{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:42:48Z","timestamp":1791873768367,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/ejhg.2014.26","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T11:26:47Z","timestamp":1393414007000},"page":"1314-1320","source":"Crossref","is-referenced-by-count":24,"title":["Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy"],"prefix":"10.1038","volume":"22","author":[{"given":"Fiona C","family":"Mansergh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Chadderton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F","family":"Kenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliviero L","family":"Gobbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Jane","family":"Farrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"BFejhg201426_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1136\/jmg.2007.054270","volume":"46","author":"P Yu-Wai-Man","year":"2009","unstructured":"Yu-Wai-Man P, Griffiths PG, Hudson G et al: Inherited mitochondrial optic neuropathies. J Med Genet 2009; 46: 145\u2013158.","journal-title":"J Med Genet"},{"key":"BFejhg201426_CR2","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.tig.2013.05.005","volume":"29","author":"GJ Farrar","year":"2013","unstructured":"Farrar GJ, Chadderton N, Kenna PF et al: Mitochondrial disorders: aetiologies, models systems, and candidate therapies. Trends Genet 2013; 29: 488\u2013497.","journal-title":"Trends Genet"},{"key":"BFejhg201426_CR3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/ejhg.2012.112","volume":"21","author":"N Chadderton","year":"2013","unstructured":"Chadderton N, Palfi A, Millington-Ward S et al: J. Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy. Eur J Hum Genet 2013; 21: 62\u201368.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg201426_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.preteyeres.2010.11.002","volume":"30","author":"P Yu-Wai-Man","year":"2011","unstructured":"Yu-Wai-Man P, Griffiths PG, Chinnery PF : Mitochondrial optic neuropathies- disease mechanisms and therapeutic strategies. Prog Retin Eye Res 2011; 30: 81\u2013114.","journal-title":"Prog Retin Eye Res"},{"key":"BFejhg201426_CR5","doi-asserted-by":"publisher","first-page":"20065","DOI":"10.1073\/pnas.1217113109","volume":"109","author":"CS Lin","year":"2012","unstructured":"Lin CS, Sharpley MS, Fan W : Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci USA 2012; 109: 20065\u201320070.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFejhg201426_CR6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/79944","volume":"26","author":"C Alexander","year":"2000","unstructured":"Alexander C, Votruba M, Pesch UE et al: OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat Genet 2000; 26: 211\u2013215.","journal-title":"Nat Genet"},{"key":"BFejhg201426_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s00439-001-0645-7","volume":"110","author":"T Aung","year":"2002","unstructured":"Aung T, Ocaka L, Ebenezer ND et al: A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene. Hum Genet 2002; 110: 52\u201356.","journal-title":"Hum Genet"},{"key":"BFejhg201426_CR8","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1167\/iovs.12-9596","volume":"53","author":"S Lee","year":"2012","unstructured":"Lee S, Sheck L, Crowston JG et al: Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts. Invest Ophthalmol Vis Sci 2012; 53: 2431\u20132437.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFejhg201426_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0304-3940(02)00327-0","volume":"326","author":"X Zhang","year":"2002","unstructured":"Zhang X, Jones D, Gonzalez-Lima F : Mouse model of optic neuropathy caused by mitochondrial complex I dysfunction. Neurosci Lett 2002; 326: 97\u2013100.","journal-title":"Neurosci Lett"},{"key":"BFejhg201426_CR10","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1080\/15287390600630203","volume":"69","author":"X Zhang","year":"2006","unstructured":"Zhang X, Jones D, Gonzalez-Lima F : Neurodegeneration produced by rotenone in the mouse retina: a potential model to investigate environmental pesticide contributions to neurodegenerative diseases. J Toxicol Environ Health A 2006; 69: 1681\u20131697.","journal-title":"J