{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:08:14Z","timestamp":1761059294266},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1038\/ejhg.2012.46","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T17:09:04Z","timestamp":1331744944000},"page":"965-972","source":"Crossref","is-referenced-by-count":7,"title":["A genome-wide search for linkage to allergic rhinitis in Danish sib-pair families"],"prefix":"10.1038","volume":"20","author":[{"given":"Lisbeth Ven\u00f8","family":"Kruse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Nyegaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"M\u00f8ller-Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Haagerup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Deleuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Gudmund","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stine Krogh","family":"Ven\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgen","family":"Del-Favero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders Dupont","family":"B\u00f8rglum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,3,14]]},"reference":[{"key":"BFejhg201246_CR1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.jaci.2008.06.003","volume":"122","author":"DV Wallace","year":"2008","unstructured":"Wallace DV, Dykewicz MS, Bernstein DI et al: The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008; 122: S1\u201384.","journal-title":"J Allergy Clin Immunol"},{"key":"BFejhg201246_CR2","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1136\/thx.2004.029561","volume":"60","author":"IK Zollner","year":"2005","unstructured":"Zollner IK, Weiland SK, Piechotowski I et al: No increase in the prevalence of asthma, allergies, and atopic sensitisation among children in Germany: 1992-2001. Thorax 2005; 60: 545\u2013548.","journal-title":"Thorax"},{"key":"BFejhg201246_CR3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1183\/09031936.04.00074004","volume":"23","author":"C Braun-Fahrlander","year":"2004","unstructured":"Braun-Fahrlander C, Gassner M, Grize L et al: No further increase in asthma, hay fever and atopic sensitisation in adolescents living in Switzerland. Eur Respir J 2004; 23: 407\u2013413.","journal-title":"Eur Respir J"},{"key":"BFejhg201246_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1136\/thx.2004.038844","volume":"62","author":"R Gupta","year":"2007","unstructured":"Gupta R, Sheikh A, Strachan DP, Anderson HR : Time trends in allergic disorders in the UK. Thorax 2007; 62: 91\u201396.","journal-title":"Thorax"},{"key":"BFejhg201246_CR5","first-page":"1268","volume":"10","author":"SF Thomsen","year":"2006","unstructured":"Thomsen SF, Ulrik CS, Kyvik KO, Skadhauge LR, Steffensen I, Backer V : Findings on the atopic triad from a Danish twin registry. Int J Tuberc Lung Dis 2006; 10: 1268\u20131272.","journal-title":"Int J Tuberc Lung Dis"},{"key":"BFejhg201246_CR6","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/j.1398-9995.1998.tb03996.x","volume":"53","author":"M Rasanen","year":"1998","unstructured":"Rasanen M, Laitinen T, Kaprio J, Koskenvuo M, Laitinen LA : Hay fever - a Finnish nationwide study of adolescent twins and their parents. Allergy 1998; 53: 885\u2013890.","journal-title":"Allergy"},{"key":"BFejhg201246_CR7","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1183\/09031936.00065706","volume":"29","author":"CE van Beijsterveldt","year":"2007","unstructured":"van Beijsterveldt CE, Boomsma DI : Genetics of parentally reported asthma, eczema and rhinitis in 5-yr-old twins. Eur Respir J 2007; 29: 516\u2013521.","journal-title":"Eur Respir J"},{"key":"BFejhg201246_CR8","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/sj.ejhg.5200753","volume":"9","author":"A Haagerup","year":"2001","unstructured":"Haagerup A, Bjerke T, Schoitz PO, Binderup HG, Dahl R, Kruse TA : Allergic rhinitis - a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27. Eur J Hum Genet 2001; 9: 945\u2013952.