{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:52:10Z","timestamp":1790175130482,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"},{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1038\/ejhg.2016.42","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T10:22:57Z","timestamp":1462962177000},"page":"1460-1466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Clinical exome sequencing for cerebellar ataxia and spastic paraplegia uncovers novel gene\u2013disease associations and unanticipated rare disorders"],"prefix":"10.1038","volume":"24","author":[{"given":"Bart P","family":"van de Warrenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meyke I","family":"Schouten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne T","family":"de Bot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Vermeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowdy","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"Pennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gilissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8l AAP","family":"Willemsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Scheffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik-Jan","family":"Kamsteeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"BFejhg201642_CR1","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1093\/brain\/awt236","volume":"136","author":"AH Nemeth","year":"2013","unstructured":"Nemeth AH, Kwasniewska AC, Lise S et al: Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model. Brain 2013; 136: 3106\u20133118.","journal-title":"Brain"},{"key":"BFejhg201642_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10048-013-0375-8","volume":"14","author":"C Ohba","year":"2013","unstructured":"Ohba C, Osaka H, Iai M et al: Diagnostic utility of whole exome sequencing in patients showing cerebellar and\/or vermis atrophy in childhood. Neurogenetics 2013; 14: 225\u2013232.","journal-title":"Neurogenetics"},{"key":"BFejhg201642_CR3","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1126\/science.1247363","volume":"343","author":"G Novarino","year":"2014","unstructured":"Novarino G, Fenstermaker AG, Zaki MS et al: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science 2014; 343: 506\u2013511.","journal-title":"Science"},{"key":"BFejhg201642_CR4","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1001\/jamaneurol.2014.1944","volume":"71","author":"BL Fogel","year":"2014","unstructured":"Fogel BL, Lee H, Deignan JL et al: Exome sequencing in the clinical diagnosis of sporadic or familial cerebellar ataxia. JAMA Neurol 2014; 71: 1237\u20131246.","journal-title":"JAMA Neurol"},{"key":"BFejhg201642_CR5","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1002\/humu.22450","volume":"34","author":"K Neveling","year":"2013","unstructured":"Neveling K, Feenstra I, Gilissen C et al: A post-hoc comparison of the utility of sanger sequencing and exome sequencing for the diagnosis of heterogeneous diseases. Hum Mutat 2013; 34: 1721\u20131726.","journal-title":"Hum Mutat"},{"key":"BFejhg201642_CR6","unstructured":"Bird TD : Hereditary ataxia overview; in: Pagon RA, Adam MP, Ardinger HH et al (eds): GeneReviews(R): Seattle, WA, 1993."},{"key":"BFejhg201642_CR7","unstructured":"Fink JK : Hereditary spastic paraplegia overview; in: Pagon RA Adam MP, Ardinger HH et al (eds): GeneReviews(R): Seattle, WA, 1993."},{"key":"BFejhg201642_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.nbd.2008.06.002","volume":"32","author":"TD Graves","year":"2008","unstructured":"Graves TD, Imbrici P, Kors EE et al: Premature stop codons in a facilitating EF-hand splice variant of CaV2.1 cause episodic ataxia type 2. Neurobiol Dis 2008; 32: 10\u201315.","journal-title":"Neurobiol Dis"},{"key":"BFejhg201642_CR9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.ajhg.2011.04.011","volume":"88","author":"MA Corbett","year":"2011","unstructured":"Corbett MA, Schwake M, Bahlo M et al: A mutation in the Golgi Qb-SNARE gene GOSR2 causes progressive myoclonus epilepsy with early ataxia. Am J Hum Genet 2011; 88: 657\u2013663.