Toxicol Environ Health A"},{"key":"BFejhg201426_CR11","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1080\/15287390802414190","volume":"71","author":"CR Hayworth","year":"2008","unstructured":"Hayworth CR, Rojas JC, Gonzalez-Lima F : Transgenic mice expressing cyan fluorescent protein as a reporter strain to detect the effects of rotenone toxicity on retinal ganglion cells. J Toxicol Environ Health A 2008; 71: 1582\u20131592.","journal-title":"J Toxicol Environ Health A"},{"key":"BFejhg201426_CR12","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.exer.2008.01.018","volume":"86","author":"U Bartsch","year":"2008","unstructured":"Bartsch U, Oriyakhel W, Kenna PF et al: Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice. Exp Eye Res 2008; 86: 691\u2013700.","journal-title":"Exp Eye Res"},{"key":"BFejhg201426_CR13","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3727\/096368911X623871","volume":"21","author":"E West","year":"2012","unstructured":"West E, Pearson R, Duran Y et al: Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival. Cell Transplant 2012; 21: 871\u2013887.","journal-title":"Cell Transplant"},{"key":"BFejhg201426_CR14","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.exer.2010.07.003","volume":"91","author":"FC Mansergh","year":"2010","unstructured":"Mansergh FC, Vawda R, Millington-Ward S et al: Loss of photoreceptor potential from retinal progenitor cell cultures, despite improvements in survival. Exp Eye Res 2010; 91: 500\u2013512.","journal-title":"Exp Eye Res"},{"key":"BFejhg201426_CR15","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1093\/hmg\/ddi336","volume":"14","author":"F Mansergh","year":"2005","unstructured":"Mansergh F, Orton NC, Vessey JP et al: Mutation of the calcium channel gene Cacna1f disrupts calcium signaling, synaptic transmission and cellular organization in mouse retina. Hum Mol Genet 2005; 14: 3035\u20133046.","journal-title":"Hum Mol Genet"},{"key":"BFejhg201426_CR16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.ymthe.2005.03.028","volume":"12","author":"S Kiang","year":"2005","unstructured":"Kiang S, Palfi A, Ader M et al: Toward a gene therapy for dominant disease; validation of an RNA interference based mutation independent approach. Mol Ther 2005; 12: 555\u2013561.","journal-title":"Mol Ther"},{"key":"BFejhg201426_CR17","first-page":"365","volume":"124","author":"RG Pautler","year":"2006","unstructured":"Pautler RG : Biological applications of manganese-enhanced magnetic resonance imaging. Methods Mol Med 2006; 124: 365\u2013386.","journal-title":"Methods Mol Med"},{"key":"BFejhg201426_CR18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nature05161","volume":"444","author":"RE MacLaren","year":"2006","unstructured":"MacLaren RE, Pearson RA, MacNeil A et al: Retinal repair by transplantation of photoreceptor precursors. Nature 2006; 444: 203\u2013207.","journal-title":"Nature"},{"key":"BFejhg201426_CR19","doi-asserted-by":"publisher","first-page":"e46305","DOI":"10.1371\/journal.pone.0046305","volume":"7","author":"D Eberle","year":"2012","unstructured":"Eberle D, Kurth T, Santos-Ferreira T et al: Outer segment formation of transplanted photoreceptor precursor cells. PLoS One 2012; 7: e46305.","journal-title":"PLoS One"},{"key":"BFejhg201426_CR20","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/stem.602","volume":"29","author":"VA Wallace","year":"2011","unstructured":"Wallace VA : Concise review: making a retina\u2014from the building blocks to clinical applications. Stem Cells 2011; 29: 412\u2013417.","journal-title":"Stem Cells"},{"key":"BFejhg201426_CR21","doi-asserted-by":"publisher","first-page":"e41798","DOI":"10.1371\/journal.pone.0041798","volume":"7","author":"M Czekaj","year":"2012","unstructured":"Czekaj M, Haas J, Gebhardt M et al: In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes. PLoS One 2012; 7: e41798.","journal-title":"PLoS One"},{"key":"BFejhg201426_CR22","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1002\/cne.22062","volume":"515","author":"F Richter","year":"2009","unstructured":"Richter F, Meurers BH, Zhu C et al: Neurons express hemoglobin alpha- and beta-chains in rat and human brains. J Comp Neurol 2009; 515: 538\u2013547.","journal-title":"J Comp Neurol"},{"key":"BFejhg201426_CR23","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1167\/iovs.09-4014","volume":"51","author":"G Tezel","year":"2010","unstructured":"Tezel G, Yang X, Luo C et al: Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation. Invest Ophthalmol Vis Sci 2010; 51: 907\u2013919.