","year":"2003","unstructured":"Wenzel T, Elssner T, Fahr K et al: Genosnip: SNP genotyping by MALDI-TOF MS using photocleavable oligonucleotides. Nucleosides Nucleotides Nucleic Acids 2003; 22: 1579\u20131581.","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"BFejhg2011160_CR26","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2144\/000112115","volume":"40","author":"H Kirsten","year":"2006","unstructured":"Kirsten H, Dienst S, Emmrich F, Ahnert P : CalcDalton: a tool for multiplex genotyping primer design for single-base extension reactions using cleavable primers. Biotechniques 2006; 40: 158\u2013162.","journal-title":"Biotechniques"},{"key":"BFejhg2011160_CR27","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00109-006-0129-2","volume":"85","author":"H Kirsten","year":"2007","unstructured":"Kirsten H, Teupser D, Weissfuss J et al: Robustness of single-base extension against mismatches at the site of primer attachment in a clinical assay. J Mol Med 2007; 85: 361\u2013369.","journal-title":"J Mol Med"},{"key":"BFejhg2011160_CR28","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1093\/bioinformatics\/bti643","volume":"21","author":"D Gordon","year":"2005","unstructured":"Gordon D, Haynes C, Blumenfeld J, Finch SJ : PAWE-3D: visualizing power for association with error in case-control genetic studies of complex traits. Bioinformatics 2005; 21: 3935\u20133937.","journal-title":"Bioinformatics"},{"key":"BFejhg2011160_CR29","first-page":"758","volume":"10","author":"ES Tasheva","year":"2004","unstructured":"Tasheva ES, Klocke B, Conrad GW : Analysis of transcriptional regulation of the small leucine rich proteoglycans. Mol Vis 2004; 10: 758\u2013772.","journal-title":"Mol Vis"},{"key":"BFejhg2011160_CR30","volume-title":"Hamburg-Wechsler-Intelligenz-Test f\u00fcr Kinder III (HAWIK III)","author":"U Tewes","year":"2002","unstructured":"Tewes U, Rossmann P, Schallberger U : Hamburg-Wechsler-Intelligenz-Test f\u00fcr Kinder III (HAWIK III). Bern: Verlag Hans Huber, 2002."},{"key":"BFejhg2011160_CR31","volume-title":"KiTAP Kinderversion der Testbatterie zur Aufmerksamkeitspr\u00fcfung","author":"P Zimmermann","year":"2002","unstructured":"Zimmermann P, Gondan M, Fimm B : KiTAP Kinderversion der Testbatterie zur Aufmerksamkeitspr\u00fcfung. Herzogenrath: Vera Fimm - Psychologische Testsysteme, 2002."},{"key":"BFejhg2011160_CR32","volume-title":"ZLVT 4-6 Z\u00fcrcher Leseverst\u00e4ndnistest f\u00fcr das 4. bis 6. Schuljahr","author":"H Grissemann","year":"2000","unstructured":"Grissemann H, Baumberger W : ZLVT 4-6 Z\u00fcrcher Leseverst\u00e4ndnistest f\u00fcr das 4. bis 6. Schuljahr. Bern: Verlag Hans Huber, 2000."},{"key":"BFejhg2011160_CR33","volume-title":"Diagnostischer Rechtschreibtest f\u00fcr 4. Klassen (DRT 4)","author":"M Grund","year":"2004","unstructured":"Grund M, Haug G, Naumann CL : Diagnostischer Rechtschreibtest f\u00fcr 4. Klassen (DRT 4), 2nd edn. G\u00f6ttingen: Beltz, 2004."},{"key":"BFejhg2011160_CR34","volume-title":"Diagnostischer Rechtschreibtest f\u00fcr 5. Klassen (DRT 5)","author":"M Grund","year":"2004","unstructured":"Grund M, Haug G, Naumann CL : Diagnostischer Rechtschreibtest f\u00fcr 5. Klassen (DRT 5). G\u00f6ttingen: Beltz, 2004."},{"key":"BFejhg2011160_CR35","volume-title":"Diagnostischer Rechtschreibtest f\u00fcr 2. Klassen (DRT 2)","author":"R M\u00fcller","year":"1990","unstructured":"M\u00fcller R : Diagnostischer Rechtschreibtest f\u00fcr 2. Klassen (DRT 2). Weinheim: Beltz, 1990."},{"key":"BFejhg2011160_CR36","volume-title":"Westermann Rechtschreibtest 6+","author":"P Rathenow","year":"1981","unstructured":"Rathenow P, Laupenm\u00fchle D, V\u00f6ge J : Westermann Rechtschreibtest 6+, 2nd edn. Braunschweig: Westermann, 1981."},{"key":"BFejhg2011160_CR37","first-page":"439","volume":"60","author":"H Bickeboller","year":"1997","unstructured":"Bickeboller H, Campion D, Brice A et al: Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. Am J Hum Genet 1997; 60: 439\u2013446.