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201642_CR10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/humu.21165","volume":"31","author":"KP Figueroa","year":"2010","unstructured":"Figueroa KP, Minassian NA, Stevanin G et al: KCNC3: phenotype, mutations, channel biophysics-a study of 260 familial ataxia patients. Hum Mutat 2010; 31: 191\u2013196.","journal-title":"Hum Mutat"},{"key":"BFejhg201642_CR11","doi-asserted-by":"publisher","first-page":"E376","DOI":"10.1002\/humu.20920","volume":"30","author":"C Goizet","year":"2009","unstructured":"Goizet C, Boukhris A, Mundwiller E et al: Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10. Hum Mutat 2009; 30: E376\u2013E385.","journal-title":"Hum Mutat"},{"key":"BFejhg201642_CR12","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1159\/000105160","volume":"4","author":"J Johnson","year":"2007","unstructured":"Johnson J, Paisan-Ruiz C, Lopez G et al: Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation. Neurodegener Dis 2007; 4: 386\u2013391.","journal-title":"Neurodegener Dis"},{"key":"BFejhg201642_CR13","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1007\/s00439-001-0633-y","volume":"109","author":"C Delettre","year":"2001","unstructured":"Delettre C, Griffoin JM, Kaplan J et al: Mutation spectrum and splicing variants in the OPA1 gene. Hum Genet 2001; 109: 584\u2013591.","journal-title":"Hum Genet"},{"key":"BFejhg201642_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ng0597-88","volume":"16","author":"G Matthijs","year":"1997","unstructured":"Matthijs G, Schollen E, Pardon E et al: Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Nat Genet 1997; 16: 88\u201392.","journal-title":"Nat Genet"},{"key":"BFejhg201642_CR15","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1006\/mgme.1999.2914","volume":"68","author":"G Matthijs","year":"1999","unstructured":"Matthijs G, Schollen E, Heykants L, Grunewald S : Phosphomannomutase deficiency: the molecular basis of the classical Jaeken syndrome (CDGS type Ia). Mol Genet Metab 1999; 68: 220\u2013226.","journal-title":"Mol Genet Metab"},{"key":"BFejhg201642_CR16","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1136\/jmedgenet-2014-102813","volume":"52","author":"MG Blanchard","year":"2015","unstructured":"Blanchard MG, Willemsen MH, Walker JB et al: De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy. J Med Genet 2015; 52: 330\u2013337.","journal-title":"J Med Genet"},{"key":"BFejhg201642_CR17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1212\/WNL.56.4.467","volume":"56","author":"CJ McDermott","year":"2001","unstructured":"McDermott CJ, Dayaratne RK, Tomkins J et al: Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees in northeast England. Neurology 2001; 56: 467\u2013471.","journal-title":"Neurology"},{"key":"BFejhg201642_CR18","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1212\/01.wnl.0000319700.11606.21","volume":"71","author":"F Brugman","year":"2008","unstructured":"Brugman F, Scheffer H, Wokke JH et al: Paraplegin mutations in sporadic adult-onset upper motor neuron syndromes. Neurology 2008; 71: 1500\u20131505.","journal-title":"Neurology"},{"key":"BFejhg201642_CR19","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1101\/gr.176601","volume":"11","author":"PC Ng","year":"2001","unstructured":"Ng PC, Henikoff S : Predicting deleterious amino acid substitutions. Genome Res 2001; 11: 863\u2013874.","journal-title":"Genome Res"},{"key":"BFejhg201642_CR20","unstructured":"Casari G, Marconi R : Spastic paraplegia 7; in: Pagon RA, Adam MP, Ardinger HH et al (eds): GeneReviews(R): Seattle, WA, 1993."},{"key":"BFejhg201642_CR21","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1093\/brain\/aws224","volume":"135","author":"KL van Gassen","year":"2012","unstructured":"van Gassen KL, van der Heijden CD, de Bot ST et al: Genotype-phenotype correlations in spastic paraplegia type 7: a study in a large Dutch cohort. Brain 2012; 135: 2994\u20133004.","journal-title":"Brain"},{"key":"BFejhg201642_CR22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fgene.2013.00213","volume":"4","author":"JE O'Brien","year":"2013","unstructured":"O'Brien JE, Meisler MH : Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability. Front Genet 2013; 4: 213.","journal-title":"Front Genet"},{"key":"BFejhg201642_CR23","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1093\/brain\/awt021","volume":"136","author":"L Boisse Lomax","year":"2013","unstructured":"Boisse Lomax L, Bayly