{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:36:19Z","timestamp":1768926979087,"version":"3.49.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1038\/ejhg.2014.158","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T10:19:00Z","timestamp":1410949140000},"page":"678-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Identification of possible pathogenic pathways in Beh\u00e7et\u2019s disease using genome-wide association study data from two different populations"],"prefix":"10.1038","volume":"23","author":[{"given":"Burcu","family":"Bakir-Gungor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine F","family":"Remmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Meguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Mizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L","family":"Kastner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Gul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman U","family":"Sezerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,9,17]]},"reference":[{"key":"BFejhg2014158_CR1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/ng.625","volume":"42","author":"EF Remmers","year":"2010","unstructured":"Remmers EF, Cosan F, Kirino Y et al: Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet\u2019s disease. Nat Genet 2010; 42: 698\u2013U678.","journal-title":"Nat Genet"},{"key":"BFejhg2014158_CR2","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/ng.624","volume":"42","author":"N Mizuki","year":"2010","unstructured":"Mizuki N, Meguro A, Ota M et al: Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet\u2019s disease susceptibility loci. Nat Genet 2010; 42: 703\u2013U783.","journal-title":"Nat Genet"},{"key":"BFejhg2014158_CR3","first-page":"S6","volume":"19","author":"A Gul","year":"2001","unstructured":"Gul A : Behcet\u2019s disease: an update on the pathogenesis. Clin Exp Rheumatol 2001; 19: S6\u2013S12.","journal-title":"Clin Exp Rheumatol"},{"key":"BFejhg2014158_CR4","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/ejhg.2008.12","volume":"16","author":"KC Seng","year":"2008","unstructured":"Seng KC, Seng CK : The success of the genome-wide association approach: a brief story of a long struggle. Eur J Hum Genet 2008; 16: 554\u2013564.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg2014158_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ajhg.2011.11.029","volume":"90","author":"PM Visscher","year":"2012","unstructured":"Visscher PM, Brown MA, McCarthy MI, Yang J : Five years of GWAS discovery. Am J Hum Genet 2012; 90: 7\u201324.","journal-title":"Am J Hum Genet"},{"key":"BFejhg2014158_CR6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrg2779","volume":"11","author":"ET Cirulli","year":"2010","unstructured":"Cirulli ET, Goldstein DB : Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet 2010; 11: 415\u2013425.","journal-title":"Nat Rev Genet"},{"key":"BFejhg2014158_CR7","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/ejhg.2011.57","volume":"19","author":"BL Fridley","year":"2011","unstructured":"Fridley BL, Biernacka JM : Gene set analysis of SNP data: benefits, challenges, and future directions. Eur J Hum Genet 2011; 19: 837\u2013843.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg2014158_CR8","doi-asserted-by":"publisher","first-page":"e26277","DOI":"10.1371\/journal.pone.0026277","volume":"6","author":"B Bakir-Gungor","year":"2011","unstructured":"Bakir-Gungor B, Sezerman OU : A new methodology to associate SNPs with human diseases according to their pathway related context. PLoS One 2011; 6: e26277.","journal-title":"PLoS One"},{"key":"BFejhg2014158_CR9","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/hmg\/ddp120","volume":"18","author":"SE Baranzini","year":"2009","unstructured":"Baranzini SE, Galwey NW, Wang J et al: Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet 2009; 18: 2078\u20132090.","journal-title":"Hum Mol Genet"},{"key":"BFejhg2014158_CR10","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1093\/bib\/bbr075","volume":"13","author":"G Bebek","year":"2012","unstructured":"Bebek G, Koyuturk M, Price ND, Chance MR : Network biology methods integrating biological data for translational science. Brief Bioinform 2012; 13: 446\u2013459.","journal-title":"Brief Bioinform"},{"key":"BFejhg2014158_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/ejhg.2009.115","volume":"18","author":"G Peng","year":"2010","unstructured":"Peng G, Luo L, Siu HC et al: Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet 2010; 18: 111\u2013117.