{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:46:27Z","timestamp":1780490787970,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/ejhg.2011.185","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T10:24:23Z","timestamp":1319624663000},"page":"326-332","source":"Crossref","is-referenced-by-count":47,"title":["Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata"],"prefix":"10.1038","volume":"20","author":[{"given":"Lina M","family":"Forstbauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix F","family":"Brockschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Moskvina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Herold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Redler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel M","family":"Hillmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Meesters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Heilmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margrieta","family":"Alblas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hanneken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Eigelshoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin A","family":"Giehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagny","family":"Jagielska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Blume-Peytavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie Garcia","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian","family":"Hennies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke K","family":"Peitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Katrin","family":"Kort\u00fcm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Blaumeiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M","family":"N\u00f6then","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina C","family":"Betz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"BFejhg2011185_CR1","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4065\/70.7.628","volume":"70","author":"KH Safavi","year":"1995","unstructured":"Safavi KH, Muller SA, Suman VJ, Moshell AN, Melton 3rd LJ : Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc 1995; 70: 628\u2013633.","journal-title":"Mayo Clin Proc"},{"key":"BFejhg2011185_CR2","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jaad.2005.12.007","volume":"54","author":"B Blaumeiser","year":"2006","unstructured":"Blaumeiser B, van der Goot I, Fimmers R et al: Familial aggregation of alopecia areata. J Am Acad Dermatol 2006; 54: 627\u2013632.","journal-title":"J Am Acad Dermatol"},{"key":"BFejhg2011185_CR3","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S0190-9622(98)70499-2","volume":"38","author":"C Jackow","year":"1998","unstructured":"Jackow C, Puffer N, Hordinsky M, Nelson J, Tarrand J, Duvic M : Alopecia areata and cytomegalovirus infection in twins: genes versus environment? J Am Acad Dermatol 1998; 38: 418\u2013425.","journal-title":"J Am Acad Dermatol"},{"key":"BFejhg2011185_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1046\/j.1087-0024.2003.00805.x","volume":"8","author":"DJ Tobin","year":"2003","unstructured":"Tobin DJ : Characterization of hair follicle antigens targeted by the anti-hair follicle immune response. J Investig Dermatol Symp Proc 2003; 8: 176\u2013181.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"BFejhg2011185_CR5","first-page":"363","volume":"16","author":"P Entz","year":"2006","unstructured":"Entz P, Blaumeiser B, Betz RC et al: Investigation of the HLA-DRB1 locus in alopecia areata. Eur J Dermatol 2006; 16: 363\u2013367.","journal-title":"Eur J Dermatol"},{"key":"BFejhg2011185_CR6","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/sj.jidsp.5640214","volume":"4","author":"BW Colombe","year":"1999","unstructured":"Colombe BW, Lou CD, Price VH : The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. J Investig Dermatol Symp Proc 1999; 4: 216\u2013219.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"BFejhg2011185_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jdermsci.2005.07.008","volume":"41","author":"FL Xiao","year":"2006","unstructured":"Xiao FL, Yang S, Yan KL et al: Association of HLA class I alleles with alopecia areata in Chinese Hans. J Dermatol Sci 2006; 41: 109\u2013119.","journal-title":"J Dermatol Sci"},{"key":"BFejhg2011185_CR8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/sj.jidsp.5640215","volume":"4","author":"M de Andrade","year":"1999","unstructured":"de Andrade M, Jackow CM, Dahm N, Hordinsky M, Reveille JD, Duvic M : Alopecia areata in families: association with the HLA locus. J Investig Dermatol Symp Proc 1999; 4: 220\u2013223.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"BFejhg2011185_CR9","first-page":"389","volume":"158","author":"RC Betz","year":"2008","unstructured":"Betz RC, Konig K, Flaquer A et al: The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata. Br J Dermatol 2008; 158: 389\u2013391.","journal-title":"Br J Dermatol"},{"key":"BFejhg2011185_CR10","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.humimm.2006.04.006","volume":"67","author":"EH Kemp","year":"2006","unstructured":"Kemp EH, McDonagh AJ, Wengraf DA et al: The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. Hum Immunol 2006; 67: 535\u2013539.","journal-title":"Hum Immunol"},{"key":"BFejhg2011185_CR11","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1086\/511442","volume":"80","author":"A Martinez-Mir","year":"2007","unstructured":"Martinez-Mir A, Zlotogorski A, Gordon D et al: Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet 2007; 80: 316\u2013328.