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg201246_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.gene.6363815","volume":"3","author":"Y Yokouchi","year":"2002","unstructured":"Yokouchi Y, Shibasaki M, Noguchi E et al: A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families. Genes Immun 2002; 3: 9\u201313.","journal-title":"Genes Immun"},{"key":"BFejhg201246_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/sj.gene.6364163","volume":"6","author":"MH Dizier","year":"2005","unstructured":"Dizier MH, Bouzigon E, Guilloud-Bataille M et al: Genome screen in the French EGEA study: detection of linked regions shared or not shared by allergic rhinitis and asthma. Genes Immun 2005; 6: 95\u2013102.","journal-title":"Genes Immun"},{"key":"BFejhg201246_CR11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1365-2222.2006.02397.x","volume":"36","author":"LM Bu","year":"2006","unstructured":"Bu LM, Bradley M, Soderhall C, Wahlgren CF, Kockum I, Nordenskjold M : Genome-wide linkage analysis of allergic rhinoconjunctivitis in a Swedish population. Clin Exp Allergy 2006; 36: 204\u2013210.","journal-title":"Clin Exp Allergy"},{"key":"BFejhg201246_CR12","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0091-6749(99)70398-2","volume":"104","author":"KC Barnes","year":"1999","unstructured":"Barnes KC, Freidhoff LR, Nickel R et al: Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy. J Allergy Clin Immunol 1999; 104: 485\u2013491.","journal-title":"J Allergy Clin Immunol"},{"key":"BFejhg201246_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1398-9995.2004.00294.x","volume":"59","author":"A Haagerup","year":"2004","unstructured":"Haagerup A, Borglum AD, Binderup HG, Kruse TA : Fine-scale mapping of type I allergy candidate loci suggests central susceptibility genes on chromosomes 3q, 4q and Xp. Allergy 2004; 59: 88\u201394.","journal-title":"Allergy"},{"key":"BFejhg201246_CR14","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1136\/jmg.2005.035519","volume":"43","author":"C Brasch-Andersen","year":"2006","unstructured":"Brasch-Andersen C, Haagerup A, Borglum AD, Vestbo J, Kruse TA : Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases. J Med Genet 2006; 43: e10.","journal-title":"J Med Genet"},{"key":"BFejhg201246_CR15","doi-asserted-by":"crossref","unstructured":"Christensen U, Moller-Larsen S, Nyegaard M et al: Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21. Hum Genet 2009.","DOI":"10.1007\/s00439-009-0692-z"},{"key":"BFejhg201246_CR16","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1034\/j.1398-9995.2002.23523.x","volume":"57","author":"A Haagerup","year":"2002","unstructured":"Haagerup A, Bjerke T, Schiotz PO, Binderup HG, Dahl R, Kruse TA : Asthma and atopy - a total genome scan for susceptibility genes. Allergy 2002; 57: 680\u2013686.","journal-title":"Allergy"},{"key":"BFejhg201246_CR17","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/ajmg.b.31023","volume":"153B","author":"M Nyegaard","year":"2010","unstructured":"Nyegaard M, Severinsen JE, Als TD et al: Support of association between BRD1 and both schizophrenia and bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 582\u2013591.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BFejhg201246_CR18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1086\/381563","volume":"74","author":"C Lange","year":"2004","unstructured":"Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM : PBAT: tools for family-based association studies. Am J Hum Genet 2004; 74: 367\u2013369.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201246_CR19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1056\/NEJMoa0901867","volume":"362","author":"PM Sleiman","year":"2010","unstructured":"Sleiman PM, Flory J, Imielinski M et al: Variants of DENND1B associated with asthma in children. N Engl J Med 2010; 362: 36\u201344.","journal-title":"N Engl J Med"},{"key":"BFejhg201246_CR20","doi-asserted-by":"crossref","DOI":"10.56021\/9780801861406","volume-title":"Analysis of Human Genetic Linkage","author":"J Ott","year":"1999","unstructured":"Ott J : Analysis of Human Genetic Linkage, 3rd edn. Baltimore: The John Hopkins University Press, 1999."},{"key":"BFejhg201246_CR21","first-page":"1347","volume":"58","author":"L Kruglyak","year":"1996","unstructured":"Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES : Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996; 58: 1347\u20131363.