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg2014158_CR12","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ygeno.2008.07.011","volume":"92","author":"A Torkamani","year":"2008","unstructured":"Torkamani A, Topol EJ, Schork NJ : Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 2008; 92: 265\u2013272.","journal-title":"Genomics"},{"key":"BFejhg2014158_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/gm328","volume":"4","author":"BE Stranger","year":"2012","unstructured":"Stranger BE, Bjorkegren J, Dolan ME, Ritchie MD : Systems and genome-wide approaches unite to provide a route to personalized medicine. Genome Med 2012; 4: 29.","journal-title":"Genome Med"},{"key":"BFejhg2014158_CR14","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/ejhg.2012.66","volume":"20","author":"L de las Fuentes","year":"2012","unstructured":"de las Fuentes L, Yang W, Davila-Roman VG, Gu CC : Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets. Eur J Hum Genet 2012; 20: 1168\u20131173.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg2014158_CR15","doi-asserted-by":"publisher","first-page":"e1002820","DOI":"10.1371\/journal.pcbi.1002820","volume":"8","author":"DY Cho","year":"2012","unstructured":"Cho DY, Kim YA, Przytycka TM : Chapter 5: Network biology approach to complex diseases. PLoS Comput Biol 2012; 8: e1002820.","journal-title":"PLoS Comput Biol"},{"key":"BFejhg2014158_CR16","first-page":"227","volume":"3","author":"YA Kim","year":"2012","unstructured":"Kim YA, Przytycka TM : Bridging the gap between genotype and phenotype via network approaches. Front Genet 2012; 3: 227.","journal-title":"Front Genet"},{"key":"BFejhg2014158_CR17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrg2918","volume":"12","author":"AL Barabasi","year":"2011","unstructured":"Barabasi AL, Gulbahce N, Loscalzo J : Network medicine: a network-based approach to human disease. Nat Rev Genet 2011; 12: 56\u201368.","journal-title":"Nat Rev Genet"},{"key":"BFejhg2014158_CR18","doi-asserted-by":"publisher","first-page":"115rv1","DOI":"10.1126\/scitranslmed.3002132","volume":"4","author":"EE Schadt","year":"2012","unstructured":"Schadt EE, Bjorkegren JLM : NEW: network-enabled wisdom in biology, medicine, and health care. Sci Transl Med 2012; 4: 115rv1.","journal-title":"Sci Transl Med"},{"key":"BFejhg2014158_CR19","doi-asserted-by":"publisher","first-page":"e57022","DOI":"10.1371\/journal.pone.0057022","volume":"8","author":"B Bakir-Gungor","year":"2013","unstructured":"Bakir-Gungor B, Sezerman OU : The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations. PLoS One 2013; 8: e57022.","journal-title":"PLoS One"},{"key":"BFejhg2014158_CR20","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.eplepsyres.2013.02.008","volume":"105","author":"B Bakir-Gungor","year":"2013","unstructured":"Bakir-Gungor B, Baykan B, Iseri SU, Tuncer FN, Sezerman OU : Identifying SNP targeted pathways in partial epilepsies with genome-wide association study data. Epilepsy Res 2013; 105: 92\u2013102.","journal-title":"Epilepsy Res"},{"key":"BFejhg2014158_CR21","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1002\/humu.21047","volume":"30","author":"R Calabrese","year":"2009","unstructured":"Calabrese R, Capriotti E, Fariselli P, Martelli PL, Casadio R : Functional annotations improve the predictive score of human disease-related mutations in proteins. Hum Mutat 2009; 30: 1237\u20131244.","journal-title":"Hum Mutat"},{"key":"BFejhg2014158_CR22","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.gene.2012.09.075","volume":"511","author":"CT Liu","year":"2012","unstructured":"Liu CT, Lin HW, Lin HH : Functional analysis of HapMap SNPs. Gene 2012; 511: 