{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:46Z","timestamp":1791246166613,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1038\/ejhg.2012.112","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T12:20:23Z","timestamp":1338985223000},"page":"62-68","source":"Crossref","is-referenced-by-count":69,"title":["Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy"],"prefix":"10.1038","volume":"21","author":[{"given":"Naomi","family":"Chadderton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpad","family":"Palfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Millington-Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliverio","family":"Gobbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Overlack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Carrigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Ehrhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Wolfrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Humphries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F","family":"Kenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Jane Farrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"BFejhg2012112_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","volume":"30","author":"P Yu-Wai-Man","year":"2011","unstructured":"Yu-Wai-Man P, Griffiths PG, Chinnery PF : Mitrochondrial optic neuropathies \u2013 disease mechanisms and therapeutic strategies. Prog Retin Eye Res 2011; 30: 81\u2013114.","journal-title":"Prog Retin Eye Res"},{"key":"BFejhg2012112_CR2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0005-2728(98)00163-7","volume":"1410","author":"RM Chalmers","year":"1999","unstructured":"Chalmers RM, Schapira AH : Clinical biochemical and molecular genetic features of Leber\u2019s hereditary optic neuropathy. Biochim Biophys Acta 1999; 1410: 147\u2013158.","journal-title":"Biochim Biophys Acta"},{"key":"BFejhg2012112_CR3","first-page":"481","volume":"59","author":"DA Mackey","year":"1996","unstructured":"Mackey DA, Oostra RJ, Rosenberg T et al. Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy. Am J Hum Genet 1996; 59: 481\u2013485.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2012112_CR4","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.preteyeres.2008.09.001","volume":"27","author":"SG Jarrett","year":"2008","unstructured":"Jarrett SG, Lin H, Godley BF, Boulton ME : Mitrochondrial DNA damage and its potential role in retinal degeneration. Prog Retin Eye Res 2008; 27: 596\u2013607.","journal-title":"Prog Retin Eye Res"},{"key":"BFejhg2012112_CR5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S0165-0173(00)00038-2","volume":"34","author":"A Ames","year":"2000","unstructured":"Ames A : CNS energy metabolism as related to function. Brain Res Brain Res Rev 2000; 34: 42\u201368.","journal-title":"Brain Res Brain Res Rev"},{"key":"BFejhg2012112_CR6","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.preteyeres.2006.05.002","volume":"25","author":"MY Yen","year":"2006","unstructured":"Yen MY, Wang AG, Wei YH : Leber\u2019s hereditary optic neuropathy: a multifactorial disease. Prog Retin Eye Res 2006; 25: 381\u2013396.","journal-title":"Prog Retin Eye Res"},{"issue":"Suppl 6","key":"BFejhg2012112_CR7","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1038\/sj.ijo.0800937","volume":"23","author":"RK Porter","year":"1999","unstructured":"Porter RK, Joyce OJ, Farmer MK et al. Indirect measurement of mitochondrial proton leak and its application. Int J Obes Relat Metab Disord 1999; 23 (Suppl 6): S12\u2013S18.