{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:17:08Z","timestamp":1791271028449,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:00:00Z","timestamp":1372809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1038\/ejhg.2013.136","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T06:35:47Z","timestamp":1372833347000},"page":"358-362","source":"Crossref","is-referenced-by-count":33,"title":["THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge"],"prefix":"10.1038","volume":"22","author":[{"name":"CEGEC","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Bondar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Plaza-Izurieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Fernandez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Irastorza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebo","family":"Withoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cisca","family":"Wijmenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Chirdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Ramon","family":"Bilbao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,3]]},"reference":[{"key":"BFejhg2013136_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","volume":"29","author":"V Abadie","year":"2011","unstructured":"Abadie V, Sollid LM, Barreiro LB, Jabri B : Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol 2011; 29: 493\u2013525.","journal-title":"Annu Rev Immunol"},{"key":"BFejhg2013136_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ng.543","volume":"42","author":"PC Dubois","year":"2010","unstructured":"Dubois PC, Trynka G, Franke L et al: Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 2010; 42: 295\u2013302.","journal-title":"Nat Genet"},{"key":"BFejhg2013136_CR3","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ng2058","volume":"39","author":"DA van Heel","year":"2007","unstructured":"van Heel DA, Franke L, Hunt KA et al: A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 2007; 39: 827\u2013829.","journal-title":"Nat Genet"},{"key":"BFejhg2013136_CR4","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/ng.998","volume":"43","author":"G Trynka","year":"2011","unstructured":"Trynka G, Hunt KA, Bockett NA et al: Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet 2011; 43: 1193\u20131201.","journal-title":"Nat Genet"},{"key":"BFejhg2013136_CR5","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/ni.1768","volume":"10","author":"R Lesourne","year":"2009","unstructured":"Lesourne R, Uehara S, Lee J et al: Themis, a new T cell specific protein important for late thymocyte development. Nat Immunol 2009; 10: 840\u2013847.","journal-title":"Nat Immunol"},{"key":"BFejhg2013136_CR6","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/ni.1766","volume":"10","author":"G Fu","year":"2009","unstructured":"Fu G, Vall\u00e9e S, Rybakin V et al: Themis controls thymocyte selection through modulation of T cell antigen receptor-mediated signalling. Nat Immunol 2009; 10: 848\u2013856.","journal-title":"Nat Immunol"},{"key":"BFejhg2013136_CR7","doi-asserted-by":"publisher","first-page":"7535","DOI":"10.1074\/jbc.M110.201236","volume":"286","author":"C Brockmeyer","year":"2011","unstructured":"Brockmeyer C, Paster W, Pepper D et al: T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem 2011; 286: 7535\u20137547.","journal-title":"J Biol Chem"},{"key":"BFejhg2013136_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MCB.14.1.1","volume":"14","author":"J Sap","year":"1994","unstructured":"Sap J, Jiang YP, Friedlander D, Grumet M, Schlessinger J : Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding. Mol Cell Biol 1994; 14: 1\u20139.","journal-title":"Mol Cell Biol"},{"key":"BFejhg2013136_CR9","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1136\/gut.2004.063164","volume":"54","author":"J Schnekenburger","year":"2005","unstructured":"Schnekenburger J, Mayerle J, Kr\u00fcger B et al: Protein tyrosine phosphatase kappa and SHP-1 are involved in the regulation of cell-cell contacts at adherens junctions in the exocrine pancreas. Gut 2005; 54: 1445\u20131455.","journal-title":"Gut"},{"key":"BFejhg2013136_CR10","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1128\/MCB.26.10.3917-3934.2006","volume":"26","author":"L Anders","year":"2006","unstructured":"Anders L, Mertins P, Lammich S et al: Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Mol Cell Biol 2006; 26: 3917\u20133934.","journal-title":"Mol Cell Biol"},{"key":"BFejhg2013136_CR11","doi-asserted-by":"publisher","first-page":"27389","DOI":"10.1074\/jbc.M602355200","volume":"281","author":"Y Xu","year":"2006","unstructured":"Xu Y, Shao Y, Voorhees JJ, Fisher GJ : Oxidative inhibition of receptor type protein tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes. J Biol Chem 2006; 281: 27389\u201327397.","journal-title":"J Biol Chem"},{"key":"BFejhg2013136_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1091\/mbc.e09-08-0710","volume":"21","author":"Y Xu","year":"2010","unstructured":"Xu Y, Baker D, Quan T, Baldassare JJ, Voorhees JJ, Fisher GJ : Receptor type protein tyrosine phosphatase-kappa mediates cross-talk between transforming growth factor-beta and epidermal growth factor receptor signaling pathways in human keratinocytes. Mol Biol Cell 2010; 21: 29\u201335.","journal-title":"Mol Biol Cell"},{"key":"BFejhg2013136_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2220\/biomedres.31.83","volume":"31","author":"R Iwata","year":"2010","unstructured":"Iwata R, Sasaki N, Agui T : Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat. Biomed Res 2010; 31: 83\u201387.","journal-title":"Biomed Res"},{"key":"BFejhg2013136_CR14","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00251-004-0724-8","volume":"56","author":"A Martin-Pagola","year":"2004","unstructured":"Martin-Pagola A, Perez-Nanclares G, Ortiz L et al: MICA response to gliadin in intestinal mucosa from celiac patients. Immunogenetics 2004; 56: 549\u2013554.","journal-title":"Immunogenetics"},{"key":"BFejhg2013136_CR15","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K et al: PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet 2007; 81: 559\u2013575.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2013136_CR16","doi-asserted-by":"publisher","first-page":"W621","DOI":"10.1093\/nar\/gkl071","volume":"34","author":"L Conde","year":"2006","unstructured":"Conde L, Vaquerizas JM, Dopazo H et al: PupaSuite: finding functional SNPs for large-scale genotyping purposes. Nucleic Acid Res 2006; 34: W621\u2013W625.","journal-title":"Nucleic Acid Res"},{"key":"BFejhg2013136_CR17","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","volume":"40","author":"KellisM WardL","year":"2012","unstructured":"WardL Kellis M : HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acid Res 2012; 40: D930\u2013D934.","journal-title":"Nucleic Acid Res"},{"key":"BFejhg2013136_CR18","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1136\/jmg.2011.089714","volume":"48","author":"L Plaza-Izurieta","year":"2011","unstructured":"Plaza-Izurieta L, Castellanos-Rubio A, Irastorza I et al: Revisiting genome wide association studies (GWAS) in coeliac disease: replication study in Spanish population and expression analysis of candidate genes. J Med Genet 2011; 48: 493\u2013496.","journal-title":"J Med Genet"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg2013136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2013136","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2013136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:08:41Z","timestamp":1684415321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg2013136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["BFejhg2013136"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2013.136","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,3]]}}}