358\u2013363.","journal-title":"Gene"},{"key":"BFejhg2014158_CR23","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot JP, Chamaillard M, Zouali H et al: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease. Nature 2001; 411: 599\u2013603.","journal-title":"Nature"},{"key":"BFejhg2014158_CR24","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/ng1767","volume":"38","author":"CN Palmer","year":"2006","unstructured":"Palmer CN, Irvine AD, Terron-Kwiatkowski A et al: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441\u2013446.","journal-title":"Nat Genet"},{"key":"BFejhg2014158_CR25","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrg2760","volume":"11","author":"NA Rosenberg","year":"2010","unstructured":"Rosenberg NA, Huang L, Jewett EM, Szpiech ZA, Jankovic I, Boehnke M : Genome-wide association studies in diverse populations. Nat Rev Genet 2010; 11: 356\u2013366.","journal-title":"Nat Rev Genet"},{"key":"#cr-split#-BFejhg2014158_CR26.1","doi-asserted-by":"crossref","unstructured":"1. Bakir-Gungor B, Sezerman OU : Identification of SNP targeted pathways from genome-wide association study (GWAS) data. Protoc Exch 2012","DOI":"10.1038\/protex.2012.019"},{"key":"#cr-split#-BFejhg2014158_CR26.2","doi-asserted-by":"crossref","unstructured":"10.1038\/protex.2012.019","DOI":"10.1038\/protex.2012.019"},{"key":"BFejhg2014158_CR27","volume-title":"Bioinformatics Approaches to Associate Single Nucleotide Polymorphisms with Human Diseases According to Their Pathway Related Context","author":"B Bakir-Gungor","year":"2012","unstructured":"Bakir-Gungor B : Bioinformatics Approaches to Associate Single Nucleotide Polymorphisms with Human Diseases According to Their Pathway Related Context, PhD thesis. Sabanc\u0131 University: \u0130stanbul, Turkey, 2012."},{"key":"BFejhg2014158_CR28","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1093\/bioinformatics\/btt743","volume":"30","author":"B Bakir-Gungor","year":"2013","unstructured":"Bakir-Gungor B, Egemen E, Sezerman OU : PANOGA: a web-server for identification of SNP targeted pathways from genome-wide association study data. Bioinformatics 2013; 30: 1287\u20131289.","journal-title":"Bioinformatics"},{"key":"BFejhg2014158_CR29","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nmeth.1282","volume":"6","author":"JM Wu","year":"2009","unstructured":"Wu JM, Vallenius T, Ovaska K, Westermarck J, Makela TP, Hautaniemi S : Integrated network analysis platform for protein-protein interactions. Nat Methods 2009; 6: 75\u201377.","journal-title":"Nat Methods"},{"key":"BFejhg2014158_CR30","doi-asserted-by":"publisher","first-page":"W201","DOI":"10.1093\/nar\/gkq513","volume":"38","author":"SF Saccone","year":"2010","unstructured":"Saccone SF, Bolze R, Thomas P et al: SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res 2010; 38: W201\u2013W209.","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 1","key":"BFejhg2014158_CR31","doi-asserted-by":"publisher","first-page":"S233","DOI":"10.1093\/bioinformatics\/18.suppl_1.S233","volume":"18","author":"T Ideker","year":"2002","unstructured":"Ideker T, Ozier O, Schwikowski B, Siegel AF : Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics 2002; 18 (Suppl 1): S233\u2013S240.","journal-title":"Bioinformatics"},{"key":"BFejhg2014158_CR32","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/ng.2520","volume":"45","author":"Y Kirino","year":"2013","unstructured":"Kirino Y, Bertsias G, Ishigatsubo Y et al: Genome-wide association analysis identifies new susceptibility loci for Behcet\u2019s disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013; 45: 202\u2013207.","journal-title":"Nat Genet"},{"key":"BFejhg2014158_CR33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/ng.2551","volume":"45","author":"T Hughes","year":"2013","unstructured":"Hughes T, Coit P, Adler A et al: Identification of multiple independent susceptibility loci in the HLA region in Behcet\u2019s disease. Nat Genet 2013; 45: 319\u2013324.","journal-title":"Nat Genet"},{"key":"BFejhg2014158_CR34","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1034\/j.1600-0420.2003.00068.x","volume":"81","author":"F