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFejhg2012112_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0014-5793(97)01533-0","volume":"421","author":"T Kitajima-Ihara","year":"1998","unstructured":"Kitajima-Ihara T, Yagi T : Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. FEBS Lett 1998; 421: 37\u201340.","journal-title":"FEBS Lett"},{"key":"BFejhg2012112_CR9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10863-009-9249-z","volume":"41","author":"M Marella","year":"2009","unstructured":"Marella M, Seo BB, Yagi T, Matsuno-Yagi A : Parkinson\u2019s disease and mitochondrial complex I: a perspective on the Ndi1 therapy. J Bioenerg Biomembr 2009; 41: 493\u2013497.","journal-title":"J Bioenerg Biomembr"},{"key":"BFejhg2012112_CR10","doi-asserted-by":"publisher","first-page":"e11472","DOI":"10.1371\/journal.pone.0011472","volume":"5","author":"M Marella","year":"2010","unstructured":"Marella M, Seo BB, Thomas BB, Matsuno-Yagi A, Yagi T : Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model. PLoS One 2010; 5: e11472.","journal-title":"PLoS One"},{"key":"BFejhg2012112_CR11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/ana.20243","volume":"56","author":"G Manfredi","year":"2004","unstructured":"Manfredi G, Beal MF : Poison and antidote: a novel model to study pathogenesis and therapy of LHON. Ann Neurol 2004; 56: 171\u2013172.","journal-title":"Ann Neurol"},{"key":"BFejhg2012112_CR12","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/81834","volume":"3","author":"R Betarbet","year":"2000","unstructured":"Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT : Chronic systemic pesticide exposure reproduces features of Parkinson\u2019s disease. Nat Neurosci 2000; 3: 1301\u20131306.","journal-title":"Nat Neurosci"},{"key":"BFejhg2012112_CR13","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.neuroscience.2011.01.038","volume":"181","author":"P Mulcahy","year":"2011","unstructured":"Mulcahy P, Walsh S, Paucard A, Rea K, Dowd E : Characterisation of a novel model of Parkinson\u2019s disease by intra-striatal infusion of the pesticide rotenone. Neuroscience 2011; 181: 234\u2013242.","journal-title":"Neuroscience"},{"key":"BFejhg2012112_CR14","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1007\/s11064-009-0014-9","volume":"34","author":"C Ullrich","year":"2009","unstructured":"Ullrich C, Humpel C : Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model. Neurochem Res 2009; 34: 2147\u20132153.","journal-title":"Neurochem Res"},{"key":"BFejhg2012112_CR15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0304-3940(02)00327-0","volume":"326","author":"X Zhang","year":"2002","unstructured":"Zhang X, Jones D, Gonzalez-Lima F : Mouse model of optic neuropathy caused by mitrochondrial complex I dysfunction. Neurosci Lett 2002; 326: 97\u2013100.","journal-title":"Neurosci Lett"},{"key":"BFejhg2012112_CR16","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1080\/15287390600630203","volume":"69","author":"X Zhang","year":"2006","unstructured":"Zhang X, Jones D, Gonzalez-Lima F : Neurodegeneration produced by rotenone in the mouse retina: a potential model to investigate environmental pesticide contributions to neurodegenerative diseases. J Toxicol Environ Health A 2006; 69: 1681\u20131697.","journal-title":"J Toxicol Environ Health A"},{"key":"BFejhg2012112_CR17","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1080\/15287390802414190","volume":"71","author":"CR Hayworth","year":"2008","unstructured":"Hayworth CR, Rojas JC, Gonzalez-Lima F : Transgenic mice expressing cyan fluorescent protein as a reporter starin to detect the effects of rotenone toxicity on retinal ganglion cells. J Toxicol Environ Health A 2008; 71: 1582\u20131592.","journal-title":"J Toxicol Environ Health A"},{"key":"BFejhg2012112_CR18","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1016\/S0042-6989(98)00308-3","volume":"39","author":"L Dudas","year":"1999","unstructured":"Dudas L, Anand V, Acland GM et al. Persistant transgene product in retina, optic nerve and brain after intraocular injection of rAAV. Vision Res 1999; 39: 2545\u20132553.","journal-title":"Vision Res"},{"key":"BFejhg2012112_CR19","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1006\/mcne.2002.1168","volume":"21","author":"AR Harvey","year":"2002","unstructured":"Harvey AR, Kamphuis W, Eggers R et al. Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors. Mol Cell Neurosci 2002; 21: 141\u2013157.","journal-title":"Mol Cell Neurosci"},{"key":"BFejhg2012112_CR20","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/mt.2010.230","volume":"19","author":"M Lukason","year":"2011","unstructured":"Lukason M, DuFresne E, Rubin H et al. Inhibition of choroidal neovascularisation in a nonhuman primate model by intravitreal administration of an AAV2 vector expressing a novel anti-VEGF molecule. Mol Ther 2011; 19: 260\u2013265.","journal-title":"Mol Ther"},{"key":"BFejhg2012112_CR21","doi-asserted-by":"publisher","first-page":"e7467","DOI":"10.1371\/journal.pone.0007467","volume":"4","author":"RR Klimczak","year":"2009","unstructured":"Klimczak RR, Koerber JT, Dalkara D, Flannery JG, Schaffer DV : A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat M\u00fcller cells. PLoS One 2009; 4: e7467.","journal-title":"PLoS One"},{"key":"BFejhg2012112_CR22","doi-asserted-by":"publisher","first-page":"6012","DOI":"10.1074\/jbc.M610646200","volume":"282","author":"T Yamashita","year":"2007","unstructured":"Yamashita T, Nakamaru-Ogiso E, Miyoshi H, Matsuno-Yagi A, Yagi T : Roles of bound quinone in the single subunit NADH-quinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae. J Biol Chem 2007; 282: 6012\u20136020.","journal-title":"J Biol Chem"},{"key":"BFejhg2012112_CR23","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1101\/gad.3.7.1019","volume":"3","author":"N Levitt","year":"1989","unstructured":"Levitt N, Briggs D, Gil A, Proudfoot NJ : Definition of an efficient synthetic poly(A) site. Genes Dev 1989; 3: 1019\u20131025.","journal-title":"Genes Dev"},{"key":"BFejhg2012112_CR24","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/hum.2009.119","volume":"21","author":"A Palfi","year":"2010","unstructured":"Palfi A, Millington-Ward S, Chadderton N et al. Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene. Hum Gene Ther 2010; 21: 311\u2013323.","journal-title":"Hum Gene Ther"},{"key":"BFejhg2012112_CR25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1086\/519025","volume":"81","author":"M O\u2019Reilly","year":"2007","unstructured":"O\u2019Reilly M, Palfi A, Chadderton N et al. RNA interference-mediated suppression and replacement of human rhodopsin in vivo. Am J Hum Genet 2007; 81: 127\u2013135.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2012112_CR26","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/mt.2008.301","volume":"17","author":"N Chadderton","year":"2009","unstructured":"Chadderton N, Millington-Ward S, Palfi A et al. Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy. Mol Ther 2009; 17: 593\u2013599.","journal-title":"Mol Ther"},{"key":"BFejhg2012112_CR27","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0248-4900(92)90441-3","volume":"176","author":"U Wolfrum","year":"1992","unstructured":"Wolfrum U : Cytoskeletal elements in arthropod sensilla and mammalian photoreceptors. Biol Cell 1992; 176: 373\u2013381.","journal-title":"Biol Cell"},{"key":"BFejhg2012112_CR28","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/mrm.1910380305","volume":"38","author":"YJ Lin","year":"1997","unstructured":"Lin YJ, Koretsky AP : Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn Reson Med 1997; 38: 378\u2013388.","journal-title":"Magn Reson Med"},{"key":"BFejhg2012112_CR29","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/mrm.1209","volume":"46","author":"T Watanabe","year":"2001","unstructured":"Watanabe T, Michaelis T, Frahm J : Mapping of retinal projections in the living rat using high-resolution 3D gradient-echo MRI with Mn2+-induced contrast. Magn Reson Med 2001; 46: 424\u2013429.","journal-title":"Magn Reson Med"},{"key":"BFejhg2012112_CR30","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.neuroimage.2006.07.048","volume":"34","author":"JD Lindsey","year":"2007","unstructured":"Lindsey JD, Scadeng M, Dubowitz DJ, Crowston JG, Weinreb RN : Magnetic resonance imaging of the visual system in vivo: transsynaptic illumination of V1 and V2 visual cortex. Neuroimage 2007; 34: 