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFejhg201426_CR24","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1387\/ijdb.082597fm","volume":"52","author":"FC Mansergh","year":"2008","unstructured":"Mansergh FC, Hunter SM, Geatrell JC et al: Developmentally regulated expression of hemoglobin subunits in avascular tissues. Int J Dev Biol 2008; 52: 873\u2013886.","journal-title":"Int J Dev Biol"},{"key":"BFejhg201426_CR25","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1002\/stem.520","volume":"28","author":"EL West","year":"2010","unstructured":"West EL, Pearson RA, Barker SE et al: Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem Cells 2010; 28: 1997\u20132007.","journal-title":"Stem Cells"},{"key":"BFejhg201426_CR26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.4065\/84.10.859","volume":"84","author":"T O'Brien","year":"2009","unstructured":"O'Brien T, Barry FP : Stem cell therapy and regenerative medicine. Mayo Clin Proc 2009; 84: 859\u2013861.","journal-title":"Mayo Clin Proc"},{"key":"BFejhg201426_CR27","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/leu.2011.389","volume":"26","author":"MZ Ratajczak","year":"2012","unstructured":"Ratajczak MZ, Kucia M, Jadczyk T et al: Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? Leukemia 2012; 26: 1166\u20131173.","journal-title":"Leukemia"},{"key":"BFejhg201426_CR28","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1002\/stem.1364","volume":"31","author":"R Manuguerra-Gagn\u00e9","year":"2013","unstructured":"Manuguerra-Gagn\u00e9 R, Boulos PR, Ammar A et al: Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment. Stem Cells 2013; 31: 1136\u20131148.","journal-title":"Stem Cells"},{"key":"BFejhg201426_CR29","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1006\/exer.1997.0388","volume":"65","author":"T FitzGibbon","year":"1997","unstructured":"FitzGibbon T, Nestorovski Z : Morphological consequences of myelination in the human retina. Exp Eye Res 1997; 65: 809\u2013819.","journal-title":"Exp Eye Res"},{"key":"BFejhg201426_CR30","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.jaapos.2010.08.008","volume":"14","author":"R Duval","year":"2010","unstructured":"Duval R, Hammamji K, Aroichane M et al: Acquired myelinated nerve fibers in association with optic disk drusen. J AAPOS 2010; 14: 544\u2013547.","journal-title":"J AAPOS"},{"key":"BFejhg201426_CR31","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/978-1-61779-370-7_8","volume":"807","author":"K Stieger","year":"2011","unstructured":"Stieger K, Cronin T, Bennett J, Rolling F : Adeno-associated virus mediated gene therapy for retinal degenerative diseases. Methods Mol Biol 2011; 807: 179\u2013218.","journal-title":"Methods Mol Biol"},{"key":"BFejhg201426_CR32","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ajhg.2008.08.013","volume":"83","author":"S Ellouze","year":"2008","unstructured":"Ellouze S, Augustin S, Bouaita A et al: Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction. Am J Hum Genet 2008; 83: 373\u2013387.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201426_CR33","doi-asserted-by":"publisher","first-page":"E1238","DOI":"10.1073\/pnas.1119577109","volume":"109","author":"H Yu","year":"2012","unstructured":"Yu H, Koilkonda RD, Chou TH et al: Gene delivery to mitochondria by targeting modified adeno-associated virus suppresses Leber's hereditary optic neuropathy in a mouse model. Proc Natl Acad Sci USA 2012; 109: E1238\u2013E1247.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg201426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201426","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:12:36Z","timestamp":1684429956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg201426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["BFejhg201426"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2014.26","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]}}}