Batioglu","year":"2003","unstructured":"Batioglu F, Atmaca LS, Karabulut HG, Beyza Sayin D : Factor V Leiden and prothrombin gene G20210A mutations in ocular Behcet disease. Acta Ophthalmol Scand 2003; 81: 283\u2013285.","journal-title":"Acta Ophthalmol Scand"},{"key":"BFejhg2014158_CR35","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1093\/rheumatology\/kes399","volume":"52","author":"F Ture-Ozdemir","year":"2013","unstructured":"Ture-Ozdemir F, Tulunay A, Elbasi MO et al: Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet\u2019s disease. Rheumatology 2013; 52: 800\u2013805.","journal-title":"Rheumatology"},{"key":"BFejhg2014158_CR36","first-page":"S35","volume":"30","author":"J Shimizu","year":"2012","unstructured":"Shimizu J, Izumi T, Arimitsu N et al: Skewed TGF beta\/Smad signalling pathway of T cells in patients with Behcet\u2019s disease. Clin Exp Rheumatol 2012; 30: S35\u2013S39.","journal-title":"Clin Exp Rheumatol"},{"key":"BFejhg2014158_CR37","first-page":"S71","volume":"29","author":"K Hamzaoui","year":"2011","unstructured":"Hamzaoui K : Th17 cells in Behcet\u2019s disease: a new immunoregulatory axis. Clin Exp Rheumat 2011; 29: S71\u2013S76.","journal-title":"Clin Exp Rheumat"},{"key":"BFejhg2014158_CR38","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.autrev.2011.11.026","volume":"11","author":"MP de Chambrun","year":"2012","unstructured":"de Chambrun MP, Wechsler B, Geri G, Cacoub P, Saadoun D : New insights into the pathogenesis of Behcet\u2019s disease. Autoimmun Rev 2012; 11: 687\u2013698.","journal-title":"Autoimmun Rev"},{"key":"BFejhg2014158_CR39","first-page":"9","volume":"3","author":"FZ Shahneh","year":"2013","unstructured":"Shahneh FZ, Mohammadian M, Babaloo Z, Baradaran B : New approaches in the immunotherapy of Beh\u00e7et disease. Adv Pharm Bull 2013; 3: 9\u201311.","journal-title":"Adv Pharm Bull"},{"key":"BFejhg2014158_CR40","doi-asserted-by":"publisher","first-page":"8134","DOI":"10.1073\/pnas.1306352110","volume":"110","author":"Y Kirino","year":"2013","unstructured":"Kirino Y, Zhou Q, Ishigatsubo Y et al: Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease. Proc Natl Acad Sci USA 2013; 110: 8134\u20138139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg2014158_CR41","first-page":"105205","volume":"2012","author":"J Shimizu","year":"2012","unstructured":"Shimizu J, Izumi T, Suzuki N : Aberrant activation of heat shock protein 60\/65 reactive T cells in patients with Behcet\u2019s disease. Autoimmune Dis 2012; 2012: 105205.","journal-title":"Autoimmune Dis"},{"key":"BFejhg2014158_CR42","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.4049\/jimmunol.0903418","volume":"184","author":"L Lu","year":"2010","unstructured":"Lu L, Wang J, Zhang F et al: Role of SMAD and Non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol 2010; 184: 4295\u20134306.","journal-title":"J Immunol"},{"key":"BFejhg2014158_CR43","doi-asserted-by":"publisher","first-page":"3290","DOI":"10.1182\/blood-2011-02-336552","volume":"118","author":"R Noubade","year":"2011","unstructured":"Noubade R, Krementsov DN, del Rio R et al: Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood 2011; 118: 3290\u20133300.","journal-title":"Blood"},{"key":"BFejhg2014158_CR44","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1046\/j.1365-2796.1996.396853000.x","volume":"240","author":"IC Haznedaroglu","year":"1996","unstructured":"Haznedaroglu IC, Ozcebe OI, Ozdemir O, Celik I, Dundar SV, Kirazli S : Impaired haemostatic kinetics and endothelial function in Behcet\u2019s disease. J Intern Med 1996; 240: 181\u2013187.","journal-title":"J Intern Med"},{"key":"BFejhg2014158_CR45","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0002-9343(01)01048-8","volume":"112","author":"G Espinosa","year":"2002","unstructured":"Espinosa G, Font J, Tassies D et al: Vascular involvement in Behcet\u2019s disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med 2002; 112: 37\u201343.","journal-title":"Am J Med"},{"key":"BFejhg2014158_CR46","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1053\/ejvs.2000.1091","volume":"19","author":"S Demirer","year":"2000","unstructured":"Demirer