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201246_CR22","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1086\/302911","volume":"66","author":"K Strauch","year":"2000","unstructured":"Strauch K, Fimmers R, Kurz T, Deichmann KA, Wienker TF, Baur MP : Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization. Am J Hum Genet 2000; 66: 1945\u20131957.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201246_CR23","first-page":"834","volume":"55","author":"DA Greenberg","year":"1994","unstructured":"Greenberg DA, Berger B : Using lod-score differences to determine mode of inheritance: a simple, robust method even in the presence of heterogeneity and reduced penetrance. Am J Hum Genet 1994; 55: 834\u2013840.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201246_CR24","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng1195-241","volume":"11","author":"E Lander","year":"1995","unstructured":"Lander E, Kruglyak L : Genetic dissection of complex traits - guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241\u2013247.","journal-title":"Nat Genet"},{"key":"BFejhg201246_CR25","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/sj.ejhg.5200625","volume":"9","author":"S Horvath","year":"2001","unstructured":"Horvath S, Xu X, Laird NM : The family based association test method: strategies for studying general genotype--phenotype associations. Eur J Hum Genet 2001; 9: 301\u2013306.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg201246_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/gepi.10295","volume":"26","author":"S Horvath","year":"2004","unstructured":"Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM : Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 2004; 26: 61\u201369.","journal-title":"Genet Epidemiol"},{"key":"BFejhg201246_CR27","volume-title":"Approaches to Gene Mapping in Comlex Human Diseases","author":"JL Haines","year":"1998","unstructured":"Haines JL, Pericak-Vance M : Approaches to Gene Mapping in Comlex Human Diseases. New York: Wiley-Liss, 1998."},{"key":"BFejhg201246_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1465-9921-9-38","volume":"9","author":"S Denham","year":"2008","unstructured":"Denham S, Koppelman GH, Blakey J et al: Meta-analysis of genome-wide linkage studies of asthma and related traits. Respir Res 2008; 9: 38.","journal-title":"Respir Res"},{"key":"BFejhg201246_CR29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/sj.gene.6364284","volume":"7","author":"C Ober","year":"2006","unstructured":"Ober C, Hoffjan S : Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006; 7: 95\u2013100.","journal-title":"Genes Immun"},{"key":"BFejhg201246_CR30","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1164\/rccm.200506-890OC","volume":"172","author":"S Bierbaum","year":"2005","unstructured":"Bierbaum S, Nickel R, Koch A et al: Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma. Am J Respir Crit Care Med 2005; 172: 1505\u20131509.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFejhg201246_CR31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00439-003-1030-5","volume":"114","author":"MN Blumenthal","year":"2004","unstructured":"Blumenthal MN, Langefeld CD, Beaty TH et al: A genome-wide search for allergic response (atopy) genes in three ethnic groups: collaborative study on the genetics of asthma. Hum Genet 2004; 114: 157\u2013164.","journal-title":"Hum Genet"},{"key":"BFejhg201246_CR32","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2217\/14622416.9.4.399","volume":"9","author":"E Rodriguez","year":"2008","unstructured":"Rodriguez E, Illig T, Weidinger S : Filaggrin loss-of-function mutations and association with allergic diseases. Pharmacogenomics 2008; 9: 399\u2013413.","journal-title":"Pharmacogenomics"},{"issue":"Suppl 1","key":"BFejhg201246_CR33","doi-asserted-by":"publisher","first-page":"S258","DOI":"10.1002\/gepi.2001.21.s1.s258","volume":"21","author":"VS Pankratz","year":"2001","unstructured":"Pankratz VS, Iturria SJ : A pedigree partitioning approach to quantitative trait loci mapping of IgE serum level in the GAW12 Hutterite data. Genet Epidemiol 2001; 21 (Suppl 1): S258\u2013S263.","journal-title":"Genet Epidemiol"},{"key":"BFejhg201246_CR34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00439-006-0285-z","volume":"121","author":"BT Webb","year":"2007","unstructured":"Webb BT, van den Oord E, Akkari A et al: Quantitative linkage genome scan for atopy in a large collection of Caucasian families. Hum Genet 2007; 121: 83\u201392.","journal-title":"Hum Genet"},{"key":"BFejhg201246_CR35","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S1081-1206(10)63530-2","volume":"91","author":"VP Joki-Erkkila","year":"2003","unstructured":"Joki-Erkkila VP, Karjalainen J, Hulkkonen J et al: Allergic rhinitis and polymorphisms of the interleukin 1 gene complex. Ann Allergy Asthma Immunol 2003; 91: 275\u2013279.