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2011160_CR38","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.schres.2004.05.012","volume":"73","author":"J Sanjuan","year":"2005","unstructured":"Sanjuan J, Tolosa A, Gonzalez JC et al: FOXP2 polymorphisms in patients with schizophrenia. Schizophr Res 2005; 73: 253\u2013256.","journal-title":"Schizophr Res"},{"key":"BFejhg2011160_CR39","doi-asserted-by":"publisher","first-page":"W621","DOI":"10.1093\/nar\/gkl071","volume":"34","author":"L Conde","year":"2006","unstructured":"Conde L, Vaquerizas JM, Dopazo H et al: PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes. Nucleic Acids Res 2006; 34: W621\u2013W625.","journal-title":"Nucleic Acids Res"},{"key":"BFejhg2011160_CR40","doi-asserted-by":"publisher","first-page":"26840","DOI":"10.1074\/jbc.270.45.26840","volume":"270","author":"Y Miura","year":"1995","unstructured":"Miura Y, Tam T, Ido A et al: Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner. J Biol Chem 1995; 270: 26840\u201326848.","journal-title":"J Biol Chem"},{"key":"BFejhg2011160_CR41","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1093\/emboj\/18.8.2196","volume":"18","author":"T Ohtsuka","year":"1999","unstructured":"Ohtsuka T, Ishibashi M, Gradwohl G et al: Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J 1999; 18: 2196\u20132207.","journal-title":"EMBO J"},{"key":"BFejhg2011160_CR42","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.gene.2008.01.017","volume":"412","author":"L Sansregret","year":"2008","unstructured":"Sansregret L, Nepveu A : The multiple roles of CUX1: insights from mouse models and cell-based assays. Gene 2008; 412: 84\u201394.","journal-title":"Gene"},{"key":"BFejhg2011160_CR43","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1128\/MCB.14.2.1395","volume":"14","author":"H Yasuda","year":"1994","unstructured":"Yasuda H, Mizuno A, Tamaoki T, Morinaga T : ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene. Mol Cell Biol 1994; 14: 1395\u20131401.","journal-title":"Mol Cell Biol"},{"key":"BFejhg2011160_CR44","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature01458","volume":"422","author":"C Jamora","year":"2003","unstructured":"Jamora C, DasGupta R, Kocieniewski P, Fuchs E : Links between signal transduction, transcription and adhesion in epithelial bud development. Nature 2003; 422: 317\u2013322.","journal-title":"Nature"},{"key":"BFejhg2011160_CR45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1242\/dev.116.4.1011","volume":"116","author":"K Shimamura","year":"1992","unstructured":"Shimamura K, Takeichi M : Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis. Development 1992; 116: 1011\u20131019.","journal-title":"Development"},{"key":"BFejhg2011160_CR46","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1093\/brain\/awg247","volume":"126","author":"CS Lai","year":"2003","unstructured":"Lai CS, Gerrelli D, Monaco AP, Fisher SE, Copp AJ : FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain 2003; 126: 2455\u20132462.","journal-title":"Brain"}],"updated-by":[{"DOI":"10.1038\/ejhg.2012.31","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T00:00:00Z","timestamp":1337212800000}}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg2011160","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2011160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2011160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:03:21Z","timestamp":1684429401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg2011160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,7]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["BFejhg2011160"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2011.160","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/ejhg.2012.31","asserted-by":"object"}]},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,7]]},"assertion":[{"value":"21 December 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}