S, Sengul N, Yerdel MA et al: Haemostasis in patients with Behcet\u2019s disease. Eur J Vasc Endovasc 2000; 19: 570\u2013574.","journal-title":"Eur J Vasc Endovasc"},{"key":"BFejhg2014158_CR47","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3109\/03009749509095184","volume":"24","author":"K Ozoran","year":"1995","unstructured":"Ozoran K, Duzgun N, Gurler A, Tutkak H, Tokgoz G : Plasma von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, and antithrombin III levels in Behcet\u2019s disease. Scand J Rheumatol 1995; 24: 376\u2013382.","journal-title":"Scand J Rheumatol"},{"key":"BFejhg2014158_CR48","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1055\/s-0038-1646409","volume":"66","author":"KK Hampton","year":"1991","unstructured":"Hampton KK, Chamberlain MA, Menon DK, Davies JA : Coagulation and fibrinolytic-activity in Behcets-disease. Thromb Haemostasis 1991; 66: 292\u2013294.","journal-title":"Thromb Haemostasis"},{"key":"BFejhg2014158_CR49","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/ajh.20317","volume":"79","author":"E Beyan","year":"2005","unstructured":"Beyan E, Sadikoglu B, Ertugrul E, Beyan C : von Willebrand factor antigen levels in Behcet disease. Am J Hematol 2005; 79: 70\u201372.","journal-title":"Am J Hematol"},{"key":"BFejhg2014158_CR50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.4077\/CJP.2011.AMM042","volume":"54","author":"H Shang","year":"2011","unstructured":"Shang H, Ye JJ, Ji M, Wang FF, Zhu YY, Qi XM : Anticoagulant and fibrinolytic disorders in patients with Behcet\u2019s disease and recurrent aphthous ulcer. Chin J Physiol 2011; 54: 235\u2013240.","journal-title":"Chin J Physiol"},{"key":"BFejhg2014158_CR51","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1160\/TH05-10-0659","volume":"95","author":"JM Ricart","year":"2006","unstructured":"Ricart JM, Vaya A, Todoli J et al: Thrombophilic risk factors and homocysteine levels in Behcet\u2019s disease in eastern Spain and their association with thrombotic events. Thromb Haemostasis 2006; 95: 618\u2013624.","journal-title":"Thromb Haemostasis"},{"key":"BFejhg2014158_CR52","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1093\/rheumatology\/35.11.1178","volume":"35","author":"A Gul","year":"1996","unstructured":"Gul A, Ozbek U, Inanc M, Konice M, Ozcelik T : Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet\u2019s disease. Brit J Rheumatol 1996; 35: 1178\u20131180.","journal-title":"Brit J Rheumatol"},{"key":"BFejhg2014158_CR53","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1056\/NEJMra1202117","volume":"368","author":"JJ O'Shea","year":"2013","unstructured":"O'Shea JJ, Holland SM, Staudt LM : JAKs and STATs in immunity, immunodeficiency, and cancer. New Engl J Med 2013; 368: 161\u2013170.","journal-title":"New Engl J Med"},{"key":"BFejhg2014158_CR54","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1744-313X.2012.01084.x","volume":"39","author":"N Polgar","year":"2012","unstructured":"Polgar N, Csongei V, Szabo M et al: Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease. Int J Immunogenet 2012; 39: 247\u2013252.","journal-title":"Int J Immunogenet"},{"key":"BFejhg2014158_CR55","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1056\/NEJMra1100030","volume":"365","author":"JH Cho","year":"2011","unstructured":"Cho JH, Gregersen PK : Genomics and the multifactorial nature of human autoimmune disease. New Engl J Med 2011; 365: 1612\u20131623.","journal-title":"New Engl J Med"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg2014158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2014158","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg2014158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:11:39Z","timestamp":1684429899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg2014158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,17]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["BFejhg2014158"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2014.158","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,17]]},"assertion":[{"value":"27 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}