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"BFejhg201246_CR36","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1111\/j.1365-2222.2004.02008.x","volume":"34","author":"L Cheng","year":"2004","unstructured":"Cheng L, Enomoto T, Hirota T et al: Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. Clin Exp Allergy 2004; 34: 1192\u20131201.","journal-title":"Clin Exp Allergy"},{"key":"BFejhg201246_CR37","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1136\/thx.2007.094128","volume":"63","author":"S Moller-Larsen","year":"2008","unstructured":"Moller-Larsen S, Nyegaard M, Haagerup A, Vestbo J, Kruse TA, Borglum AD : Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. Thorax 2008; 63: 1064\u20131069.","journal-title":"Thorax"},{"key":"BFejhg201246_CR38","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/ng1256","volume":"35","author":"M Allen","year":"2003","unstructured":"Allen M, Heinzmann A, Noguchi E et al: Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet 2003; 35: 258\u2013263.","journal-title":"Nat Genet"},{"key":"BFejhg201246_CR39","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jaci.2009.11.018","volume":"125","author":"X Li","year":"2010","unstructured":"Li X, Howard TD, Zheng SL et al: Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR\/DQ regions. J Allergy Clin Immunol 2010; 125: 328\u2013335, e311.","journal-title":"J Allergy Clin Immunol"},{"key":"BFejhg201246_CR40","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","volume":"363","author":"MF Moffatt","year":"2010","unstructured":"Moffatt MF, Gut IG, Demenais F et al: A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211\u20131221.","journal-title":"N Engl J Med"},{"key":"BFejhg201246_CR41","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1056\/NEJMoa0708801","volume":"358","author":"C Ober","year":"2008","unstructured":"Ober C, Tan Z, Sun Y et al: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 2008; 358: 1682\u20131691.","journal-title":"N Engl J Med"},{"key":"BFejhg201246_CR42","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1111\/j.1365-2222.2009.03316.x","volume":"39","author":"T Kawai","year":"2009","unstructured":"Kawai T, Takeshita S, Imoto Y et al: Associations between decay-accelerating factor polymorphisms and allergic respiratory diseases. Clin Exp Allergy 2009; 39: 1508\u20131514.","journal-title":"Clin Exp Allergy"},{"key":"BFejhg201246_CR43","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/j.1398-9995.2009.02291.x","volume":"65","author":"RW Bottema","year":"2010","unstructured":"Bottema RW, Kerkhof M, Reijmerink NE et al: X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. Allergy 2010; 65: 865\u2013874.","journal-title":"Allergy"},{"key":"BFejhg201246_CR44","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/bioinformatics\/btl539","volume":"23","author":"J Dietter","year":"2007","unstructured":"Dietter J, Mattheisen M, Furst R, Ruschendorf F, Wienker TF, Strauch K : Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE. Bioinformatics 2007; 23: 64\u201370.","journal-title":"Bioinformatics"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg201246.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201246","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201246.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T03:12:54Z","timestamp":1687317174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg201246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,14]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["BFejhg201246"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2012.46","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,14]]}}}