MA, Hjalgrim H et al: 'North Sea' progressive myoclonus epilepsy: phenotype of subjects with GOSR2 mutation. Brain 2013; 136: 1146\u20131154.","journal-title":"Brain"},{"key":"BFejhg201642_CR24","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s10545-011-9328-2","volume":"34","author":"AI Vega","year":"2011","unstructured":"Vega AI, Perez-Cerda C, Abia D et al: Expression analysis revealing destabilizing mutations in phosphomannomutase 2 deficiency (PMM2-CDG): expression analysis of PMM2-CDG mutations. J Inherit Metab Dis 2011; 34: 929\u2013939.","journal-title":"J Inherit Metab Dis"},{"key":"BFejhg201642_CR25","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1007\/s00415-007-0546-3","volume":"254","author":"S Vermeer","year":"2007","unstructured":"Vermeer S, Kremer HP, Leijten QH et al: Cerebellar ataxia and congenital disorder of glycosylation Ia (CDG-Ia) with normal routine CDG screening. J Neurol 2007; 254: 1356\u20131358.","journal-title":"J Neurol"},{"key":"BFejhg201642_CR26","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.jocn.2006.04.008","volume":"14","author":"D Coman","year":"2007","unstructured":"Coman D, McGill J, MacDonald R et al: Congenital disorder of glycosylation type 1a: three siblings with a mild neurological phenotype. J Clin Neurosci 2007; 14: 668\u2013672.","journal-title":"J Clin Neurosci"},{"key":"BFejhg201642_CR27","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1093\/brain\/awu165","volume":"137","author":"T Bonifert","year":"2014","unstructured":"Bonifert T, Karle KN, Tonagel F et al: Pure and syndromic optic atrophy explained by deep intronic OPA1 mutations and an intralocus modifier. Brain 2014; 137: 2164\u20132177.","journal-title":"Brain"},{"key":"BFejhg201642_CR28","doi-asserted-by":"publisher","first-page":"e1000408","DOI":"10.1371\/journal.pbio.1000408","volume":"8","author":"M Slabicki","year":"2010","unstructured":"Slabicki M, Theis M, Krastev DB et al: A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol 2010; 8: e1000408.","journal-title":"PLoS Biol"},{"key":"BFejhg201642_CR29","first-page":"4","volume":"2","author":"NA Schlipf","year":"2014","unstructured":"Schlipf NA, Sch\u00fcle R, Klimpe S et al: AP5Z1\/SPG48 frequency in autosomal recessive and sporadic spastic paraplegia. Mol Genet Genom Med 2014; 2: 4.","journal-title":"Mol Genet Genom Med"},{"key":"BFejhg201642_CR30","doi-asserted-by":"publisher","first-page":"e1003066","DOI":"10.1371\/journal.pgen.1003066","volume":"8","author":"P Fuger","year":"2012","unstructured":"Fuger P, Sreekumar V, Schule R et al: Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model. PLoS Genet 2012; 8: e1003066.","journal-title":"PLoS Genet"},{"key":"BFejhg201642_CR31","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1172\/JCI60560","volume":"122","author":"G Montenegro","year":"2012","unstructured":"Montenegro G, Rebelo AP, Connell J et al: Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12. J Clin Invest 2012; 122: 538\u2013544.","journal-title":"J Clin Invest"},{"key":"BFejhg201642_CR32","doi-asserted-by":"publisher","first-page":"e223","DOI":"10.1093\/brain\/aws201","volume":"135","author":"ST de Bot","year":"2012","unstructured":"de Bot ST, Schelhaas HJ, Kamsteeg EJ, van de Warrenburg BP : Hereditary spastic paraplegia caused by a mutation in the VCP gene. Brain 2012; 135: e223, author reply e224.","journal-title":"Brain"},{"key":"BFejhg201642_CR33","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1212\/01.wnl.0000225184.14578.d3","volume":"67","author":"L Guyant-Marechal","year":"2006","unstructured":"Guyant-Marechal L, Laquerriere A, Duyckaerts C et al: Valosin-containing protein gene mutations: clinical and neuropathologic features. Neurology 2006; 67: 644\u2013651.","journal-title":"Neurology"},{"key":"BFejhg201642_CR34","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1093\/brain\/awq087","volume":"133","author":"MA Willemsen","year":"2010","unstructured":"Willemsen MA, Verbeek MM, Kamsteeg EJ et al: Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis. Brain 2010; 133: 1810\u20131822.","journal-title":"Brain"},{"key":"BFejhg201642_CR35","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1007\/s00415-014-7265-3","volume":"261","author":"Z Fan","year":"2014","unstructured":"Fan Z, Greenwood R, Felix AC et al: GCH1 heterozygous mutation identified by whole-exome sequencing as a treatable condition in a patient presenting with progressive spastic paraplegia. J Neurol 2014; 261: 622\u2013624.","journal-title":"J Neurol"},{"key":"BFejhg201642_CR36","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/ejhg.2011.261","volume":"20","author":"S Klebe","year":"2012","unstructured":"Klebe S, Lossos A, Azzedine H et al: KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations. Eur J Hum Genet 2012; 20: 645\u2013649.