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2011185_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature09114","volume":"466","author":"L Petukhova","year":"2010","unstructured":"Petukhova L, Duvic M, Hordinsky M et al: Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 2010; 466: 113\u2013117.","journal-title":"Nature"},{"key":"BFejhg2011185_CR13","first-page":"55","volume":"9","author":"M Krawczak","year":"2006","unstructured":"Krawczak M, Nikolaus S, von Eberstein H, Croucher PJ, El Mokhtari NE, Schreiber S : PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet 2006; 9: 55\u201361.","journal-title":"Community Genet"},{"issue":"Suppl 1","key":"BFejhg2011185_CR14","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1055\/s-2005-858226","volume":"67","author":"HE Wichmann","year":"2005","unstructured":"Wichmann HE, Gieger C, Illig T : KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen 2005; 67 (Suppl 1): S26\u2013S30.","journal-title":"Gesundheitswesen"},{"key":"BFejhg2011185_CR15","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1067\/mhj.2002.123579","volume":"144","author":"A Schmermund","year":"2002","unstructured":"Schmermund A, Mohlenkamp S, Stang A et al: Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: rationale and design of the Heinz Nixdorf RECALL Study. Risk Factors, Evaluation of Coronary Calcium and Lifestyle. Am Heart J 2002; 144: 212\u2013218.","journal-title":"Am Heart J"},{"key":"BFejhg2011185_CR16","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1126\/science.1129837","volume":"314","author":"A Papassotiropoulos","year":"2006","unstructured":"Papassotiropoulos A, Stephan DA, Huentelman MJ et al: Common Kibra alleles are associated with human memory performance. Science 2006; 314: 475\u2013478.","journal-title":"Science"},{"key":"BFejhg2011185_CR17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/gepi.20062","volume":"28","author":"V Moskvina","year":"2005","unstructured":"Moskvina V, Norton N, Williams N, Holmans P, Owen M, O\u2032Donovan M : Streamlined analysis of pooled genotype data in SNP-based association studies. Genet Epidemiol 2005; 28: 273\u2013282.","journal-title":"Genet Epidemiol"},{"key":"BFejhg2011185_CR18","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1755-8794-1-44","volume":"1","author":"R Abraham","year":"2008","unstructured":"Abraham R, Moskvina V, Sims R et al: A genome-wide association study for late-onset Alzheimer\u2032s disease using DNA pooling. BMC Med Genomics 2008; 1: 44.","journal-title":"BMC Med Genomics"},{"key":"BFejhg2011185_CR19","unstructured":"Moskvina V : Signal detection in genome-wide association studies. In: Ermakov SM, Melas VB, Pepelyshev AN (eds). Proceedings of the 6th St Petersburg Workshop on Simulation; June 28\u2013July 4 2009; St Petersburg: VVM com. Ltd., 2009, pp 301\u2013307."},{"key":"BFejhg2011185_CR20","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1093\/bioinformatics\/btn581","volume":"25","author":"C Herold","year":"2009","unstructured":"Herold C, Becker T : Genetic association analysis with FAMHAP: a major program update. Bioinformatics 2009; 25: 134\u2013136.","journal-title":"Bioinformatics"},{"key":"BFejhg2011185_CR21","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2307\/3001775","volume":"11","author":"P Armitage","year":"1955","unstructured":"Armitage P : Tests for linear trends in proportions and frequencies. Biometrics 1955; 11: 375\u2013386.","journal-title":"Biometrics"},{"key":"BFejhg2011185_CR22","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","author":"Consortium. TWTCC","year":"2007","unstructured":"Consortium. TWTCC: Genome-wide association study of 14\u2009000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661\u2013678.","journal-title":"Nature"},{"key":"BFejhg2011185_CR23","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/sj.jid.5700973","volume":"128","author":"N Barahmani","year":"2008","unstructured":"Barahmani N, de Andrade M, Slusser JP et al: Human leukocyte antigen class II alleles are associated with risk of alopecia areata. J Invest Dermatol 2008; 128: 240\u2013243.","journal-title":"J Invest Dermatol"},{"key":"BFejhg2011185_CR24","first-page":"757","volume":"33","author":"BW Colombe","year":"1995","unstructured":"Colombe BW, Price VH, Khoury EL, Garovoy MR, Lou CD : HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol 1995; 33: 757\u2013764.","journal-title":"J Am Acad Dermatol"},{"key":"BFejhg2011185_CR25","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1086\/510686","volume":"80","author":"JV Pearson","year":"2007","unstructured":"Pearson JV, Huentelman MJ, Halperin RF et al: Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies. Am J Hum Genet 2007; 80: 126\u2013139.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2011185_CR26","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00439-009-0626-9","volume":"125","author":"Y Bosse","year":"2009","unstructured":"Bosse Y, Bacot F, Montpetit A et al: Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans. Hum Genet 2009; 125: 305\u2013318.","journal-title":"Hum Genet"},{"key":"BFejhg2011185_CR27","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1093\/hmg\/ddn091","volume":"17","author":"F Capon","year":"2008","unstructured":"Capon F, Bijlmakers MJ, Wolf N et al: Identification of ZNF313\/RNF114 as a novel psoriasis susceptibility gene. Hum Mol Genet 2008; 17: 1938\u20131945.","journal-title":"Hum Mol Genet"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg2011185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2011185","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2011185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:03:34Z","timestamp":1684429414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg2011185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["BFejhg2011185"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2011.185","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]}}}