1619\u20131626.","journal-title":"Neuroimage"},{"issue":"S1","key":"BFejhg2012112_CR31","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1016\/j.neuroimage.2007.04.053","volume":"37","author":"EL Bearer","year":"2007","unstructured":"Bearer EL, Falzone TL, Zhang X, Biris O, Rasin A, Jacobs RE : Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI). Neuroimage 2007; 37 (S1): S37\u2013S46.","journal-title":"Neuroimage"},{"key":"BFejhg2012112_CR32","first-page":"36","volume":"11","author":"MD Abramoff","year":"2004","unstructured":"Abramoff MD, Magalhaes PJ, Ram SJ : Image processing with ImageJ. Biophotonics International 2004; 11: 36\u201342.","journal-title":"Biophotonics International"},{"key":"BFejhg2012112_CR33","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1167\/iovs.04-0541","volume":"45","author":"GT Prusky","year":"2004","unstructured":"Prusky GT, Alam NM, Beekman S, Douglas RM : Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Invest Ophthalmol Vis Sci 2004; 45: 4611\u20134616.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFejhg2012112_CR34","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1523\/JNEUROSCI.16-22-07193.1996","volume":"16","author":"RW Williams","year":"1996","unstructured":"Williams RW, Strom RC, Rice DS, Goldowitz D : Genetic and environmental control of variation in retinal ganglion cell number in mice. J Neurosci 1996; 16: 7193\u20137205.","journal-title":"J Neurosci"},{"key":"BFejhg2012112_CR35","doi-asserted-by":"publisher","first-page":"9167","DOI":"10.1073\/pnas.95.16.9167","volume":"95","author":"BB Seo","year":"1998","unstructured":"Seo BB, Kitajima-Ihara T, Chan EK, Scheffler IE, Matsuno-Yagi A, Yagi T : Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Proc Natl Acad Sci USA 1998; 95: 9167\u20139171.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg2012112_CR36","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/gt.2011.134","volume":"19","author":"S Iyer","year":"2012","unstructured":"Iyer S, Xiao E, Alsayegh K, Eroshenko N, Riggs MJ, Bennett JP, Rao RR : Mitochondrial gene replacement in human pluripotent stem cell-derived neural progenitors. Gene Ther 2012; 19: 469\u2013475.","journal-title":"Gene Ther"},{"key":"BFejhg2012112_CR37","doi-asserted-by":"publisher","first-page":"e25910","DOI":"10.1371\/journal.pone.0025910","volume":"6","author":"M Marella","year":"2011","unstructured":"Marella M, Seo BB, Flotte TR, Matsuno-Yagi A, Yagi T : No immune responses by the expression of the yeast ndi1 protein in rats. PLoS One 2011; 6: e25910.","journal-title":"PLoS One"},{"key":"BFejhg2012112_CR38","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1056\/NEJMoa0802268","volume":"358","author":"JW Bainbridge","year":"2008","unstructured":"Bainbridge JW, Smith AJ, Barker SS et al. Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med 2008; 358: 2231\u20132239.","journal-title":"N Engl J Med"},{"key":"BFejhg2012112_CR39","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1056\/NEJMoa0802315","volume":"358","author":"AM Maguire","year":"2008","unstructured":"Maguire AM, Simonelli F, Pierce EA et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008; 358: 2240\u20132248.","journal-title":"N Engl J Med"},{"key":"BFejhg2012112_CR40","doi-asserted-by":"publisher","first-page":"15112","DOI":"10.1073\/pnas.0807027105","volume":"105","author":"AV Cideciyan","year":"2008","unstructured":"Cideciyan AV, Aleman TS, Boye SL et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc Natl Acad Sci USA 2008; 105: 15112\u201315117.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg2012112_CR41","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/mt.2009.277","volume":"18","author":"F Simonelli","year":"2010","unstructured":"Simonelli F, Maguire AM, Testa F et al. Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther 2010; 18: 643\u2013650.","journal-title":"Mol Ther"},{"key":"BFejhg2012112_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1001\/archophthalmol.2011.298","volume":"130","author":"SG Jacobson","year":"2012","unstructured":"Jacobson SG, Cideciyan AV, Ratnakaram R et al. Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol 2012; 130: 9\u201324.","journal-title":"Arch Ophthalmol"},{"key":"BFejhg2012112_CR43","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ajhg.2008.08.013","volume":"83","author":"S Ellouze","year":"2008","unstructured":"Ellouze S, Augustin S, Bouaita A et al. Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction. Am J Hum Genet 2008; 83: 373\u2013387.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2012112_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.06-0789","volume":"48","author":"X Qi","year":"2007","unstructured":"Qi X, Sun L, Lewin AS, Hauswirth WW, Guy J : The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse. Invest Ophthalmol Vis Sci 2007; 48: 1\u201310.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFejhg2012112_CR45","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/gt.2011.161","volume":"19","author":"AJ Smith","year":"2012","unstructured":"Smith AJ, Bainbridge JW, Ali RR : Gene supplementation therapy for recessive forms of inherited retinal dystrophies. Gene Ther 2012; 19: 154\u2013161.","journal-title":"Gene Ther"},{"key":"BFejhg2012112_CR46","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1001\/archophthalmol.2010.201","volume":"128","author":"BL Lam","year":"2010","unstructured":"Lam BL, Feuer WJ, Abukhalil F, Porciatti V, Hauswirth WW, Guy J : Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1. Arch Ophthalmol 2010; 128: 1129\u20131135.","journal-title":"Arch Ophthalmol"},{"key":"BFejhg2012112_CR47","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/ana.20175","volume":"56","author":"X Qi","year":"2004","unstructured":"Qi X, Lewin AS, Sun L, Hauswirth WW, Guy J : SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I. Ann Neurol 2004; 56: 182\u2013191.","journal-title":"Ann Neurol"},{"issue":"Part 9","key":"BFejhg2012112_CR48","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1093\/brain\/awr170","volume":"134","author":"T Klopstock","year":"2011","unstructured":"Klopstock T, Yu-Wai-Man P, Dimitriadis K et al. A randomized placebo-controlled trial of idebenone in Leber\u2019s hereditary optic neuropathy. Brain 2011; 134 (Part 9): 2677\u20132686.","journal-title":"Brain"},{"key":"BFejhg2012112_CR49","doi-asserted-by":"publisher","first-page":"13511","DOI":"10.1523\/JNEUROSCI.3457-08.2008","volume":"28","author":"JC Rojas","year":"2008","unstructured":"Rojas JC, Lee J, John JM, Gonzalez-Lima F : Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy. J Neurosci 2008; 28: 13511\u201313521.","journal-title":"J Neurosci"},{"key":"BFejhg2012112_CR50","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1167\/iovs.09-3903","volume":"51","author":"J Biermann","year":"2010","unstructured":"Biermann J, Grieshaber P, Goebel U, Martin G, Thanos S, Di Giovanni S : Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells. Invest Ophthalmol Vis Sci 2010; 51: 526\u2013534.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFejhg2012112_CR51","first-page":"395","volume":"17","author":"J Biermann","year":"2011","unstructured":"Biermann J, Boyle J, Pielen A, Lagr\u00e8ze WA : Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells. Mol Vis 2011; 17: 395\u2013403.","journal-title":"Mol Vis"},{"key":"BFejhg2012112_CR52","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3109\/08820538.2010.541318","volume":"26","author":"RD Doshi","year":"2011","unstructured":"Doshi RD, Bakri SJ, Fung AE : Intravitreal Injection Technique. Sem Ophthalmol 2011; 26: 104\u2013113.","journal-title":"Sem Ophthalmol"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg2012112.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:05:31Z","timestamp":1684429531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg2012112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,6]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["BFejhg2012112"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2012.112","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,6]]}}}