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg201642_CR37","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.ajhg.2011.02.001","volume":"88","author":"FF Hamdan","year":"2011","unstructured":"Hamdan FF, Gauthier J, Araki Y et al: Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am J Hum Genet 2011; 88: 306\u2013316.","journal-title":"Am J Hum Genet"},{"key":"BFejhg201642_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/humu.22709","volume":"36","author":"JR Lee","year":"2015","unstructured":"Lee JR, Srour M, Kim D et al: De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy. Hum Mutat 2015; 36: 69\u201378.","journal-title":"Hum Mutat"},{"key":"BFejhg201642_CR39","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1038\/ejhg.2014.297","volume":"23","author":"E Ylikallio","year":"2015","unstructured":"Ylikallio E, Kim D, Isohanni P et al: Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia. Eur J Hum Genet 2015; 23: 1427\u20131430.","journal-title":"Eur J Hum Genet"},{"key":"BFejhg201642_CR40","unstructured":"Durr A, Tallaksen C, Depienne C : Spastic paraplegia 4; in: Pagon RA, Adam MP, Ardinger HH et al (eds): GeneReviews(R): Seattle, WA, 1993."},{"key":"BFejhg201642_CR41","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1212\/WNL.0b013e31826d5fb0","volume":"79","author":"ST de Bot","year":"2012","unstructured":"de Bot ST, Willemsen MA, Vermeer S, Kremer HP, van de Warrenburg BP : Reviewing the genetic causes of spastic-ataxias. Neurology 2012; 79: 1507\u20131514.","journal-title":"Neurology"},{"key":"BFejhg201642_CR42","doi-asserted-by":"publisher","first-page":"e383","DOI":"10.1093\/brain\/awv087","volume":"138","author":"E Sandford","year":"2015","unstructured":"Sandford E, Li JZ, Burmeister M : Evaluation of exome sequencing variation in undiagnosed ataxias. Brain 2015; 138: e383.","journal-title":"Brain"},{"key":"BFejhg201642_CR43","doi-asserted-by":"publisher","first-page":"e384","DOI":"10.1093\/brain\/awv088","volume":"138","author":"A Pyle","year":"2015","unstructured":"Pyle A, Griffin H, Keogh MJ, Horvath R, Chinnery PF : Reply: Evaluation of exome sequencing variation in undiagnosed ataxias. Brain 2015; 138: e384.","journal-title":"Brain"},{"key":"BFejhg201642_CR44","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/brain\/awu348","volume":"138","author":"A Pyle","year":"2015","unstructured":"Pyle A, Smertenko T, Bargiela D et al: Exome sequencing in undiagnosed inherited and sporadic ataxias. Brain 2015; 138: 276\u2013283.","journal-title":"Brain"},{"key":"BFejhg201642_CR45","doi-asserted-by":"publisher","first-page":"e1002325","DOI":"10.1371\/journal.pgen.1002325","volume":"7","author":"TM Pierson","year":"2011","unstructured":"Pierson TM, Adams D, Bonn F et al: Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases. PLoS Genet 2011; 7: e1002325.","journal-title":"PLoS Genet"}],"updated-by":[{"DOI":"10.1038\/ejhg.2016.168","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T00:00:00Z","timestamp":1486598400000}}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ejhg201642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201642","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ejhg201642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:17:30Z","timestamp":1684430250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ejhg201642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,11]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["BFejhg201642"],"URL":"https:\/\/doi.org\/10.1038\/ejhg.2016.42","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/ejhg.2016.168","asserted-by":"object"}]},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,11]]},"assertion":[{"value":"14 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}